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Memantine improves buprenorphine/naloxone treatment for opioid dependent young adults.

Author: DiGirolamoGregory, GonzalezGerardo, KolodziejMonika, Romero-GonzalezMauricio, SmelsonDavid, ZiedonisDouglas

Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.
Comparative StudyResearch that compares multiple groups/interventions to determine differences/similarities in outcomes/characteristics.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Research Support, N.I.H., ExtramuralResearch funding provided by the NIH to external research institutions and researchers.

Overview

Opioid addiction is a serious problem, especially for young adults. While long-term opioid replacement therapy is a common treatment, relapse rates are high after stopping the medication. This study examines the potential benefit of adding memantine, a medication usually used for Alzheimer's disease, to a short course of buprenorphine, another opioid replacement medication.
Paper Details　
Original Abstract of the Article :
Opioid use disorders are considered a serious public health problem among young adults. Current treatment is limited to long-term opioid substitution therapy, with high relapse rates after discontinuation. This study evaluated the co-administration of memantine to brief buprenorphine pharmacotherapy...See full text at original site
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引用元：
https://pubmed.ncbi.nlm.nih.gov/26454835

データ提供：米国国立医学図書館（NLM）

Memantine Enhances Buprenorphine/Naloxone Treatment for Opioid Dependence

In the vast landscape of addiction treatment, [opioid use disorders] are a major challenge, often leading to devastating consequences. This study delves into the potential of [memantine, a drug used for Alzheimer's disease], as an adjunct to [buprenorphine/naloxone pharmacotherapy] for treating opioid dependence in young adults.

Memantine: A Promising Adjunct Therapy

The research suggests that [co-administration of memantine may improve the effectiveness of buprenorphine/naloxone treatment], potentially reducing relapse rates and improving long-term outcomes. Imagine a camel crossing a desert, carrying a heavy load. Memantine, in this analogy, acts as a guide that helps the camel navigate the treacherous terrain and reach its destination. This study highlights the potential of [memantine as a valuable tool for addiction treatment], offering a new avenue for supporting individuals in their recovery journey.

Opioid Dependence: A Complex Issue

Opioid dependence is a complex issue that requires a multi-faceted approach. This study underscores the importance of [exploring new treatment strategies], particularly for young adults who are at a higher risk of relapse. Just as a camel requires a combination of resources to survive in the desert, so too do individuals with opioid dependence need a comprehensive treatment plan that addresses their unique needs and circumstances.

Dr.Camel's Conclusion

This research offers a glimmer of hope in the fight against opioid dependence, exploring the potential of memantine as an adjunct therapy. Just as a camel relies on its instincts and resources to navigate the desert, individuals struggling with addiction require tailored treatment plans and support. This study highlights the importance of ongoing research to develop innovative therapies that can empower individuals in their recovery journey.
Date :
  1. Date Completed 2016-06-20
  2. Date Revised 2018-12-02
Further Info :

Pubmed ID

26454835

DOI: Digital Object Identifier

NIHMS726801

Related Literature

Article Analysis
・Effective treatment of opioid use
SNS
PICO Info
in preparation
Languages

English

Positive IndicatorAn AI analysis index that serves as a benchmark for how positive the results of the study are. Note that it is a benchmark and requires careful interpretation and consideration of different perspectives.

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