Effective treatment of opioid use: A Synthesis of Findings from 90 Studies

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Original Abstract of the Article

Major Research Findings

Opioid use disorder (OUD) and psychiatric conditions often occur together, but are rarely treated with evidence-based therapeutic approaches, resulting in poor outcomes. 86 These conditions, separately, present challenges to treatment initiation, retention, and success. These challenges are compounded when individuals have OUD and psychiatric conditions. 86

Medication-assisted treatment (MAT) is a commonly used approach to treating OUD, involving medications like methadone and buprenorphine, combined with counseling. 87 While MAT has proven effective, there are gaps in research on its cost and effectiveness in adolescents and young adults. 87

Treatment retention is a significant challenge in OUD, particularly for pregnant and postpartum women. 13 The use of MAT for pregnant and postpartum women with OUD is increasing, necessitating further research on discontinuation rates and effective strategies for maintaining treatment. 13

The economic burden of opioid misuse is substantial. 15 While effective interventions exist, economic evaluations are crucial to guide resource allocation and ensure adoption of cost-effective therapies. 15

Hospitalizations related to opioid use consequences are on the rise. 75 While national guidelines for in-hospital OUD management are lacking, existing guidelines for other settings can inform effective management strategies in hospital environments. 75

Despite evidence-based treatments, medications for OUD face stigma and controversy. 61 Addressing intervention stigma through education and awareness campaigns is crucial to improve access to effective treatment. 61

Methadone treatment has been shown to effectively reduce HIV risk behaviors and infections in injecting drug users. 3

treatment まとめ

Different treatment approaches are used for OUD, including medication-assisted treatment (MAT), which involves medications like methadone, buprenorphine, and naltrexone, combined with counseling, psychotherapy, or other supportive therapies. 28 41 53 59 75 Personalized psychosocial interventions, including individual counseling, group therapy, and 12-step programs, can also play a crucial role in treatment success. 35 46

Buprenorphine is a partial opioid agonist used in MAT to reduce cravings and withdrawal symptoms. 18 90 34 28 17 85 26 64 11 It is generally considered safer than methadone. 28 17 Research suggests that buprenorphine implants may help address challenges associated with medication adherence. 18 88

Methadone is a full opioid agonist used in MAT to suppress cravings and withdrawal symptoms. 1 51 6 28 88 Methadone is a stronger medication than buprenorphine. 28 Research on methadone take-home dosing has focused on safety and efficiency during the COVID-19 pandemic. 51

Naltrexone is an opioid antagonist that blocks the effects of opioids. 17 72 26 It is used in MAT to help prevent relapse and reduce cravings. 17 72

Benefits and Risks

Benefits Summary

Opioid use disorder treatment can improve quality of life, reduce the risk of infectious diseases such as HIV, and promote social reintegration. 3 41 28

Risks Summary

Treatment for opioid use disorder carries risks of drug dependence and side effects. 1 28 Treatment also requires time and resources. 87 15

Research Comparisons

Research Similarities

Many studies suggest that treatment for opioid use disorder is effective and can improve quality of life. 6 28 17 Additionally, these studies indicate that treatment can reduce the risk of infections, such as HIV. 3

Research Differences

Several studies have compared the effectiveness of different treatment approaches. 6 28 17 For instance, buprenorphine and methadone have proven to be effective medications for OUD. 6 28 17 However, the effectiveness of these medications may vary depending on individual needs and circumstances. 28 17

Consistency and Contradictions of Findings

The research consistently shows that treatment for OUD can be very effective and improve quality of life. 6 28 17 However, the research also consistently emphasizes the risks of drug dependence and side effects associated with treatment. 1 28 17 Therefore, careful consideration of these risks and benefits is crucial when evaluating OUD treatment. 28

Practical Applications and Considerations

There are multiple treatment options for OUD. 15 The best treatment approach depends on individual needs and circumstances. 15 41 Consulting with a healthcare professional to determine the most suitable treatment option is crucial. 41

Limitations of Current Research

Many of these studies involve small sample sizes. 4 Therefore, their findings need to be validated with larger sample sizes. 4 Additionally, many studies have been conducted on specific populations, such as those with chronic pain. 39 64 It is unclear whether these findings apply to other populations. 39 64

