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Antiviral treatment and other therapeutic interventions for herpes simplex virus epithelial keratitis.

Author: WilhelmusKirk R

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Meta-AnalysisA statistical technique that integrates the results of multiple studies to draw more general conclusions about a particular issue.
Research Support, N.I.H., ExtramuralResearch funding provided by the NIH to external research institutions and researchers.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.
ReviewAn article that critically examines existing research on a particular topic and summarizes the current state of knowledge in the field.
Systematic ReviewA review that systematically collects, evaluates, and integrates relevant research to answer a specific research question.

Overview

A systematic review of 137 studies found that trifluridine and acyclovir are more effective than idoxuridine or vidarabine for treating HSV epithelial keratitis. Brivudine and foscarnet were not substantially different from trifluridine or acyclovir. The addition of interferon or debridement to antiviral treatment needs further research to determine its effectiveness.
Paper Details　
Original Abstract of the Article :
BACKGROUND: Eye disease due to herpes simplex virus (HSV) commonly presents as epithelial keratitis which, though usually self-limiting, may persist or progress without treatment. OBJECTIVES: To compare the relative effectiveness of antiviral agents, interferon, and corneal debridement in the treat...See full text at original site
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ラクダ博士は、Health Journal が論文の内容を分かりやすく解説するために作成した架空のキャラクターです。
難解な医学論文を、専門知識のない方にも理解しやすいように、噛み砕いて説明することを目指しています。

* ラクダ博士による解説は、あくまで論文の要点をまとめたものであり、原論文の完全な代替となるものではありません。詳細な内容については、必ず原論文をご参照ください。
* ラクダ博士は架空のキャラクターであり、実際の医学研究者や医療従事者とは一切関係がありません。
* 解説の内容は Health Journal が独自に解釈・作成したものであり、原論文の著者または出版社の見解を反映するものではありません。


引用元：
https://doi.org/10.1002/14651858.CD002898.pub5

データ提供：米国国立医学図書館（NLM）

Navigating the Sands of Herpes Simplex Virus Epithelial Keratitis: A Treatment Landscape

Like a mirage in the desert, herpes simplex virus (HSV) epithelial keratitis can be a perplexing and potentially debilitating condition. This study delves deep into the vast expanse of antiviral treatments, evaluating their effectiveness in combating HSV epithelial keratitis. The authors embarked on an extensive search, sifting through mountains of research to analyze the effectiveness of various antiviral agents, interferon, and corneal debridement. Their findings reveal a clear picture of the most effective treatments, with trifluridine and acyclovir emerging as frontrunners, offering a beacon of hope in the quest to heal HSV epithelial keratitis.

Acyclovir and Trifluridine: Guiding Light in the Treatment of HSV

The researchers conducted a rigorous analysis of 137 studies, involving a staggering 8333 eyes. The results highlighted the superiority of trifluridine and acyclovir over other treatments like idoxuridine or vidarabine. This suggests that these antiviral agents could be the preferred approach for effectively managing HSV epithelial keratitis.

Navigating the Eye: Understanding the Implications of HSV

This research provides a roadmap for clinicians treating HSV epithelial keratitis. The findings underscore the importance of selecting effective antiviral agents, such as trifluridine and acyclovir, to improve patient outcomes. The authors also emphasize the need for further research to fully assess the potential benefits of combining antiviral treatments with interferon or debridement.

Dr. Camel's Conclusion

Navigating the complexities of HSV epithelial keratitis can feel like traversing a shifting desert landscape. However, this research offers valuable insights into the most effective treatments, highlighting trifluridine and acyclovir as potential beacons of hope in the fight against this challenging condition. As we continue to explore the vast expanse of HSV, further research is critical to understanding the complete picture and improving patient outcomes.

Date :
  1. Date Completed 2017-05-16
  2. Date Revised 2023-10-23
Further Info :

Pubmed ID

25879115

DOI: Digital Object Identifier

10.1002/14651858.CD002898.pub5

SNS
PICO Info
in preparation
Languages

English

Positive IndicatorAn AI analysis index that serves as a benchmark for how positive the results of the study are. Note that it is a benchmark and requires careful interpretation and consideration of different perspectives.

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