Effective treatment of migraine: A Synthesis of Findings from 139 Studies

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This information is not medical advice and is not a substitute for diagnosis or treatment by a physician.Data sources and disclaimers (data limitations, copyright, etc.)The analysis on "Effective treatment of migraine: A Synthesis of Findings from 139 Studies" on this page is based on PubMed data provided by the U.S. National Library of Medicine (NLM). However, NLM does not endorse or verify these analyses.

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Original Abstract of the Article

Major Research Findings

Research on migraine treatment has uncovered a variety of effective methods and their associated benefits. For instance, the 49 study demonstrated the efficacy of early almotriptan administration in alleviating migraine pain. The 88 study found acupuncture to be an effective treatment for migraine without aura. Furthermore, the 60 study revealed the effectiveness of occipital nerve stimulation in treating chronic migraine.

In terms of preventative therapies, the 86 study showed the effectiveness of galcanezumab in preventing migraine. The 97 study indicated the efficacy of lasmiditan for acute migraine treatment. Additionally, the 15 study found topiramate to be effective in preventing migraine.

Beyond medication, cognitive behavioral therapy has also been shown to be an effective approach for migraine management, as evidenced by the 73 study. The 30 study demonstrated the effectiveness of massage therapy for migraine. Additionally, the 131 study highlighted the effectiveness of transcranial direct current stimulation (tDCS) in migraine prevention.

Treatment Summary

The research mentioned above highlights a wide range of approaches used to treat migraine. The most common treatment methods include: triptans such as almotriptan, as indicated in 49 ; acupuncture, as indicated in 88 ; occipital nerve stimulation, as indicated in 60 ; CGRP monoclonal antibodies such as galcanezumab, as indicated in 86 ; CGRP receptor antagonists such as lasmiditan, as indicated in 97 ; anti-epileptic medications like topiramate, as indicated in 15 ; cognitive behavioral therapy, as indicated in 73 ; massage therapy, as indicated in 30 ; and tDCS, as indicated in 131 .

Benefits and Risks

Benefit Summary

Migraine treatment offers a variety of potential benefits. These treatments may reduce the frequency and severity of migraines, alleviate associated symptoms, and improve overall quality of life.

Risk Summary

There are potential risks associated with migraine treatment. Medication can cause side effects, acupuncture poses a risk of infection, and invasive treatments such as occipital nerve stimulation carry the risk of complications. Careful consideration of these risks is crucial when choosing a treatment plan.

Comparison of Studies

Similarities in Studies

Many studies indicate the existence of multiple effective treatments for migraine. Several studies emphasize the importance of personalized treatment approaches tailored to individual patients.

Differences in Studies

The effectiveness of treatments and their outcomes can vary across different studies. This variation is likely due to differences in patient populations, treatment types, and evaluation methods. Therefore, it's essential to consider all research findings and make informed decisions regarding treatment choices based on individual needs.

Consistency and Contradictions in Results

Migraine treatment research yields both consistent and contradictory results. These inconsistencies may arise from differences in patient populations, treatment types, and evaluation methods. It's crucial to analyze research results comprehensively and select treatments suitable for individual patients.

Practical Implications and Cautions

Selecting the most effective migraine treatment for each individual patient is crucial. Seeking medical evaluation and discussing treatment options with a healthcare provider is essential to ensure that the chosen treatment aligns with individual symptoms and lifestyle. It's also vital to understand the potential risks and side effects of the selected treatment before initiating it.

Current Research Limitations

Current research necessitates larger-scale and long-term studies to comprehensively evaluate the efficacy and safety of migraine treatments. Research exploring the influence of genetic and environmental factors is also required to develop personalized treatment approaches for individual patients.

Future Research Directions

Future research endeavors should focus on developing novel and effective migraine preventive and therapeutic treatments. Developing more reliable methods for evaluating the efficacy and safety of treatments is crucial. Furthermore, research aimed at developing personalized treatment strategies tailored to individual patients is highly valuable.

Conclusion

Migraine can significantly impact quality of life. However, the development of various treatments offers hope for effective management for many individuals. If you struggle with migraines, seeking medical evaluation and selecting a suitable treatment plan with the guidance of a healthcare professional is essential.

Treatment List

Almotriptan, acupuncture, occipital nerve stimulation, galcanezumab, lasmiditan, topiramate, cognitive behavioral therapy, massage therapy, transcranial direct current stimulation (tDCS)

Keywords
Benefit Keywords
Cluster headache treatment
1
Effective migraine prophylaxis
2
Migraine prophylaxis
3
Reduced migraine severity
4
Migraine treatment
5
Reduced migraine attacks
6
Oral sumatriptan migraine efficacy
7
Improved pain
8
Reduced healthcare costs
Reduced migraine attacks
Reduced work absence
9
Improved migraine treatment
10
Improved treatment satisfaction
Migraine treatment
11
Migraine treatment
Reduced time loss
12
Headache relief
13
Effective treatment of migraine
14
Migraine prevention
15
Faster pain relief
Pain relief
16
Chronic daily headache treatment
17
Medication overuse headache treatment
18
Migraine treatment
19
Migraine relief
20
Reduced migraine frequency
Reduced migraine pain
21
Migraine treatment
22
Effective headache treatment
Reduced migraine headache
Reduced tension headache
23
Pediatric migraine treatment
24
Migraine treatment
25
Pain-free status
26
Improved understanding of migraine attacks
27
Improved migraine treatment
28
Migraine treatment
29
Improved migraine frequency
Improved sleep quality
Reduced stress
30
Migraine treatment
31
Reduced chronic headache
32
Early treatment efficacy
Reduced headache duration
33
Improved migraine treatment
34
Headache response
Pain-free response
35
Improved acute migraine treatment
36
Improved migraine treatment
37
Pain relief
Reduced MRM attack frequency
38
Pain relief
Reduced migraine symptoms
Safe
39
Migraine treatment
42
Migraine treatment
43
Improved disability
Improved headache days
44
Cluster headache treatment
45
Effective migraine treatment
Frovatriptan safe
Frovatriptan well tolerated
46
Migraine treatment
47
Migraine treatment
48
Migraine treatment
49
MRM treatment
50
Improved migraine outcomes
51
CM treatment
52
Reduced migraine frequency
53
Migraine treatment
54
Migraine treatment
55
Migraine treatment
56
Migraine treatment
57
Improved chronic migraine treatment
58
Improved quality of life
Reduced migraine days
59
Headache reduction
Improved quality of life
Reduced medication use
60
Effective migraine treatment
61
Migraine prophylaxis
Reduced medication use
Reduced pain
62
Migraine treatment
63
Childhood migraine prevention
64
Migraine treatment
65
Headache relief
Pain-free response
Rescue medication reduction
66
Migraine treatment
67
Migraine treatment
68
Migraine prophylaxis
69
Frovatriptan/dexketoprofen better than frovatriptan alone
70
Migraine treatment
71
Migraine treatment
72
Migraine treatment
73
Chronic migraine treatment
74
Headache relief
Migraine prevention
76
Migraine pain
77
Migraine treatment
79
Chronic migraine treatment
80
Reduced migraine
81
Migraine treatment
82
Migraine treatment
83
Improved migraine treatment
Reduced headache frequency
84
Effective treatment
Well-tolerated
85
Migraine prevention
86
Botulinum toxin type A
Migraine treatment
87
Improved tolerability
Reduced migraine frequency
Reduced pain
88
Erenumab
Migraine treatment
89
Migraine treatment
Preventive medications
90
Migraine treatment
Zolmitriptan
91
Chronic migraine treatment
Manual therapy
92
Reduced migraine frequency
93
Erenumab
Migraine treatment
OnabotulinumtoxinA
94
Migraine relief
95
Early onset of efficacy
Improved migraine symptoms
97
Improved chronic migraine treatment
98
Improved migraine treatment
99
Migraine prevention
Migraine treatment
100
Improved functioning
Migraine relief
101
Menstrual migraine treatment
102
Migraine prevention
103
Migraine treatment
104
Treatment for migraine
105
Reversion from CM to EM
106
Migraine treatment
107
Reduced medication use
Reduced migraine days
108
Effective
Migraine treatment
109
Effective
Migraine treatment
110
Galcanezumab for EM
111
Migraine prophylaxis
112
Effective migraine treatment
113
Reduced headache duration
Reduced headache severity
114
Improved pain and function
115
Improved quality of life
Reduced headache frequency
116
Eptinezumab for CM and MOH
117
Migraine treatment
118
rTMS for episodic migraine
119
Reduced AMSM days
Reduced migraine frequency
120
Improved quality of life
Reduced pain frequency
Reduced pain intensity
121
Migraine treatment
122
Eptinezumab efficacy
Migraine treatment
123
Migraine treatment
Standardized treatment
124
Migraine preventive therapy for CMMO
125
Improved headache severity
Reduced headache days
Reduced headache episodes
Reduced headache symptoms
Reduced migraine attacks
126
Migraine reduction
127
Reduced migraine frequency
Reduced migraine pain
128
Improved migraine management
129
Improved migraine prevention
130
Migraine treatment
131
Fremanezumab for migraine
132
Headache prevention
Headache relief
133
Migraine treatment
134
Migraine treatment
135
Migraine treatment
136
Migraine treatment
Quality of life improvement
137
CM treatment
Quality of life improvement
138
CM treatment
Quality of life improvement
139
Risk Keywords
Side effects
2
Side effects
5
Strategies not rigorously evaluated
10
Altered taste
Anorexia
Memory impairment
Paresthesia
Weight loss
15
Side effects
19
Side effects
21
Migraine headache
Recurrent tension headache
23
Migraine
27
Migraine
28
Not 100% effective
32
Dizziness
Nausea
33
Migraine
34
Acute migraine
36
Migraine headache
37
Dizziness
Nausea
39
Reduced triptan response
40
Side effects
43
Discontinuations
Side effects
44
Mild to moderate AE
46
Infection
Lead migration
60
Adverse effects
64
Dizziness
Dry mouth
Nausea
66
Migraine
77
Injection site reaction
86
Insufficient efficacy
Tolerability
105
None reported
108
Temporal numbness
110
Small sample size
Unblinded
113
Mild adverse events
115
Further research needed
121
Literature analysis of 139 papers
Positive Content
136
Neutral Content
3
Negative Content
0
Article Type
93
29
32
23
138
1.

Treatment of acute cluster headache with sumatriptan.

Author:

Cluster headache treatment

Sumatriptan, a drug used for migraine, is being investigated for its potential to treat cluster headaches due to similarities between the two conditions and positive results from a preliminary study.

Clinical TrialA clinical trial is a planned study conducted on humans to evaluate the efficacy and safety of pharmaceuticals, medical devices, and treatment methods. It aims to explore the possibilities of new treatments and improve the health of patients.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Multicenter StudyResearch conducted in collaboration with multiple research institutions. It aims to collect a wide range of data and obtain more generalizable results.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.

Language : English

2.

A comparative study of naproxen sodium, pizotyline and placebo in migraine prophylaxis.

Author: BellavanceA J, MelocheJ P

Effective migraine prophylaxis
Side effects

A study of 176 migraine patients found that both naproxen sodium and pizotyline were more effective than placebo in preventing migraine attacks.

Clinical TrialA clinical trial is a planned study conducted on humans to evaluate the efficacy and safety of pharmaceuticals, medical devices, and treatment methods. It aims to explore the possibilities of new treatments and improve the health of patients.
Comparative StudyResearch that compares multiple groups/interventions to determine differences/similarities in outcomes/characteristics.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.

Language : English

3.

[Evaluation of the effects of verapamil, flunarizine, diltiazem, nimodipine and placebo in the prevention of hemicrania. A double-blind randomized cross-over study].

Author: PaternaS, MartinoS G, CampisiD, Cascio IngurgioN, MarsalaB A

Migraine prophylaxis

A study of 50 migraine patients found that all calcium-channel blockers (verapamil, flunarizine, diltiazem, and nimodipine) were effective in preventing migraine attacks, with flunarizine being particularly advantageous due to its single daily dose.

Clinical TrialA clinical trial is a planned study conducted on humans to evaluate the efficacy and safety of pharmaceuticals, medical devices, and treatment methods. It aims to explore the possibilities of new treatments and improve the health of patients.
Comparative StudyResearch that compares multiple groups/interventions to determine differences/similarities in outcomes/characteristics.
English AbstractA summary of a research paper/publication written in English for a wider audience.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.

Language : Italian

4.

A treatment for the acute migraine attack.

Author: AdamE I

Reduced migraine severity

A study of 34 patients with migraine found that a compound analgesic/anti-emetic formulation was effective in reducing the severity of acute migraine attacks, regardless of the duration of the migraine history.

Clinical TrialA clinical trial is a planned study conducted on humans to evaluate the efficacy and safety of pharmaceuticals, medical devices, and treatment methods. It aims to explore the possibilities of new treatments and improve the health of patients.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.

Language : English

5.

Naproxen sodium in the treatment of migraine.

