Effective treatment of uterine fibroids: A Synthesis of Findings from 60 Studies

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Original Abstract of the Article

Key research findings

Uterine fibroids are the most common benign uterine tumors found in women of reproductive age. 18 . Fibroids can cause symptoms such as heavy menstrual bleeding, pelvic pressure, and pain. 18 . Treatments for uterine fibroids include medication, surgery, and minimally invasive procedures. 21 . Recent research has focused on minimally invasive procedures such as uterine artery embolization (UAE) and magnetic resonance imaging-guided focused ultrasound surgery (MRgFUS). 22 , 30 , 36 . UAE involves injecting tiny particles into the uterine arteries to block blood flow to fibroids. 26 . MRgFUS uses focused ultrasound waves to heat and destroy fibroid tissue. 22 .

Treatment summary

Treatment for uterine fibroids can include surgery, medications, and minimally invasive procedures. 21 . Surgical treatments include myomectomy (removal of fibroids) and hysterectomy (removal of the uterus). 8 , 25 , 28 , 37 , 51 . Medications include progesterone receptor modulators, GnRH analogs, and danazol. 17 , 18 , 21 , 31 , 10 , 27 , 14 , 46 . Minimally invasive procedures include UAE and MRgFUS. 22 , 26 , 23 , 30 , 36 , 50 , 45 , 4 , 53 , 38 , 57 , 12 , 49 , 6 , 11 , 3 , 2 .

Benefits and risks

Benefit summary

Treatments for uterine fibroids can help improve symptoms and preserve the uterus. 22 , 25 , 28 , 30 , 36 , 50 . Preserving the uterus is important for women who wish to have children in the future. 22 , 25 , 33 , 16 , 9 , 57 .

Risk summary

Treatments for uterine fibroids can carry risks such as bleeding, infection, and pain. 25 , 37 . Medications, such as GnRH analogs, can have side effects such as osteoporosis and menopause-like symptoms. 27 . Minimally invasive procedures like UAE and MRgFUS have potential concerns about uterine function and impact on future pregnancies. 33 , 22 .

Comparison between studies

Commonalities among studies

Many studies examine various treatment options for uterine fibroids, including surgical, medical, and minimally invasive approaches. 21 . These studies highlight that each treatment approach has its own benefits and drawbacks. 25 , 30 .

Differences among studies

Studies often vary in their findings regarding effectiveness, side effects, and safety. 25 , 30 . For example, UAE has shown to be effective in shrinking fibroids, but concerns about its impact on future pregnancies exist. 33 . MRgFUS might have a lesser impact on future pregnancies compared to UAE, but its effectiveness can be less significant. 22 .

Consistency and contradictions in results

Research on treatments for uterine fibroids is still in progress. 21 . As a result, research findings can be inconsistent and contradictions may emerge. 22 , 30 . Additionally, differences in research methods and evaluation criteria make direct comparison of study results challenging. 25 .

Cautions in applying results to real life

Treatment for uterine fibroids should be tailored to each individual patient's circumstances. 21 . Therefore, it's essential to discuss treatment options with a doctor and select the most appropriate one. 25 . It's also important to understand the benefits and drawbacks of each treatment option and obtain sufficient information before making a decision. 30 .

Limitations of current research

Research on treatments for uterine fibroids is still limited. 21 . Specifically, research on long-term effectiveness, side effects, and safety is lacking. 22 , 30 . Differences in research methods and evaluation criteria make direct comparison of study results difficult. 25 .

Future research directions

Research on treatments for uterine fibroids needs to focus on evaluating long-term effectiveness, side effects, and safety. 21 . Standardizing research methods and evaluation criteria is crucial for easier comparison of study results. 25 . Developing new treatment options is also essential. 21 .

Conclusion

Uterine fibroids are a common condition affecting women of reproductive age. 18 . Treatment options for uterine fibroids include surgery, medications, and minimally invasive procedures. 21 . Each treatment has its own advantages and disadvantages. 25 , 30 . When choosing a treatment for uterine fibroids, consult a doctor to select the best option for your individual circumstances. 21 . Understanding the benefits and drawbacks of each treatment and obtaining sufficient information before treatment is critical. 30 .

Treatment list

The following treatments were mentioned in the research articles for uterine fibroids:

  • Myomectomy
  • Hysterectomy
  • Progesterone receptor modulators
  • GnRH analogs
  • Danazol
  • Uterine artery embolization (UAE)
  • Magnetic resonance imaging-guided focused ultrasound surgery (MRgFUS)
Keywords
Benefit Keywords
Fast recovery
Fibroid volume reduction
1
Improved uterine fibroid treatment
2
Controlled bleeding
Fibroid shrinkage
Reduced uterine volume
3
Improved uterine fibroid treatment
4
Faster return to activities
Less pain
5
Faster recovery
Shorter hospitalization
6
Improved bone density
Reduced vasomotor symptoms
7
Improved uterine fibroid treatment
9
None reported
10
Uterine Fibroids Treatment
11
Improved quality of life
12
Bleeding control
Fibroid reduction
13
Bleeding control
Hot flash reduction
14
Treatment of uterine fibroids
15
Improved uterine fibroids treatment
16
Improved uterine fibroids treatment
17
Uterine fibroid treatment
18
Uterine fibroid treatment
19
Fertility
Fibroid treatment
Improved quality of life
MRgFUS safety
20
Uterine fibroid treatment
21
Improved quality of life
22
Higher patient satisfaction
Lower clinical failure rates
Lower re-intervention rates
Quicker recovery
Shorter hospitalization
23
Fibroid treatment
24
Uterine fibroid treatment
25
Fibroid treatment
26
Uterine fibroid treatment
27
Uterine fibroid treatment
28
Fibroid treatment
29
Fibroid treatment
30
Fibroid treatment
31
clinical improvement
few complications
32
Fibroid treatment
33
Fibroid treatment
34
Pregnancy outcomes
35
FUS
RFA
UAE
Uterine fibroids treatment
36
Reduced blood loss
37
Uterine fibroid treatment
38
Fibroid volume reduction
Improved quality of life
39
Fibroid treatment
40
Uterine fibroids treatment
41
Uterine fibroids treatment
43
Reduced abnormal uterine bleeding
44
Improved fibroid treatment
45
Uterine fibroids treatment
46
Mifepristone for fibroids
47
Uterine fibroids treatment
48
Fibroid treatment
49
Complication reduction
Fibroid severity reduction
Hospital stay reduction
QoL improvement
Return to work time reduction
50
UF treatment
51
Minimally invasive treatment for uterine fibroids
52
Reduced adverse events
53
Ovarian function
Pregnancy rate
54
Uterine leyomyomas treatment
55
Uterine fibroids treatment
56
Pregnancy rates improvement
57
Improved access to care
58
Fertility preservation
Uterine fibroids treatment
59
Uterine fibroid treatment
60
Risk Keywords
Poor responders
1
Bone loss
Unacceptable symptoms
3
Uterine fibroids
4
Need for further treatment
Treatment failure
6
Ovarian failure
8
Uterine fibroids
9
None reported
10
Need for re-intervention
12
Uterine fibroids
20
Miscarriage risk
Pregnancy rate reduction
33
Delivery complications
Spontaneous abortion
35
Reinterventions
39
Spotting
44
Abdominal pain
47
Re-intervention
51
Re-intervention
Symptom severity
54
Racial disparities
58
Miscarriage
Placental abnormalities
59
Literature analysis of 60 papers
Positive Content
55
Neutral Content
2
Negative Content
3
Article Type
22
22
34
22
60
1.

