Depressor effect of chymase inhibitor in mice with high salt-induced moderate hypertension.

Author: DevarajanSankar, HabeShigehisa, MiuraShin-ichiro, NishiyamaAkira, SakuKeijiro, UeharaYoshinari, UrataHidenori, YahiroEiji

Paper Details 
Original Abstract of the Article :
The aim of the present study was to determine whether long-term high salt intake in the drinking water induces hypertension in wild-type (WT) mice and whether a chymase inhibitor or other antihypertensive drugs could reverse the increase of blood pressure. Eight-week-old male WT mice were supplied w...See full text at original site
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引用元:
https://doi.org/10.1152/ajpheart.00721.2014

データ提供:米国国立医学図書館(NLM)

Investigating the Role of Chymase in Salt-Sensitive Hypertension

The study of [hypertension] is an ongoing field of research, seeking to understand the underlying mechanisms and develop effective treatment strategies. This research explores the role of [chymase] in the development of [salt-sensitive hypertension]. The authors utilize a [mouse model] to investigate the effects of long-term high salt intake on blood pressure and the involvement of [chymase] in this process. The study sheds light on the potential therapeutic benefits of [chymase inhibitors] in managing [salt-sensitive hypertension].

Chymase Plays a Key Role in Salt-Sensitive Hypertension

This research reveals that [chymase] plays a significant role in the development of [salt-sensitive hypertension]. The study found that long-term high salt intake in mice led to an increase in blood pressure and that a [chymase inhibitor] effectively suppressed this elevation. The findings suggest that [chymase] may be a potential target for the development of new therapies for [salt-sensitive hypertension].

Managing Salt Intake for Cardiovascular Health

This research emphasizes the importance of managing salt intake for maintaining cardiovascular health. The authors highlight the potential role of [chymase] in the development of [salt-sensitive hypertension], emphasizing the need to consider the impact of dietary factors on cardiovascular health. This research underscores the need for a balanced diet, low in sodium, to promote cardiovascular well-being.

Dr.Camel's Conclusion

This research adds to our understanding of the mechanisms underlying [salt-sensitive hypertension], revealing the crucial role of [chymase] in this process. The findings suggest that [chymase inhibitors] may be a promising avenue for developing novel therapies for [salt-sensitive hypertension].

Date :
  1. Date Completed 2016-04-11
  2. Date Revised 2020-09-30
Further Info :

Pubmed ID

26432844

DOI: Digital Object Identifier

10.1152/ajpheart.00721.2014

Related Literature

SNS
PICO Info
in preparation
Languages

English

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