Effects of glycopyrronium topical: A Synthesis of Findings from 21 Studies

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Original Abstract of the Article

Main Research Findings

Topical glycopyrronium is effective in treating primary axillary hyperhidrosis, a condition characterized by excessive sweating in the underarms. 5 found that glycopyrronium tosylate significantly reduced sweat severity and production compared to a placebo. indicated the safety and efficacy of topical glycopyrronium bromide in treating primary axillary hyperhidrosis. Additionally, suggests the effectiveness of glycopyrronium for this condition.

Topical glycopyrronium has also shown promise in treating craniofacial hyperhidrosis, which involves excessive sweating on the face. 19 found topical glycopyrronium to be effective and safe for this condition. 16 reported the successful treatment of craniofacial hyperhidrosis with topical glycopyrronium.

The potential benefits of topical glycopyrronium extend beyond axillary and facial hyperhidrosis. 12 documented its effectiveness in treating hyperhidrosis associated with herpes zoster neuralgia. reported its effectiveness in treating gustatory sweating. 20 suggests its potential for treating compensatory sweating following sympathectomy. 14 reported topical glycopyrronium's effectiveness in treating Frey's syndrome, which is characterized by sweating after eating.

Benefits and Risks

Benefit Summary

Topical glycopyrronium holds potential for effectively treating various types of hyperhidrosis, including primary axillary hyperhidrosis, craniofacial hyperhidrosis, gustatory sweating, hyperhidrosis related to herpes zoster neuralgia, and compensatory sweating after sympathectomy. 5 , , , 19 , 16 , 12 , , 20 , 14

Risk Summary

While generally considered safe, topical glycopyrronium can cause side effects. found that it can cause dilated pupils and difficulty focusing. reported unilateral mydriasis, a condition where one pupil dilates. found that topical glycopyrronium can cause dilated pupils. reported urinary retention as a potential side effect. 20 reported accommodative failure and dry mouth. These side effects are usually mild and resolve when the medication is stopped.

Comparison of Studies

Similarities

Numerous studies highlight the effectiveness of topical glycopyrronium in treating various types of hyperhidrosis. A common thread across these studies is the generally safe nature of the medication.

Differences

Significant variations exist between studies in their evaluation methods, the types of hyperhidrosis studied, and the types and severity of side effects reported. This makes direct comparison of results challenging.

Consistency and Contradictions

The majority of research suggests the effectiveness of topical glycopyrronium for hyperhidrosis treatment. However, some studies indicate the potential for side effects. These findings indicate that while topical glycopyrronium is a potentially beneficial treatment option, the risk of side effects should be carefully considered.

Practical Considerations and Precautions

It's crucial to use topical glycopyrronium as directed by a healthcare professional. To minimize the risk of side effects, avoid self-medication. If side effects occur, seek immediate medical attention.

Limitations of Current Research

Further research is necessary to comprehensively understand the long-term effects of topical glycopyrronium, its efficacy and safety for treating various hyperhidrosis types, and optimal dosage and administration methods.

Future Research Directions

Future research should focus on long-term effects of topical glycopyrronium, its efficacy and safety for treating diverse hyperhidrosis types, and identifying optimal dosage and administration methods.

Conclusion

Topical glycopyrronium is a promising treatment option for various types of hyperhidrosis. However, potential side effects must be considered. Individuals struggling with hyperhidrosis should consult with a healthcare professional to determine if topical glycopyrronium is an appropriate treatment for them.

Literature analysis of 21 papers
Positive Content
21
Neutral Content
0
Negative Content
0
Article Type
6
0
1
5
21
1.

The Frey syndrome: a review and double blind evaluation of the topical use of a new anticholinergic agent.

Author: HaysL L

Gustatory sweating control
Central nervous system side effects

Glycopyrrolate was found to be effective in controlling gustatory sweating in patients with Frey syndrome. In a double-blind clinical trial, topical glycopyrrolate at concentrations of 0.5% and 1.0% provided complete control of gustatory sweating for at least several days after a single application.

Clinical TrialA clinical trial is a planned study conducted on humans to evaluate the efficacy and safety of pharmaceuticals, medical devices, and treatment methods. It aims to explore the possibilities of new treatments and improve the health of patients.
Controlled Clinical TrialA clinical trial that evaluates the effectiveness of a treatment by comparing a group that receives the intervention with a group that receives a placebo or standard treatment.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Research Support, U.S. Gov't, Non-P.H.S.Research funding provided by US government agencies other than the Public Health Service.