Future Research Directions

Further research on OUD treatment is needed. 4 39 64 Studies comparing the effectiveness of different treatment approaches are particularly important. 6 28 17 Long-term research on OUD treatment is also needed. 56 These studies can help assess the long-term effectiveness and risks of treatment. 56

Conclusion

Opioid use disorder is a serious problem, but there are many effective treatments available. 28 15 Consulting with a healthcare professional to find the most suitable treatment is crucial. 41 85 Treatment retention is crucial for achieving long-term success. 6

treatment List

  • Medication-assisted treatment (MAT)
  • Methadone
  • Buprenorphine
  • Naltrexone
  • Counseling
  • Psychotherapy
  • Individual counseling
  • Group therapy
  • 12-step program
Keywords
Benefit Keywords
Opioid dependence treatment
1
HIV risk reduction
Opioid dependence treatment
Withdrawal symptom relief
2
Reduce HIV infection
Reduce injecting use
3
Reduced illicit opioid use
Reduced pain
4
Opioid replacement therapy
5
Improved retention
Reduced opioid use
6
OMT for opioid dependence
7
Pain management
8
Opioid dependence treatment
9
Buprenorphine-naloxone
10
BUP/NX reduce HIV risk
BUP/NX reduce injection
11
Improved MAT retention
13
Opioid use reduction
14
Interventions for opioid use disorders
15
Opioid use disorder treatment
16
XR-NTX for opioid dependence
17
Opioid abstinence
Reduced opioid use
18
Heroin use disorder treatment
Opioid use disorder treatment
19
Reduced withdrawal symptoms
23
treatment outcomes
24
Increased MAT access
Reduced mortality
25
OUD treatment
26
Opioid use disorder treatment
27
OAT efficacy
OUD treatment
28
MAT access for pain patients
30
Improved OUD treatment
31
Improved OUD treatment
32
Buprenorphine
Opioid use disorder treatment
33
Buprenorphine
Opioid use disorder treatment
34
Opioid use disorder treatment
Personalised psychosocial intervention
35
Improved smoking cessation
36
Improved quality of life
Reduced mortality
37
Sustained benefits
38
Improved health outcomes
Reduced opioid use
39
Improved OUD treatment
40
Improved OUD treatment
41
OUD treatment
42
Increased retention
43
Improved cognitive development
44
Improved OUD treatment
45
OUD treatment
46
Improved OUD treatment
47
OUD treatment
48
OUD treatment
49
Opioid use disorder treatment
50
Methadone dispensing
Remote monitoring
51
OST initiation
52
Primary care treatment for OUD
53
OUD treatment for PEH
54
Remotely delivered incentive intervention for OUD
55
XR-NTX and BUP-NX for opioid treatment
56
Smoking cessation
57
OT-assisted treatment for OUD
58
Pharmacologic treatment of OUD
59
Medication adherence
Polysubstance use reduction
Stimulant use reduction
60
Improved adherence
Opioid abstinence
62
Treatment seeking
63
Increased MOUD exposure
64
OUD treatment
65
MOUD access for veterans
66
Opioid use disorder treatment
67
HIV viral suppression
Opioid use reduction
68
Opioid agonist treatment for OUD
69
OUD treatment linkage
70
Treatment for OUD and comorbid chronic pain
71
BUP-NX and XR-NTX for OUD
72
MOUD engagement
73
Methadone/buprenorphine treatment
Multimodal therapy
Naloxone access
Non-stigmatizing language
Psychosocial treatment
75
Craving reduction
76
Opioid withdrawal relief
77
Opioid addiction
78
BUP iOAT for OUD
79
Opioid use disorder treatment
80
Cocaine abstinence
81
OUD treatment
82
OAT treatment
83
OUD treatment
84
OUD treatment
86
MOUD treatment
87
Care linkage
OUD treatment
88
OUD treatment
90
Risk Keywords
Opioid use
Treatment attrition
5
Dropout
6
Nonmedical prescription opioid use
8
Opioid use
Substance dependence
10
BUP/NX not sustain reduction
11
Prescription opioid addiction
12
Postpartum discontinuation
13
Implant-related adverse events
Non-implant-related adverse events
18
None mentioned
19
Drug misuse
Opioid misuse
29
Opioid addiction
30
Overdose risk
37
Non-adherence
38
Opioid dependence
Opioid overdose
39
Prenatal tobacco exposure
44
Barriers to OST
52
Low treatment receipt
Variable treatment quality
53
Intervention stigma
61
Relapse risk
62
Low treatment seeking
63
Suboptimal MOUD exposure
64
Opioid relapse
74
Fentanyl use
Pain management
75
POUD
76
OUD
77
Stigmatization
78
Cocaine use disorder
Opioid use disorder
81
Adherence
82
Access barriers to OUD treatment
85
Nonfatal overdose
89
Literature analysis of 90 papers
Positive Content
79
Neutral Content
6
Negative Content
5
Article Type
58
10
30
16
89
1.