Treatment of uterine fibroids with a slow-release formulation of the gonadotrophin releasing hormone antagonist Cetrorelix.

Author: FelberbaumR E, GermerU, LudwigM, Riethmüller-WinzenH, HeiseS, ButtgeI, BauerO, ReissmannT, EngelJ, DiedrichK

Fast recovery
Fibroid volume reduction
Poor responders

This study evaluated the effectiveness of Cetrorelix, a gonadotrophin-releasing hormone (GnRH) antagonist, in premenopausal patients with symptomatic uterine fibroids. Cetrorelix significantly reduced fibroid size, highlighting its potential benefits in treating this condition.

Clinical TrialA clinical trial is a planned study conducted on humans to evaluate the efficacy and safety of pharmaceuticals, medical devices, and treatment methods. It aims to explore the possibilities of new treatments and improve the health of patients.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.

Language : English

2.

Pre-operative GnRH analogue therapy before hysterectomy or myomectomy for uterine fibroids.

Author: LethabyA, VollenhovenB, SowterM

Improved uterine fibroid treatment

Uterine fibroids are common, affecting 25-35% of women over 35. While some fibroids don’t cause symptoms, up to 50% cause severe problems requiring treatment. Surgery is the standard treatment for fibroids, which are stimulated to grow by estrogen. Gonadotropin-releasing hormone agonists (GnRHa) can shrink fibroids by reducing estrogen levels, but cannot be used long-term due to side effects. GnRHa can be used before surgery to shrink the fibroids and reduce bleeding.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
ReviewAn article that critically examines existing research on a particular topic and summarizes the current state of knowledge in the field.
Systematic ReviewA review that systematically collects, evaluates, and integrates relevant research to answer a specific research question.

Language : English

3.

Pre-operative GnRH analogue therapy before hysterectomy or myomectomy for uterine fibroids.

Author: LethabyA, VollenhovenB, SowterM

Controlled bleeding
Fibroid shrinkage
Reduced uterine volume
Bone loss
Unacceptable symptoms

Uterine fibroids are common, affecting 25-35% of women over 35. While some fibroids don’t cause symptoms, up to 50% cause severe problems requiring treatment. Surgery is the standard treatment for fibroids, which are stimulated to grow by estrogen. Gonadotropin-releasing hormone agonists (GnRHa) can shrink fibroids by reducing estrogen levels, but cannot be used long-term due to side effects. GnRHa can be used before surgery to shrink the fibroids and reduce bleeding.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
ReviewAn article that critically examines existing research on a particular topic and summarizes the current state of knowledge in the field.
Systematic ReviewA review that systematically collects, evaluates, and integrates relevant research to answer a specific research question.

Language : English

4.

Uterine artery embolization for symptomatic uterine fibroids.

Author: GuptaJ K, SinhaA S, LumsdenM A, HickeyM

Improved uterine fibroid treatment
Uterine fibroids

Uterine fibroids are common growths that can cause heavy bleeding, pain, pressure, and fertility issues, but they are usually not cancerous. While surgery has been the main treatment, long-term medication has not been effective. Uterine artery embolization (UAE) is a procedure that blocks blood flow to the fibroids, which has been reported as an effective and safe alternative for women who don't want to have children, but more research is needed as current evidence is based on smaller studies.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Meta-AnalysisA statistical technique that integrates the results of multiple studies to draw more general conclusions about a particular issue.
ReviewAn article that critically examines existing research on a particular topic and summarizes the current state of knowledge in the field.
Systematic ReviewA review that systematically collects, evaluates, and integrates relevant research to answer a specific research question.

Language : English

5.

Pain and return to daily activities after uterine artery embolization and hysterectomy in the treatment of symptomatic uterine fibroids: results from the randomized EMMY trial.

Author: HehenkampWouter J K, VolkersNicole A, BirnieErwin, ReekersJim A, AnkumWillem M

Faster return to activities
Less pain

Pain was significantly less after UAE during hospital stay. Return to several daily activities was in favor of UAE in comparison with hysterectomy.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Multicenter StudyResearch conducted in collaboration with multiple research institutions. It aims to collect a wide range of data and obtain more generalizable results.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.

Language : English

6.

Uterine-artery embolization versus surgery for symptomatic uterine fibroids.

Author: EdwardsRichard D, MossJonathan G, LumsdenMary Ann, WuOlivia, MurrayLilian S, TwaddleSara, MurrayGordon D,

Faster recovery
Shorter hospitalization
Need for further treatment
Treatment failure

Uterine-artery embolization resulted in a faster recovery compared with surgery but a higher need for further treatment.

Comparative StudyResearch that compares multiple groups/interventions to determine differences/similarities in outcomes/characteristics.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Multicenter StudyResearch conducted in collaboration with multiple research institutions. It aims to collect a wide range of data and obtain more generalizable results.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.

Language : English

7.

Efficacy of tibolone as "add-back therapy" in conjunction with a gonadotropin-releasing hormone analogue in the treatment of uterine fibroids.

Author: MorrisEdward Patrick, RymerJanice, RobinsonJill, FogelmanIgnac

Improved bone density
Reduced vasomotor symptoms

Tibolone is a safe and effective add-back therapy for women receiving GnRH analogue treatment for fibroids. Tibolone did not affect GnRH analogue-induced fibroid shrinkage, but it led to a significant decrease in vasomotor symptoms.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.

Language : English

8.

Loss of ovarian reserve after uterine artery embolization: a randomized comparison with hysterectomy.

Author: HehenkampWouter J K, VolkersNicole A, BroekmansFrank J M, de JongFrank H, ThemmenAxel P N, BirnieErwin, ReekersJim A, AnkumWillem M

Ovarian failure

Both uterine artery embolization (UAE) and hysterectomy affect ovarian reserve, potentially leading to premature menopause. Therefore, UAE should only be considered for women who still wish to conceive after appropriate counselling.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Multicenter StudyResearch conducted in collaboration with multiple research institutions. It aims to collect a wide range of data and obtain more generalizable results.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.

Language : English

9.

Midterm clinical and first reproductive results of a randomized controlled trial comparing uterine fibroid embolization and myomectomy.

