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Maternal Antibiotic Treatment Protects Offspring from Diabetes Development in Nonobese Diabetic Mice by Generation of Tolerogenic APCs.

Author: HuChangyun, HuYoujia, PengJian, TaiNingwen, WenLi, WongF Susan, ZhangXiaojun

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Research Support, N.I.H., ExtramuralResearch funding provided by the NIH to external research institutions and researchers.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.

Overview

This study investigated the impact of targeting Gram-negative bacteria in the gut of NOD mice at different time points in their life using a combination of three antibiotics--neomycin, polymyxin B, and streptomycin--on diabetes development. Prenatal neomycin, polymyxin B, and streptomycin treatment protected NOD mice from diabetes development through alterations in the gut microbiota, as well as induction of tolerogenic APCs.
Paper Details　
Original Abstract of the Article :
Type 1 diabetes (T1D) is a T cell-mediated autoimmune disease that involves the slow, progressive destruction of islet β cells and loss of insulin production, as a result of interaction with environmental factors, in genetically susceptible individuals. The gut microbiome is established very early i...See full text at original site
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引用元：
https://pubmed.ncbi.nlm.nih.gov/26401004

データ提供：米国国立医学図書館（NLM）

Maternal Antibiotic Treatment: Shaping Offspring's Immune System

Hello, fellow researchers! I'm Dr. Camel, ready to take you on a journey through the fascinating world of the immune system. This study, published in [Journal Title], explores the intricate relationship between maternal antibiotic treatment and the development of type 1 diabetes (T1D) in offspring.

T1D, like a sandstorm sweeping across the desert, is an autoimmune disease that affects the pancreas. This study investigates the impact of prenatal antibiotic treatment on the immune system of offspring, focusing on the development of T1D.

Prenatal Antibiotic Treatment: A Protective Effect

The study found that prenatal antibiotic treatment, targeting specific types of bacteria in the gut, protected offspring from developing T1D. This is like a camel caravan finding a hidden oasis, shielded from the harsh desert conditions.

Health Benefits and Lifestyle Implications

This research highlights the crucial role of the gut microbiome in shaping the immune system. While the study focuses on prenatal antibiotic treatment, it emphasizes the importance of a healthy gut microbiome throughout life.

Dr.Camel's Conclusion

This research offers valuable insights into the complex interactions between the gut microbiome and the immune system. It's a reminder that we must pay attention to the delicate balance within our bodies, just as a camel caravan relies on a harmonious ecosystem to thrive in the desert.

Date :
  1. Date Completed 2016-01-27
  2. Date Revised 2018-12-02
Further Info :

Pubmed ID

26401004

DOI: Digital Object Identifier

NIHMS721098

Related Literature

Article Analysis
・Effects of neomycin polymyxin
SNS
PICO Info
in preparation
Languages

English

Positive IndicatorAn AI analysis index that serves as a benchmark for how positive the results of the study are. Note that it is a benchmark and requires careful interpretation and consideration of different perspectives.

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