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Nano and Microparticulate Chitosan Based System for Formulation of Carvedilol Rapid Melt Tablet.
Author: PandeVishal, PatilRavindra, SonawaneRaju
Original Abstract of the Article :
PURPOSE: In the present study rapid melt tablets (RMT's) of carvedilol were prepared by using ionotropic-gelated chitosan nanoparticles using a spray-drying method. Carvedilol is beta-adrenergic antagonist and its oral bioavailability is about 25-35% because of first pass metabolism. METHODS: The s...See full text at original site
Dr.Camel's Paper Summary Blogラクダ博士について
ラクダ博士は、Health Journal が論文の内容を分かりやすく解説するために作成した架空のキャラクターです。
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* ラクダ博士は架空のキャラクターであり、実際の医学研究者や医療従事者とは一切関係がありません。
* 解説の内容は Health Journal が独自に解釈・作成したものであり、原論文の著者または出版社の見解を反映するものではありません。
引用元:
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4517086/
データ提供:米国国立医学図書館(NLM)
Rapid Melt Tablets: A New Frontier in Drug Delivery
The world of drug delivery is like a vast desert, full of challenges to overcome. One of these challenges is the poor oral bioavailability of certain medications, which is like a thirsty traveler in a desert. This means that the drug doesn't get absorbed well into the body, leaving the traveler feeling weak and unsatisfied. Researchers are constantly searching for new ways to improve drug delivery, like finding an oasis in the desert.
This particular study focuses on a new type of tablet called a rapid melt tablet (RMT). RMTs are designed to dissolve quickly in the mouth, like a refreshing spring of water in the desert. The researchers used nanoparticles of chitosan, a natural substance derived from shellfish, to improve the solubility and absorption of carvedilol, a drug used to treat heart problems. This approach is like using a camel's hump to store water for a long journey.
The study found that the RMTs made with these chitosan nanoparticles were effective in dissolving quickly, providing a faster and more convenient way for patients to take their medication. This could potentially lead to improved patient compliance and better treatment outcomes.
Unlocking the Potential of Rapid Melt Tablets
These findings are exciting because they suggest a potential solution for the poor bioavailability of certain medications. Using RMTs could potentially improve the effectiveness of many drugs, making it easier for patients to manage their conditions.
A New Oasis in the Desert of Drug Delivery
This study demonstrates the potential of RMTs as a new approach to drug delivery. The use of chitosan nanoparticles for improving drug solubility could be a valuable tool in the fight against various diseases. This is like finding a hidden oasis in the desert, offering hope and a chance for survival.
Dr.Camel's Conclusion
This study provides a valuable insight into the potential of rapid melt tablets for improving the oral bioavailability of poorly soluble drugs. The researchers' use of chitosan nanoparticles to enhance drug solubility is an innovative approach that could revolutionize the way we deliver medications.
Date :
- Date Completed 2015-08-03
- Date Revised 2020-09-29
Further Info :
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