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Add-back therapy with GnRH analogues for uterine fibroids.

Author: BritoLuiz Gustavo, Candido Dos ReisFrancisco José, FerrianiRui A, MartinsWellington P, MoroniRafael M, NastriCarolina O, VieiraCarolina S

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Overview

Uterine fibroids are common in women and can cause bleeding and pain. GnRH analogues are the most effective medication for fibroids, but long-term use causes side effects. Adding other medications (add-back therapy) may reduce these side effects, but could also decrease the effectiveness of GnRH analogues and may not completely prevent side effects.
Paper Details　
Original Abstract of the Article :
Uterine fibroids (also known as leiomyomas) are the most common benign pelvic tumours among women. They may be asymptomatic, or may be associated with pelvic symptoms such as bleeding and pain. Medical treatment of this condition is limited and gonadotropin-releasing hormone (GnRH) analogues are the...See full text at original site
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引用元：
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6984643/

データ提供：米国国立医学図書館（NLM）

Uterine Fibroids: Navigating the Shifting Sands of Treatment

Uterine fibroids, benign tumors that can affect the uterus, can cause a range of symptoms, from discomfort to more serious complications. This research delves into the world of uterine fibroid treatment, focusing on the use of gonadotropin-releasing hormone (GnRH) analogues, which are effective but often come with unwanted side effects. The study investigates the potential benefits and limitations of add-back therapy, a strategy that combines GnRH analogues with other medications to mitigate these side effects. Researchers explore the complexities of managing uterine fibroids, seeking to find a balance between efficacy and safety.

Add-Back Therapy: A Potential Oasis in the Desert of Side Effects

The study explores the use of add-back therapy, a strategy that aims to mitigate the side effects of GnRH analogues while preserving their efficacy. While further research is needed to fully understand the effectiveness of this approach, the study provides valuable insights into the potential benefits of add-back therapy for managing uterine fibroids. This strategy offers a glimmer of hope for individuals seeking to minimize side effects while maintaining effective treatment.

A Journey Toward Managing Uterine Fibroids

Managing uterine fibroids, like navigating a shifting sandscape, requires a multifaceted approach. Understanding the potential benefits and limitations of various treatments, including GnRH analogues and add-back therapy, is crucial for making informed decisions about care. Working closely with healthcare professionals can help individuals navigate the complexities of uterine fibroid management and find the most effective approach for their individual needs.

Dr.Camel's Conclusion

This research illuminates the challenges and complexities of managing uterine fibroids, emphasizing the importance of finding a balance between treatment efficacy and minimizing side effects. Add-back therapy offers a potential oasis in the desert of side effects associated with GnRH analogues. By understanding the potential benefits and limitations of various treatment options, individuals can make informed decisions and embark on a journey toward managing uterine fibroids effectively and safely.

Date :
  1. Date Completed 2015-10-02
  2. Date Revised 2023-09-26
Further Info :

Pubmed ID

25793972

DOI: Digital Object Identifier

PMC6984643

SNS
PICO Info
in preparation
Languages

English

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