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Once daily nisoldipine in hypertension: cuff and ambulatory intra-arterial blood pressure.
Author: BrigdenG, CaruanaM, HeberM, LahiriA, RafteryE B
Original Abstract of the Article :
Cuff blood pressure data has suggested that the calcium channel antagonist nisoldipine has full twenty four hour efficacy. To test this, 24 h ambulatory intra-arterial blood pressure monitoring was performed on 18 untreated hypertensive subjects (12 men, 6 women) (cuff blood pressure greater than 15...See full text at original site
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引用元：
https://doi.org/10.1007/BF00562542
データ提供：米国国立医学図書館（NLM）
Nisoldipine: A One-Dose Wonder or a Short-Lived Hero?
The management of hypertension is a crucial aspect of cardiovascular health, and the development of effective antihypertensive medications is a constant pursuit. This study investigated the efficacy of nisoldipine, a calcium channel blocker, in controlling blood pressure over a 24-hour period. The researchers used ambulatory intra-arterial blood pressure monitoring to assess the effects of a single daily dose of nisoldipine. They found that nisoldipine effectively lowered blood pressure during the daytime, but its effects diminished significantly during the nighttime. This suggests that a single daily dose of nisoldipine may not provide consistent blood pressure control throughout the entire day.
A Daytime Hero, A Nighttime Mystery
This study highlights the importance of understanding the temporal dynamics of antihypertensive medications. While nisoldipine effectively lowers blood pressure during the daytime, its efficacy wanes during the nighttime. This finding raises concerns about the potential for nighttime blood pressure surges, which can contribute to cardiovascular risk.
Tailoring Therapy: Beyond a One-Size-Fits-All Approach
This research underscores the need for individualized treatment strategies for hypertension. The findings suggest that a single daily dose of nisoldipine may not be sufficient for all patients, particularly those who experience significant nocturnal blood pressure elevation. Further investigation is needed to explore alternative dosing regimens or combination therapies to optimize blood pressure control over a 24-hour period.
Dr.Camel's Conclusion
This study emphasizes the importance of personalized medicine in the management of hypertension. While nisoldipine has shown promise as an effective antihypertensive medication, its limited efficacy during the nighttime highlights the need for tailored treatment strategies to address individual patient needs. Further research is needed to explore alternative dosing regimens or combination therapies to achieve optimal blood pressure control over a 24-hour period.
Date :
- Date Completed 1990-02-28
- Date Revised 2019-08-13
Further Info :
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