Methadone maintenance at different dosages for opioid dependence.

Author: FaggianoF, Vigna-TagliantiF, VersinoE, LemmaP

Opioid dependence treatment

Methadone maintenance treatment (MMT) is a long-term approach to managing opioid addiction, and it is considered effective. While higher doses of methadone are recommended to reduce illicit opioid use and help people stay in treatment longer, the way MMT is organized and regulated varies greatly.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
ReviewAn article that critically examines existing research on a particular topic and summarizes the current state of knowledge in the field.
Systematic ReviewA review that systematically collects, evaluates, and integrates relevant research to answer a specific research question.

Language : English

2.

Comparison of pharmacological treatments for opioid-dependent adolescents: a randomized controlled trial.

Author: MarschLisa A, BickelWarren K, BadgerGary J, StothartMarne E, QuesnelKimberly J, StangerCatherine, BrooklynJohn

HIV risk reduction
Opioid dependence treatment
Withdrawal symptom relief

This study found that buprenorphine, combined with behavioral interventions, is significantly more efficacious in the treatment of opioid-dependent adolescents than clonidine combined with behavioral interventions.

Clinical TrialA clinical trial is a planned study conducted on humans to evaluate the efficacy and safety of pharmaceuticals, medical devices, and treatment methods. It aims to explore the possibilities of new treatments and improve the health of patients.
Comparative StudyResearch that compares multiple groups/interventions to determine differences/similarities in outcomes/characteristics.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.
Research Support, N.I.H., ExtramuralResearch funding provided by the NIH to external research institutions and researchers.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.
Research Support, U.S. Gov't, P.H.S.Research funding provided by the Public Health Service (PHS).

Language : English

3.

Brief report: Methadone treatment of injecting opioid users for prevention of HIV infection.

Author: GowingLinda R, FarrellMichael, BornemannReinhard, SullivanLynn E, AliRobert L

Reduce HIV infection
Reduce injecting use

Methadone maintenance treatment for injecting drug users significantly reduces the risk of HIV transmission by decreasing injecting use, sharing of injecting equipment, and multiple sex partners. However, it has little effect on condom use.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.
ReviewAn article that critically examines existing research on a particular topic and summarizes the current state of knowledge in the field.
Systematic ReviewA review that systematically collects, evaluates, and integrates relevant research to answer a specific research question.

Language : English

4.

A preliminary study comparing methadone and buprenorphine in patients with chronic pain and coexistent opioid addiction.

Author: NeumannAnne M, BlondellRichard D, JaanimägiUrmo, GiambroneAmanda K, HomishGregory G, LozanoJacqueline R, KowalikUrszula, AzadfardMohammadreza

Reduced illicit opioid use
Reduced pain

This study compared the effectiveness of methadone and buprenorphine/naloxone in patients with opioid addiction and chronic pain. Both treatments resulted in pain reduction, but methadone showed a lower rate of illicit opioid use.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.
Research Support, N.I.H., ExtramuralResearch funding provided by the NIH to external research institutions and researchers.

Language : English

5.

