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Comparison of Drug Concentrations in Human Aqueous Humor after the Administration of 0.3% Gatifloxacin Ophthalmic Gel, 0.3% Gatifloxacin and 0.5% Levofloxacin Ophthalmic Solutions.
Author: ChenHuilian, DingWenting, HuangXiaodan, NiWeiling, WangYao, YaoKe, YuYibo, YuanJingqun, ZhangZheng
Original Abstract of the Article :
PURPOSE: To investigate the penetration of 0.3% gatifloxacin ophthalmic gel, 0.3% gatifloxacin ophthalmic solution and 0.5% levofloxacin ophthalmic solution into aqueous humor after topical application. MATERIALS AND METHODS: Age-related cataract patients (150 eyes in 150 cases) receiving phacoemul...See full text at original site
Dr.Camel's Paper Summary Blogラクダ博士について
ラクダ博士は、Health Journal が論文の内容を分かりやすく解説するために作成した架空のキャラクターです。
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* 解説の内容は Health Journal が独自に解釈・作成したものであり、原論文の著者または出版社の見解を反映するものではありません。
引用元:
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4466517/
データ提供:米国国立医学図書館(NLM)
Gatifloxacin Ophthalmic Gel: A New Frontier for Eye Infections
This study explores the effectiveness of a novel ophthalmic gel formulation of gatifloxacin, an antibiotic used to treat eye infections. The research compares the penetration of gatifloxacin gel to that of gatifloxacin solution and levofloxacin solution, commonly used ophthalmic medications. The study examines the concentration of these medications in the aqueous humor, the fluid that nourishes the eye, after topical application, assessing their bioavailability and penetration into the eye.
Gatifloxacin Gel: Superior Penetration and Bioavailability
The study demonstrates that gatifloxacin ophthalmic gel achieves higher and more sustained concentrations in the aqueous humor compared to both gatifloxacin solution and levofloxacin solution. The research suggests that gatifloxacin gel may offer a more effective treatment option for eye infections, potentially improving therapeutic outcomes.
Treating Eye Infections: Choosing the Right Approach
The study highlights the importance of choosing the right medication and formulation for treating eye infections. The research emphasizes the need for ophthalmologists to consider the bioavailability and penetration of different medications to select the most effective treatment option for each patient.
Dr.Camel's Conclusion
This study, like a clear desert well, reveals the promising potential of gatifloxacin ophthalmic gel for treating eye infections. The findings demonstrate that this new formulation offers superior penetration and bioavailability compared to traditional ophthalmic solutions, potentially leading to improved treatment outcomes. This research provides valuable insights for ophthalmologists, guiding their choice of medications and formulations for effective and personalized eye care.
Date :
- Date Completed 2016-03-18
- Date Revised 2018-12-02
Further Info :
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