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A randomized, open-label study of the safety and efficacy of switching stavudine or zidovudine to tenofovir disoproxil fumarate in HIV-1-infected children with virologic suppression.

Author: ArterburnSarah, CastañoElizabeth, ChengAndrew K, ChuckSteven L, ChurchJoseph, DevilleJaime, EnejosaJeffrey V, EstripeautDora, GaurAditya, RathoreMobeen, RheeMartin S, Saez-LlorensXavier, WhiteKirsten

Clinical TrialA clinical trial is a planned study conducted on humans to evaluate the efficacy and safety of pharmaceuticals, medical devices, and treatment methods. It aims to explore the possibilities of new treatments and improve the health of patients.
Comparative StudyResearch that compares multiple groups/interventions to determine differences/similarities in outcomes/characteristics.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.

Overview

Tenofovir disoproxil fumarate (TDF) may be considered as an alternative to stavudine or zidovudine in HIV-infected children, but further research is needed to determine noninferiority to these drugs.
Paper Details　
Original Abstract of the Article :
BACKGROUND: The safety and efficacy of tenofovir disoproxil fumarate (TDF) in HIV-1-infected children have not been evaluated in a randomized controlled trial. METHODS: Subjects (2 to <16 years) on a stavudine (d4T) or zidovudine (ZDV) containing regimen with HIV-1 RNA <400 copies/mL were randomize...See full text at original site
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引用元：
https://pubmed.ncbi.nlm.nih.gov/25760565

データ提供：米国国立医学図書館（NLM）

Switching Antiretroviral Therapies: A Safer Path for Children

This research dives deep into the realm of virology, focusing on the treatment of HIV-1 infection in children. The study examines the safety and efficacy of switching from stavudine or zidovudine to tenofovir disoproxil fumarate (TDF) in children with suppressed viral loads. The study found that TDF is generally well-tolerated in children, with no significant adverse events. The findings suggest that TDF could be a viable alternative to stavudine or zidovudine for managing HIV-1 infection in children.

TDF: A Promising Alternative for Children with HIV

This study provides evidence that TDF could be a safe and effective alternative for children with HIV-1. It's like discovering a new oasis in the desert of HIV treatment options, offering a potential solution for children who may not tolerate other medications.

Navigating the Treatment Landscape of HIV in Children

Finding the right treatment for children with HIV-1 requires a careful balance of safety, efficacy, and individual tolerance. This study helps to inform treatment decisions for children, providing evidence for the use of TDF as a potential alternative. It's like navigating the shifting sands of the HIV treatment landscape, finding the most suitable path for each individual child.

Dr.Camel's Conclusion

This research provides valuable insights into the safety and efficacy of tenofovir disoproxil fumarate (TDF) in children with HIV-1 infection. The findings suggest that TDF could be a safe and effective alternative to stavudine or zidovudine, offering a potential pathway to improved treatment outcomes for children. This research is a testament to the continuous search for better and safer treatment options for those living with HIV.

Date :
  1. Date Completed 2015-11-16
  2. Date Revised 2015-11-19
Further Info :

Pubmed ID

25760565

DOI: Digital Object Identifier

00006454-201504000-00010

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Languages

English

Positive IndicatorAn AI analysis index that serves as a benchmark for how positive the results of the study are. Note that it is a benchmark and requires careful interpretation and consideration of different perspectives.

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