Paper Details

  1. Home
  2. Paper Details

Polyanionic carbosilane dendrimer-conjugated antiviral drugs as efficient microbicides: Recent trends and developments in HIV treatment/therapy.

Author: De La MataFrancisco Javier, GómezRafael, JiménezJosé Luis, Muñoz-FernándezM Ángeles, Sepúlveda-CrespoDaniel

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.
ReviewAn article that critically examines existing research on a particular topic and summarizes the current state of knowledge in the field.

Overview

This study discusses the potential of polyanionic carbosilane dendrimers (PCDs) as microbicides for the prevention of HIV transmission. The study reviews and discusses the combination of various PCDs with tenofovir (TFV) and/or maraviroc (MRV) for their anti-HIV-1 activity and synergistic combinatory potential.
Paper Details　
Original Abstract of the Article :
Polyanionic carbosilane dendrimers (PCDs) are potential candidates for the development of new microbicides for the prevention of HIV transmission. Tenofovir (TFV), which has dual antiviral activity (anti-HIV/HSV-2), and maraviroc (MRV) are the most studied antiretrovirals as microbicides. Here, we i...See full text at original site
Dr.Camel IconDr.Camel's Paper Summary Blogラクダ博士について

ラクダ博士は、Health Journal が論文の内容を分かりやすく解説するために作成した架空のキャラクターです。
難解な医学論文を、専門知識のない方にも理解しやすいように、噛み砕いて説明することを目指しています。

* ラクダ博士による解説は、あくまで論文の要点をまとめたものであり、原論文の完全な代替となるものではありません。詳細な内容については、必ず原論文をご参照ください。
* ラクダ博士は架空のキャラクターであり、実際の医学研究者や医療従事者とは一切関係がありません。
* 解説の内容は Health Journal が独自に解釈・作成したものであり、原論文の著者または出版社の見解を反映するものではありません。


引用元：
https://doi.org/10.1016/j.nano.2015.03.008

データ提供：米国国立医学図書館（NLM）

Polyanionic Carbosilane Dendrimers for HIV Treatment

This study explores the potential of polyanionic carbosilane dendrimers (PCDs) as a new class of microbicides for preventing HIV transmission. The researchers focus on the combination of PCDs with antiretroviral drugs, tenofovir (TFV) and maraviroc (MRV), to enhance their anti-HIV activity and potentially overcome drug resistance.

PCDs: A New Frontier in HIV Treatment

The use of PCDs combined with antiretroviral drugs offers a promising strategy for preventing HIV infection. This approach combines the potent antiviral effects of TFV and MRV with the delivery and targeting capabilities of PCDs. It's like using a caravan to transport valuable goods across the desert, ensuring their safe and efficient delivery to their destination.

Hope for Combating HIV

The study suggests that combining PCDs with antiretroviral drugs may lead to improved treatment outcomes for HIV infection. This approach could potentially enhance efficacy, minimize side effects, and hinder the development of drug resistance. It's like finding a new source of water in the desert, providing a renewed sense of hope and resilience in the fight against HIV.

Dr.Camel's Conclusion

This research explores the potential of polyanionic carbosilane dendrimers (PCDs) as a novel approach to HIV treatment. The combination of PCDs with antiretroviral drugs holds promise for enhanced efficacy and reduced drug resistance. This study represents a step towards finding new solutions to combat this challenging global health issue.

Date :
  1. Date Completed 2016-05-17
  2. Date Revised 2022-03-09
Further Info :

Pubmed ID

25835558

DOI: Digital Object Identifier

10.1016/j.nano.2015.03.008

Related Literature

Article Analysis
・Side Effects of maraviroc
SNS
PICO Info
in preparation
Languages

English

Positive IndicatorAn AI analysis index that serves as a benchmark for how positive the results of the study are. Note that it is a benchmark and requires careful interpretation and consideration of different perspectives.

This site uses cookies. Visit our privacy policy page or click the link in any footer for more information and to change your preferences.