Language : English

3.

Treatment of diabetic gustatory sweating with topical glycopyrrolate cream.

Author: AtkinS L, BrownP M

Diabetic gustatory sweating treatment

A case report describes the successful treatment of severe bilateral gustatory sweating in an insulin-dependent diabetic man with topical 0.5% glycopyrrolate cream. Topical glycopyrrolate cream effectively eliminated gustatory sweating without the adverse effects associated with oral antimuscarinic medication.

Case ReportsIn the medical field, a report that describes in detail a unique case, an unusual medical condition, or the effect of a treatment. Provides new insights and possibilities for treatment through individual patient cases.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.

Language : English

4.

Nonsurgical management of hyperhidrosis.

Author: GeeSarah, YamauchiPaul S

HH treatment
Side effects

This article discusses the treatment options for hyperhidrosis (HH), a chronic disease that can have a significant negative impact on quality of life. The article emphasizes the importance of conservative measures before progressing to surgical options and highlights the efficacy of botulinum toxin (BTX) injections as a minimally invasive treatment option.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
ReviewAn article that critically examines existing research on a particular topic and summarizes the current state of knowledge in the field.

Language : English

5.

Topical Glycopyrronium Tosylate for the Treatment of Primary Axillary Hyperhidrosis: Patient-Reported Outcomes from the ATMOS-1 and ATMOS-2 Phase III Randomized Controlled Trials.

Author: PariserDavid M, HebertAdelaide A, DrewJanice, QuiringJohn, GopalanRamanan, GlaserDee Anna

Hyperhidrosis treatment
None mentioned

Glycopyrronium tosylate (GT), a topical anticholinergic, effectively reduces sweating severity and production in patients with primary axillary hyperhidrosis. The treatment is generally well tolerated.

Clinical Trial, Phase IIIA Phase III trial is a trial that further rigorously verifies the efficacy and safety of a new drug or treatment, whose efficacy and safety have been confirmed in a Phase II trial, in a large number of patients, and evaluates whether it is superior to existing treatments.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Multicenter StudyResearch conducted in collaboration with multiple research institutions. It aims to collect a wide range of data and obtain more generalizable results.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.

Language : English

6.

Limited Systemic Exposure with Topical Glycopyrronium Tosylate in Primary Axillary Hyperhidrosis.

Author: PariserDavid M, LainEdward L, MamelokRichard D, DrewJanice, MouldDiane R

GT efficacy
GT safety
Dry mouth

This study evaluated the pharmacokinetics and safety of topical glycopyrronium tosylate (GT) for primary axillary hyperhidrosis. The study found that GT had limited systemic absorption compared to oral glycopyrrolate and a low risk of anticholinergic adverse events. The study suggests that GT may be a safe and effective treatment option for primary axillary hyperhidrosis.

Clinical Trial, Phase IThe first stage of clinical trials in humans. Evaluates the safety, tolerability, and pharmacokinetics of a new drug/treatment.
Clinical Trial, Phase IIA Phase II trial is a trial that further evaluates the efficacy and safety of a new drug or treatment, whose safety has been confirmed to some extent in a Phase I trial, in a small number of patients.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.

Language : English

7.

Hyperhidrosis: A Review of Recent Advances in Treatment with Topical Anticholinergics.

Author: WongNikita S, AdlamTaylor M, PottsGeoffrey A, FarshchianMehdi

Topical anticholinergics

This review examined the effectiveness and safety of emerging topical anticholinergics for hyperhidrosis (HH). Glycopyrrolate is the only FDA-approved topical anticholinergic for HH, but other agents such as oxybutynin, sofpironium bromide, and umeclidinium are being investigated. While available safety data are limited, emerging topical anticholinergics pose minimal known human risks.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
ReviewAn article that critically examines existing research on a particular topic and summarizes the current state of knowledge in the field.

Language : English

8.

A 44-Week Open-Label Study Evaluating Safety and Efficacy of Topical Glycopyrronium Tosylate in Patients with Primary Axillary Hyperhidrosis.

