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Effect of sulfonylureas administered centrally on the blood glucose level in immobilization stress model.
Author: HongJae-Seung, JungJun-Sub, KimSung-Su, LimSu-Min, ParkSoo-Hyun, SharmaNaveen, SimYun-Beom, SuhHong-Won
Original Abstract of the Article :
Sulfonylureas are widely used as an antidiabetic drug. In the present study, the effects of sulfonylurea administered supraspinally on immobilization stress-induced blood glucose level were studied in ICR mice. Mice were once enforced into immobilization stress for 30 min and returned to the cage. T...See full text at original site
Dr.Camel's Paper Summary Blogラクダ博士について
ラクダ博士は、Health Journal が論文の内容を分かりやすく解説するために作成した架空のキャラクターです。
難解な医学論文を、専門知識のない方にも理解しやすいように、噛み砕いて説明することを目指しています。
* ラクダ博士による解説は、あくまで論文の要点をまとめたものであり、原論文の完全な代替となるものではありません。詳細な内容については、必ず原論文をご参照ください。
* ラクダ博士は架空のキャラクターであり、実際の医学研究者や医療従事者とは一切関係がありません。
* 解説の内容は Health Journal が独自に解釈・作成したものであり、原論文の著者または出版社の見解を反映するものではありません。
引用元:
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4422958/
データ提供:米国国立医学図書館(NLM)
Sulfonylureas: A New Twist in the Desert of Diabetes
Sulfonylureas are a common class of medications used to treat type 2 diabetes. This study explores the effects of sulfonylureas when administered centrally in mice. It's like discovering a hidden spring in the desert, revealing a new perspective on how these drugs work.
Unlocking the Potential of Sulfonylureas
The researchers found that administering sulfonylureas directly into the brain of mice during immobilization stress had a significant effect on blood glucose levels. This suggests that sulfonylureas may have additional mechanisms of action beyond their well-known role in stimulating insulin release from the pancreas. It's like finding a new oasis in the desert – a source of hope for better diabetes management.
Implications for Diabetes Management
This research opens new doors for understanding the potential of sulfonylureas in diabetes management. It suggests that targeting the brain may be a promising approach to improving blood glucose control. It's like finding a new path through the desert, leading to more effective ways to manage this complex condition.
Dr.Camel's Conclusion
This research, like a camel caravan exploring new routes, delves into the hidden potential of sulfonylureas in diabetes management. The findings suggest that these drugs may have a wider range of effects, offering exciting possibilities for future research and development in diabetes treatment.
Date :
- Date Completed 2015-05-08
- Date Revised 2020-09-30
Further Info :
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