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Reduced efficacy of sumatriptan in migraine with aura vs without aura.

Author: CharlesAndrew, GoadsbyPeter J, HansenJakob Møller

Clinical Trial, Phase IIIA Phase III trial is a trial that further rigorously verifies the efficacy and safety of a new drug or treatment, whose efficacy and safety have been confirmed in a Phase II trial, in a large number of patients, and evaluates whether it is superior to existing treatments.
Comparative StudyResearch that compares multiple groups/interventions to determine differences/similarities in outcomes/characteristics.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Multicenter StudyResearch conducted in collaboration with multiple research institutions. It aims to collect a wide range of data and obtain more generalizable results.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.

Overview

A pooled analysis of multiple randomized trials indicated that sumatriptan was less effective for treating migraine attacks with aura compared to attacks without aura. Inhaled dihydroergotamine (DHE) had similar efficacy for both types of attacks.
Paper Details　
Original Abstract of the Article :
OBJECTIVE: To determine whether acute migraine treatment outcome is different in migraine with aura compared with migraine without aura. METHODS: We examined pooled outcome data for sumatriptan treatment of migraine with and without aura from the sumatriptan/naratriptan aggregate patient database. ...See full text at original site
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引用元：
https://doi.org/10.1212/WNL.0000000000001535

データ提供：米国国立医学図書館（NLM）

Migraine with Aura: A More Stubborn Desert to Conquer

Greetings, fellow travelers! Dr. Camel here, your guide through the perplexing world of migraine, a condition that can cause debilitating headaches and other symptoms. This study delves into the unique challenges of treating migraine attacks with aura, a specific type of migraine characterized by visual disturbances and other neurological symptoms. The researchers compared the effectiveness of sumatriptan, a common migraine medication, in treating migraine attacks with and without aura.

Understanding the Nuances of Migraine Treatment

The study found that sumatriptan was less effective in providing pain relief for migraine attacks with aura compared to those without aura. This suggests that migraine with aura may be a more challenging form of the condition to treat, perhaps due to the underlying neurological disturbances that accompany it.

Navigating the Varied Landscape of Migraine

Think of migraine attacks as a vast desert landscape, with different types of terrain and challenges. This study highlights the importance of understanding these variations, recognizing that some forms of migraine may require different approaches to treatment. By recognizing the specific challenges of migraine with aura, healthcare providers can develop more effective strategies for managing this complex condition.

Dr. Camel's Conclusion

This study provides valuable insights into the unique challenges of treating migraine attacks with aura. While sumatriptan remains a valuable tool for managing migraine, it may be less effective for those experiencing aura symptoms. This research underscores the importance of tailoring treatment strategies to the specific needs of individual patients, ensuring that we effectively navigate the diverse landscape of migraine.

Date :
  1. Date Completed 2015-07-13
  2. Date Revised 2015-05-05
Further Info :

Pubmed ID

25841032

DOI: Digital Object Identifier

10.1212/WNL.0000000000001535

Related Literature

Article Analysis
・Effective treatment of migraine
SNS
PICO Info
in preparation
Languages

English

Positive IndicatorAn AI analysis index that serves as a benchmark for how positive the results of the study are. Note that it is a benchmark and requires careful interpretation and consideration of different perspectives.

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