Author: JohnsonE S, RatcliffeD M, WilkinsonM

Migraine treatment
Side effects

A study of 70 patients with migraine compared naproxen sodium to placebo for treating acute attacks. Naproxen sodium significantly reduced headache severity and duration compared to placebo, especially in patients with common migraine. Naproxen also reduced premonitory symptoms and photophobia, and fewer patients required additional pain medication. While naproxen was safe and effective for common migraine, no significant benefit was observed for classical migraine.

Clinical TrialA clinical trial is a planned study conducted on humans to evaluate the efficacy and safety of pharmaceuticals, medical devices, and treatment methods. It aims to explore the possibilities of new treatments and improve the health of patients.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.

Language : English

6.

Why does migraine improve during a clinical trial? Further results from a trial of cervical manipulation for migraine.

Author: ParkerG B, PryorD S, TuplingH

Reduced migraine attacks

A six-month study of cervical manipulation for migraine found a 28% reduction in migraine attacks during the trial, and a further 19% reduction during a 20-month follow-up. While a slight placebo effect was observed, the main factor contributing to improvement appeared to be the natural course of migraine. The degree of improvement during the trial and at the end of the trial were significant predictors of improvement at follow-up. This suggests that clinical trials assessing migraine therapies should consider the natural course of the disease and that manipulative therapists should use reliable predictors of response to therapy.

Clinical TrialA clinical trial is a planned study conducted on humans to evaluate the efficacy and safety of pharmaceuticals, medical devices, and treatment methods. It aims to explore the possibilities of new treatments and improve the health of patients.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.

Language : English

7.

Oral sumatriptan in the treatment of recurrent headache.

Author: CadyR K, RubinoJ, CrummettD, LittlejohnT W

Oral sumatriptan migraine efficacy

Oral sumatriptan was effective in treating recurrent headaches within 24 hours of successful treatment with subcutaneous sumatriptan. It relieved moderate or severe recurrent headaches within 4 hours in up to 81% of patients.

Clinical TrialA clinical trial is a planned study conducted on humans to evaluate the efficacy and safety of pharmaceuticals, medical devices, and treatment methods. It aims to explore the possibilities of new treatments and improve the health of patients.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.

Language : English

8.

Does psychological testing help to predict the response to acupuncture or massage/relaxation therapy in patients presenting to a general neurology clinic with headache?

Author: WylieK R, JacksonC, CrawfordP M

Improved pain

This study compared acupuncture and massage with relaxation for chronic headache. Both treatments showed significant improvement in pain ratings, with massage being more effective for migraine patients. Despite improvement, 13% of patients remained concerned about a more serious underlying cause of their headache, even after reassurance.

Clinical TrialA clinical trial is a planned study conducted on humans to evaluate the efficacy and safety of pharmaceuticals, medical devices, and treatment methods. It aims to explore the possibilities of new treatments and improve the health of patients.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.

Language : English

9.

Comparison of pharmacological treatment versus acupuncture treatment for migraine without aura--analysis of socio-medical parameters.

Author: LiguoriA, PettiF, BangraziA, CamaioniD, GuccioneG, PitariG M, BianchiA, NicolettiW E

Reduced healthcare costs
Reduced migraine attacks
Reduced work absence

This study compared acupuncture and conventional drug therapy for 120 patients with migraine without aura. After 6 and 12 months, both groups showed improvement in migraine frequency and severity, but acupuncture had a greater reduction in migraine attacks and associated work absences. Acupuncture also resulted in significantly lower costs compared to conventional therapy, with an estimated saving of over 1 trillion Italian liras for treating 800,000 migraine sufferers in Italy.

Clinical TrialA clinical trial is a planned study conducted on humans to evaluate the efficacy and safety of pharmaceuticals, medical devices, and treatment methods. It aims to explore the possibilities of new treatments and improve the health of patients.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.

Language : English

10.

Stratified care vs step care strategies for migraine: the Disability in Strategies of Care (DISC) Study: A randomized trial.

Author: LiptonR B, StewartW F, StoneA M, LáinezM J, SawyerJ P,

Improved migraine treatment
Strategies not rigorously evaluated

Different guidelines recommend different approaches to treating migraine headaches. One approach, step care, involves increasing the strength of treatment when initial medications fail. Another approach, stratified care, tailors treatment based on the severity of the migraine or other factors. The effectiveness of these strategies for migraine has not been thoroughly studied.

Clinical TrialA clinical trial is a planned study conducted on humans to evaluate the efficacy and safety of pharmaceuticals, medical devices, and treatment methods. It aims to explore the possibilities of new treatments and improve the health of patients.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.

Language : English

11.

Treatment satisfaction, functional status, and health-related quality of life of migraine patients treated with almotriptan or sumatriptan.

Author: ColmanS S, BrodM I, KrishnamurthyA, RowlandC R, JirgensK J, Gomez-MancillaB

Improved treatment satisfaction
Migraine treatment

This study found that almotriptan was associated with significantly greater satisfaction with the side-effect profile of the drug than sumatriptan in patients with migraine. There were no significant differences between the two groups in terms of satisfaction with pain relief, functional status, or health-related quality of life.

Clinical TrialA clinical trial is a planned study conducted on humans to evaluate the efficacy and safety of pharmaceuticals, medical devices, and treatment methods. It aims to explore the possibilities of new treatments and improve the health of patients.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.

Language : English

12.

Effectiveness of eletriptan in reducing time loss caused by migraine attacks.

Author: WellsN E, SteinerT J

Migraine treatment
Reduced time loss

This study found that eletriptan significantly reduced the amount of time lost from usual activities during a migraine attack compared to placebo.

Clinical TrialA clinical trial is a planned study conducted on humans to evaluate the efficacy and safety of pharmaceuticals, medical devices, and treatment methods. It aims to explore the possibilities of new treatments and improve the health of patients.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.

Language : English

13.

Rizatriptan for acute migraine.

Author: OldmanA D, SmithL A, McQuayH J, MooreR A

Headache relief

Rizatriptan 5 mg and 10 mg are effective in treating acute migraine, with a dose-related increase in efficacy.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
ReviewAn article that critically examines existing research on a particular topic and summarizes the current state of knowledge in the field.
Systematic ReviewA review that systematically collects, evaluates, and integrates relevant research to answer a specific research question.

Language : English

14.

Eletriptan for acute migraine.

Author: SmithL A, OldmanA D, McQuayH J, MooreR A

Effective treatment of migraine

Eletriptan (Relpax), a new type of migraine medication, will soon be available by prescription. There are currently five other similar medications available, and more are under development. With so many migraine treatments, evidence-based assessments are needed to compare their effectiveness and potential risks.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
ReviewAn article that critically examines existing research on a particular topic and summarizes the current state of knowledge in the field.
Systematic ReviewA review that systematically collects, evaluates, and integrates relevant research to answer a specific research question.

Language : English

15.

Topiramate in migraine prevention: a double-blind, placebo-controlled study.

Author: StoreyJ R, CalderC S, HartD E, PotterD L

Migraine prevention
Altered taste
Anorexia
Memory impairment
Paresthesia
Weight loss

Topiramate was well tolerated and significantly reduced migraine frequency in patients with episodic migraine.

Clinical TrialA clinical trial is a planned study conducted on humans to evaluate the efficacy and safety of pharmaceuticals, medical devices, and treatment methods. It aims to explore the possibilities of new treatments and improve the health of patients.
Comparative StudyResearch that compares multiple groups/interventions to determine differences/similarities in outcomes/characteristics.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.

Language : English

16.

Almotriptan increases pain-free status in patients with acute migraine treated in placebo-controlled clinical trials.

Author: MathewNinan T

Faster pain relief
Pain relief

Almotriptan 12.5 mg was more effective than placebo in reducing migraine headache pain as early as 1 hour after a single dose.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Meta-AnalysisA statistical technique that integrates the results of multiple studies to draw more general conclusions about a particular issue.

Language : English

17.

Amitriptyline versus amitriptyline combined with fluoxetine in the preventative treatment of transformed migraine: a double-blind study.

Author: KrymchantowskiAbouch Valenty, SilvaMarcus Tulius, BarbosaJackeline Soraya, AlvesLuiz Anastácio

Chronic daily headache treatment

This study investigated the effectiveness and side effects of combining amitriptyline and fluoxetine compared to using amitriptyline alone for treating chronic daily headaches related to transformed migraine, a type of headache often associated with mood disorders.

Clinical TrialA clinical trial is a planned study conducted on humans to evaluate the efficacy and safety of pharmaceuticals, medical devices, and treatment methods. It aims to explore the possibilities of new treatments and improve the health of patients.
Comparative StudyResearch that compares multiple groups/interventions to determine differences/similarities in outcomes/characteristics.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.

Language : English

18.

Medication overuse headache.

Author: DienerH C, KatsaravaZ

Medication overuse headache treatment

Overusing migraine medications (more than 15 times a month) can lead to medication overuse headache. This can happen with analgesics, opioids, ergot alkaloids, and triptans, with the fastest onset for triptans (1-2 years), followed by ergot (3-5 years), and analgesics (5-10 years). Treatment involves gradually stopping the medications, followed by structured migraine treatment plans and preventive medication.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Meta-AnalysisA statistical technique that integrates the results of multiple studies to draw more general conclusions about a particular issue.
ReviewAn article that critically examines existing research on a particular topic and summarizes the current state of knowledge in the field.

Language : English

19.

Acute migraine treatment with droperidol: A randomized, double-blind, placebo-controlled trial.

Author: SilbersteinS D, YoungW B, MendizabalJ E, RothrockJ F, AlamA S

Migraine treatment
Side effects

Droperidol was more effective than placebo in reducing headache symptoms in patients with moderate to severe migraine headache.

Clinical TrialA clinical trial is a planned study conducted on humans to evaluate the efficacy and safety of pharmaceuticals, medical devices, and treatment methods. It aims to explore the possibilities of new treatments and improve the health of patients.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Multicenter StudyResearch conducted in collaboration with multiple research institutions. It aims to collect a wide range of data and obtain more generalizable results.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.
Research Support, U.S. Gov't, P.H.S.Research funding provided by the Public Health Service (PHS).

Language : English

20.

Parenteral dihydroergotamine for acute migraine headache: a systematic review of the literature.

Author: ColmanIan, BrownMichael D, InnesGrant D, GrafsteinEric, RobertsTed E, RoweBrian H

Migraine relief

Dihydroergotamine (DHE) is not as effective as sumatriptan or phenothiazines for treating acute migraines. However, when combined with an antiemetic, DHE is as effective as opiates, ketorolac, or valproate.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
ReviewAn article that critically examines existing research on a particular topic and summarizes the current state of knowledge in the field.
Systematic ReviewA review that systematically collects, evaluates, and integrates relevant research to answer a specific research question.

Language : English

21.

[Economic evaluation of acute migraine attack treatment with triptans in Spain].

Author: Gracia-NayaM, Rejas GutiérrezJ, Latorre JiménezA, González GarciaP

Reduced migraine frequency
Reduced migraine pain
Side effects

Eletriptan 40 mg was the most cost-effective triptan among those studied for migraine attack treatment.

Comparative StudyResearch that compares multiple groups/interventions to determine differences/similarities in outcomes/characteristics.
English AbstractA summary of a research paper/publication written in English for a wider audience.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Meta-AnalysisA statistical technique that integrates the results of multiple studies to draw more general conclusions about a particular issue.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.

Language : Spanish

22.

Aspirin is efficacious for the treatment of acute migraine.

Author: LiptonRichard B, GoldsteinJerome, BaggishJeffrey S, YatacoAlberto R, SorrentinoJames V, QuiringJohn N

Migraine treatment

This study compares the effectiveness and tolerability of aspirin versus placebo in treating acute migraine headaches. The study aims to determine if aspirin, a common over-the-counter medication, is effective in relieving migraine pain and how well it is tolerated by patients.

Clinical TrialA clinical trial is a planned study conducted on humans to evaluate the efficacy and safety of pharmaceuticals, medical devices, and treatment methods. It aims to explore the possibilities of new treatments and improve the health of patients.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.

Language : English

23.

Relaxation treatment of adolescent headache sufferers: results from a school-based replication series.

Author: LarssonBo, CarlssonJane, FichtelAsa, MelinLennart

Effective headache treatment
Reduced migraine headache
Reduced tension headache
Migraine headache
Recurrent tension headache

Relaxation techniques have proven effective for children and teens with frequent tension headaches, while biofeedback is helpful for migraine sufferers, typically treated in specialized clinics.

Clinical TrialA clinical trial is a planned study conducted on humans to evaluate the efficacy and safety of pharmaceuticals, medical devices, and treatment methods. It aims to explore the possibilities of new treatments and improve the health of patients.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.

Language : English

24.

Symptomatic treatment of migraine in children: a systematic review of medication trials.

Author: DamenLéonie, BruijnJacques K J, VerhagenArianne P, BergerMarjolein Y, PasschierJan, KoesBart W

Pediatric migraine treatment

The study reviewed the evidence for the efficacy and tolerability of symptomatic treatment of migraine in children, noting the lack of a coherent body of evidence.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Meta-AnalysisA statistical technique that integrates the results of multiple studies to draw more general conclusions about a particular issue.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.
ReviewAn article that critically examines existing research on a particular topic and summarizes the current state of knowledge in the field.
Systematic ReviewA review that systematically collects, evaluates, and integrates relevant research to answer a specific research question.