Buprenorphine/naloxone and methadone maintenance treatment outcomes for opioid analgesic, heroin, and combined users: findings from starting treatment with agonist replacement therapies (START).

Author: PotterJennifer S, MarinoElise N, HillhouseMaureen P, NielsenSuzanne, WiestKatharina, CanamarCatherine P, MartinJudith A, AngAlfonso, BakerRachael, SaxonAndrew J, LingWalter

Opioid replacement therapy
Opioid use
Treatment attrition

Heroin use and injecting are associated with treatment attrition and opioid misuse during treatment, regardless of medication assignment (methadone or buprenorphine/naloxone).

Comparative StudyResearch that compares multiple groups/interventions to determine differences/similarities in outcomes/characteristics.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.

Language : English

6.

Treatment retention among patients randomized to buprenorphine/naloxone compared to methadone in a multi-site trial.

Author: HserYih-Ing, SaxonAndrew J, HuangDavid, HassonAl, ThomasChristie, HillhouseMaureen, JacobsPetra, TeruyaCheryl, McLaughlinPaul, WiestKatharina, CohenAllan, LingWalter

Improved retention
Reduced opioid use
Dropout

Methadone was associated with better retention in treatment for opioid dependence than buprenorphine, and higher doses of both medications were associated with improved retention. Buprenorphine was associated with lower continued use of illicit opioids.

Comparative StudyResearch that compares multiple groups/interventions to determine differences/similarities in outcomes/characteristics.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Multicenter StudyResearch conducted in collaboration with multiple research institutions. It aims to collect a wide range of data and obtain more generalizable results.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.
Research Support, N.I.H., ExtramuralResearch funding provided by the NIH to external research institutions and researchers.

Language : English

7.

Predictors of non-prescribed opioid use after one year of methadone treatment: an attributable-risk approach (ANRS-Methaville trial).

Author: LionsCaroline, CarrieriM Patrizia, MichelLaurent, MoraMarion, MarcellinFabienne, MorelAlain, SpireBruno, RouxPerrine,

OMT for opioid dependence

Methadone is an effective treatment for opioid dependence. However, many people on methadone continue to use other opioids. There is limited research on the causes and ways to prevent this.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Multicenter StudyResearch conducted in collaboration with multiple research institutions. It aims to collect a wide range of data and obtain more generalizable results.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.

Language : English

8.

Prevalence of pain among nonmedical prescription opioid users in substance use treatment populations: systematic review and meta-analyses.

Author: LustedAnna, RoereckeMichael, GoldnerElliot, RehmJürgen, FischerBenedikt

Pain management
Nonmedical prescription opioid use

This study explores the link between non-medical use of prescription opioids (NMPOU) and pain problems in various populations, particularly those receiving treatment for substance use. While existing data suggest a connection, the study emphasizes the need for more thorough research to assess the extent of this relationship.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Meta-AnalysisA statistical technique that integrates the results of multiple studies to draw more general conclusions about a particular issue.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.
ReviewAn article that critically examines existing research on a particular topic and summarizes the current state of knowledge in the field.
Systematic ReviewA review that systematically collects, evaluates, and integrates relevant research to answer a specific research question.

Language : English

9.

Reasons for opioid use among patients with dependence on prescription opioids: the role of chronic pain.

Author: WeissRoger D, PotterJennifer Sharpe, GriffinMargaret L, McHughR Kathryn, HallerDeborah, JacobsPetra, GardinJohn, FischerDan, RosenKristen D

Opioid dependence treatment

This study investigated the reasons why people seek treatment for opioid dependence. The study found that people with chronic pain were more likely to initially use opioids for pain, while avoiding withdrawal was the main reason for continued use in both groups. This highlights the importance of understanding pain as a driver of opioid use in people with chronic pain.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Multicenter StudyResearch conducted in collaboration with multiple research institutions. It aims to collect a wide range of data and obtain more generalizable results.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.
Research Support, N.I.H., ExtramuralResearch funding provided by the NIH to external research institutions and researchers.

Language : English

10.

Who benefits from additional drug counseling among prescription opioid-dependent patients receiving buprenorphine-naloxone and standard medical management?

