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A Global Perspective on Pyrazinamide Resistance: Systematic Review and Meta-Analysis.

Author: SampsonSamantha L, SoetersHeidi M, StreicherElizabeth M, WarrenRobin M, WhitfieldMichael G, YorkTalita, van HeldenPaul D, van RieAnnelies

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Meta-AnalysisA statistical technique that integrates the results of multiple studies to draw more general conclusions about a particular issue.
Research Support, N.I.H., ExtramuralResearch funding provided by the NIH to external research institutions and researchers.
ReviewAn article that critically examines existing research on a particular topic and summarizes the current state of knowledge in the field.
Systematic ReviewA review that systematically collects, evaluates, and integrates relevant research to answer a specific research question.

Overview

A systematic review of 1,815 phenotypically resistant isolates found that pyrazinamide (PZA) resistance is ubiquitous, with an estimated one in six incident TB cases and more than half of all MDR-TB cases resistant to PZA globally. The diversity of SNPs across the pncA gene complicates the development of rapid molecular diagnostics.
Paper Details　
Original Abstract of the Article :
BACKGROUND: Pyrazinamide (PZA) is crucial for tuberculosis (TB) treatment, given its unique ability to eradicate persister bacilli. The worldwide burden of PZA resistance remains poorly described. METHODS: Systematic PubMed, Science Direct and Scopus searches for articles reporting phenotypic (liqu...See full text at original site
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引用元：
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4517823/

データ提供：米国国立医学図書館（NLM）

Pyrazinamide Resistance: A Growing Threat

This study explores the widespread challenge of pyrazinamide resistance in tuberculosis treatment. It's like navigating a desert landscape riddled with hidden dangers, where the effectiveness of a crucial treatment is being eroded. The research highlights the alarming prevalence of pyrazinamide resistance, particularly among multidrug-resistant tuberculosis cases, emphasizing the need for new strategies and therapies to combat this growing threat.

The researchers conducted a systematic review and meta-analysis, compiling data from various studies to paint a global picture of pyrazinamide resistance. They discovered a significant proportion of tuberculosis cases exhibiting resistance, highlighting the urgent need for research into new drugs and treatment strategies. It's like facing a dwindling water supply in the desert, forcing us to seek alternative sources and conserve precious resources.

A Global Challenge

This study reveals the global scale of pyrazinamide resistance, emphasizing the need for international collaboration and coordinated efforts to address this public health challenge. It's like realizing that the desert's dwindling water supply is a shared problem, requiring cooperation and resource sharing to ensure everyone's survival.

Developing New Tools

The findings highlight the need for rapid molecular diagnostics to identify pyrazinamide resistance. It's like developing new tools to navigate a treacherous desert, enabling us to identify and avoid hidden dangers. These tools will be crucial in guiding effective treatment strategies and ultimately saving lives.

Dr.Camel's Conclusion

This research serves as a stark reminder of the ongoing battle against tuberculosis. Pyrazinamide resistance poses a significant challenge, but with innovative research, collaborative efforts, and a commitment to developing new strategies, we can find a way to reclaim the desert oasis of health and well-being.

Date :
  1. Date Completed 2016-05-03
  2. Date Revised 2022-03-30
Further Info :

Pubmed ID

26218737

DOI: Digital Object Identifier

PMC4517823

SNS
PICO Info
in preparation
Languages

English

Positive IndicatorAn AI analysis index that serves as a benchmark for how positive the results of the study are. Note that it is a benchmark and requires careful interpretation and consideration of different perspectives.

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