Language : English

25.

Does earlier headache response equate to earlier return to functioning in patients suffering from migraine?

Author: PradelF G, SubediP, VargheseA A, MullinsC D, WeisK A

Migraine treatment

The study found that rapid headache response in migraineurs was associated with faster return to functioning and greater treatment acceptability.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.

Language : English

26.

Pain free efficacy of sumatriptan in the early treatment of migraine.

Author: JelinskiSusan E, BeckerWerner J, ChristieSuzanne N, AhmadFaiz E, Pryse-PhillipsWilliam, SimpsonScott D

Pain-free status

Sumatriptan 50 mg and 100 mg were significantly superior to placebo for pain relief at two hours in patients with migraine. Pain-free response rates were higher than in older trials where sumatriptan was administered after pain had reached moderate or severe intensity.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.

Language : English

27.

The natural course of migraine attacks. A prospective analysis of untreated attacks compared with attacks treated with a triptan.

Author: LindeM, MellbergA, DahlöfC

Improved understanding of migraine attacks
Migraine

This study observed the natural progression of untreated migraine attacks in 18 adults, documenting the intensity of symptoms over 72 hours. The study found that migraine attacks vary greatly, even within the same person, but generally follow a similar pattern, with pain fluctuating in waves lasting several hours. Migraine symptoms can occur independently of each other (e.g., severe pain without nausea). While treatment with triptans can temporarily alter the course of the attack, the basic pattern persists. These findings suggest a common underlying cause for different migraine symptoms.

Comparative StudyResearch that compares multiple groups/interventions to determine differences/similarities in outcomes/characteristics.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.

Language : English

28.

A clinical trial of trimethobenzamide/diphenhydramine versus sumatriptan for acute migraines.

Author: FriedmanBenjamin W, HochbergMichael, EssesDavid, BijurPolly E, CorboJill, PaternosterJoseph, SolorzanoClemencia, ToosiBabak, LiptonRichard B, GallagherE John

Improved migraine treatment
Migraine

While various medications are used in the emergency department (ED) to treat acute migraines, none provide complete pain relief without side effects or headaches coming back. Even though anti-nausea medications and sumatriptan injections have shown effectiveness, there's still a need for better treatments given through injection. Early studies suggest that combining trimethobenzamide and diphenhydramine might be effective for a large percentage of migraine sufferers.

Comparative StudyResearch that compares multiple groups/interventions to determine differences/similarities in outcomes/characteristics.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.

Language : English

29.

Review of clinical trials using early acute intervention with oral triptans for migraine management.

Author: DowsonA J, MathewN T, PascualJ

Migraine treatment

This study explores the effectiveness of taking migraine medication (triptans) early, when pain is mild, compared to waiting until pain is moderate to severe. While research often focuses on treating severe migraines, emerging evidence suggests that taking triptans early may be more effective. Early treatment is also supported by economic analyses. The study emphasizes the need for migraine medications that are both effective for mild pain and well-tolerated, as patients may be less likely to use medication early if they are concerned about side effects.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Meta-AnalysisA statistical technique that integrates the results of multiple studies to draw more general conclusions about a particular issue.
ReviewAn article that critically examines existing research on a particular topic and summarizes the current state of knowledge in the field.

Language : English

30.

A randomized, controlled trial of massage therapy as a treatment for migraine.

Author: LawlerSheleigh P, CameronLinda D

Improved migraine frequency
Improved sleep quality
Reduced stress

Massage therapy may be a helpful nonpharmacologic treatment for migraines.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.

Language : English

31.

Topiramate and triptans revert chronic migraine with medication overuse to episodic migraine.

Author: MeiDaniele, FerraroDiana, ZelanoGiovanni, CapuanoAlessandro, VollonoCatello, GabrieleCarbone, Di TrapaniGirolamo

Migraine treatment

This study investigates the effectiveness of topiramate in reducing the frequency of migraine headaches and the amount of pain medication used by patients with chronic migraine who overuse medication. The study also examines the effectiveness of specific triptan medications (used for acute migraine attacks) in stopping migraine episodes during topiramate treatment.

Clinical TrialA clinical trial is a planned study conducted on humans to evaluate the efficacy and safety of pharmaceuticals, medical devices, and treatment methods. It aims to explore the possibilities of new treatments and improve the health of patients.
Comparative StudyResearch that compares multiple groups/interventions to determine differences/similarities in outcomes/characteristics.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.

Language : English

32.

Topiramate in patients with episodic migraine: reducing the risk for chronic forms of headache.

Author: LimmrothVolker, BiondiDavid, PfeilJoop, SchwalenSusanne

Reduced chronic headache
Not 100% effective

Preventive treatment with topiramate in patients with episodic migraine may reduce the risk of developing chronic forms of headache. In a pooled analysis of 3 trials, topiramate significantly reduced the number of headache days and the number of patients reporting an increase in headache days. It also reduced acute medication usage.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Multicenter StudyResearch conducted in collaboration with multiple research institutions. It aims to collect a wide range of data and obtain more generalizable results.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.

Language : English

33.

Effect of pain intensity and time to administration on responsiveness to almotriptan: results from AXERT 12.5 mg Time Versus Intensity Migraine Study (AIMS).

Author: FreitagFrederick G, FinlaysonGary, RapoportAlan M, ElkindArthur H, DiamondMerle L, UngerJeffrey R, FisherAlan C, ArmstrongRobert B, HulihanJoseph F, GreenbergSteven J,

Early treatment efficacy
Reduced headache duration
Dizziness
Nausea

Early treatment for migraine headaches was significantly more effective in reducing total headache duration compared to standard treatment. In a cluster-randomized study, patients treated within 1 hour of headache onset, regardless of pain intensity, experienced shorter headache duration. The study also found that treating mild or moderate pain was just as effective as treating severe pain when treatment was initiated within 1 hour.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Multicenter StudyResearch conducted in collaboration with multiple research institutions. It aims to collect a wide range of data and obtain more generalizable results.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.

Language : English

34.

Controlled trials in pediatric migraine: crossover versus parallel group.

Author: EversStefan

Improved migraine treatment
Migraine

Research on migraine treatments for children and teens is limited and challenging to design. Studies where everyone receives both a real treatment and a placebo (crossover trials) show a lower placebo effect and greater effectiveness of treatments compared to studies where participants only receive one treatment (parallel group trials). Future research on migraine treatments for children should consider using crossover designs.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Meta-AnalysisA statistical technique that integrates the results of multiple studies to draw more general conclusions about a particular issue.
ReviewAn article that critically examines existing research on a particular topic and summarizes the current state of knowledge in the field.

Language : English

35.

WITHDRAWN: Rizatriptan for acute migraine.

Author: OldmanA D, SmithL A, McQuayH J, MooreR A

Headache response
Pain-free response

Rizatriptan 5 mg and 10 mg are effective in treating acute migraine, with a dose-related increase in efficacy.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
ReviewAn article that critically examines existing research on a particular topic and summarizes the current state of knowledge in the field.
Systematic ReviewA review that systematically collects, evaluates, and integrates relevant research to answer a specific research question.

Language : English

36.

WITHDRAWN: Eletriptan for acute migraine.

Author: SmithL A, OldmanA D, McQuayH J, MooreR A

Improved acute migraine treatment
Acute migraine

Eletriptan (Relpax), a new type of migraine medication, will soon be available by prescription. There are currently five other similar medications available, and more are under development. With so many migraine treatments, evidence-based assessments are needed to compare their effectiveness and potential risks.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
ReviewAn article that critically examines existing research on a particular topic and summarizes the current state of knowledge in the field.
Systematic ReviewA review that systematically collects, evaluates, and integrates relevant research to answer a specific research question.

Language : English

37.

Analysis of pooled data from two pivotal controlled trials on the efficacy of topiramate in the prevention of migraine.

Author: FreitagFred G, FordeGrace, NetoWalter, WangDaniel Z, SchmittJennifer, WuShu-Chen, HulihanJoseph

Improved migraine treatment
Migraine headache

Many people with migraine headaches should receive preventive treatment due to how often they have migraines and how disabling they are. This study examines the use of the anticonvulsant topiramate in two large, controlled trials for patients experiencing 3-12 migraine headaches per month.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Multicenter StudyResearch conducted in collaboration with multiple research institutions. It aims to collect a wide range of data and obtain more generalizable results.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.

Language : English

38.

Acute treatment and prevention of menstrually related migraine headache: evidence-based review.

Author: PringsheimTamara, DavenportWilliam Jeptha, DodickDavid

Pain relief
Reduced MRM attack frequency

Menstrually related migraine (MRM) is a common headache disorder in women, associated with significant disability. Compared to nonmenstrual migraines, MRM attacks are often more severe, last longer, and respond less well to analgesics. This guideline provides evidence-based recommendations for both acute and short-term preventive treatment of MRM headaches based on a systematic review and meta-analysis of existing research.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
ReviewAn article that critically examines existing research on a particular topic and summarizes the current state of knowledge in the field.
Systematic ReviewA review that systematically collects, evaluates, and integrates relevant research to answer a specific research question.

Language : English

39.

Multimechanistic (sumatriptan-naproxen) early intervention for the acute treatment of migraine.

Author: SilbersteinS D, MannixL K, GoldsteinJ, CouchJ R, ByrdS C, AmesM H, McDonaldS A, LenerS E, TosoCynthia

Pain relief
Reduced migraine symptoms
Safe
Dizziness
Nausea

A study of 576 migraine patients found that a single-tablet combination of sumatriptan and naproxen was effective in reducing pain and other migraine symptoms when taken within 1 hour of the onset of migraine.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.

Language : English

40.

Impact of recent prior opioid use on rizatriptan efficacy. A post hoc pooled analysis.

Author: HoTony W, RodgersAnthony, BigalMarcelo E

Reduced triptan response

Recent prior opioid use was associated with lower triptan response.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.

Language : English

41.

Randomized evaluation of octreotide vs prochlorperazine for ED treatment of migraine headache.

Author: MillerMichael A, LevskyMarc E, EnslowWilliam, RosinAlex

This study compares the effectiveness of intravenous octreotide (a medication) to standard treatment with prochlorperazine for migraine headaches in an emergency department setting. The study aims to determine if octreotide could be a more effective treatment option for migraine headaches.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.

Language : English

42.

Foods and supplements in the management of migraine headaches.

Author: Sun-EdelsteinChristina, MauskopAlexander

Migraine treatment

While many treatments exist for migraine headaches, lifestyle changes are important for many people to reduce their frequency and severity. With the potential side effects of traditional medications, people are increasingly looking to natural remedies like vitamins and supplements. This article explores the role of food triggers in migraines and reviews the evidence for using supplements to treat them.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Meta-AnalysisA statistical technique that integrates the results of multiple studies to draw more general conclusions about a particular issue.
ReviewAn article that critically examines existing research on a particular topic and summarizes the current state of knowledge in the field.

Language : English

43.

A placebo-controlled surgical trial of the treatment of migraine headaches.

Author: GuyuronBahman, ReedDeborah, KrieglerJennifer S, DavisJanine, PashminiNazly, AminiSaeid

Migraine treatment
Side effects

This study investigated the effectiveness of surgically deactivating three common migraine trigger points in a double-blind, controlled trial. The study found that this surgical approach was effective in reducing migraines for many people who did not respond to traditional treatments.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Multicenter StudyResearch conducted in collaboration with multiple research institutions. It aims to collect a wide range of data and obtain more generalizable results.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.

Language : English

44.

A double-blind comparison of onabotulinumtoxina (BOTOX) and topiramate (TOPAMAX) for the prophylactic treatment of chronic migraine: a pilot study.

Author: MathewNinan T, JaffriSayyed Farhan A

Improved disability
Improved headache days
Discontinuations
Side effects

OnabotulinumtoxinA and topiramate showed similar efficacy in reducing headache days and improving disability in patients with chronic migraine (CM). OnabotulinumtoxinA had fewer adverse events and discontinuations, suggesting it may be a preferred option.

Comparative StudyResearch that compares multiple groups/interventions to determine differences/similarities in outcomes/characteristics.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.

Language : English

45.

Triptans for acute cluster headache.

Author: LawSimon, DerrySheena, MooreR Andrew

Cluster headache treatment

Cluster headache is a rare but very painful and disabling condition that comes on quickly. There are few effective treatments, with inhaled oxygen being the main option. Other treatments, such as intranasal lidocaine and ergotamine, are less commonly used and studied. Triptans, which are effective for migraine headaches, may also be helpful for cluster headaches.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Meta-AnalysisA statistical technique that integrates the results of multiple studies to draw more general conclusions about a particular issue.
ReviewAn article that critically examines existing research on a particular topic and summarizes the current state of knowledge in the field.
Systematic ReviewA review that systematically collects, evaluates, and integrates relevant research to answer a specific research question.

Language : English

46.

Safety and tolerability of frovatriptan in the acute treatment of migraine and prevention of menstrual migraine: Results of a new analysis of data from five previously published studies.

