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Identification of dual active agents targeting 5-HT1A and SERT by combinatorial virtual screening methods.

Author: LiuDuo, WangPanpan, XuXiaofei, XueWeiwei, YangFengyuan, YangHong, ZhuFeng

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.

Overview

Selective serotonin reuptake inhibitors (SSRIs) are most adopted therapeutics marketed for major depression, and the efficacy of which are greatly reduced by their delayed onset of action and undesirable side effects. This work applied a combinatorial virtual screening method (CVSM) to identify novel 5-HT1A receptor partial agonist and SERT inhibitor (SPARI) dual target leads. CVSM surpasses single virtual screening methods in terms of hit rates and enrichment factors.
Paper Details　
Original Abstract of the Article :
Selective serotonin reuptake inhibitors (SSRIs) are most adopted therapeutics marketed for major depression, and the efficacy of which are greatly reduced by their delayed onset of action and undesirable side effects. 5-HT1A receptor partial agonist and SERT inhibitor (SPARI) was proposed as a novel...See full text at original site
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引用元：
https://doi.org/10.3233/BME-151529

データ提供：米国国立医学図書館（NLM）

Dual Active Agents for Depression: Finding New Oases in the Desert of Mental Health

Selective serotonin reuptake inhibitors (SSRIs) are widely used to treat depression, but their delayed onset of action and potential side effects can be a challenge. This study explores the potential of dual active agents that target both the 5-HT1A receptor and the serotonin transporter (SERT), known as SPARIs. The researchers employed a combinatorial virtual screening method (CVSM) to identify promising dual-target leads that could potentially overcome the limitations of current antidepressants. The results suggest that CVSM could be a valuable tool for discovering novel SPARIs, potentially leading to more effective and safer treatments for depression.

A New Approach: SPARIs as a Potential Oasis in Depression Treatment

This study offers a refreshing perspective on depression treatment by exploring the potential of SPARIs, dual active agents targeting both the 5-HT1A receptor and the SERT. The research suggests that CVSM could be a valuable tool for identifying promising dual-target leads, potentially paving the way for more effective and safer antidepressants. It’s like discovering a hidden oasis in the vast desert of depression research, offering hope for new and improved treatments.

Navigating the Desert of Depression: The Promise of SPARIs

This research highlights the promise of SPARIs as a potential new approach to treating depression. It’s like finding a clear path through the desert of mental health, offering hope for more effective and safer treatments. The study underscores the potential of CVSM as a powerful tool for identifying promising dual-target leads, potentially leading to a new generation of antidepressants.

Dr.Camel's Conclusion

Depression is a vast and unforgiving desert, but research is constantly seeking new oases. This study explores the potential of SPARIs, a new class of dual-target agents that could offer a more effective and safer approach to treating depression. It’s like finding a hidden spring in the desert, offering hope for a brighter future for those struggling with this debilitating condition.

Date :
  1. Date Completed 2016-07-22
  2. Date Revised 2022-12-07
Further Info :

Pubmed ID

26406003

DOI: Digital Object Identifier

10.3233/BME-151529

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Languages

English

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