Author: MaraMichal, MaskovaJana, FucikovaZuzana, KuzelDavid, BelsanTomas, SosnaOndrej

Improved uterine fibroid treatment
Uterine fibroids

This study compared the outcomes of two treatments for uterine fibroids in women who wanted to have children: uterine artery embolization (UAE) and myomectomy. UAE was less invasive, required shorter hospital stays and recovery, and had lower inflammation levels compared to myomectomy. Both treatments were equally successful in relieving symptoms and had similar complication rates. However, myomectomy resulted in more pregnancies and births in the first two years after treatment compared to UAE.

Comparative StudyResearch that compares multiple groups/interventions to determine differences/similarities in outcomes/characteristics.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.

Language : English

10.

Danazol for uterine fibroids.

Author: KeLin-Qiu, YangKun, LiJing, LiChun-Mei

None reported
None reported

There is no reliable evidence available from randomised controlled trials regarding the benefits and or harms of the use of danazol for treating uterine fibroids.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
ReviewAn article that critically examines existing research on a particular topic and summarizes the current state of knowledge in the field.
Systematic ReviewA review that systematically collects, evaluates, and integrates relevant research to answer a specific research question.

Language : English

11.

Uterine artery occlusion for treatment of symptomatic uterine myomas.

Author: HelalAdel, MashalyAbd El-Mageed, AmerTalal

Uterine Fibroids Treatment

Laparoscopic occlusion and uterine artery embolization were equally effective in improving clinical symptoms of uterine fibroids, with a higher rate of heavy periods in the occlusion group after 12 months.

Comparative StudyResearch that compares multiple groups/interventions to determine differences/similarities in outcomes/characteristics.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.

Language : English

12.

Randomised comparison of uterine artery embolisation (UAE) with surgical treatment in patients with symptomatic uterine fibroids (REST trial): 5-year results.

Author: MossJ G, CooperK G, KhaundA, MurrayL S, MurrayG D, WuO, CraigL E, LumsdenM A

Improved quality of life
Need for re-intervention

Uterine artery embolisation (UAE) was found to be a satisfactory alternative to surgery for fibroids. While less invasive, UAE requires re-intervention in almost a third of patients. The choice between UAE and surgery should be made by the informed patient.

Comparative StudyResearch that compares multiple groups/interventions to determine differences/similarities in outcomes/characteristics.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Multicenter StudyResearch conducted in collaboration with multiple research institutions. It aims to collect a wide range of data and obtain more generalizable results.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.

Language : English

13.

Ulipristal acetate versus placebo for fibroid treatment before surgery.

Author: DonnezJacques, TatarchukTetyana F, BouchardPhilippe, PuscasiuLucian, ZakharenkoNataliya F, IvanovaTatiana, UgocsaiGyula, MaraMichal, JillaManju P, BestelElke, TerrillPaul, OsterlohIan, LoumayeErnest,

Bleeding control
Fibroid reduction

Ulipristal acetate was effective in controlling excessive bleeding due to uterine fibroids and reducing the size of the fibroids.

Clinical Trial, Phase IIIA Phase III trial is a trial that further rigorously verifies the efficacy and safety of a new drug or treatment, whose efficacy and safety have been confirmed in a Phase II trial, in a large number of patients, and evaluates whether it is superior to existing treatments.
Comparative StudyResearch that compares multiple groups/interventions to determine differences/similarities in outcomes/characteristics.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Multicenter StudyResearch conducted in collaboration with multiple research institutions. It aims to collect a wide range of data and obtain more generalizable results.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.

Language : English

14.

Ulipristal acetate versus leuprolide acetate for uterine fibroids.

Author: DonnezJacques, TomaszewskiJanusz, VázquezFrancisco, BouchardPhilippe, LemieszczukBoguslav, BaróFrancesco, NouriKazem, SelvaggiLuigi, SodowskiKrzysztof, BestelElke, TerrillPaul, OsterlohIan, LoumayeErnest,

Bleeding control
Hot flash reduction

Ulipristal acetate was found to be noninferior to leuprolide acetate in controlling uterine bleeding and was significantly less likely to cause hot flashes.

Clinical Trial, Phase IIIA Phase III trial is a trial that further rigorously verifies the efficacy and safety of a new drug or treatment, whose efficacy and safety have been confirmed in a Phase II trial, in a large number of patients, and evaluates whether it is superior to existing treatments.
Comparative StudyResearch that compares multiple groups/interventions to determine differences/similarities in outcomes/characteristics.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Multicenter StudyResearch conducted in collaboration with multiple research institutions. It aims to collect a wide range of data and obtain more generalizable results.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.

Language : English

15.

Uterine artery embolization for symptomatic uterine fibroids.

Author: GuptaJanesh K, SinhaAnju, LumsdenM A, HickeyMartha

Treatment of uterine fibroids

Uterine fibroids are growths in the uterus that can cause heavy bleeding, pain, and difficulty getting pregnant. While surgery has been the standard treatment, a procedure called uterine artery embolization (UAE) has emerged as a safe and effective alternative for women who do not want to have children in the future.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Meta-AnalysisA statistical technique that integrates the results of multiple studies to draw more general conclusions about a particular issue.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.
ReviewAn article that critically examines existing research on a particular topic and summarizes the current state of knowledge in the field.
Systematic ReviewA review that systematically collects, evaluates, and integrates relevant research to answer a specific research question.

Language : English

16.

[Effect of GnRH analogues pre-treatment on myomectomy outcomes in reproductive age women].

Author: HudecekR, IvanováZ, SmerdováM, PánkováS, KrajcovicováR

Improved uterine fibroids treatment

This study compares the outcomes of myomectomy for women with uterine fibroids who received pre-treatment with gonadothropin releasing hormone (GnRH) analogues three months before surgery to those who did not.

English AbstractA summary of a research paper/publication written in English for a wider audience.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.

Language : Czech

17.

Mifepristone for uterine fibroids.

Author: TristanMario, OrozcoLeonardo J, SteedAntonia, Ramírez-MoreraAnggie, StonePeter

Improved uterine fibroids treatment

Uterine fibroids are common non-cancerous growths in the uterus, affecting women of childbearing age. Mifepristone blocks the effects of progesterone, a hormone that can contribute to fibroid growth. Studies have shown that mifepristone can shrink fibroids. This review summarizes the effects of mifepristone treatment on fibroids, as well as its potential side effects, based on research studies.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Meta-AnalysisA statistical technique that integrates the results of multiple studies to draw more general conclusions about a particular issue.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.
ReviewAn article that critically examines existing research on a particular topic and summarizes the current state of knowledge in the field.
Systematic ReviewA review that systematically collects, evaluates, and integrates relevant research to answer a specific research question.

Language : English

18.

Progestogens or progestogen-releasing intrauterine systems for uterine fibroids.