Author: GlaserDee Anna, HebertAdelaide A, NastAlexander, WerschlerWilliam P, GreenLawrence, MamelokRichard D, QuiringJohn, DrewJanice, PariserDavid M

Hyperhidrosis treatment
Application-site pain
Blurred vision
Dry mouth
Mydriasis
Nasopharyngitis

Daily long-term application of glycopyrronium tosylate for up to 48 weeks was generally well tolerated and efficacy was maintained. The Hyperhidrosis Disease Severity Scale responder rate was 63.2% at week 44. No new safety signals emerged.

Clinical Trial, Phase IIIA Phase III trial is a trial that further rigorously verifies the efficacy and safety of a new drug or treatment, whose efficacy and safety have been confirmed in a Phase II trial, in a large number of patients, and evaluates whether it is superior to existing treatments.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Multicenter StudyResearch conducted in collaboration with multiple research institutions. It aims to collect a wide range of data and obtain more generalizable results.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.

Language : English

9.

Hyperhidrosis: anatomy, pathophysiology and treatment with emphasis on the role of botulinum toxins.

Author: LakrajAmanda-Amrita D, MoghimiNarges, JabbariBahman

Hyperhidrosis treatment

Hyperhidrosis is a condition characterized by excessive sweating. This review discusses treatment options for hyperhidrosis, including topical agents, oral agents, and botulinum toxin injections.

Comparative StudyResearch that compares multiple groups/interventions to determine differences/similarities in outcomes/characteristics.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
ReviewAn article that critically examines existing research on a particular topic and summarizes the current state of knowledge in the field.

Language : English

10.

Gustatory sweating recurring on peritoneal dialysis but resolving during periods of hemodialysis.

Author: DiskinCharles J, StokesThomas J, DansbyLinda M, RadcliffLautrec, CarterThomas B

Gustatory sweating treatment
Neuropathy

Gustatory sweating, a rare disorder, can be effectively treated with topical glycopyrrolate.

Case ReportsIn the medical field, a report that describes in detail a unique case, an unusual medical condition, or the effect of a treatment. Provides new insights and possibilities for treatment through individual patient cases.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.

Language : English

11.

A glycopyrronium bromide 1% cream for topical treatment of primary axillary hyperhidrosis: efficacy and safety results from a phase IIIa randomized controlled trial.

Author: AbelsC, SoeberdtM, KilicA, ReichH, KnieU, JourdanC, SchrammK, Heimstaedt-MuskettS, MasurC, SzeimiesR-M

GPB efficacy
GPB safety
Dry mouth

This phase IIIa study assessed the efficacy, safety, and tolerability of a 4-week topical treatment of glycopyrronium bromide (GPB) 1% cream in patients with primary axillary hyperhidrosis. The study found that GPB 1% cream significantly reduced sweat production, improved quality of life, and was well-tolerated. The study suggests that GPB 1% cream may provide an effective and safe new treatment option for patients with primary axillary hyperhidrosis.

Clinical Trial, Phase IIIA Phase III trial is a trial that further rigorously verifies the efficacy and safety of a new drug or treatment, whose efficacy and safety have been confirmed in a Phase II trial, in a large number of patients, and evaluates whether it is superior to existing treatments.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.

Language : English

12.

Topical glycopirrolate for the management of hyperhidrosis in herpetic neuralgia.

Author: LadjevicNebojsa Gojko, Likic-LadjevicIvana Spasoje

Hyperhidrosis relief
Pain relief

Glycopirrolate cream effectively reduced pain intensity by 28.5% within 24 hours and completely eliminated hyperhidrosis in a pregnant woman with herpetic neuralgia. The pain completely disappeared after 48 hours of use. No side effects were observed during the therapy.

Case ReportsIn the medical field, a report that describes in detail a unique case, an unusual medical condition, or the effect of a treatment. Provides new insights and possibilities for treatment through individual patient cases.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.

Language : English

13.

Pharmacometrics-guided drug development of antihyperhidrosis agents.

Author: MehrotraShailly, SchmithVirginia D, DumitrescuTeodora Pene, GobburuJogarao

Hyperhidrosis treatment
Reduced sample size

This study investigated the use of a model-based method to design a proof-of-concept study for agents used in the treatment of hyperhidrosis. The model-based method using longitudinal data required fewer subjects (27) compared with the conventional single-point method (120).

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.

Language : English

14.

Frey's syndrome: treatment with topical glycopyrrolate.