Author: WeissRoger D, GriffinMargaret L, PotterJennifer Sharpe, DoddDorian R, DreifussJessica A, ConneryHilary S, CarrollKathleen M

Buprenorphine-naloxone
Opioid use
Substance dependence

This study investigated whether adding individual counseling to standard treatment (buprenorphine-naloxone and medical management) for opioid addiction improved outcomes. Overall, counseling did not show a significant benefit for the entire group. However, the study notes that certain subgroups of individuals within larger populations may still benefit from specific treatments, even if those treatments don't work for everyone.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Multicenter StudyResearch conducted in collaboration with multiple research institutions. It aims to collect a wide range of data and obtain more generalizable results.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.
Research Support, N.I.H., ExtramuralResearch funding provided by the NIH to external research institutions and researchers.

Language : English

11.

Expanding substance use treatment options for HIV prevention with buprenorphine-naloxone: HIV Prevention Trials Network 058.

Author: MetzgerDavid S, DonnellDeborah, CelentanoDavid D, JacksonJ Brooks, ShaoYiming, AramrattanaApinun, WeiLiu, FuLiping, MaJun, LucasGregory M, ChawarskiMarek, RuanYuhua, RichardsonPaul, ShinKatherine, ChenRay Y, SugarmanJeremy, DyeBonnie J, RoseScott M, BeauchampGeetha, BurnsDavid N,

BUP/NX reduce HIV risk
BUP/NX reduce injection
BUP/NX not sustain reduction

Participants receiving thrice-weekly buprenorphine/naloxone (BUP/NX) were more likely to reduce opioid injection while on active treatment than those receiving short-term BUP/NX. Both treatment strategies were associated with reductions in injection-related risk behavior, supporting the use of thrice-weekly BUP/NX to reduce HIV risk.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.
Research Support, N.I.H., ExtramuralResearch funding provided by the NIH to external research institutions and researchers.

Language : English

12.

Using behavioral economics to predict opioid use during prescription opioid dependence treatment.

Author: WorleyMatthew J, ShoptawSteven J, BickelWarren K, LingWalter

Prescription opioid addiction

This study explores the role of drug reinforcement value in predicting opioid use during outpatient treatment of prescription opioid addiction. The research examines the connection between decision-making and reward-processing and the development of opioid addiction.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Multicenter StudyResearch conducted in collaboration with multiple research institutions. It aims to collect a wide range of data and obtain more generalizable results.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.
Research Support, N.I.H., ExtramuralResearch funding provided by the NIH to external research institutions and researchers.

Language : English

13.

Medication assisted treatment discontinuation in pregnant and postpartum women with opioid use disorder.

Author: WilderChristine, LewisDaniel, WinhusenTheresa

Improved MAT retention
Postpartum discontinuation

The postpartum period is a time of increased risk for discontinuation of medication assisted treatment (MAT).

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
ReviewAn article that critically examines existing research on a particular topic and summarizes the current state of knowledge in the field.
Systematic ReviewA review that systematically collects, evaluates, and integrates relevant research to answer a specific research question.

Language : English

14.

Memantine improves buprenorphine/naloxone treatment for opioid dependent young adults.

Author: GonzalezGerardo, DiGirolamoGregory, Romero-GonzalezMauricio, SmelsonDavid, ZiedonisDouglas, KolodziejMonika

Opioid use reduction

Opioid addiction is a serious problem, especially for young adults. While long-term opioid replacement therapy is a common treatment, relapse rates are high after stopping the medication. This study examines the potential benefit of adding memantine, a medication usually used for Alzheimer's disease, to a short course of buprenorphine, another opioid replacement medication.

Comparative StudyResearch that compares multiple groups/interventions to determine differences/similarities in outcomes/characteristics.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.
Research Support, N.I.H., ExtramuralResearch funding provided by the NIH to external research institutions and researchers.

Language : English

15.

Economic Evaluations of Opioid Use Disorder Interventions.

