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Effects of captopril, hydrochlorothiazide, and their combination on timed urinary excretions of water and solutes.

Author: Acosta-BarriosT N, LearyW P, ReyesA J, van der BylK V

Clinical TrialA clinical trial is a planned study conducted on humans to evaluate the efficacy and safety of pharmaceuticals, medical devices, and treatment methods. It aims to explore the possibilities of new treatments and improve the health of patients.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Comparative StudyResearch that compares multiple groups/interventions to determine differences/similarities in outcomes/characteristics.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.

Overview

Captopril, hydrochlorothiazide, and a combination of both have different effects on 24-hour urinary outputs of fluid and electrolytes. Captopril has diuretic and uricosuric effects.
Paper Details　
Original Abstract of the Article :
The effects of single doses of captopril 100 mg, hydrochlorothiazide 25 mg, and a combination of both on 24-h outputs of fluid and several solutes were compared in healthy volunteers. Thirteen subjects were studied in a metabolic ward under strictly controlled conditions. Single doses of placebo, ca...See full text at original site
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引用元：
https://doi.org/10.1097/00005344-198507001-00012

データ提供：米国国立医学図書館（NLM）

Unraveling the Complex Effects of Captopril and Hydrochlorothiazide on Urinary Excretion

This study explores the intricate interplay between two commonly prescribed drugs, captopril and hydrochlorothiazide, and their influence on urinary excretion patterns in healthy volunteers. The authors meticulously analyzed the effects of these medications on the timed urinary excretions of water and various solutes, revealing a complex and nuanced picture of their renal actions.

A Tale of Two Drugs: Captopril and Hydrochlorothiazide on Urinary Excretion

The study found that hydrochlorothiazide significantly increased the urinary outputs of chloride, sodium, fluid, and potassium, while captopril did not have a notable effect on these parameters. However, captopril did demonstrate a unique effect on the time course of urinary flow, suggesting a more prolonged renal action than anticipated.

A Closer Look at Urinary Excretion: Implications for Drug Therapy

This research sheds light on the intricate renal actions of captopril and hydrochlorothiazide. The findings highlight the importance of considering the individual effects of these drugs and their potential interactions when prescribing them for patients.

Dr.Camel's Conclusion

Imagine the kidneys as a desert oasis, where the body’s waste is carefully filtered and excreted. This study reveals how captopril and hydrochlorothiazide, like two distinct desert plants, impact this vital process in unique ways. Understanding these nuanced effects is crucial for optimizing drug therapy and achieving optimal patient outcomes.

Date :
  1. Date Completed 1985-05-20
  2. Date Revised 2019-07-24
Further Info :

Pubmed ID

2580178

DOI: Digital Object Identifier

10.1097/00005344-198507001-00012

Related Literature

Article Analysis
・Effects of captopril and hydrochlorothiazide
SNS
PICO Info
in preparation
Languages

English

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