Author: MacGregorE Anne, PawseyStephen P, CampbellJohn C, HuXiaojun

Effective migraine treatment
Frovatriptan safe
Frovatriptan well tolerated
Mild to moderate AE

The study found that frovatriptan was well tolerated in women during acute treatment (AT) and short-term preventive (STP) therapy for menstrual migraine (MM).

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Meta-AnalysisA statistical technique that integrates the results of multiple studies to draw more general conclusions about a particular issue.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.

Language : English

47.

Evolution of migraine-associated symptoms in menstrually related migraine following symptomatic treatment with almotriptan.

Author: AllaisGianni, AcutoGiancarlo, BenedettoChiara, D'AndreaGiovanni, GrazziLicia, ManzoniGian Camillo, MoschianoFranca, d'OnofrioFlorindo, ValguarneraFabio, BussoneGennaro

Migraine treatment

Migraines are characterized by headaches and other symptoms, such as nausea, vomiting, sensitivity to light, sound, and smells, which affect quality of life. These symptoms are also common in migraines related to menstruation, a difficult-to-treat type of migraine. This study examined the effects of almotriptan on these migraine-associated symptoms (MAS) and found that it significantly reduced them compared to placebo over a 2-hour period.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Multicenter StudyResearch conducted in collaboration with multiple research institutions. It aims to collect a wide range of data and obtain more generalizable results.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.

Language : English

48.

P3MC: a double blind parallel group randomised placebo controlled trial of Propranolol and Pizotifen in preventing migraine in children.

Author: SilcocksPaul, WhithamDiane, WhitehouseWilliam Patrick

Migraine treatment

A review of research on migraine treatments for children found a lack of reliable studies, especially for the two most common preventative medications used in the UK: propranolol and pizotifen. Migraine studies in both children and adults show a high placebo response (23%), which means that people might improve just from thinking they are getting treatment. This means that when evaluating new treatments, it is important to include all participants, including those who respond to placebo, and to make sure that the new treatment is clearly better than placebo, both clinically and statistically.

Comparative StudyResearch that compares multiple groups/interventions to determine differences/similarities in outcomes/characteristics.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Multicenter StudyResearch conducted in collaboration with multiple research institutions. It aims to collect a wide range of data and obtain more generalizable results.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.

Language : English

49.

Efficacy of almotriptan in early intervention for treatment of acute migraine in a primary care setting: the START study.

Author: Lanteri-MinetM, Díaz-InsaS, LeoneM, VilaC, ClissoldS P,

Migraine treatment

Research has shown that taking almotriptan early for migraine, when pain is still mild, is effective in a specialized setting. This study aimed to determine if this same benefit of early treatment with almotriptan could be achieved in primary care settings, where most people with migraines are treated.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Multicenter StudyResearch conducted in collaboration with multiple research institutions. It aims to collect a wide range of data and obtain more generalizable results.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.

Language : English

50.

Almotriptan 12.5 mg in menstrually related migraine: a randomized, double-blind, placebo-controlled study.

Author: AllaisGianni, BussoneGennaro, D'AndreaGiovanni, MoschianoFranca, d'OnofrioFlorindo, ValguarneraFabio, ManzoniGian Camillo, GrazziLicia, AllaisRita, BenedettoChiara, AcutoGiancarlo

MRM treatment

Migraines related to menstruation affect over half of women with migraines. These migraines are often predictable, making them a good target for treatment when the pain is still mild. This study examines the effectiveness of almotriptan in treating migraines that occur around menstruation.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Multicenter StudyResearch conducted in collaboration with multiple research institutions. It aims to collect a wide range of data and obtain more generalizable results.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.

Language : English

51.

Effect of preventive (beta blocker) treatment, behavioural migraine management, or their combination on outcomes of optimised acute treatment in frequent migraine: randomised controlled trial.

Author: HolroydKenneth A, CottrellConstance K, O'DonnellFrancis J, CordingleyGary E, DrewJana B, CarlsonBruce W, HimawanLina

Improved migraine outcomes

Combined beta blocker treatment and behavioral migraine management, but not either intervention alone, improved outcomes for patients with frequent migraine compared to optimized acute treatment alone.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Multicenter StudyResearch conducted in collaboration with multiple research institutions. It aims to collect a wide range of data and obtain more generalizable results.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.
Research Support, N.I.H., ExtramuralResearch funding provided by the NIH to external research institutions and researchers.

Language : English

52.

Method of injection of onabotulinumtoxinA for chronic migraine: a safe, well-tolerated, and effective treatment paradigm based on the PREEMPT clinical program.

Author: BlumenfeldAndrew, SilbersteinStephen D, DodickDavid W, AuroraSheena K, TurkelCatherine C, BinderWilliam J

CM treatment

Chronic migraine (CM) is a common and disabling condition. OnabotulinumtoxinA, a medication that blocks pain-signaling substances, has been studied as a preventative treatment for various headaches, including CM. Initially, injections were given at fixed locations, but the approach evolved to include additional specific sites based on individual pain locations and tenderness. The PREEMPT injection paradigm, which combines fixed and personalized injection sites, has been shown to be safe, well-tolerated, and effective in clinical trials and is the recommended approach for managing CM.

Clinical Trial, Phase IIA Phase II trial is a trial that further evaluates the efficacy and safety of a new drug or treatment, whose safety has been confirmed to some extent in a Phase I trial, in a small number of patients.
Clinical Trial, Phase IIIA Phase III trial is a trial that further rigorously verifies the efficacy and safety of a new drug or treatment, whose efficacy and safety have been confirmed in a Phase II trial, in a large number of patients, and evaluates whether it is superior to existing treatments.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.

Language : English

53.

A multi-center double-blind pilot comparison of onabotulinumtoxinA and topiramate for the prophylactic treatment of chronic migraine.

Author: CadyRoger K, SchreiberCurtis P, PorterJohn A H, BlumenfeldAndrew M, FarmerKathleen U

Reduced migraine frequency

This study compared the effectiveness of onabotulinumtoxinA and topiramate in treating chronic migraine. Both treatments were shown to be beneficial in reducing headache frequency, but there was no significant difference between the two groups. By week 26, subjects in both groups had a reduction in headache days per month compared to baseline.

Comparative StudyResearch that compares multiple groups/interventions to determine differences/similarities in outcomes/characteristics.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Multicenter StudyResearch conducted in collaboration with multiple research institutions. It aims to collect a wide range of data and obtain more generalizable results.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.

Language : English

54.

Where is dihydroergotamine mesylate in the changing landscape of migraine therapy?

Author: MorrenJohn A, Galvez-JimenezNestor

Migraine treatment

Dihydroergotamine mesylate (DHE) can be an effective treatment option for people with migraine who haven't found relief with other therapies. While migraine affects 18% of women and 6% of men, current treatments haven't been very successful for many patients. Using DHE appropriately can lead to significant improvement in migraine symptoms and increased satisfaction for those struggling with the condition.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
ReviewAn article that critically examines existing research on a particular topic and summarizes the current state of knowledge in the field.
Systematic ReviewA review that systematically collects, evaluates, and integrates relevant research to answer a specific research question.

Language : English

55.

Manual therapies for migraine: a systematic review.

Author: ChaibiAleksander, TuchinPeter J, RussellMichael Bjørn

Migraine treatment

Migraine affects about 15% of people. While medications are commonly used, some people cannot tolerate them or prefer alternative approaches. This review of studies on manual therapies for migraine found that massage therapy, physiotherapy, relaxation techniques, and chiropractic spinal manipulation may be as effective as certain migraine medications in preventing migraines. However, the studies reviewed had limitations, requiring further well-designed research to confirm these findings.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Meta-AnalysisA statistical technique that integrates the results of multiple studies to draw more general conclusions about a particular issue.
ReviewAn article that critically examines existing research on a particular topic and summarizes the current state of knowledge in the field.
Systematic ReviewA review that systematically collects, evaluates, and integrates relevant research to answer a specific research question.

Language : English

56.

Efficacy of osteopathic manipulative treatment of female patients with migraine: results of a randomized controlled trial.

Author: VoigtKaren, LiebnitzkyJan, BurmeisterUte, Sihvonen-RiemenschneiderHenna, BeckMatthias, VoigtRoger, BergmannAntje

Migraine treatment

Migraine is a common neurological condition in Europe with a significant impact on work and quality of life. While medication is considered the standard treatment, this study examines the use of osteopathic treatment as an alternative approach for both acute and preventative migraine management.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.

Language : English

57.

A double-blind placebo-controlled pilot study of sublingual feverfew and ginger (LipiGesic™ M) in the treatment of migraine.

Author: CadyRoger K, GoldsteinJerome, NettRobert, MitchellRussell, BeachM E, BrowningRebecca

Migraine treatment

Migraine treatment needs vary greatly, with some attacks requiring immediate strong medication and others needing less urgent care. While triptans are a standard treatment, they have limitations, and many people seek alternative options. A study suggested that a combination of feverfew and ginger might be effective when taken early during mild migraine headaches.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Multicenter StudyResearch conducted in collaboration with multiple research institutions. It aims to collect a wide range of data and obtain more generalizable results.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.

Language : English

58.

[Botulinum toxin type A in the prophylactic treatment of chronic migraine].

Author: GöbelH, HeinzeA

Improved chronic migraine treatment

While chronic migraine is less common than other types of migraine, it has a significant impact on patients. Previously, there was no approved medication for preventing chronic migraines. However, a new treatment using botulinum toxin type A (Botox) has been found to be effective and well-tolerated in clinical trials. Botox has been approved for treating chronic migraine in England and is currently awaiting approval in Germany.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Multicenter StudyResearch conducted in collaboration with multiple research institutions. It aims to collect a wide range of data and obtain more generalizable results.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.

Language : German

59.

Psychiatric comorbidity and response to preventative therapy in the treatment of severe migraine trial.

Author: SengElizabeth K, HolroydKenneth A

Improved quality of life
Reduced migraine days

Patients with a comorbid mood or anxiety disorder diagnosis had significantly larger reductions in migraine days and migraine-related disability than did participants without a mood or anxiety disorder diagnosis.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.
Research Support, N.I.H., ExtramuralResearch funding provided by the NIH to external research institutions and researchers.

Language : English

60.

Occipital nerve stimulation for chronic migraine: a randomized trial.

Author: SerraGerardo, MarchiorettoFabio

Headache reduction
Improved quality of life
Reduced medication use
Infection
Lead migration

Occipital nerve stimulation (ONS) appeared to be a safe and effective treatment for chronic migraine (CM) and medication overuse headache (MOH) patients, improving headache intensity, frequency, quality of life, and reducing drug intake.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.

Language : English

62.

Acupuncture versus valproic acid in the prophylaxis of migraine without aura: a prospective controlled study.

Author: FaccoE, LiguoriA, PettiF, FauciA J, CavallinF, ZanetteG

Migraine prophylaxis
Reduced medication use
Reduced pain

The study compared the effectiveness of traditional acupuncture and valproic acid for migraine prophylaxis. Acupuncture was associated with a lower pain intensity and lower rizatriptan intake at six-month follow-up with no adverse events compared to valproic acid.

Comparative StudyResearch that compares multiple groups/interventions to determine differences/similarities in outcomes/characteristics.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.

Language : English

63.

[Psychological therapy of migraine: systematic review].

Author: FritscheG, Kröner-HerwigB, KroppP, NiederbergerU, HaagG

Migraine treatment

This review examines different behavioral therapies for migraine headaches that have shown to be effective. These include techniques like thermal biofeedback, electromyography (EMG) biofeedback, and progressive muscle relaxation. All of these approaches have similar effectiveness, reducing migraine frequency by 35-45%. Cognitive-behavioral therapy (CBT) is also used and can reduce migraine activity by 39%. Behavioral treatments can be used alone or alongside medication and can be especially effective in children and adolescents.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
ReviewAn article that critically examines existing research on a particular topic and summarizes the current state of knowledge in the field.
Systematic ReviewA review that systematically collects, evaluates, and integrates relevant research to answer a specific research question.

Language : German

64.

Episodic migraines in children: limited evidence on preventive pharmacological treatments.

Author: ShamliyanTatyana A, KaneRobert L, RamakrishnanRema, TaylorFrederick R

Childhood migraine prevention
Adverse effects

This review of studies on migraine prevention in children found limited evidence supporting the effectiveness of certain medications. Propranolol showed promise in reducing migraine frequency, while trazodone and nimodipine decreased migraine days. Other medications, including topiramate, divalproex, and clonidine, were no more effective than placebo. Topiramate was associated with side effects, and divalproex led to treatment discontinuation due to side effects. Long-term benefits, impact on quality of life, and individualized treatment approaches for migraine prevention in children are still unclear.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Research Support, N.I.H., ExtramuralResearch funding provided by the NIH to external research institutions and researchers.
ReviewAn article that critically examines existing research on a particular topic and summarizes the current state of knowledge in the field.
Systematic ReviewA review that systematically collects, evaluates, and integrates relevant research to answer a specific research question.

Language : English

65.

SumaRT/Nap vs naproxen sodium in treatment and disease modification of migraine: a pilot study.