Author: SangkomkamhangUssanee S, LumbiganonPisake, LaopaiboonMalinee, MolBen Willem J

Uterine fibroid treatment

Uterine fibroids are common growths in the uterus that can cause heavy bleeding, pressure, and pain. While progesterone-based medications are used for fibroids, their effectiveness is still being studied. Progesterone can be given by injection (depot medroxyprogesterone acetate, DMPA), which can either stimulate or inhibit fibroid growth. Progesterone-releasing intrauterine devices (IUS) reduce menstrual bleeding by thinning the uterine lining and may also shrink fibroids, but their effectiveness for fibroids needs more research.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Meta-AnalysisA statistical technique that integrates the results of multiple studies to draw more general conclusions about a particular issue.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.
ReviewAn article that critically examines existing research on a particular topic and summarizes the current state of knowledge in the field.
Systematic ReviewA review that systematically collects, evaluates, and integrates relevant research to answer a specific research question.

Language : English

19.

Effect of high-intensity focused ultrasound on sexual function in the treatment of uterine fibroids: comparison to conventional myomectomy.

Author: WangXiaoyan, QinJuan, WangLifang, ChenJinyun, ChenWenzhi, TangLiangdan

Uterine fibroid treatment

This study explores the use of high-intensity focused ultrasound (HIFU) for treating uterine fibroids. While HIFU is a minimally invasive treatment option, its impact on sexual function has not been evaluated using objective criteria.

Comparative StudyResearch that compares multiple groups/interventions to determine differences/similarities in outcomes/characteristics.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.

Language : English

20.

Magnetic resonance-guided focused ultrasound myomectomy: safety, efficacy, subsequent fertility and quality-of-life improvements, a systematic review.

Author: GizzoSalvatore, SaccardiCarlo, PatrelliTito Silvio, AnconaEmanuele, NoventaMarco, FagherazziSimone, MozzanegaBruno, D'AntonaDonato, NardelliGiovanni Battista

Fertility
Fibroid treatment
Improved quality of life
MRgFUS safety
Uterine fibroids

This systematic review examines the use of magnetic resonance-guided focused ultrasound (MRgFUS) for myomectomy. MRgFUS is a safe, effective, and minimally invasive technique for treating uterine fibroids. It improves quality of life and may be an alternative to traditional surgical or radiological procedures.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
ReviewAn article that critically examines existing research on a particular topic and summarizes the current state of knowledge in the field.
Systematic ReviewA review that systematically collects, evaluates, and integrates relevant research to answer a specific research question.

Language : English

21.

Aromatase inhibitors for uterine fibroids.

Author: SongHuan, LuDongHao, NavaratnamKate, ShiGang

Uterine fibroid treatment

Uterine fibroids are common noncancerous growths in the uterus that can cause heavy bleeding, pressure, and pain in women of childbearing age. While surgery is a common treatment, it can have complications like pain and difficulty getting pregnant. New research suggests that aromatase inhibitors (AIs), a type of medication that blocks estrogen, might be effective in shrinking fibroids, potentially eliminating the need for surgery.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.
ReviewAn article that critically examines existing research on a particular topic and summarizes the current state of knowledge in the field.
Systematic ReviewA review that systematically collects, evaluates, and integrates relevant research to answer a specific research question.

Language : English

22.

Reproductive impact of MRI-guided focused ultrasound surgery for fibroids: a systematic review of the evidence.

Author: ClarkNatalie A, MumfordSunni L, SegarsJames H

Improved quality of life

MRgFUS is a minimally invasive treatment for uterine fibroids that can improve quality of life and fibroid size with durability. While case series report uncomplicated pregnancy after MRgFUS, further research is needed to determine if it is the treatment of choice for patients planning future fertility.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Meta-AnalysisA statistical technique that integrates the results of multiple studies to draw more general conclusions about a particular issue.
Research Support, N.I.H., IntramuralFunding provided by the NIH for research projects within the NIH.
ReviewAn article that critically examines existing research on a particular topic and summarizes the current state of knowledge in the field.
Systematic ReviewA review that systematically collects, evaluates, and integrates relevant research to answer a specific research question.

Language : English

23.

Uterine-sparing minimally invasive interventions in women with uterine fibroids: a systematic review and indirect treatment comparison meta-analysis.

Author: PanagiotopoulouNikoletta, NethraShankaralingaiah, KaravolosStamatios, AhmadGaity, KarabisAndreas, BurlsAmanda

Higher patient satisfaction
Lower clinical failure rates
Lower re-intervention rates
Quicker recovery
Shorter hospitalization

Myomectomy and uterine artery embolization are more effective than laparoscopic uterine artery occlusion in the treatment of symptomatic uterine fibroids. Myomectomy resulted in higher patient satisfaction, lower rates of clinical failure and re-intervention than the other two methods. Uterine artery embolization also resulted in higher patient satisfaction and lower rates of clinical failure, but had a higher re-intervention rate than myomectomy. Laparoscopic uterine artery occlusion was less effective than the other two methods, but offered a shorter hospitalization and quicker recovery.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Meta-AnalysisA statistical technique that integrates the results of multiple studies to draw more general conclusions about a particular issue.
ReviewAn article that critically examines existing research on a particular topic and summarizes the current state of knowledge in the field.
Systematic ReviewA review that systematically collects, evaluates, and integrates relevant research to answer a specific research question.

Language : English

24.

Minimally invasive surgical techniques versus open myomectomy for uterine fibroids.

Author: Bhave ChittawarPriya, FranikSebastian, PouwerAnnefloor W, FarquharCindy

Fibroid treatment

Fibroids are common noncancerous growths in the uterus. Surgery to remove fibroids (myomectomy) is the preferred treatment for women who want to preserve their uterus. Myomectomy can be performed through a traditional incision, a smaller incision, or minimally invasive techniques using a scope.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Meta-AnalysisA statistical technique that integrates the results of multiple studies to draw more general conclusions about a particular issue.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.
ReviewAn article that critically examines existing research on a particular topic and summarizes the current state of knowledge in the field.
Systematic ReviewA review that systematically collects, evaluates, and integrates relevant research to answer a specific research question.

Language : English

25.

A randomised trial of treating fibroids with either embolisation or myomectomy to measure the effect on quality of life among women wishing to avoid hysterectomy (the FEMME study): study protocol for a randomised controlled trial.

Author: McPhersonKlim, ManyondaIsaac, LumsdenMary-Ann, BelliAnna-Maria, MossJon, WuOlivia, MiddletonLee, DanielsJane

Uterine fibroid treatment

Uterine fibroids are common noncancerous growths in the uterus, affecting about 80% of women by age 50. Half of these women will experience symptoms that negatively impact their quality of life. Hysterectomy (removing the uterus) is the standard treatment, but women who don't want this option have two common alternatives: surgery to remove the fibroids (myomectomy) or a procedure that blocks blood flow to the fibroids (uterine artery embolization, UAE).

