Pharmacometrics-guided drug development of antihyperhidrosis agents.

Author: DumitrescuTeodora Pene, GobburuJogarao, MehrotraShailly, SchmithVirginia D

Paper Details 
Original Abstract of the Article :
The objective of the present work was to use modeling and simulation to inform trial design of a proof-of-concept study for agents used in the treatment of hyperhidrosis. Data were available from 36 subjects who received the vehicle, 2% or 4% topical glycopyrrolate wipes daily for 4 weeks, with resp...See full text at original site
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引用元:
https://doi.org/10.1002/jcph.536

データ提供:米国国立医学図書館(NLM)

Pharmacometrics-Guided Drug Development: Optimizing Antihyperhidrosis Treatment

This research delves into the field of

pharmacometrics and clinical trial design

. It explores the application of modeling and simulation techniques to optimize the development of antihyperhidrosis agents, which are used to treat excessive sweating. The authors used data from a clinical trial involving 36 subjects treated with topical glycopyrrolate to develop a model that predicts the effectiveness of the drug based on dose and time. This model allowed for the estimation of optimal sample size for future clinical trials, demonstrating the potential of pharmacometrics to optimize drug development.

Pharmacometrics: A Powerful Tool for Clinical Trials

The study emphasizes the power of pharmacometrics in designing more efficient and effective clinical trials. By leveraging modeling and simulation, researchers can reduce the number of subjects required for trials, potentially saving time and resources. The use of pharmacometrics can also help to identify the optimal dose and treatment duration for a given drug, leading to improved therapeutic outcomes.

Pharmacometrics: A New Era for Drug Development

The study showcases how pharmacometrics can revolutionize the development of new drugs. By integrating data from clinical trials and leveraging predictive models, researchers can significantly enhance the process of drug development, ultimately leading to safer and more effective treatments for patients.

Dr. Camel's Conclusion

This research is like finding a hidden spring in the desert, a source of life-giving water. Pharmacometrics, a powerful tool for drug development, can quench the thirst for more efficient and effective treatments. It is like finding a hidden spring in the desert, a source of life-giving water.

Date :
  1. Date Completed 2016-07-06
  2. Date Revised 2015-10-02
Further Info :

Pubmed ID

25939678

DOI: Digital Object Identifier

10.1002/jcph.536

Related Literature

SNS
PICO Info
in preparation
Languages

English

Positive IndicatorAn AI analysis index that serves as a benchmark for how positive the results of the study are. Note that it is a benchmark and requires careful interpretation and consideration of different perspectives.

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