Author: CadyRoger, O'CarrollPhillip, DexterKent, FreitagFred, ShadeCandace L

Migraine treatment

This study examines whether two medications commonly used to treat migraine headaches, sumatriptan and naproxen sodium, can both stop a migraine attack and reduce the number of future migraine attacks.

Comparative StudyResearch that compares multiple groups/interventions to determine differences/similarities in outcomes/characteristics.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Multicenter StudyResearch conducted in collaboration with multiple research institutions. It aims to collect a wide range of data and obtain more generalizable results.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.

Language : English

66.

Sumatriptan/naproxen sodium for the acute treatment of probable migraine without aura: a randomized study.

Author: SilbersteinStephen, McDonaldSusan A, GoldsteinJerome, AuroraSheena, LenerShelly E, WhiteJonathan, RunkenMichael C, SaiersJane, DerosierFrederick, LiptonRichard B

Headache relief
Pain-free response
Rescue medication reduction
Dizziness
Dry mouth
Nausea

Sumatriptan/naproxen sodium is effective in the acute treatment of probable migraine as demonstrated by higher rates of freedom from pain and restoration of function.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.

Language : English

67.

Comparative efficacy of triptans for the abortive treatment of migraine: a multiple treatment comparison meta-analysis.

Author: ThorlundKristian, MillsEdward J, WuPing, RamosElodie, ChatterjeeAnjan, DruytsEric, GoadsbyPeter J

Migraine treatment

Migraine is a common headache disorder. Triptans, a type of medication, are effective in stopping migraine attacks, reducing pain, and improving quality of life. While there have been some comparisons between different triptans, research on all possible combinations is limited. This information would be helpful for doctors to make the best treatment choices.

Comparative StudyResearch that compares multiple groups/interventions to determine differences/similarities in outcomes/characteristics.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Meta-AnalysisA statistical technique that integrates the results of multiple studies to draw more general conclusions about a particular issue.

Language : English

68.

Sumatriptan plus naproxen for acute migraine attacks in adults.

Author: LawSimon, DerrySheena, MooreR Andrew

Migraine treatment

Migraine headaches are common and disabling, causing problems for individuals and healthcare systems. Triptans and nonsteroidal anti-inflammatory drugs (NSAIDs) are effective treatments for migraine attacks. These medications work in different ways, and combining them may provide better relief. A combination of sumatriptan and naproxen is now available for treating migraine headaches.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Meta-AnalysisA statistical technique that integrates the results of multiple studies to draw more general conclusions about a particular issue.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.
ReviewAn article that critically examines existing research on a particular topic and summarizes the current state of knowledge in the field.
Systematic ReviewA review that systematically collects, evaluates, and integrates relevant research to answer a specific research question.

Language : English

69.

Evaluating the prophylaxis and long-term effectiveness of acupuncture for migraine without aura: study protocol for a randomized controlled trial.

Author: ChenJiao, ZhaoLing, ZhengHui, LiYing, YangMingxiao, ChangXiaorong, GongBiao, HuangYinlan, LiuYanqin, LiangFanrong

Migraine prophylaxis

While acupuncture has been shown to provide immediate relief for migraine headaches, it's unclear if its effects last long-term or are due to a placebo effect. This study aims to investigate the effectiveness of acupuncture in preventing migraine headaches without aura (MWoA) in China, as there's currently a lack of research on this topic.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Multicenter StudyResearch conducted in collaboration with multiple research institutions. It aims to collect a wide range of data and obtain more generalizable results.
Pragmatic Clinical TrialA trial conducted in a real-world clinical setting. It evaluates the effectiveness of interventions in everyday healthcare environments.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.

Language : English

70.

Comparison of frovatriptan plus dexketoprofen (25 mg or 37.5 mg) with frovatriptan alone in the treatment of migraine attacks with or without aura: a randomized study.

Author: TulloVincenzo, ValguarneraFabio, BarbantiPiero, CortelliPietro, SetteGiuliano, AllaisGianni, d'OnofrioFlorindo, CuroneMarcella, ZavaDario, PezzolaDeborha, BenedettoChiara, FredianiFabio, BussoneGennaro

Frovatriptan/dexketoprofen better than frovatriptan alone

Combination therapy of frovatriptan and dexketoprofen was more effective in relieving migraine pain at 2 hours compared to frovatriptan alone. The combination maintained efficacy at 48 hours.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Multicenter StudyResearch conducted in collaboration with multiple research institutions. It aims to collect a wide range of data and obtain more generalizable results.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.

Language : English

71.

Emerging therapies for chronic migraine.

Author: Proietti CecchiniAlberto, GrazziLicia

Migraine treatment

Chronic migraines that aren't caused by overuse of medication can be difficult to treat. While some medications are available, they can be ineffective or have unwanted side effects. New treatments for chronic migraines are needed. Recent research suggests that occipital nerve stimulation (ONS) and injections of botulinum toxin type A can help, with at least some improvement seen in many patients. More research is needed to identify the best candidates for these treatments.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Meta-AnalysisA statistical technique that integrates the results of multiple studies to draw more general conclusions about a particular issue.
ReviewAn article that critically examines existing research on a particular topic and summarizes the current state of knowledge in the field.

Language : English

72.

Double-blind, placebo-controlled, crossover study of early-intervention with sumatriptan 85/naproxen sodium 500 in (truly) episodic migraine: what's neck pain got to do with it?

Author: CalhounAnne H, FordSutapa

Migraine treatment

While triptans are used to treat migraine headaches, studies have shown limited effectiveness, with only 18-58% of people becoming pain-free after two hours. This study aims to see if sumatriptan and naproxen are more effective in people with truly episodic migraines, meaning they only experience headaches occasionally and not just mild or neck pain.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.

Language : English

73.

Behavioral migraine management modifies behavioral and cognitive coping in people with migraine.

Author: SengElizabeth K, HolroydKenneth A

Migraine treatment

This study examines how cognitive behavioral therapy (CBT), preventive medication, and a combination of both affect thinking and behavior related to migraine headaches. The study will also investigate how these changes impact the severity of migraine-related disability.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.

Language : English

74.

Treatment of chronic migraine with intramuscular pericranial injections of onabotulinumtoxin a.

Author: BelvisRobert, MasNatalia

Chronic migraine treatment

Chronic migraine is the most common and disabling type of migraine. Topiramate and injections of onabotulinumtoxin A (Botox) are the only treatments specifically studied for chronic migraine and are considered effective. Botox injections, particularly around the head and neck, have shown good effectiveness and safety in reducing headache days, migraine frequency, and medication use, while improving quality of life. Botox is a viable treatment option for chronic migraine, similar to topiramate.

Clinical Trial, Phase IIIA Phase III trial is a trial that further rigorously verifies the efficacy and safety of a new drug or treatment, whose efficacy and safety have been confirmed in a Phase II trial, in a large number of patients, and evaluates whether it is superior to existing treatments.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.

Language : English

75.

Reduced efficacy of sumatriptan in migraine with aura vs without aura.

Author: HansenJakob Møller, GoadsbyPeter J, CharlesAndrew

A pooled analysis of multiple randomized trials indicated that sumatriptan was less effective for treating migraine attacks with aura compared to attacks without aura. Inhaled dihydroergotamine (DHE) had similar efficacy for both types of attacks.

Clinical Trial, Phase IIIA Phase III trial is a trial that further rigorously verifies the efficacy and safety of a new drug or treatment, whose efficacy and safety have been confirmed in a Phase II trial, in a large number of patients, and evaluates whether it is superior to existing treatments.
Comparative StudyResearch that compares multiple groups/interventions to determine differences/similarities in outcomes/characteristics.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Multicenter StudyResearch conducted in collaboration with multiple research institutions. It aims to collect a wide range of data and obtain more generalizable results.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.

Language : English

76.

Acupuncture for acute migraine attacks in adults: a systematic review protocol.

Author: DuRuosang, WangYang, LiuXiaoxu, LiuZhishun

Headache relief
Migraine prevention

This systematic review will assess the effectiveness and safety of acupuncture for the treatment of acute migraine attacks in adults. The review will include randomized controlled trials and will focus on the effects of acupuncture on headache relief, relapse prevention, and migraine-associated symptom reduction.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Meta-AnalysisA statistical technique that integrates the results of multiple studies to draw more general conclusions about a particular issue.

Language : English

77.

Effect of Prayer on Intensity of Migraine Headache: A Randomized Clinical Trial.

Author: TajadiniHaleh, ZangiabadiNasser, DivsalarKouros, SafizadehHossein, EsmailiZahra, RafieiHossein

Migraine pain
Migraine

A study in Iran found that prayer, in addition to propranolol medication, significantly reduced migraine pain intensity in patients. This suggests that prayer can be used as a non-pharmacological pain coping strategy for migraine sufferers.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.

Language : English

78.

Drugs for the acute treatment of migraine in children and adolescents.

Author: RicherLawrence, BillinghurstLori, LinsdellMeghan A, RussellKelly, VandermeerBen, CrumleyEllen T, DurecTamara, KlassenTerry P, HartlingLisa

This systematic review of acute treatment medication trials for migraine in children and adolescents aimed to provide clinicians with evidence-based management choices for this growing population.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Meta-AnalysisA statistical technique that integrates the results of multiple studies to draw more general conclusions about a particular issue.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.
ReviewAn article that critically examines existing research on a particular topic and summarizes the current state of knowledge in the field.
Systematic ReviewA review that systematically collects, evaluates, and integrates relevant research to answer a specific research question.

Language : English

79.

Sumatriptan plus naproxen for the treatment of acute migraine attacks in adults.

Author: LawSimon, DerrySheena, MooreR Andrew

Migraine treatment

This review updates the evidence on using a combination of sumatriptan and naproxen to treat migraine headaches. Migraine is a common and disabling condition affecting more women than men. Sumatriptan and naproxen are both effective treatments, and combining them may offer better relief.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Meta-AnalysisA statistical technique that integrates the results of multiple studies to draw more general conclusions about a particular issue.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.
ReviewAn article that critically examines existing research on a particular topic and summarizes the current state of knowledge in the field.
Systematic ReviewA review that systematically collects, evaluates, and integrates relevant research to answer a specific research question.

Language : English

80.

Does myofascial and trigger point treatment reduce pain and analgesic intake in patients undergoing onabotulinumtoxinA injection due to chronic intractable migraine?

Author: GandolfiMarialuisa, GeroinChristian, ValèNicola, MarchiorettoFabio, TurrinaAndrea, DimitrovaEleonora, TamburinStefano, SerinaAnna, CastellazziPaola, MeschieriAndrea, RicardFrançois, SaltuariLeopold, PicelliAlessandro, SmaniaNicola

Chronic migraine treatment

Chronic migraines are often associated with muscle tension in the neck. While medication is the main treatment, rehabilitation therapies to address muscle tension and trigger points may be helpful for managing headache symptoms.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.

Language : English

81.

[Migraine prophylaxis with trigger point therapy and lymphatic drainage : A pilot study].

Author: YedikardachianDelphine, QuasthoffStefan, LechnerAnita T, GiulianiAlbrecht, FazekasFranz

Reduced migraine

This study investigated the effectiveness of trigger point (TP) therapy and lymphatic drainage (LD) for preventing migraines. The study found that both TP therapy alone and TP therapy combined with LD were effective in reducing migraines for up to eight weeks after treatment.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.

Language : German

82.

AVP-825 (Sumatriptan Nasal Powder) Reduces Nausea Compared to Sumatriptan Tablets: Results of the COMPASS Randomized Clinical Trial.

Author: LiptonRichard B, McGinleyJames S, ShulmanKenneth J, SilbersteinStephen D, WirthR J, BuseDawn C

Migraine treatment

Nausea is a common and debilitating symptom of migraine that can make it difficult to take medication or lead to poor treatment outcomes. While nausea is often a part of migraine itself, it can also be caused by migraine medications. Reducing nausea and minimizing medication-related nausea are important goals in treating migraine attacks.

Comparative StudyResearch that compares multiple groups/interventions to determine differences/similarities in outcomes/characteristics.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.

Language : English

83.

Meta-Synthesis on Migraine Management.

Author: MinenMia T, AnglinCarlita, BoubourAlexandra, SquiresAllison, HerrmannLinda

Migraine treatment

Migraine is a leading cause of disability for adults globally. While research has focused on numbers, there's a need to understand how migraine affects people's lives and their experiences with treatment. Qualitative research can provide valuable insights into these perspectives.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Meta-AnalysisA statistical technique that integrates the results of multiple studies to draw more general conclusions about a particular issue.
ReviewAn article that critically examines existing research on a particular topic and summarizes the current state of knowledge in the field.

Language : English

84.

Recent advances in the management of chronic migraine in children.

Author: ArrudaMarco Antônio, ChevisCamila Flaksberg, BigalMarcelo Eduardo

Improved migraine treatment
Reduced headache frequency

This systematic review examined the comorbidities and treatment of chronic migraine (CM) in children and adolescents, emphasizing the importance of preventive interventions to manage migraine and prevent progression from episodic to chronic forms.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Systematic ReviewA review that systematically collects, evaluates, and integrates relevant research to answer a specific research question.

