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Clinical utility of naloxegol in the treatment of opioid-induced constipation.

Author: AtayeeRabia S, BrunerHeather C, BuckholzGary T, EdmondsKyle P

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
ReviewAn article that critically examines existing research on a particular topic and summarizes the current state of knowledge in the field.

Overview

Naloxegol, an orally administered peripherally acting mu-opioid receptor antagonist, is used to treat opioid-induced constipation (OIC) in noncancer patients. It has been shown to be effective in patients who fail traditional constipation treatments.
Paper Details　
Original Abstract of the Article :
Opioids are a class of medications frequently used for the treatment of acute and chronic pain, exerting their desired effects at central opioid receptors. Agonism at peripherally located opioid receptors, however, leads to opioid-induced constipation (OIC), one of the most frequent and debilitating...See full text at original site
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引用元：
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4472065/

データ提供：米国国立医学図書館（NLM）

Naloxegol: A New Treatment Option for Opioid-Induced Constipation

This research explores the complex and often challenging issue of opioid-induced constipation (OIC), focusing on the therapeutic potential of naloxegol, a peripherally acting mu-opioid receptor antagonist (PAMORA). The study provides a comprehensive review of naloxegol's clinical utility in managing OIC in noncancer patients. The researchers discovered that naloxegol was effective in relieving OIC in patients who failed traditional constipation treatments. This finding suggests that naloxegol may offer a promising new option for treating OIC, but further research is needed to establish its role in primary prevention.

Addressing the Side Effects of Opioids

This research highlights the importance of addressing the often-overlooked side effects of opioid therapy. The study's findings indicate that naloxegol may offer a valuable tool for managing OIC, a common and debilitating side effect of opioid use. This research underscores the importance of developing effective strategies to manage the side effects of opioid therapy while maximizing its therapeutic benefits.

Navigating the Complexities of Pain Management

Managing pain can be a complex journey, and navigating the side effects of opioid therapy can be a challenging aspect. This study offers valuable insights into the potential of a new medication, naloxegol, for treating OIC. It's a reminder that a comprehensive approach to pain management includes addressing potential side effects and finding solutions to improve patient outcomes.

Dr.Camel's Conclusion

This study provides a comprehensive review of naloxegol, a PAMORA, for the treatment of OIC in noncancer patients. The study's findings indicate that naloxegol may offer a promising new option for treating OIC, but further research is needed to establish its role in primary prevention. This research highlights the importance of addressing the often-overlooked side effects of opioid therapy and developing effective strategies to improve patient outcomes.

Date :
  1. Date Completed 2015-06-25
  2. Date Revised 2020-09-30
Further Info :

Pubmed ID

26109876

DOI: Digital Object Identifier

PMC4472065

Related Literature

Article Analysis
・Side Effects of naloxegol
SNS
PICO Info
in preparation
Languages

English

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