Author: MurphySean M, PolskyDaniel

Interventions for opioid use disorders

Opioid misuse has significant economic costs. While effective treatments exist, the need for evidence of cost-effectiveness is crucial due to limited resources. Economic evaluations can help make informed decisions about allocating resources for opioid addiction treatment.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
ReviewAn article that critically examines existing research on a particular topic and summarizes the current state of knowledge in the field.
Systematic ReviewA review that systematically collects, evaluates, and integrates relevant research to answer a specific research question.

Language : English

16.

Hydromorphone Compared With Diacetylmorphine for Long-term Opioid Dependence: A Randomized Clinical Trial.

Author: Oviedo-JoekesEugenia, GuhDaphne, BrissetteSuzanne, MarchandKirsten, MacDonaldScott, LockKurt, HarrisonScott, JanmohamedAmin, AnisAslam H, KrauszMichael, MarshDavid C, SchechterMartin T

Opioid use disorder treatment

Supervised heroin treatment is effective for severe opioid addiction, but it's not available in many places due to legal and political barriers. This limits treatment options for people who inject heroin and haven't responded to other programs.

Clinical Trial, Phase IIIA Phase III trial is a trial that further rigorously verifies the efficacy and safety of a new drug or treatment, whose efficacy and safety have been confirmed in a Phase II trial, in a large number of patients, and evaluates whether it is superior to existing treatments.
Comparative StudyResearch that compares multiple groups/interventions to determine differences/similarities in outcomes/characteristics.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.

Language : English

17.

Design of a randomized controlled trial of extended-release naltrexone versus daily buprenorphine-naloxone for opioid dependence in Norway (NTX-SBX).

Author: KunøeNikolaj, OpheimArild, SolliKristin Klemmetsby, GaulenZhanna, Sharma-HaaseKamni, LatifZill-E-Huma, TanumLars

XR-NTX for opioid dependence

This research examines the effectiveness of extended-release naltrexone (XR-NTX) for treating opioid dependence. While XR-NTX shows promise, more research is needed to understand its long-term safety and effectiveness compared to daily maintenance treatment.

Comparative StudyResearch that compares multiple groups/interventions to determine differences/similarities in outcomes/characteristics.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Multicenter StudyResearch conducted in collaboration with multiple research institutions. It aims to collect a wide range of data and obtain more generalizable results.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.

Language : English

18.

Effect of Buprenorphine Implants on Illicit Opioid Use Among Abstinent Adults With Opioid Dependence Treated With Sublingual Buprenorphine: A Randomized Clinical Trial.

Author: RosenthalRichard N, LofwallMichelle R, KimSonnie, ChenMichael, BeebeKatherine L, VocciFrank J,

Opioid abstinence
Reduced opioid use
Implant-related adverse events
Non-implant-related adverse events

Buprenorphine implants were not inferior to daily sublingual buprenorphine in maintaining opioid abstinence in patients with opioid dependence.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Multicenter StudyResearch conducted in collaboration with multiple research institutions. It aims to collect a wide range of data and obtain more generalizable results.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.

Language : English

19.

Cognitive Behavioral Therapy Improves Treatment Outcomes for Prescription Opioid Users in Primary Care Buprenorphine Treatment.

Author: MooreBrent A, FiellinDavid A, CutterChristopher J, BuonoFrank D, BarryDeclan T, FiellinLynn E, O'ConnorPatrick G, SchottenfeldRichard S

Heroin use disorder treatment
Opioid use disorder treatment
None mentioned

This secondary analysis examined whether treatment outcomes differed for prescription opioid and heroin use disorder patients receiving buprenorphine/naloxone treatment.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.

Language : English

20.

Distinctive Trajectories of Opioid Use Over an Extended Follow-up of Patients in a Multisite Trial on Buprenorphine + Naloxone and Methadone.

Author: HserYih-Ing, HuangDavid, SaxonAndrew J, WoodyGeorge, MoskowitzAndrew L, MatthewsAbigail G, LingWalter

This study aims to identify different patterns of opioid use in individuals with opioid use disorder and the factors associated with these patterns. The study explores the potential of this research to improve treatment responses and care for this population.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Multicenter StudyResearch conducted in collaboration with multiple research institutions. It aims to collect a wide range of data and obtain more generalizable results.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.
Research Support, N.I.H., ExtramuralResearch funding provided by the NIH to external research institutions and researchers.