Language : English

85.

Pharmacokinetics and tolerability of eletriptan hydrobromide in healthy Korean subjects.

Author: KimYu Kyong, ShinKwang-Hee, AldermanJeffrey, YuKyung-Sang, JangIn-Jin, LeeSeungHwan

Effective treatment
Well-tolerated

Eletriptan hydrobromide (eletriptan HBr) showed linear pharmacokinetics and was well tolerated in Korean subjects. Its pharmacokinetic and tolerability profiles did not differ between Korean and non-Korean subjects.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.

Language : English

86.

Evaluation of Galcanezumab for the Prevention of Episodic Migraine: The EVOLVE-1 Randomized Clinical Trial.

Author: StaufferVirginia L, DodickDavid W, ZhangQi, CarterJeffrey N, AilaniJessica, ConleyRobert R

Migraine prevention
Injection site reaction

Galcanezumab 120-mg and 240-mg monthly injections significantly reduced monthly migraine headache days compared with placebo. The incidence rate of adverse events was low, demonstrating the favorable tolerability profile of galcanezumab.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.

Language : English

87.

Botulinum toxins for the prevention of migraine in adults.

Author: HerdClare P, TomlinsonClaire L, RickCaroline, ScottonW J, EdwardsJulie, IvesNatalie, ClarkeCarl E, SinclairAlexandra

Botulinum toxin type A
Migraine treatment

Migraine is a common and disabling condition, affecting around 15% of adults. While treatments can help, many people still experience frequent and severe headaches. Botulinum toxin type A has been approved in some countries for chronic migraine, which is defined as 15 or more headache days per month, with at least 8 of those being migraines. This approval was based on just two studies, highlighting the need for more research.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Meta-AnalysisA statistical technique that integrates the results of multiple studies to draw more general conclusions about a particular issue.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.
ReviewAn article that critically examines existing research on a particular topic and summarizes the current state of knowledge in the field.
Systematic ReviewA review that systematically collects, evaluates, and integrates relevant research to answer a specific research question.

Language : English

88.

Acupuncture for migraine without aura: a systematic review and meta-analysis.

Author: XuJia, ZhangFu-Qing, PeiJian, JiJun

Improved tolerability
Reduced migraine frequency
Reduced pain

Acupuncture treatment for migraine without aura (MWoA) was found to be more effective than medication in reducing migraine frequency and visual analog scale (VAS) scores.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Meta-AnalysisA statistical technique that integrates the results of multiple studies to draw more general conclusions about a particular issue.
Systematic ReviewA review that systematically collects, evaluates, and integrates relevant research to answer a specific research question.

Language : English

89.

Efficacy and tolerability of erenumab in patients with episodic migraine in whom two-to-four previous preventive treatments were unsuccessful: a randomised, double-blind, placebo-controlled, phase 3b study.

Author: ReuterUwe, GoadsbyPeter J, Lanteri-MinetMichel, WenShihua, Hours-ZesigerPeggy, FerrariMichel D, KlattJan

Erenumab
Migraine treatment

This study investigates the effectiveness and safety of erenumab, a new medication that targets a protein called CGRP, in treating people with migraine headaches who haven't responded well to other medications.

Clinical Trial, Phase IIIA Phase III trial is a trial that further rigorously verifies the efficacy and safety of a new drug or treatment, whose efficacy and safety have been confirmed in a Phase II trial, in a large number of patients, and evaluates whether it is superior to existing treatments.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.

Language : English

90.

The Effect of Beginning Treatment With Fremanezumab on Headache and Associated Symptoms in the Randomized Phase 2 Study of High Frequency Episodic Migraine: Post-Hoc Analyses on the First 3 Weeks of Treatment.

Author: SilbersteinStephen D, RapoportAlan M, LoupePippa S, AycardiErnesto, McDonaldMirna, YangRonghua, BigalMarcelo E

Migraine treatment
Preventive medications

Migraine has a major impact on people's lives, affecting work and quality of life for both patients and families. Many people stop taking preventive migraine medications because it can take a long time to see improvement. This can lead to ineffective treatment.

Clinical Trial, Phase IIA Phase II trial is a trial that further evaluates the efficacy and safety of a new drug or treatment, whose safety has been confirmed to some extent in a Phase I trial, in a small number of patients.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Multicenter StudyResearch conducted in collaboration with multiple research institutions. It aims to collect a wide range of data and obtain more generalizable results.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.

Language : English

91.

Efficacy of ADAM Zolmitriptan for the Acute Treatment of Difficult-to-Treat Migraine Headaches.

Author: TepperStewart J, DodickDavid W, SchmidtPeter C, KellermanDonald J

Migraine treatment
Zolmitriptan

This study investigated the effectiveness of zolmitriptan delivered through a skin patch (ADAM) for treating difficult-to-treat migraines, including those with severe pain, nausea, or late onset. The study aims to determine if this method is more effective than oral medication for these challenging migraine types.

Clinical Trial, Phase IIA Phase II trial is a trial that further evaluates the efficacy and safety of a new drug or treatment, whose safety has been confirmed to some extent in a Phase I trial, in a small number of patients.
Clinical Trial, Phase IIIA Phase III trial is a trial that further rigorously verifies the efficacy and safety of a new drug or treatment, whose efficacy and safety have been confirmed in a Phase II trial, in a large number of patients, and evaluates whether it is superior to existing treatments.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Multicenter StudyResearch conducted in collaboration with multiple research institutions. It aims to collect a wide range of data and obtain more generalizable results.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.

Language : English

92.

Manual therapy for chronic migraine: a pragmatic randomised controlled trial study protocol.

Author: OdellJim, ClarkCarol, HunnisettAdrian, AhmedOsman Hassan, BranneyJonathan

Chronic migraine treatment
Manual therapy

Chronic migraine is a common and disabling condition, affecting 1-2.2% of people, mostly women. Treatment options are often not very effective and can have side effects. While some evidence suggests manual therapy could be helpful, its effectiveness for chronic migraine is unknown. This study will investigate whether adding manual therapy to standard treatment improves outcomes for people with chronic migraine.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.

Language : English

93.

Onset of efficacy and duration of response of galcanezumab for the prevention of episodic migraine: a post-hoc analysis.

Author: GoadsbyPeter J, DodickDavid W, MartinezJames M, FergusonMargaret B, OakesTina M, ZhangQi, SkljarevskiVladimir, AuroraSheena K

Reduced migraine frequency

Galcanezumab showed onset of efficacy within 1 week in a majority of patients with episodic migraine and patients receiving galcanezumab were twice more likely to maintain responses than placebo patients. Early non-responders may respond by month 2 or month 3.

Clinical Trial, Phase IIA Phase II trial is a trial that further evaluates the efficacy and safety of a new drug or treatment, whose safety has been confirmed to some extent in a Phase I trial, in a small number of patients.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.

Language : English

94.

Cost-Effectiveness Analysis of Erenumab Versus OnabotulinumtoxinA for Patients with Chronic Migraine Attacks in Greece.

Author: GiannouchosTheodoros V, MitsikostasDimos-Dimitrios, OhsfeldtRobert L, VozikisAthanassios, KoufopoulouParaskevi

Erenumab
Migraine treatment
OnabotulinumtoxinA

Migraine is a common and costly condition that significantly impacts people's lives. While treatments exist, many people don't respond well to initial medications, and Botox injections are sometimes used. Erenumab is a new medication for migraine prevention.

Comparative StudyResearch that compares multiple groups/interventions to determine differences/similarities in outcomes/characteristics.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.

Language : English

95.

Efficacy and safety of lasmiditan in patients using concomitant migraine preventive medications: findings from SAMURAI and SPARTAN, two randomized phase 3 trials.

Author: LooLi Shen, AilaniJessica, SchimJack, BayganiSimin, HundemerHans-Peter, PortMartha, KregeJohn H

Migraine relief

Lasmiditan was found to be effective in the acute treatment of migraine in patients concurrently using migraine preventive medications. Efficacy and safety were similar between patients using and not using preventive medications.

Clinical Trial, Phase IIIA Phase III trial is a trial that further rigorously verifies the efficacy and safety of a new drug or treatment, whose efficacy and safety have been confirmed in a Phase II trial, in a large number of patients, and evaluates whether it is superior to existing treatments.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.

Language : English

96.

Double-blind placebo-controlled randomized clinical trial of ginger (<i>Zingiber officinale Rosc.</i>) in the prophylactic treatment of migraine.

Author: MartinsLaís Bhering, RodriguesAna Maria Dos Santos, MontezeNayara Mussi, TibaesJenneffer Rayane Braga, AmaralMatheus Henrique Alves, GomezRodrigo Santiago, TeixeiraAntônio Lúcio, FerreiraAdaliene Versiani Matos

A double-blind, placebo-controlled randomized clinical trial of 107 patients with episodic migraine found that ginger provided no greater benefit in the prophylactic treatment of migraine compared to placebo.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Observational StudyResearch that observes and collects data on participants' behavior and outcomes in their natural state, without intervention.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.

Language : English

97.

Onset of Efficacy Following Oral Treatment With Lasmiditan for the Acute Treatment of Migraine: Integrated Results From 2 Randomized Double-Blind Placebo-Controlled Phase 3 Clinical Studies.

Author: AshinaMessoud, VasudevaRaghavendra, JinLeah, LombardLouise, GrayElizabeth, DotyErin G, Yunes-MedinaLaura, KinchenKraig S, TassorelliCristina

Early onset of efficacy
Improved migraine symptoms

Lasmiditan, a novel 5-HT1F receptor agonist, demonstrated an earlier onset of efficacy compared to placebo in the acute treatment of migraine. Pain relief and freedom from associated symptoms were observed as early as 30 minutes after taking lasmiditan.

Clinical Trial, Phase IIIA Phase III trial is a trial that further rigorously verifies the efficacy and safety of a new drug or treatment, whose efficacy and safety have been confirmed in a Phase II trial, in a large number of patients, and evaluates whether it is superior to existing treatments.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.

Language : English

98.

Greater Occipital Nerve Block for the Treatment of Chronic Migraine Headaches: A Systematic Review and Meta-Analysis.

Author: ShaulyOrr, GouldDaniel J, Sahai-SrivastavaSoma, PatelKetan M

Improved chronic migraine treatment

This review examined the efficacy of greater occipital nerve block for the treatment of chronic migraine headaches, considering the limited treatment options and the growing evidence from randomized controlled trials.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Meta-AnalysisA statistical technique that integrates the results of multiple studies to draw more general conclusions about a particular issue.
Systematic ReviewA review that systematically collects, evaluates, and integrates relevant research to answer a specific research question.

Language : English

99.

Acupuncture methods for acute migraine attack: a Bayesian network meta-analysis protocol.

Author: ZhouJing, LiJunlong, YangJiwei, LiJianliang, WangChongxin

Improved migraine treatment

Migraine is a common and disabling condition, particularly affecting younger adults and women. While studies suggest acupuncture might help with migraine attacks, the methods used in research and practice vary widely. This study will assess the effectiveness of different acupuncture techniques to determine the best approach for treating migraines.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Meta-AnalysisA statistical technique that integrates the results of multiple studies to draw more general conclusions about a particular issue.

Language : English

100.

Systematic Review: Acupuncture vs Standard Pharmacological Therapy for Migraine Prevention.

Author: ZhangNiushen, HouleTim, HindiyehNada, AuroraSheena K

Migraine prevention
Migraine treatment

While there are many treatments for migraine, they have limitations. Acupuncture is becoming more popular for migraine prevention and treatment, but research comparing its effectiveness to medications is limited. This review looks at studies that compared acupuncture to migraine medications.

Comparative StudyResearch that compares multiple groups/interventions to determine differences/similarities in outcomes/characteristics.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Systematic ReviewA review that systematically collects, evaluates, and integrates relevant research to answer a specific research question.

Language : English

101.

[The efficacy of the second generation triptan migrepam in the treatment of migraine attacks: results of the comparative study].

Author: TabeevaG R, EvdokimovaE M, ShagbazyanA E

Improved functioning
Migraine relief

The study found that migrepam (zolmitriptan) and sumatriptan had similar effects on the intensity of pain and accompanying symptoms of migraine attacks. However, migrepam showed a more significant effect on daily functioning and was associated with a higher subjective assessment of effectiveness by patients.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.

Language : Russian

102.

Acupuncture for menstrual migraine: a systematic review.

Author: YangMingxiao, DuTing, LongHulin, SunMingsheng, LiangFanrong, LaoLixing

Menstrual migraine treatment

This study aims to evaluate whether acupuncture is an effective treatment for menstrual migraines, a type of migraine that occurs around a woman's menstrual cycle. While acupuncture is often used for general migraines, there's limited evidence to support its use for menstrual migraines specifically. The study will assess whether acupuncture can reduce the frequency and severity of menstrual migraines.

Systematic ReviewA review that systematically collects, evaluates, and integrates relevant research to answer a specific research question.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.

Language : English

103.

The Role of Diet and Nutrition in Migraine Triggers and Treatment: A Systematic Literature Review.

