Paper Details

  1. Home
  2. Paper Details

The impact of a three-factor prothrombin complex concentrate on the anticoagulatory effects of the factor Xa inhibitor edoxaban.

Author: BrownKaren S, DishyVictor, HeLing, KochanJarema, ParasrampuriaDolly A, ShiMinggao, WeissDaniel, WickremasinghaPrachi

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.

Overview

This study evaluated the ability of a 3-factor prothrombin complex concentrate (3F-PCC) to reverse the anticoagulatory effects of edoxaban, a direct factor Xa inhibitor.
Paper Details　
Original Abstract of the Article :
Edoxaban, a direct factor Xa inhibitor, is a once-daily, non-vitamin K antagonist oral anticoagulant. There is no established method to reverse the activity of non-vitamin K oral anticoagulants in cases of hemorrhage or urgent surgery. This study evaluated the ability of a 3-factor prothrombin compl...See full text at original site
Dr.Camel IconDr.Camel's Paper Summary Blogラクダ博士について

ラクダ博士は、Health Journal が論文の内容を分かりやすく解説するために作成した架空のキャラクターです。
難解な医学論文を、専門知識のない方にも理解しやすいように、噛み砕いて説明することを目指しています。

* ラクダ博士による解説は、あくまで論文の要点をまとめたものであり、原論文の完全な代替となるものではありません。詳細な内容については、必ず原論文をご参照ください。
* ラクダ博士は架空のキャラクターであり、実際の医学研究者や医療従事者とは一切関係がありません。
* 解説の内容は Health Journal が独自に解釈・作成したものであり、原論文の著者または出版社の見解を反映するものではありません。


引用元：
https://doi.org/10.1016/j.thromres.2015.07.012

データ提供：米国国立医学図書館（NLM）

The impact of a three-factor prothrombin complex concentrate on the anticoagulatory effects of the factor Xa inhibitor edoxaban

Edoxaban is a commonly used medication for preventing blood clots. However, in cases of bleeding or urgent surgery, it can be challenging to reverse its anticoagulant effects. This study investigated the ability of a three-factor prothrombin complex concentrate (3F-PCC) to reverse the anticoagulatory effects of edoxaban.

A Potential Solution for Reversing Edoxaban's Effects

The study explored the effectiveness of 3F-PCC in reversing the anticoagulant effects of edoxaban. While the study results are encouraging, further research is needed to fully understand the optimal dosage and timing of 3F-PCC administration. This study sheds light on a potential solution for managing the anticoagulant effects of edoxaban in urgent situations.

Navigating the Labyrinth of Anticoagulation

The world of anticoagulation can be complex, like a labyrinthine desert with many paths to explore. This study provides valuable insights into a potential solution for reversing the effects of edoxaban, a crucial medication for preventing blood clots. Understanding the nuances of anticoagulation is essential for ensuring patient safety.

Dr.Camel's Conclusion

This study explores the intriguing possibility of using 3F-PCC to reverse the anticoagulant effects of edoxaban. Just like a camel navigating the twists and turns of a desert, managing anticoagulation requires careful attention to detail and a thorough understanding of the various medications involved.

Date :
  1. Date Completed 2016-06-28
  2. Date Revised 2022-03-09
Further Info :

Pubmed ID

26298619

DOI: Digital Object Identifier

10.1016/j.thromres.2015.07.012

Related Literature

Article Analysis
・Effects of edoxaban
SNS
PICO Info
in preparation
Languages

English

Positive IndicatorAn AI analysis index that serves as a benchmark for how positive the results of the study are. Note that it is a benchmark and requires careful interpretation and consideration of different perspectives.

This site uses cookies. Visit our privacy policy page or click the link in any footer for more information and to change your preferences.