Language : English

21.

Effectiveness of adjunctive, personalised psychosocial intervention for non-response to opioid agonist treatment: Study protocol for a pragmatic randomised controlled trial.

Author: MarsdenJohn, StillwellGarry, HellierJennifer, BrownAnne Marie, ByfordSarah, KelleherMichael, KellyJoanne, MurphyCaroline, ShearerJames, MitchesonLuke

Opioid agonist therapy (OAT) is the primary treatment for opioid use disorder (OUD), but many patients relapse or continue using opioids. The study describes the development of a personalized psychosocial intervention (PSI) for this population, aiming to improve treatment outcomes.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Pragmatic Clinical TrialA trial conducted in a real-world clinical setting. It evaluates the effectiveness of interventions in everyday healthcare environments.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.

Language : English

22.

Women and the opioid crisis: historical context and public health solutions.

Author: TerplanMishka

This study addressed the opioid crisis in the United States, focusing on the disproportionate impact on women, particularly white reproductive-age women. It emphasized the need for responsible prescribing, expanded treatment capacity, and a shift away from criminalization of drug use and addiction.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Meta-AnalysisA statistical technique that integrates the results of multiple studies to draw more general conclusions about a particular issue.
ReviewAn article that critically examines existing research on a particular topic and summarizes the current state of knowledge in the field.

Language : English

23.

Efficacy of Tramadol Extended-Release for Opioid Withdrawal: A Randomized Clinical Trial.

Author: DunnKelly E, TompkinsD Andrew, BigelowGeorge E, StrainEric C

Reduced withdrawal symptoms

Tramadol ER is more effective than clonidine and comparable to buprenorphine in reducing opioid withdrawal symptoms.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.
Research Support, N.I.H., ExtramuralResearch funding provided by the NIH to external research institutions and researchers.

Language : English

24.

Large variation in measures used to assess outcomes of opioid dependence treatment: A systematic review of longitudinal observational studies.

Author: WiessingLucas, FerriMarica, DarkeShane, SimonRoland, GriffithsPaul

treatment outcomes

This systematic review examined the coherence of outcomes, changes, and drug use measures from observational studies on opioid use treatment. The study found wide variation in outcome measures across studies, which limits replicability and suggests a lack of common expectations on treatment success. The study recommends that future studies use a consistent set of outcome measures, including drug use, crime, health, treatment-related outcomes, social functioning, harms, and mortality.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
ReviewAn article that critically examines existing research on a particular topic and summarizes the current state of knowledge in the field.
Systematic ReviewA review that systematically collects, evaluates, and integrates relevant research to answer a specific research question.

Language : English

25.

Primary care models for treating opioid use disorders: What actually works? A systematic review.

Author: LagisettyPooja, KlasaKatarzyna, BushChristopher, HeislerMichele, ChopraVineet, BohnertAmy

Increased MAT access
Reduced mortality

This study examined 35 interventions for Opioid Use Disorder (OUD) in primary care settings. The study found that most interventions used a multidisciplinary approach with integrated clinical teams, support staff, and patient agreements. Home inductions were also used to make treatment more convenient. The study concluded that multidisciplinary and coordinated care delivery models are effective for implementing OUD treatment and increasing access to Medication-Assisted Treatment (MAT) in primary care.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Meta-AnalysisA statistical technique that integrates the results of multiple studies to draw more general conclusions about a particular issue.
ReviewAn article that critically examines existing research on a particular topic and summarizes the current state of knowledge in the field.
Systematic ReviewA review that systematically collects, evaluates, and integrates relevant research to answer a specific research question.

Language : English

26.

Test of a workforce development intervention to expand opioid use disorder treatment pharmacotherapy prescribers: protocol for a cluster randomized trial.