Comparative StudyResearch that compares multiple groups/interventions to determine differences/similarities in outcomes/characteristics.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Multicenter StudyResearch conducted in collaboration with multiple research institutions. It aims to collect a wide range of data and obtain more generalizable results.
Pragmatic Clinical TrialA trial conducted in a real-world clinical setting. It evaluates the effectiveness of interventions in everyday healthcare environments.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.

Language : English

26.

Uterine artery embolization for symptomatic uterine fibroids.

Author: GuptaJanesh K, SinhaAnju, LumsdenM A, HickeyMartha

Fibroid treatment

Uterine fibroids are common growths in the uterus that can cause heavy bleeding, pain, and difficulty getting pregnant. While surgery has been the standard treatment, a procedure called uterine artery embolization (UAE) has emerged as a safe and effective alternative for women who do not want to have children in the future.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Meta-AnalysisA statistical technique that integrates the results of multiple studies to draw more general conclusions about a particular issue.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.
ReviewAn article that critically examines existing research on a particular topic and summarizes the current state of knowledge in the field.
Systematic ReviewA review that systematically collects, evaluates, and integrates relevant research to answer a specific research question.

Language : English

27.

Add-back therapy with GnRH analogues for uterine fibroids.

Author: MoroniRafael M, MartinsWellington P, FerrianiRui A, VieiraCarolina S, NastriCarolina O, Candido Dos ReisFrancisco José, BritoLuiz Gustavo

Uterine fibroid treatment

Uterine fibroids are common in women and can cause bleeding and pain. GnRH analogues are the most effective medication for fibroids, but long-term use causes side effects. Adding other medications (add-back therapy) may reduce these side effects, but could also decrease the effectiveness of GnRH analogues and may not completely prevent side effects.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Meta-AnalysisA statistical technique that integrates the results of multiple studies to draw more general conclusions about a particular issue.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.
ReviewAn article that critically examines existing research on a particular topic and summarizes the current state of knowledge in the field.
Systematic ReviewA review that systematically collects, evaluates, and integrates relevant research to answer a specific research question.

Language : English

28.

Medical Therapies for Uterine Fibroids - A Systematic Review and Network Meta-Analysis of Randomised Controlled Trials.

Author: GurusamyKurinchi S, VaughanJessica, FraserIan S, BestLawrence M J, RichardsToby

Uterine fibroid treatment

Uterine fibroids are common growths in the uterus that can cause symptoms like heavy bleeding, pain, and pressure. About 25-50% of women with fibroids require surgery, either to remove the fibroids or the uterus. While surgery is the definitive treatment, medication is used to control symptoms and may improve the outcome of surgery by preventing the fibroids from returning.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Meta-AnalysisA statistical technique that integrates the results of multiple studies to draw more general conclusions about a particular issue.
ReviewAn article that critically examines existing research on a particular topic and summarizes the current state of knowledge in the field.
Systematic ReviewA review that systematically collects, evaluates, and integrates relevant research to answer a specific research question.

Language : English

29.

Fibroid interventions: reducing symptoms today and tomorrow: extending generalizability by using a comprehensive cohort design with a randomized controlled trial.

Author: AbdElmagiedAhmed M, VaughanLisa E, WeaverAmy L, Laughlin-TommasoShannon K, HesleyGina K, WoodrumDavid A, JacobyVanessa L, KohiMaureen P, PriceThomas M, NievesAngel, MillerMichael J, BorahBijan J, GornyKrzysztof R, LeppertPhyllis C, LemensMaureen A, StewartElizabeth A

Fibroid treatment

Uterine fibroids are a common problem for women of reproductive age, and hysterectomy is the most common treatment despite many alternatives. This study aims to compare two minimally invasive treatments for fibroids – uterine artery embolization and magnetic resonance imaging-guided focused ultrasound surgery – to hysterectomy. While randomized trials are the gold standard for comparing treatments, they are difficult to conduct for fibroid treatments. This study will also collect data on women who choose not to participate in the randomized trial to provide further information on the effectiveness of these treatments.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Multicenter StudyResearch conducted in collaboration with multiple research institutions. It aims to collect a wide range of data and obtain more generalizable results.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.

Language : English

30.

Periprocedural outcomes comparing fibroid embolization and focused ultrasound: a randomized controlled trial and comprehensive cohort analysis.

Author: BarnardEmily P, AbdElmagiedAhmed M, VaughanLisa E, WeaverAmy L, Laughlin-TommasoShannon K, HesleyGina K, WoodrumDavid A, JacobyVanessa L, KohiMaureen P, PriceThomas M, NievesAngel, MillerMichael J, BorahBijan J, GornyKrzysztof R, LeppertPhyllis C, PetersonLisa G, StewartElizabeth A

Fibroid treatment

Uterine fibroids are a common problem for women of childbearing age, but there isn't enough research to clearly guide treatment choices. This study is the first randomized controlled trial to compare two minimally invasive treatments for uterine fibroids: uterine artery embolization and magnetic resonance imaging-guided focused ultrasound surgery.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Multicenter StudyResearch conducted in collaboration with multiple research institutions. It aims to collect a wide range of data and obtain more generalizable results.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.
Research Support, N.I.H., ExtramuralResearch funding provided by the NIH to external research institutions and researchers.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.

Language : English

31.

Selective progesterone receptor modulators (SPRMs) for uterine fibroids.

Author: MurjiAlly, WhitakerLucy, ChowTiffany L, SobelMara L

Fibroid treatment

Uterine fibroids are non-cancerous growths in the uterus that can cause heavy bleeding, discomfort, and fertility problems. These fibroids are influenced by progesterone, a hormone. This review examines research on the use of selective progesterone receptor modulators (SPRMs) to treat fibroids. Studies show that SPRMs can reduce fibroid growth and improve symptoms. While SPRMs cause changes in the uterine lining, these changes are not cancerous and are reversible. The review summarizes research on the effectiveness of SPRMs in treating fibroids.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Meta-AnalysisA statistical technique that integrates the results of multiple studies to draw more general conclusions about a particular issue.
ReviewAn article that critically examines existing research on a particular topic and summarizes the current state of knowledge in the field.
Systematic ReviewA review that systematically collects, evaluates, and integrates relevant research to answer a specific research question.

Language : English

32.

High-intensity focused ultrasound (HIFU) treatment for uterine fibroids: a meta-analysis.

Author: JiYongshuo, HuKaimeng, ZhangYu, GuLijun, ZhuJunqiu, ZhuLinglin, ZhuYanfei, ZhaoHong

clinical improvement
few complications

HIFU treatment of uterine leiomyomas leads to clinical improvement with few significant clinical complications and adverse events.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Meta-AnalysisA statistical technique that integrates the results of multiple studies to draw more general conclusions about a particular issue.

Language : English

33.

Fertility after uterine artery embolization of fibroids: a systematic review.