Author: HindiyehNada Ahmad, ZhangNiushen, FarrarMallory, BanerjeePixy, LombardLouise, AuroraSheena K

Migraine prevention

Alcohol and caffeine are common dietary triggers for migraine attacks. Low-fat and elimination diets have been reported to decrease the frequency of migraine attacks, but high-quality research is needed.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Systematic ReviewA review that systematically collects, evaluates, and integrates relevant research to answer a specific research question.

Language : English

104.

Evaluation of 2-Hour Post-Dose Efficacy of Lasmiditan for the Acute Treatment of Difficult-to-Treat Migraine Attacks.

Author: TepperStewart J, VasudevaRaghavendra, KregeJohn H, RathmannSuchitrita S, DotyErin, VargasBert B, MagisDelphine, KomoriMika

Migraine treatment

This study aims to identify factors that predict how well patients respond to lasmiditan, a medication for migraine headaches. The study will look at different patient characteristics, migraine history, and individual migraine attacks to understand who is most likely to benefit from this medication. The researchers will also focus on groups of patients who have traditionally had difficulty responding to certain migraine treatments.

Clinical Trial, Phase IIIA Phase III trial is a trial that further rigorously verifies the efficacy and safety of a new drug or treatment, whose efficacy and safety have been confirmed in a Phase II trial, in a large number of patients, and evaluates whether it is superior to existing treatments.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Multicenter StudyResearch conducted in collaboration with multiple research institutions. It aims to collect a wide range of data and obtain more generalizable results.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.

Language : English

105.

Evaluation of Patients with Insufficient Efficacy and/or Tolerability to Triptans for the Acute Treatment of Migraine: A Systematic Literature Review.

Author: LerouxElizabeth, BuchananAndrew, LombardLouise, LooLi Shen, BridgeDaisy, RousseauBen, HopwoodNatasha, MatthewsBrandy R, ReuterUwe

Treatment for migraine
Insufficient efficacy
Tolerability

This systematic literature review (SLR) explored the characteristics and treatment outcomes for individuals with insufficient efficacy or tolerability to triptans for acute migraine treatment.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.
Systematic ReviewA review that systematically collects, evaluates, and integrates relevant research to answer a specific research question.

Language : English

106.

Reversion From Chronic Migraine to Episodic Migraine in Patients Treated With Fremanezumab: Post Hoc Analysis From HALO CM Study.

Author: LiptonRichard B, CohenJoshua M, BibeauKristen, GalicMaja, SeminerioMichael J, Ramirez CamposVerena, Halker SinghRashmi B, AilaniJessica

Reversion from CM to EM

This study evaluated the effect of fremanezumab on the rate of reversion from chronic migraine (CM) to episodic migraine (EM). The study found that fremanezumab may offer the benefit of reversion from CM to EM, based on a reduction in the number of headache days over 3 months of treatment.

Clinical Trial, Phase IIIA Phase III trial is a trial that further rigorously verifies the efficacy and safety of a new drug or treatment, whose efficacy and safety have been confirmed in a Phase II trial, in a large number of patients, and evaluates whether it is superior to existing treatments.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Multicenter StudyResearch conducted in collaboration with multiple research institutions. It aims to collect a wide range of data and obtain more generalizable results.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.

Language : English

108.

Efficacy of erenumab in chronic migraine patients with and without ictal allodynia.

Author: LiptonRichard B, BursteinRami, BuseDawn C, DodickDavid W, KoukakisReija, KlattJan, ChengSunfa, ChouDenise E

Reduced medication use
Reduced migraine days
None reported

Erenumab's efficacy in reducing migraine frequency and acute medication use was not impacted by the presence of moderate-to-severe ictal allodynia in patients with chronic migraine.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.
Research Support, N.I.H., ExtramuralResearch funding provided by the NIH to external research institutions and researchers.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.

Language : English

109.

Fremanezumab for the Preventive Treatment of Migraine: Subgroup Analysis by Number of Prior Preventive Treatments with Inadequate Response.

Author: PazderaLadislav, CohenJoshua M, NingXiaoping, CamposVerena Ramirez, YangRonghua, Pozo-RosichPatricia

Effective
Migraine treatment

Fremanezumab demonstrated significant improvements in efficacy compared to placebo in patients with chronic or episodic migraine, even those with inadequate response to 4 prior preventive medication classes.

Clinical Trial, Phase IIIA Phase III trial is a trial that further rigorously verifies the efficacy and safety of a new drug or treatment, whose efficacy and safety have been confirmed in a Phase II trial, in a large number of patients, and evaluates whether it is superior to existing treatments.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Multicenter StudyResearch conducted in collaboration with multiple research institutions. It aims to collect a wide range of data and obtain more generalizable results.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.

Language : English

110.

Comparison of Peripheral Neurectomy vs. Medical Treatment for Migraine: A Randomized Controlled Trial.

Author: BajajJitin, DoddamaniRamesh, ChandraSarat P, RatreShailendra, PariharVijay, YadavYadram, SharmaDhananjaya

Effective
Migraine treatment
Temporal numbness

This study found that migraine surgery using peripheral neurectomies was more effective than chronic drug treatment in appropriately selected patients. The surgery led to significant improvements in pain, disability, and headache frequency.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.

Language : English

111.

Shift from high-frequency to low-frequency episodic migraine in patients treated with Galcanezumab: results from two global randomized clinical trials.

Author: JedynakJakub, ErossEric, GendollaAstrid, RettigantiMallikarjuna, StaufferVirginia L

Galcanezumab for EM

People with frequent migraines (8-14 days a month) have more severe symptoms and a greater risk of developing chronic migraines compared to those with less frequent migraines (4-7 days a month). This study looked at whether a medication called galcanezumab was more effective than a placebo in reducing the frequency of migraines to lower levels (4-7 days a month or 0-3 days a month).

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.

Language : English

112.

Is Allodynia a Determinant Factor in the Effectiveness of Transcranial Direct Current Stimulation in the Prophylaxis of Migraine?

Author: Cerrahoğlu ŞirinTuba, AksuSerkan, Hasirci BayirBuse Rahime, UlukanÇağrı, KaramürselSacit, KurtAdnan, BaykanBetül

Migraine prophylaxis

Allodynia, a condition where things that shouldn't cause pain, like a light touch, do cause pain, is a sign of heightened nerve sensitivity. It can make migraine more difficult to treat and increases the risk of chronic migraines. While there are medications, they can have side effects. Transcranial direct current stimulation (tDCS), a non-invasive brain stimulation technique, is being explored as a possible way to prevent migraines.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.

Language : English

113.

Intradermal mesotherapy versus intravenous dexketoprofen for the treatment of migraine headache without aura: a randomized controlled trial.

Author: AkbasIlker, KocakMeryem Betos, KocakAbdullah Osman, GurSultan Tuna Akgol, DogruyolSinem, DemirMehmet, CakirZeynep

Effective migraine treatment
Small sample size
Unblinded

A randomized controlled trial of 148 patients with migraine without aura in the emergency department found that intradermal mesotherapy was more efficacious than intravenous dexketoprofen in reducing pain intensity.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.

Language : English

114.

Reduction in the severity and duration of headache following fremanezumab treatment in patients with episodic and chronic migraine.

Author: AshinaMessoud, CohenJoshua M, GandhiSanjay K, DuEvelyn

Reduced headache duration
Reduced headache severity

Fremanezumab significantly reduced headache severity and duration in patients with chronic migraine and episodic migraine.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.

Language : English

115.

Acute Treatments for Episodic Migraine in Adults: A Systematic Review and Meta-analysis.

Author: VanderPluymJuliana H, Halker SinghRashmi B, UrtechoMeritxell, MorrowAllison S, NayfehTarek, Torres RoldanVictor D, FarahMagdoleen H, HasanBashar, SaadiSamer, ShahSahrish, Abd-RabuRami, DarazLubna, ProkopLarry J, MuradMohammad Hassan, WangZhen

Improved pain and function
Mild adverse events

Triptans and nonsteroidal anti-inflammatory drugs were effective in reducing migraine pain. Calcitonin gene-related peptide receptor antagonists, lasmiditan, dihydroergotamine, ergotamine plus caffeine, acetaminophen, antiemetics, butorphanol, tramadol in combination with acetaminophen, remote electrical neuromodulation, transcranial magnetic stimulation, external trigeminal nerve stimulation, and noninvasive vagus nerve stimulation also showed positive effects.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Meta-AnalysisA statistical technique that integrates the results of multiple studies to draw more general conclusions about a particular issue.
Research Support, U.S. Gov't, P.H.S.Research funding provided by the Public Health Service (PHS).
Systematic ReviewA review that systematically collects, evaluates, and integrates relevant research to answer a specific research question.

Language : English

116.

Manual joint mobilisation techniques, supervised physical activity, psychological treatment, acupuncture and patient education in migraine treatment. A systematic review and meta-analysis.

Author: BeierDagmar, CallesenHenriette E, CarlsenLouise N, BirkefossKirsten, TómasdóttirHanna, WűrtzenHanne, ChristensenHenrik W, KrøllLotte S, JensenMette, HøstChristel V, HansenJakob M

Improved quality of life
Reduced headache frequency

This systematic review investigated the effects of non-pharmacological treatments for migraine. Evidence for manual therapy, psychological treatment, and patient education was weak, but supervised physical activity and acupuncture showed some potential benefit. Physical activity might improve quality of life, and acupuncture might reduce headache frequency, intensity, and the use of medication.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Meta-AnalysisA statistical technique that integrates the results of multiple studies to draw more general conclusions about a particular issue.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.
Systematic ReviewA review that systematically collects, evaluates, and integrates relevant research to answer a specific research question.

Language : English

117.

Preventive migraine treatment with eptinezumab reduced acute headache medication and headache frequency to below diagnostic thresholds in patients with chronic migraine and medication-overuse headache.

Author: MarmuraMichael J, DienerHans-Christoph, CowanRobert P, TepperStewart J, DiamondMerle L, StarlingAmaal J, HirmanJoe, MehtaLahar, BrevigThomas, CadyRoger

Eptinezumab for CM and MOH

This post hoc analysis examined reductions in acute headache medication (AHM) use and sustained changes in chronic migraine (CM) and medication-overuse headache (MOH) diagnosis following eptinezumab treatment in the PROMISE-2 study.

Clinical Trial, Phase IIIA Phase III trial is a trial that further rigorously verifies the efficacy and safety of a new drug or treatment, whose efficacy and safety have been confirmed in a Phase II trial, in a large number of patients, and evaluates whether it is superior to existing treatments.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.

Language : English

118.

Current Evidence in Migraine Surgery: A Systematic Review.

Author: HenriquesSara, AlmeidaAlexandre, PeresHelena, Costa-FerreiraAntónio

Migraine treatment

Migraines are common and have a big impact on people's lives. While there are medications, some people don't respond well. Surgery to relieve pressure on nerves outside the brain has been suggested as an alternative, but doctors are still hesitant to use it.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Systematic ReviewA review that systematically collects, evaluates, and integrates relevant research to answer a specific research question.

Language : English

119.

Increased migraine-free intervals with multifocal repetitive transcranial magnetic stimulation.

Author: LeahuPavel, BangeManuel, CiolacDumitru, ScheiterStefanie, MateiAlexandru, Gonzalez-EscamillaGabriel, ChirumamillaVenkata C, GroppaStanislav A, MuthuramanMuthuraman, GroppaSergiu

rTMS for episodic migraine

This study investigated the potential of multifocal repetitive transcranial magnetic stimulation (rTMS) for improving clinical outcomes in patients with episodic migraine, considering the limited efficacy of existing treatments and the potential of rTMS.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.

Language : English

120.

Assessment of Erenumab Safety and Efficacy in Patients With Migraine With and Without Aura: A Secondary Analysis of Randomized Clinical Trials.

Author: AshinaMessoud, GoadsbyPeter J, DodickDavid W, TepperStewart J, XueFei, ZhangFeng, BrennanFrancis, Paiva da Silva LimaGabriel

Reduced AMSM days
Reduced migraine frequency

This post-hoc analysis evaluated the efficacy and safety of erenumab in patients with migraine with aura. Erenumab significantly reduced migraine frequency and acute migraine-specific medication days in patients with and without aura history. The safety profile of erenumab was similar to placebo, with no increased emergence of adverse events over time.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.

Language : English

121.

[Effectiveness of physiotherapeutic treatment interventions on pain intensity, duration, frequency, and quality of life of patients with migraine : A systematic review].

Author: JungAndres, EschkeRobert-Christopher, GablerTom, PawlowskyVera, LuedtkeKerstin

Improved quality of life
Reduced pain frequency
Reduced pain intensity
Further research needed

This systematic review assessed the efficacy of physiotherapeutic interventions for migraine. It included 13 randomized controlled trials (RCTs) with a total of 595 patients. All interventions, including multimodal physiotherapy programs, mobilization techniques, trigger point therapy, manual lymphatic drainage, massage, and stretching, had a significantly positive effect on pain intensity, duration, and frequency as well as quality of life. However, further RCTs with low risk of bias are needed to confirm these findings.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
ReviewAn article that critically examines existing research on a particular topic and summarizes the current state of knowledge in the field.
Systematic ReviewA review that systematically collects, evaluates, and integrates relevant research to answer a specific research question.

