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Multimodal treatment of perianal fistulas in Crohn's disease: seton versus anti-TNF versus advancement plasty (PISA): study protocol for a randomized controlled trial.

Author: BemelmanWillem A, BodelierAlexander, BonsingBert A, BreukinkStephanie O, BrinkMenno A, BuskensChristianne J, ConstenEsther C J, CrollaRogier M P H, CullenGarret J, D'HaensGeert R A M, DaneseSilvio, DijkgraafMarcel G W, DijkstraGerard, GerhardsMichael F, HartAilsa, HawthorneA Barney, JansenJeroen M, KennellyRory P, KruytPhilip M, LangeJohan F M, OldenburgBas, PierikMarieke J, PonsioenCyriel Y, PronkApollo, SacchiMatteo, SpinelliAntonino, SrivastavaNidhi, TorkingtonJared, TuynmanJurriaan B, VrijlandWietske W, WarusavitarneJanindra, WestRachel L, WinterDesmond C, WittemanBen J M, YassinNuha A, de BoerNanne K H, de GroofE Joline, van AckerGijs J D, van TuylSebastiaan A C, van der MeulenAndrea E

Comparative StudyResearch that compares multiple groups/interventions to determine differences/similarities in outcomes/characteristics.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Multicenter StudyResearch conducted in collaboration with multiple research institutions. It aims to collect a wide range of data and obtain more generalizable results.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.

Overview

There are no clear guidelines for the treatment of Crohn's disease with high perianal fistulas. This study aims to develop treatment consensus and reduce costs associated with managing this complex condition.
Paper Details　
Original Abstract of the Article :
Currently there is no guideline for the treatment of patients with Crohn's disease and high perianal fistulas. Most patients receive anti-TNF medication, but no long-term results of this expensive medication have been described, nor has its efficiency been compared to surgical strategies. With this ...See full text at original site
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引用元：
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4545975/

データ提供：米国国立医学図書館（NLM）

Finding the Right Path for Perianal Fistulas in Crohn's Disease

The journey through Crohn's disease can be a complex and challenging one, often requiring careful navigation through a maze of treatment options. This research focuses on perianal fistulas, a common complication of Crohn's disease that can cause significant discomfort and impact quality of life. The authors delve into the intricacies of treating perianal fistulas, comparing different approaches and outlining a randomized controlled trial to determine the most effective treatment strategies.

Navigating the Desert of Treatment Options

Imagine a vast desert, where each path represents a different treatment option for perianal fistulas in Crohn's disease. This research aims to shed light on the best path forward by comparing different approaches, including seton placement, anti-TNF medication, and advancement plasty. The study's randomized controlled trial design will allow researchers to objectively evaluate the effectiveness of each approach, providing valuable guidance for clinicians seeking to optimize treatment strategies for patients with perianal fistulas.

Seeking a Solution for Perianal Fistulas in Crohn's Disease

Perianal fistulas can significantly impact the lives of individuals with Crohn's disease, often causing pain, discomfort, and difficulty with daily activities. This research aims to find the most effective solution for this challenging condition by comparing different treatment approaches and evaluating their long-term outcomes. The study's findings will provide valuable information for clinicians and patients, helping them navigate the complex landscape of treatment options and make informed decisions about their care.

Dr.Camel's Conclusion

The treatment of perianal fistulas in Crohn's disease is a complex journey, akin to traversing a vast and unforgiving desert. This research seeks to illuminate the best path forward by comparing different treatment approaches and evaluating their effectiveness. The study's findings will provide valuable insights for clinicians and patients, helping them navigate the complex landscape of treatment options and make informed decisions about their care, ultimately leading to improved outcomes and a better quality of life.

Date :
  1. Date Completed 2016-05-02
  2. Date Revised 2022-03-18
Further Info :

Pubmed ID

26289163

DOI: Digital Object Identifier

PMC4545975

SNS
PICO Info
in preparation
Languages

English

Positive IndicatorAn AI analysis index that serves as a benchmark for how positive the results of the study are. Note that it is a benchmark and requires careful interpretation and consideration of different perspectives.

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