Author: KarlsenK, HrobjartssonA, KorsholmM, MogensenO, HumaidanP, RavnP

Fibroid treatment
Miscarriage risk
Pregnancy rate reduction

Pregnancy rates were lower and miscarriage rates were higher after uterine artery embolization (UAE) than after myomectomy. The quality of evidence regarding the assessed outcomes was very low, and the reported proportions are uncertain.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.
Systematic ReviewA review that systematically collects, evaluates, and integrates relevant research to answer a specific research question.

Language : English

34.

Preoperative medical therapy before surgery for uterine fibroids.

Author: LethabyAnne, PuscasiuLucian, VollenhovenBeverley

Fibroid treatment

Uterine fibroids are common in women over 35, causing symptoms like heavy bleeding, pain, and difficulty getting pregnant. Surgery is usually the first treatment, but medications are sometimes used beforehand to improve outcomes. Hormones like GnRHa can shrink fibroids but have significant side effects with long-term use. Other potential medications include progestins and SPRMs. This review updates previous research from 2000 and 2001 to include all medications used before surgery for uterine fibroids.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Meta-AnalysisA statistical technique that integrates the results of multiple studies to draw more general conclusions about a particular issue.
ReviewAn article that critically examines existing research on a particular topic and summarizes the current state of knowledge in the field.
Systematic ReviewA review that systematically collects, evaluates, and integrates relevant research to answer a specific research question.

Language : English

35.

Pregnancy Outcomes Following Ulipristal Acetate for Uterine Fibroids: A Systematic Review.

Author: De Gasperis-BriganteCassandra, SinghSukhbir S, VilosGeorge, KivesSari, MurjiAlly

Pregnancy outcomes
Delivery complications
Spontaneous abortion

A systematic review and case series of 71 pregnancies following ulipristal acetate (UPA) treatment for uterine fibroids showed favorable pregnancy outcomes. There were 44 live births and 27 miscarriages. Five pregnancies occurred during UPA use, resulting in three live births, one miscarriage, and one termination. Five women who did not undergo myomectomy experienced delivery complications related to their fibroids.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Systematic ReviewA review that systematically collects, evaluates, and integrates relevant research to answer a specific research question.

Language : English

37.

Adjunctive use of tranexamic acid to tourniquet in reducing haemorrhage during abdominal myomectomy - A randomized controlled trial.

Author: AbdulIshaq F, AmaduMotunrayo B, AdesinaKike T, OlarinoyeAdebunmi O, OmokanyeLukman O

Reduced blood loss

Uterine fibroids are common, and while many women don't have symptoms, about a third need treatment. Surgery is often used when medication fails and women want to preserve their uterus and ability to have children. While tourniquets are effective at reducing bleeding during surgery, the combination of tourniquets and tranexamic acid, another medication to reduce bleeding, hasn't been studied.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.

Language : English

38.

Magnetic resonance-high intensity focused ultrasound (MR-HIFU) therapy of symptomatic uterine fibroids with unrestrictive treatment protocols: A systematic review and meta-analysis.

Author: VerpalenInez M, AnneveldtKimberley J, NijholtIngrid M, SchutteJoke M, DijkstraJeroen R, FranxArie, BartelsLambertus W, MoonenChrit T W, EdensMireille A, BoomsmaMartijn F

Uterine fibroid treatment

This meta-analysis found that MR-HIFU therapy for uterine fibroids is more effective with treatment guidelines aiming for complete ablation. However, controlled trials are needed to define its role in managing fibroids.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Meta-AnalysisA statistical technique that integrates the results of multiple studies to draw more general conclusions about a particular issue.
Systematic ReviewA review that systematically collects, evaluates, and integrates relevant research to answer a specific research question.

Language : English

39.

Clinical Performance of Radiofrequency Ablation for Treatment of Uterine Fibroids: Systematic Review and Meta-Analysis of Prospective Studies.

Author: BradleyLinda D, PasicResad P, MillerLarry E

Fibroid volume reduction
Improved quality of life
Reinterventions

This study reviewed the outcomes of using radiofrequency ablation (RFA) to treat uterine fibroids. RFA significantly reduced fibroid size and improved quality of life for women. The procedure was associated with short recovery times and a low rate of needing additional treatments.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Meta-AnalysisA statistical technique that integrates the results of multiple studies to draw more general conclusions about a particular issue.
Systematic ReviewA review that systematically collects, evaluates, and integrates relevant research to answer a specific research question.

Language : English

41.

Efficacy assessment of acupuncture in improving symptoms of uterine fibroids: A randomized controlled trial.

Author: ZhengMin-Qin, WengCai, HuWei, ShenChong-Qing, TaoYun, PanZheng-Wei

Uterine fibroids treatment

Uterine fibroids are common non-cancerous growths in the uterus. Current treatments focus on blocking the hormones that fuel their growth, using drugs that block progesterone or estrogen. This can shrink fibroids or slow their growth, reducing symptoms. For women who want to have children, acupuncture offers a promising alternative treatment for uterine fibroids.

Clinical Trial ProtocolA plan for conducting a clinical trial. It describes in detail the purpose, design, methodology, and statistical considerations of the trial, ensuring the transparency and consistency of the trial.
Comparative StudyResearch that compares multiple groups/interventions to determine differences/similarities in outcomes/characteristics.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Multicenter StudyResearch conducted in collaboration with multiple research institutions. It aims to collect a wide range of data and obtain more generalizable results.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.

Language : English

42.

A systematic review of the psychosocial impact of fibroids before and after treatment.

Author: GoVirginia Arlene A, ThomasMartha C, SinghBhuchitra, PrenattSarah, SimsHolly, BlanckJaime F, SegarsJames H

This study examined the psychological and social impact of uterine fibroids in women before and after treatment, comparing their experiences to those with other chronic conditions. The study aimed to understand the overall burden of fibroids on women's lives and how treatment might improve quality of life.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.
Systematic ReviewA review that systematically collects, evaluates, and integrates relevant research to answer a specific research question.

Language : English

43.

Uterine-Artery Embolization or Myomectomy for Uterine Fibroids.

Author: ManyondaIsaac, BelliAnna-Maria, LumsdenMary-Ann, MossJonathan, McKinnonWilliam, MiddletonLee J, CheedVersha, WuOlivia, SirkeciFusun, DanielsJane P, McPhersonKlim,

Uterine fibroids treatment

Uterine fibroids are common non-cancerous growths in the uterus that can cause heavy bleeding, pain, difficulty getting pregnant, and affect quality of life. For women who want to keep their uterus and haven't responded to medication, surgery to remove the fibroids (myomectomy) or blocking the blood supply to them (uterine-artery embolization) are options.

Comparative StudyResearch that compares multiple groups/interventions to determine differences/similarities in outcomes/characteristics.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Multicenter StudyResearch conducted in collaboration with multiple research institutions. It aims to collect a wide range of data and obtain more generalizable results.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.