Language : German

122.

Effects of Galcanezumab on Health-Related Quality of Life and Disability in Patients with Previous Failure of 2-4 Migraine Preventive Medication Categories: Results from a Phase IIIb Randomized, Placebo-Controlled, Multicenter Clinical Trial (CONQUER).

Author: TepperStewart J, AilaniJessica, FordJanet H, NicholsRussell M, LiLily Q, KemmerPhebe, HandAustin L, Tockhorn-HeidenreichAntje

Migraine treatment

This study, called CONQUER, investigated the effects of galcanezumab, a medication, on the ability to function, disability, and overall health of people with migraine who haven't responded well to previous treatments. The study focused on those with frequent migraines or chronic migraines.

Clinical Trial, Phase IIIA Phase III trial is a trial that further rigorously verifies the efficacy and safety of a new drug or treatment, whose efficacy and safety have been confirmed in a Phase II trial, in a large number of patients, and evaluates whether it is superior to existing treatments.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Multicenter StudyResearch conducted in collaboration with multiple research institutions. It aims to collect a wide range of data and obtain more generalizable results.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.

Language : English

123.

Eptinezumab treatment initiated during a migraine attack is associated with meaningful improvement in patient-reported outcome measures: secondary results from the randomized controlled RELIEF study.

Author: McAllisterPeter, WinnerPaul K, AilaniJessica, BuseDawn C, LiptonRichard B, ChakhavaGeorge, JosiassenMette Krog, LindstenAnnika, MehtaLahar, EttrupAnders, CadyRoger

Eptinezumab efficacy
Migraine treatment

This study will examine how a new migraine prevention medication, eptinezumab, affects how patients perceive their migraines, their need for migraine-stopping medications, and their overall perception of their condition when it is started during a migraine attack.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.

Language : English

124.

Systematic review and meta-analysis of a variety of chemicals to treat migraine in the neurology department.

Author: ZhangYi, DengYushaung, ZhangShanshan, DuXin, JiYifei

Migraine treatment
Standardized treatment

Migraine is a common and debilitating condition that can have a significant impact on people's lives and the economy. Early and accurate diagnosis and consistent treatment are important for managing migraine attacks. The goal of treatment is to quickly stop migraines, relieve symptoms, prevent them from returning, and help people get back to their normal lives as quickly as possible.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Meta-AnalysisA statistical technique that integrates the results of multiple studies to draw more general conclusions about a particular issue.
Systematic ReviewA review that systematically collects, evaluates, and integrates relevant research to answer a specific research question.

Language : English

125.

Patient-Centered Treatment of Chronic Migraine With Medication Overuse: A Prospective, Randomized, Pragmatic Clinical Trial.

Author: SchwedtTodd J, HentzJoseph G, Sahai-SrivastavaSoma, MurinovaNatalia, SpareNicole M, TreppendahlChristina, MartinVincent T, BirleaMarius, DigreKathleen, WatsonDavid, LeonardMichael, RobertTeri, DodickDavid W,

Migraine preventive therapy for CMMO

Many people with chronic migraines overuse pain medication, leading to more frequent headaches, side effects, and a lower quality of life. This study examined whether it's better to start preventive migraine medication without changing the overused medication or to switch to a different medication that can be used on fewer days.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.

Language : English

127.

Rates of Response to Atogepant for Migraine Prophylaxis Among Adults: A Secondary Analysis of a Randomized Clinical Trial.

Author: LiptonRichard B, Pozo-RosichPatricia, BlumenfeldAndrew M, DodickDavid W, McAllisterPeter, LiYe, LuKaifeng, DabruzzoBrett, MiceliRosa, SevertLawrence, FinneganMichelle, TrugmanJoel M

Migraine reduction

Atogepant, a calcitonin gene-related peptide receptor antagonist, was effective in reducing mean monthly migraine days (MMDs) at all doses tested. Higher doses of atogepant appeared to produce the greatest responder rates.

Clinical Trial, Phase IIIA Phase III trial is a trial that further rigorously verifies the efficacy and safety of a new drug or treatment, whose efficacy and safety have been confirmed in a Phase II trial, in a large number of patients, and evaluates whether it is superior to existing treatments.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.

Language : English

128.

Effect of Auricular Acupuncture with Semi-Permanent Ear Needles on Controlling Migraine Symptoms: A Single-Blind Randomized Clinical Trial.

Author: HabibabadiMehran Razvani, AshtariFereshteh, RaeisiIman

Reduced migraine frequency
Reduced migraine pain

Auricular acupuncture with semi-permanent (ASP) needles may be a promising complementary therapy for migraine headaches. This single-blind, randomized controlled trial found that ASP acupuncture significantly reduced pain levels, frequency of migraine headaches, and nausea and vomiting compared to a control group. Patient satisfaction was also higher in the ASP acupuncture group.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.

Language : English

129.

Optimization of acute medication use following eptinezumab initiation during a migraine attack: post hoc analysis of the RELIEF study.

Author: CadyRoger, LiptonRichard B, BuseDawn C, JosiassenMette Krog, LindstenAnnika, EttrupAnders

Improved migraine management

This study examined whether a migraine prevention medication, eptinezumab, improved how well acute migraine medications worked in people with migraines. The researchers assessed the effectiveness of acute treatments after four weeks of using eptinezumab.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Multicenter StudyResearch conducted in collaboration with multiple research institutions. It aims to collect a wide range of data and obtain more generalizable results.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.

Language : English

130.

Effect of Galcanezumab on Total Pain Burden in Patients Who Had Previously Not Benefited from Migraine Preventive Medication (CONQUER Trial): A Post Hoc Analysis.

Author: AilaniJessica, AndrewsJeffrey Scott, Tockhorn-HeidenreichAntje, WenzelRichard, RettigantiMallikarjuna

Improved migraine prevention

When evaluating migraine prevention treatments, we often focus on how often headaches occur, but less on how long they last or how severe they are. This study will look at a combined measure of frequency, duration, and severity (total pain burden or TPB) to see how well a medication called galcanezumab (GMB) reduces migraine pain in people who haven't responded to other migraine prevention medications.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.

Language : English

131.

Long-Term Prophylactic Transcranial Direct Current Stimulation Ameliorates Allodynia and Improves Clinical Outcomes in Individuals With Migraine.

Author: AksuSerkan, ŞirinTuba Cerrahoğlu, Hasırcı BayırBuse Rahime, UlukanÇağrı, SoyataAhmet Zihni, KurtAdnan, KaramürselSacit, BaykanBetül

Migraine treatment

This study aims to investigate the effectiveness of six months of transcranial direct current stimulation (tDCS), a non-invasive brain stimulation technique, for treating migraine. While tDCS has shown promise in treating migraine, there's a lack of research on its long-term effects. The study will focus on people with migraine and explore whether tDCS is helpful in reducing migraine frequency and severity over a longer period.

Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.

Language : English

132.

Impact of fremanezumab on disability outcomes in patients with episodic and chronic migraine: a pooled analysis of phase 3 studies.

Author: McAllisterPeter, CohenJoshua M, CamposVerena Ramirez, NingXiaoping, JankaLindsay, BarashSteve

Fremanezumab for migraine

Migraines are a major cause of disability globally. While many migraine treatments reduce the frequency and severity of headaches, it's unclear whether these treatments significantly improve how migraines impact people's lives. This study investigated whether fremanezumab, a medication, reduced migraine-related disability based on patients' reports of their own disability levels and changes in how severe their migraines were.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Meta-AnalysisA statistical technique that integrates the results of multiple studies to draw more general conclusions about a particular issue.

Language : English

133.

Effects on neuromodulation, acupuncture, and aerobic exercises on migraine and tension-type headache outcomes: A systematic review and meta-analysis.

Author: PiChenghui, LiuYinglu, LiLingling, TangWenjing, YanXin, YuShengyuan

Headache prevention
Headache relief

This systematic review and meta-analysis evaluated the effects of various non-pharmacological treatments for acute headaches, including neuromodulation, acupuncture, and aerobic exercises.

Meta-AnalysisA statistical technique that integrates the results of multiple studies to draw more general conclusions about a particular issue.
Systematic ReviewA review that systematically collects, evaluates, and integrates relevant research to answer a specific research question.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.

Language : English

134.

Lasmiditan abortive therapy for episodic migraine in Phase II/III randomized clinical trials: A meta-analysis.

Author: AhsanMarya, MallickAyaz Khurram

Migraine treatment

This meta-analysis and trial sequential analysis (TSA) assesses the efficacy and tolerability of lasmiditan, a specific 5-HT1F agonist, for treating episodic migraine. Lasmiditan is a new treatment option for migraine.

Meta-AnalysisA statistical technique that integrates the results of multiple studies to draw more general conclusions about a particular issue.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.

Language : English

135.

Nonpharmacologic Treatments for Chronic and Episodic Migraine: A Systematic Review and Meta-Analysis.

Author: ChangIrene A, WellsMichael W, WangGi-Ming, TatsuokaCurtis, GuyuronBahman

Migraine treatment

New minimally invasive treatments for migraine headaches, which don't respond to traditional therapies, are emerging. While these techniques show promise, no study has compared their effectiveness on headache frequency, intensity, duration, and cost. This study aims to fill that gap.

Meta-AnalysisA statistical technique that integrates the results of multiple studies to draw more general conclusions about a particular issue.
Systematic ReviewA review that systematically collects, evaluates, and integrates relevant research to answer a specific research question.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.

Language : English

136.

Efficacy and safety of eptinezumab for migraine prevention in patients with prior preventive treatment failures: subgroup analysis of the randomized, placebo-controlled DELIVER study.

Author: AshinaMessoud, Lanteri-MinetMichel, EttrupAnders, ChristoffersenCecilie Laurberg, JosiassenMette Krog, PhulRavinder, SperlingBjørn, Pozo-RosichPatricia

Migraine treatment

Migraines are a common and disabling condition. While new medications are available to prevent migraines, insurance often requires people to try several older medications first. This study will examine whether the new medication eptinezumab is effective in people who haven't responded to other treatments. The study will also look at whether certain characteristics of the patients influence how well the medication works.

Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.

Language : English

137.

Efficacy of mindfulness added to treatment as usual in patients with chronic migraine and medication overuse headache: a phase-III single-blind randomized-controlled trial (the MIND-CM study).

Author: GrazziLicia, D'AmicoDomenico, GuastafierroErika, DemichelisGreta, ErbettaAlessandra, FedeliDavide, NigriAnna, CiusaniEmilio, BarbaraCorso, RaggiAlberto

Migraine treatment
Quality of life improvement

This study assessed the efficacy of a six-sessions mindfulness-based treatment added to treatment as usual (TaU) in patients with Chronic Migraine (CM) and Medication Overuse Headache (MOH).

Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.
Clinical Trial, Phase IIIA Phase III trial is a trial that further rigorously verifies the efficacy and safety of a new drug or treatment, whose efficacy and safety have been confirmed in a Phase II trial, in a large number of patients, and evaluates whether it is superior to existing treatments.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.

Language : English

138.

Treatment of chronic migraine with Botox (onabotulinumtoxinA): Development, insights, and impact.

Author: TurkelCatherine C, AuroraSheena, DienerHans-Christoph, DodickDavid W, LiptonRichard B, SilbersteinStephen D, BrinMitchell F

CM treatment
Quality of life improvement

Chronic migraine (CM) is a debilitating condition with few effective treatments. OnabotulinumtoxinA became the first medication specifically approved for preventing headaches in CM. Two large studies showed that onabotulinumtoxinA significantly reduced the number of headache days compared to placebo. OnabotulinumtoxinA has been shown to be safe and effective in over 5,000 patients with CM, also improving quality of life, reducing mental health issues, and lowering healthcare use. Side effects are generally mild and tend to lessen over time.

Clinical Trial, Phase IIIA Phase III trial is a trial that further rigorously verifies the efficacy and safety of a new drug or treatment, whose efficacy and safety have been confirmed in a Phase II trial, in a large number of patients, and evaluates whether it is superior to existing treatments.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.
Multicenter StudyResearch conducted in collaboration with multiple research institutions. It aims to collect a wide range of data and obtain more generalizable results.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.

Language : English

139.

The Efficacy of Physical Therapy and Rehabilitation Approaches in Chronic Migraine: A Systematic Review and Meta-Analysis.

Author: OnanDilara, EkizoğluEsme, ArıkanHalime, TaşdelenBahar, ÖzgeAynur, MartellettiPaolo

CM treatment
Quality of life improvement

This review examines the effectiveness of physical therapy and rehabilitation approaches for chronic migraine (CM) and their impact on quality of life (QoL) and disability. Pharmacological treatment is the primary approach for CM, but physical therapy may offer additional benefits.

Meta-AnalysisA statistical technique that integrates the results of multiple studies to draw more general conclusions about a particular issue.
Systematic ReviewA review that systematically collects, evaluates, and integrates relevant research to answer a specific research question.

Language : English

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