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Nonspecifically enhanced therapeutic effects of vincristine on multidrug-resistant cancers when coencapsulated with quinine in liposomes.

Author: QiuLiyan, XuYuzhen

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.

Overview

Quinine hydrochloride (QN) can increase the effectiveness of vincristine (VCR) in treating cancer by depleting adenosine triphosphate, increasing adenosine triphosphatase activity, and decreasing P-glycoprotein expression.
Paper Details　
Original Abstract of the Article :
The use of vincristine (VCR) to treat cancer has been limited by its dose-dependent toxicity and development of drug resistance after repeated administrations. In this study, we investigated the mechanism by which quinine hydrochloride (QN) acts as a sensitizer for VCR. Our experiments used three ki...See full text at original site
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引用元：
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4494179/

データ提供：米国国立医学図書館（NLM）

Conquering Drug Resistance in Cancer Treatment

Cancer treatment is a complex and challenging field. One of the major hurdles in cancer therapy is drug resistance. This research focuses on a new approach to overcome drug resistance, using a combination of vincristine (VCR) and quinine hydrochloride (QN) encapsulated in liposomes. The researchers investigated the mechanism of action of this combination, and its effectiveness in treating multidrug-resistant cancer cells both in vitro and in vivo.

A Powerful Combination: VCR and QN

The study suggests that VCR and QN, when coencapsulated in liposomes, can effectively overcome drug resistance in cancer cells. This is like discovering a new source of water in the desert, bringing life and hope to a parched land. The researchers believe that this approach could lead to more effective cancer treatments, improving patient outcomes.

Hope for the Future: New Avenues in Cancer Treatment

This research provides a glimmer of hope in the battle against cancer. It suggests that there are promising new approaches to overcome drug resistance. This is like finding a hidden oasis in the vast and challenging desert of cancer research. The researchers' findings pave the way for new strategies and treatments that could significantly impact the lives of cancer patients.

Dr. Camel's Conclusion

This study provides a compelling example of how new drug combinations and delivery systems can overcome the challenge of drug resistance in cancer. This approach, like finding a hidden spring in the desert, offers a new source of hope for patients battling this disease. By combining these powerful drugs and using a novel delivery system, we may be able to achieve better treatment outcomes and improve the lives of cancer patients. This research is a testament to the ongoing efforts in the field of cancer research and a source of inspiration for continued exploration.

Date :
  1. Date Completed 2016-05-27
  2. Date Revised 2023-11-11
Further Info :

Pubmed ID

26170660

DOI: Digital Object Identifier

PMC4494179

Related Literature

Article Analysis
・Effects of quinine
SNS
PICO Info
in preparation
Languages

English

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