Language : English

44.

Progestogens or progestogen-releasing intrauterine systems for uterine fibroids (other than preoperative medical therapy).

Author: SangkomkamhangUssanee S, LumbiganonPisake, PattanittumPorjai

Reduced abnormal uterine bleeding
Spotting

This review assessed the effectiveness of progestogens or progestogen-releasing intrauterine systems (IUS) for treating premenopausal women with uterine fibroids. The evidence is very low quality and inconclusive due to limited studies and poor reporting of study methods. LNG-IUS may reduce abnormal uterine bleeding compared to combined oral contraceptive (COC) or norethisterone acetate, but there is insufficient evidence to determine if it reduces fibroid size. Oral progestogens may reduce abnormal uterine bleeding as effectively as goserelin acetate, but women reported fewer adverse events, such as hot flashes.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Meta-AnalysisA statistical technique that integrates the results of multiple studies to draw more general conclusions about a particular issue.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.
Systematic ReviewA review that systematically collects, evaluates, and integrates relevant research to answer a specific research question.

Language : English

45.

Contrast-Enhanced Ultrasound for Monitoring Non-surgical Treatments of Uterine Fibroids: A Systematic Review.

Author: TorkzabanMehnoosh, MachadoPriscilla, GuptaIpshita, HaiYang, ForsbergFlemming

Improved fibroid treatment

Contrast-enhanced ultrasound (CEUS) is being investigated as an alternative to magnetic resonance imaging (MRI) for evaluating the characteristics and responses of uterine fibroids to non-surgical treatments, such as UAE, HIFUA, and PMWA. The review analyzes the use of CEUS in conjunction with these procedures.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Research Support, N.I.H., ExtramuralResearch funding provided by the NIH to external research institutions and researchers.
Systematic ReviewA review that systematically collects, evaluates, and integrates relevant research to answer a specific research question.

Language : English

46.

Treatment of Uterine Fibroid Symptoms with Relugolix Combination Therapy.

Author: Al-HendyAyman, LukesAndrea S, PoindexterAlfred N, VenturellaRoberta, VillarroelClaudio, CritchleyHilary O D, LiYulan, McKainLaura, Arjona FerreiraJuan C, LangenbergAndria G M, WagmanRachel B, StewartElizabeth A

Uterine fibroids treatment

Uterine fibroids, which can cause heavy bleeding and pain, may be treated with a daily combination of relugolix, estradiol, and norethindrone acetate. This combination aims to reduce symptoms while avoiding the side effects of low estrogen levels.

Clinical Trial, Phase IIIA Phase III trial is a trial that further rigorously verifies the efficacy and safety of a new drug or treatment, whose efficacy and safety have been confirmed in a Phase II trial, in a large number of patients, and evaluates whether it is superior to existing treatments.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Multicenter StudyResearch conducted in collaboration with multiple research institutions. It aims to collect a wide range of data and obtain more generalizable results.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.

Language : English

47.

[Preoperative treatment of uterine fibroids with low-dose mifepristone: a multicenter, randomized, double-blind, placebo-controlled, parallel-group study].

Author: BianM L, HuangM L, ZhangZ Y, LiuS M, SunJ, FangF, GuY P, LiuC D, YaoC

Mifepristone for fibroids
Abdominal pain

Oral mifepristone 10 mg/day is significantly superior to placebo in reducing the size of uterine fibroids and improving anemia, without significant adverse reactions.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Multicenter StudyResearch conducted in collaboration with multiple research institutions. It aims to collect a wide range of data and obtain more generalizable results.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.

Language : Chinese

48.

Systematic review of reproductive outcomes after High Intensity Focused Ultrasound treatment of uterine fibroids.

Author: AnneveldtKimberley J, van 't OeverHeleen J, NijholtIngrid M, DijkstraJeroen R, HehenkampWouter J, VeersemaSebastiaan, HuirneJudith A F, SchutteJoke M, BoomsmaMartijn F

Uterine fibroids treatment

This study reviewed research on the effects of two non-surgical treatments for uterine fibroids, a common condition that can affect fertility: MR-guided high-intensity focused ultrasound (MR-HIFU) and ultrasound-guided HIFU (USgHIFU). The study focuses on how these newer treatments affect women's ability to get pregnant.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
ReviewAn article that critically examines existing research on a particular topic and summarizes the current state of knowledge in the field.
Systematic ReviewA review that systematically collects, evaluates, and integrates relevant research to answer a specific research question.

Language : English

49.

Uterine and Fibroid Imaging Analysis from the FIRSTT Study.

Author: Laughlin-TommasoShannon K, GornyKrzysztof R, HesleyGina K, VaughanLisa E, WoodrumDavid A, LemensMaureen A, StewartElizabeth A

Fibroid treatment

This study compared two treatments for uterine fibroids: uterine artery embolization (UAE) and magnetic resonance imaging-guided focused ultrasound surgery (MRgFUS). Both treatments reduced the size of fibroids by about 50% after 2 and 3 years. While the size of the largest fibroid decreased more with MRgFUS, the overall size of the uterus decreased more with UAE. After 2 years, the amount of non-perfused tissue (tissue without blood flow) was greater in the UAE group. This suggests that both treatments are effective at reducing fibroid size, but the effects on blood flow differ.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.
Research Support, N.I.H., ExtramuralResearch funding provided by the NIH to external research institutions and researchers.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.

Language : English

50.

High-intensity focused ultrasound (HIFU) ablation versus surgical interventions for the treatment of symptomatic uterine fibroids: a meta-analysis.

Author: LiuLu, WangTianfu, LeiBaiying

Complication reduction
Fibroid severity reduction
Hospital stay reduction
QoL improvement
Return to work time reduction

High-intensity focused ultrasound (HIFU) is superior to surgery in terms of symptomatic relief, improvement in quality of life, recovery, and significant complications for treating symptomatic uterine fibroids. HIFU showed comparable effects to surgery regarding the incidence of adverse events, symptom recurrence, re-intervention, and pregnancy.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Meta-AnalysisA statistical technique that integrates the results of multiple studies to draw more general conclusions about a particular issue.
ReviewAn article that critically examines existing research on a particular topic and summarizes the current state of knowledge in the field.

Language : English

51.

The comparison of myomectomy, UAE and MRgFUS in the treatment of uterine fibroids: a meta analysis.

Author: XuFan, DengLihong, ZhangLijun, HuHuiquan, ShiQiuling

UF treatment
Re-intervention

This meta-analysis compared the re-intervention rates of myomectomy, uterine artery embolization, and MRgFUS for uterine fibroids. Myomectomy had the lowest re-intervention rate at all time points. MRgFUS had the highest re-intervention rate, with a rapid increase in the 60th month after treatment.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Meta-AnalysisA statistical technique that integrates the results of multiple studies to draw more general conclusions about a particular issue.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.

