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Original Abstract of the Article :
Ketoconazole was the first broad-spectrum oral antifungal agent available to treat systemic and superficial mycoses. Evidence of hepatotoxicity associated with its use emerged within the first few years of its approval. Growing evidence of serious side effects including endocrine dysregulation, seve...See full text at original site
Dr.Camel's Paper Summary Blogラクダ博士について
ラクダ博士は、Health Journal が論文の内容を分かりやすく解説するために作成した架空のキャラクターです。
難解な医学論文を、専門知識のない方にも理解しやすいように、噛み砕いて説明することを目指しています。
* ラクダ博士による解説は、あくまで論文の要点をまとめたものであり、原論文の完全な代替となるものではありません。詳細な内容については、必ず原論文をご参照ください。
* ラクダ博士は架空のキャラクターであり、実際の医学研究者や医療従事者とは一切関係がありません。
* 解説の内容は Health Journal が独自に解釈・作成したものであり、原論文の著者または出版社の見解を反映するものではありません。
引用元:
https://doi.org/10.1177/1203475415574970
データ提供:米国国立医学図書館(NLM)
The Rise and Fall of Oral Ketoconazole: A Tale of Two Deserts
The world of medicine is a vast and ever-changing landscape. Drugs, like desert oases, can appear promising at first, but sometimes their true nature is revealed over time. This article delves into the history of oral ketoconazole, a drug once hailed as a beacon of hope for fungal infections, but later found to have significant side effects.
The Shifting Sands of Medical Knowledge: A Cautionary Tale
The discovery of ketoconazole was a triumph, like discovering a lush oasis in a barren desert. However, as time passed, concerns emerged about its safety, particularly regarding its potential for hepatotoxicity and endocrine disruption. The initial promise faded like a mirage, leaving behind a cautionary tale about the importance of ongoing research and monitoring in the realm of medicine.
Navigating the Medical Landscape: The Camel's Perspective
This article reminds us that even the most promising treatments can have hidden dangers. It underscores the importance of vigilance and a constant quest for safer and more effective therapies. It's a reminder that the medical landscape, like a desert, can be treacherous, but with careful navigation, we can find our way to safer shores.
Dr. Camel's Conclusion
This account of ketoconazole's rise and fall is a reminder that the medical world is a dynamic landscape, constantly evolving as our understanding of disease and treatment progresses. It's a journey of discovery, where we must be prepared to adapt and evolve alongside the sands of time.
Date :
- Date Completed 2015-10-01
- Date Revised 2016-11-25
Further Info :
Related Literature
English
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