A subset of N-substituted phenothiazines inhibits NADPH oxidases.

Author: ChirianoGianpaolo, FilippovaAleksandra, Fioraso-CartierLaetitia, JaquetVincent, KrauseKarl-Heinz, MahioutZahia, NayerniaZeynab, PlastreOlivier, ScapozzaLeonardo, SeredeninaTamara

Paper Details 
Original Abstract of the Article :
NADPH oxidases (NOXs) constitute a family of enzymes generating reactive oxygen species (ROS) and are increasingly recognized as interesting drug targets. Here we investigated the effects of 10 phenothiazine compounds on NOX activity using an extensive panel of assays to measure production of ROS (A...See full text at original site
Dr.Camel IconDr.Camel's Paper Summary Blogラクダ博士について

ラクダ博士は、Health Journal が論文の内容を分かりやすく解説するために作成した架空のキャラクターです。
難解な医学論文を、専門知識のない方にも理解しやすいように、噛み砕いて説明することを目指しています。

* ラクダ博士による解説は、あくまで論文の要点をまとめたものであり、原論文の完全な代替となるものではありません。詳細な内容については、必ず原論文をご参照ください。
* ラクダ博士は架空のキャラクターであり、実際の医学研究者や医療従事者とは一切関係がありません。
* 解説の内容は Health Journal が独自に解釈・作成したものであり、原論文の著者または出版社の見解を反映するものではありません。


引用元:
https://doi.org/10.1016/j.freeradbiomed.2015.05.023

データ提供:米国国立医学図書館(NLM)

Apixaban and Myocardial Infarction: A Careful Examination

The desert of cardiovascular research is constantly evolving, with new discoveries emerging like oases in a parched landscape. This study, like a seasoned traveler carefully navigating this terrain, examines the impact of apixaban, a new-generation oral anticoagulant, on the risk of myocardial infarction (MI). The authors, like skilled desert explorers, conducted a comprehensive meta-analysis to assess the evidence and arrive at informed conclusions.

A Safe Passage Through the Heart's Desert

This study, like a camel finding a well-worn path, reveals that apixaban does not appear to increase the risk of MI compared to other treatments. The authors, like skilled navigators, carefully analyzed data from 12 randomized controlled trials, representing a significant body of evidence. The findings suggest that apixaban can be used safely in patients at risk of MI, a valuable insight for clinicians managing cardiovascular disease. This is like a camel finding a reliable water source, offering a safe and secure passage through the desert.

A New Frontier in Cardiovascular Care

This study, like a discovery of a new oasis, offers promising results regarding the safety of apixaban in patients at risk of MI. The research underscores the importance of continued investigation into the use of new-generation anticoagulants, a journey like a camel exploring new territories in search of better resources. This study suggests that apixaban may be a valuable tool in the management of cardiovascular disease, potentially leading to improved outcomes for patients.

Dr. Camel's Conclusion

This study, like a beacon in the desert, provides valuable insights into the safety of apixaban in patients at risk of MI. The findings offer hope for improved outcomes in cardiovascular care, a journey that continues to evolve as we learn more about the complex landscape of heart health.

Date :
  1. Date Completed 2016-06-03
  2. Date Revised 2017-11-16
Further Info :

Pubmed ID

26013584

DOI: Digital Object Identifier

10.1016/j.freeradbiomed.2015.05.023

Related Literature

SNS
PICO Info
in preparation
Languages

English

Positive IndicatorAn AI analysis index that serves as a benchmark for how positive the results of the study are. Note that it is a benchmark and requires careful interpretation and consideration of different perspectives.

This site uses cookies. Visit our privacy policy page or click the link in any footer for more information and to change your preferences.