Author: MayJ S, McGuirtW F

Gustatory sweating treatment
Safe treatment
None reported

Glycopyrrolate, an anticholinergic agent, was tested topically for the treatment of gustatory sweating (Frey's syndrome) following parotidectomy. Topical glycopyrrolate showed significant improvement in symptoms with no adverse side effects.

Clinical TrialA clinical trial is a planned study conducted on humans to evaluate the efficacy and safety of pharmaceuticals, medical devices, and treatment methods. It aims to explore the possibilities of new treatments and improve the health of patients.
Controlled Clinical TrialA clinical trial that evaluates the effectiveness of a treatment by comparing a group that receives the intervention with a group that receives a placebo or standard treatment.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.

Language : English

15.

Treatment of Primary Craniofacial Hyperhidrosis: A Systematic Review.

Author: NicholasRebecca, QuddusAyyaz, BakerDaryll M

CH treatment
Compensatory sweating

Topical glycopyrrolate, oral oxybutynin, and intradermal botulinum toxin A are recommended as first-line therapies for primary craniofacial hyperhidrosis due to their efficacy and safety. T2 sympathectomy should be considered for patients refractory to first-line therapy.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
ReviewAn article that critically examines existing research on a particular topic and summarizes the current state of knowledge in the field.
Systematic ReviewA review that systematically collects, evaluates, and integrates relevant research to answer a specific research question.

Language : English

16.

Craniofacial hyperhidrosis successfully treated with topical glycopyrrolate.

Author: LuhJoin Y, BlackwellThomas A

Craniofacial hyperhidrosis treatment
Few adverse effects

Topical glycopyrrolate has been shown to be an effective treatment for craniofacial hyperhidrosis with few adverse effects.

Case ReportsIn the medical field, a report that describes in detail a unique case, an unusual medical condition, or the effect of a treatment. Provides new insights and possibilities for treatment through individual patient cases.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.

Language : English

18.

Topical glycopyrrolate for patients with facial hyperhidrosis.

Author: KimW O, KilH K, YoonK B, YoonD M

Reduced sweating
Headache

Topical glycopyrrolate application appeared to be effective and safe for the treatment of excessive facial sweating in primary craniofacial and secondary gustatory hyperhidrosis following sympathectomy.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.

Language : English

19.

Efficacy and safety of topical glycopyrrolate in patients with facial hyperhidrosis: a randomized, multicentre, double-blinded, placebo-controlled, split-face study.

Author: HyunM Y, SonI P, LeeY, ChoiH G, ParkK Y, LiK, KimB J, SeoS J, KimM N, HongC K

Reduced sweating
Safe
Transient headache

Topical glycopyrrolate is effective and safe for reducing facial hyperhidrosis. In a study of 39 patients, topical glycopyrrolate significantly reduced sweat production and slightly improved the Hyperhidrosis Disease Severity Scale score compared to placebo. No serious adverse events were reported.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Multicenter StudyResearch conducted in collaboration with multiple research institutions. It aims to collect a wide range of data and obtain more generalizable results.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.

Language : English

20.

A medical alternative to the treatment of compensatory sweating.

Author: CladellasEsther, CallejasMarco A, GrimaltRamon

Compensatory sweating treatment
Secondary effects

This study investigated the efficacy of topical glycopyrrolate in treating compensatory sweating after sympathectomy. The results showed significant improvement in sweating reduction in most patients, suggesting topical glycopyrrolate as a potential treatment option.

Clinical TrialA clinical trial is a planned study conducted on humans to evaluate the efficacy and safety of pharmaceuticals, medical devices, and treatment methods. It aims to explore the possibilities of new treatments and improve the health of patients.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.

Language : English

21.

Long-term efficacy and safety of topical glycopyrronium tosylate for the treatment of primary axillary hyperhidrosis: Post hoc pediatric subgroup analysis from a 44-week open-label extension study.

Author: HebertAdelaide A, GlaserDee Anna, GreenLawrence, HullCheryl, CatherJennifer, DrewJanice, GopalanRamanan, PariserDavid M

Hyperhidrosis treatment

This study evaluated the long-term efficacy and safety of glycopyrronium tosylate (GT) cloth for primary axillary hyperhidrosis in pediatric patients. GT cloth is a topical anticholinergic approved in the United States.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.

Language : English

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