Language : English

52.

A Systematic Review of Minimally Invasive Treatments for Uterine Fibroid-Related Bleeding.

Author: ZhangJiahui, GoVirginia-Arlene, BlanckJaime Friel, SinghBhuchitra

Minimally invasive treatment for uterine fibroids

This review analyzed the efficacy of uterus-preserving, minimally invasive treatment modalities for reducing fibroid-related bleeding in premenopausal women. Several techniques, including myomectomy, uterine artery embolization, and radiofrequency ablation, have shown promise in reducing bleeding symptoms. However, more research is needed to establish the superiority of these methods over one another.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
ReviewAn article that critically examines existing research on a particular topic and summarizes the current state of knowledge in the field.
Systematic ReviewA review that systematically collects, evaluates, and integrates relevant research to answer a specific research question.

Language : English

53.

Comparison of thermal ablative methods and myomectomy for the treatment of fibroids: a systematic review and meta-analysis.

Author: LiangDeku, LiJuan, LiuDanDan, ZhaoHu, LinYonghong

Reduced adverse events

Thermal ablative methods were not inferior to myomectomy in treating uterine fibroids, but there was a lower risk of major adverse events with ultrasound-guided high-intensity focused ultrasound.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Meta-AnalysisA statistical technique that integrates the results of multiple studies to draw more general conclusions about a particular issue.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.
Systematic ReviewA review that systematically collects, evaluates, and integrates relevant research to answer a specific research question.

Language : English

54.

High-intensity focused ultrasound treatment for symptomatic uterine fibroids: a systematic review and meta-analysis.

Author: YanLing, HuangHuimin, LinJingwen, YuRuimei

Ovarian function
Pregnancy rate
Re-intervention
Symptom severity

HIFU may offer a higher pregnancy rate and shorter pregnancy interval with little influence on ovarian function, making it an attractive option for treating symptomatic fibroids in young women who wish to plan a pregnancy.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Meta-AnalysisA statistical technique that integrates the results of multiple studies to draw more general conclusions about a particular issue.
Systematic ReviewA review that systematically collects, evaluates, and integrates relevant research to answer a specific research question.

Language : English

55.

Minimally invasive treatment options for uterine fibroids - state-of-the art 2021.

Author: KrzyzanowskiJaroslaw, WozniakSlawomir, SzkodziakPiotr, KrzyzanowskiArkadiusz, WojciechWrona, PaszkowskiTomasz

Uterine leyomyomas treatment

This study aims to examine the effectiveness and safety of minimally invasive treatments for uterine fibroids, a common condition that can cause heavy bleeding, pain, and other problems. The review focuses on high-intensity focused ultrasound (HIFU), a non-surgical treatment option that uses sound waves to destroy fibroids.

Systematic ReviewA review that systematically collects, evaluates, and integrates relevant research to answer a specific research question.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.

Language : English

56.

Uterine artery embolisation versus myomectomy for premenopausal women with uterine fibroids wishing to avoid hysterectomy: the FEMME RCT.

Author: DanielsJane, MiddletonLee J, CheedVersha, McKinnonWilliam, RanaDikshyanta, SirkeciFusun, ManyondaIsaac, BelliAnna-Maria, LumsdenMary Ann, MossJonathan, WuOlivia, McPhersonKlim

Uterine fibroids treatment

Uterine fibroids are common growths in the uterus that can cause heavy periods, pain, and difficulty getting pregnant. For women who want to keep their uterus and haven't responded to medication, surgery to remove the fibroids or blocking the blood supply to them are options.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Multicenter StudyResearch conducted in collaboration with multiple research institutions. It aims to collect a wide range of data and obtain more generalizable results.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.

Language : English

58.

Racial disparities in uterine fibroids and endometriosis: a systematic review and application of social, structural, and political context.

Author: KatonJodie G, PlowdenTorie C, MarshErica E

Improved access to care
Racial disparities

A systematic review of the literature found that the prevalence of uterine fibroids is consistently higher in Black than in White women in the United States. This disparity is linked to differential exposures to suspected etiologic agents, lack of adequate access to healthcare, and bias and discrimination within the healthcare system. Data on endometriosis were less clear, but Black women with fibroids or endometriosis experience worse clinical and surgical outcomes than their White counterparts.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Systematic ReviewA review that systematically collects, evaluates, and integrates relevant research to answer a specific research question.
Research Support, N.I.H., ExtramuralResearch funding provided by the NIH to external research institutions and researchers.

Language : English

59.

Reproductive and Obstetric Outcomes after UAE, HIFU, and TFA of Uterine Fibroids: Systematic Review and Meta-Analysis.

Author: AkhatovaAyazhan, AimagambetovaGulzhanat, BapayevaGauri, LaganàAntonio Simone, ChianteraVito, OppeltPeter, Sarria-SantameraAntonio, TerzicMilan

Fertility preservation
Uterine fibroids treatment
Miscarriage
Placental abnormalities

This study compared the outcomes of pregnancy for women who received minimally invasive treatments for uterine fibroids. The review found that the rate of live births was similar for uterine artery embolization (UAE), ultrasound-guided high-intensity focused ultrasound (USgHIFU), magnetic resonance-guided high-intensity focused ultrasound (MRgHIFU), and transcervical radiofrequency ablation (TFA) (around 70-75%). While miscarriage rates were highest for UAE, USgHIFU was associated with a higher rate of placental abnormalities. The review concluded that these minimally invasive treatments are good options for women wanting to preserve their fertility, with comparable outcomes among the different methods.

Meta-AnalysisA statistical technique that integrates the results of multiple studies to draw more general conclusions about a particular issue.
Systematic ReviewA review that systematically collects, evaluates, and integrates relevant research to answer a specific research question.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
ReviewAn article that critically examines existing research on a particular topic and summarizes the current state of knowledge in the field.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.

Language : English

60.

Endometrial Angiogenesis of Abnormal Uterine Bleeding and Infertility in Patients with Uterine Fibroids-A Systematic Review.

Author: DonEmma E, MiddelkoopMei-An, HehenkampWouter J K, MijatovicVelja, GriffioenArjan W, HuirneJudith A F

Uterine fibroid treatment

Uterine fibroids are common, non-cancerous growths in the uterus that can cause heavy bleeding and infertility. This study found that fibroids are linked to abnormal blood vessel growth in the uterine lining (endometrium). Treatments like hormone therapy seem to reduce this abnormal blood vessel growth. The study also suggests that different blood vessel pathways may be involved in fibroids that cause infertility. These findings may lead to new treatments targeting blood vessel growth to address fibroid-related symptoms.

Systematic ReviewA review that systematically collects, evaluates, and integrates relevant research to answer a specific research question.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
ReviewAn article that critically examines existing research on a particular topic and summarizes the current state of knowledge in the field.

Language : English

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