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A Review of Pharmacological Treatments for Depression in Alzheimer's Disease.

Author: KatirtzoglouEverina A, PolitisAntonios M, SiarkosKostas T

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
ReviewAn article that critically examines existing research on a particular topic and summarizes the current state of knowledge in the field.
Systematic ReviewA review that systematically collects, evaluates, and integrates relevant research to answer a specific research question.

Overview

Depression in people with Alzheimer's disease (dAD) is a common and serious problem for both patients and caregivers. While medications have been used based on their effects on brain chemicals, research suggests that depression in AD may be more complex. This review examines various treatments for dAD, aiming to better understand the disease and develop more effective treatments.
Paper Details　
Original Abstract of the Article :
Depression in Alzheimer's disease (dAD) is one of the most common behavioral and psychological symptoms of dementia, with devastating consequences not only for the affected individuals, but for caregivers as well. So far, pharmacological treatment of dAD has been based on the "monoamine hypothesis"....See full text at original site
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引用元：
https://doi.org/10.3233/JAD-148010

データ提供：米国国立医学図書館（NLM）

Depression in Alzheimer's Disease: A Journey Through the Cognitive Desert

This research takes us into the [neurology] desert, exploring the complex interplay between depression and Alzheimer's disease. Alzheimer's disease, like a treacherous desert landscape, can erode cognitive function, leading to confusion and disorientation. Depression, like a relentless sandstorm, can further cloud the mind, amplifying the challenges of this debilitating condition. This study reviews pharmacological treatment options for depression in Alzheimer's disease, seeking to find relief for those navigating this cognitive desert.

Seeking a New Oasis: Beyond the Monoamine Hypothesis

The study highlights the limitations of current pharmacological treatment approaches, which are largely based on the 'monoamine hypothesis.' This hypothesis, like a well-worn path through the desert, has provided some guidance, but it may not fully capture the complex interplay between depression and Alzheimer's disease. The researchers suggest that a more comprehensive understanding of the pathophysiological mechanisms involved is needed to develop more effective treatment strategies.

Navigating the Complexities of Cognitive Decline

This study underscores the need for continued research into the complex relationship between depression and Alzheimer's disease. The authors emphasize the importance of exploring alternative neuropathological and neurobiological pathways to identify new treatment targets. This is like searching for hidden oases in the desert – seeking novel approaches to provide relief for those suffering from this devastating condition.

Dr.Camel's Conclusion

This research emphasizes the urgency of finding more effective treatments for depression in Alzheimer's disease. The study calls for a deeper understanding of the underlying mechanisms of this complex condition, seeking to unlock new treatment possibilities and provide relief for those navigating the cognitive desert of Alzheimer's disease.
Date :
  1. Date Completed 2016-07-06
  2. Date Revised 2018-12-02
Further Info :

Pubmed ID

26401925

DOI: Digital Object Identifier

10.3233/JAD-148010

Related Literature

Article Analysis
・Effective treatment of alzheimer's disease
SNS
PICO Info
in preparation
Languages

English

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