Author: MolfenterTodd, KnudsenHannah K, BrownRandy, JacobsonNora, HorstJulie, Van EttenMark, KimJee-Seon, HaramEric, CollierElizabeth, StarrSanford, ToyAlexander, MaddenLynn

OUD treatment

Opioid overdose deaths are a major problem in the US. Buprenorphine and naltrexone are effective medications for opioid use disorder (OUD), but there's a shortage of healthcare providers willing to prescribe them. Many factors contribute to this, including concerns about treating OUD patients and difficulties with insurance reimbursement. The shortage of providers makes it hard for people with OUD to access these medications, creating a major healthcare challenge.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Multicenter StudyResearch conducted in collaboration with multiple research institutions. It aims to collect a wide range of data and obtain more generalizable results.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.

Language : English

27.

Treatment outcomes in patients with opioid use disorder initiated by prescription: a systematic review protocol.

Author: SangerNitika, BhattMeha, ZielinskiLaura, SangerStephanie, ShahidHamnah, BantotoBianca, SamaanM Constantine, de SouzaRussell, SamaanZainab

Opioid use disorder treatment

Opioid use is a major public health crisis. Opioid substitution therapy (OST) is a harm-reduction treatment for opioid use disorder, but success rates vary greatly. This review examines whether the way a person first started using opioids, either through prescription or illicitly, affects their outcomes in OST. It also notes that the types of people seeking OST are shifting from younger men who used heroin to older people and women who used prescription opioids.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Meta-AnalysisA statistical technique that integrates the results of multiple studies to draw more general conclusions about a particular issue.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.
ReviewAn article that critically examines existing research on a particular topic and summarizes the current state of knowledge in the field.

Language : English

28.

The OPTIMA study, buprenorphine/naloxone and methadone models of care for the treatment of prescription opioid use disorder: Study design and rationale.

Author: SociasM Eugenia, AhamadKeith, Le FollBernard, LimRon, BruneauJulie, FischerBenedikt, WildT Cameron, WoodEvan, Jutras-AswadDidier

OAT efficacy
OUD treatment

Opioid use and opioid use disorder (OUD) are increasing in North America. Methadone and buprenorphine/naloxone are the recommended treatments for OUD. While buprenorphine/naloxone is considered safer, most research on OUD treatments has focused on heroin users and used strict dosing schedules. This study compares the effectiveness of buprenorphine/naloxone and methadone for treating prescription opioid use disorder (POUD) in real-world clinical settings.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Multicenter StudyResearch conducted in collaboration with multiple research institutions. It aims to collect a wide range of data and obtain more generalizable results.
Pragmatic Clinical TrialA trial conducted in a real-world clinical setting. It evaluates the effectiveness of interventions in everyday healthcare environments.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.

Language : English

29.

Opioid Misuse as a Predictor of Alcohol Treatment Outcomes in the COMBINE Study: Mediation by Medication Adherence.

Author: WitkiewitzKatie, VotawVictoria R, VowlesKevin E, KranzlerHenry R

Drug misuse
Opioid misuse

Opioid misuse and other drug use were associated with poorer AUD treatment outcomes. Opioid misuse significantly predicted the time to first heavy drinking day and a higher probability of being in a heavier and more frequent drinking profile at the end of treatment and at 1 year following treatment.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Multicenter StudyResearch conducted in collaboration with multiple research institutions. It aims to collect a wide range of data and obtain more generalizable results.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.
Research Support, N.I.H., ExtramuralResearch funding provided by the NIH to external research institutions and researchers.

Language : English

30.

Opioid Initiation to Substance Use Treatment: "They Just Want to Feel Normal".

Author: WilsonMarian, ShawMichele R, RobertsMary Lee A

MAT access for pain patients
Opioid addiction

Adults with persistent pain who enter medication-assisted treatment (MAT) for opioid use disorder report that their initial use of opioids was to treat their pain. The decision to enter MAT was key to helping participants gain a sense of normalcy. Insights gained from participants' experiences, particularly in relationships with healthcare providers, can be used to guide treatment approaches.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.

Language : English

31.

Correlates of Long-Term Opioid Abstinence After Randomization to Methadone Versus Buprenorphine/Naloxone in a Multi-Site Trial.

Author: ZhuYuhui, EvansElizabeth A, MooneyLarissa J, SaxonAndrew J, KelleghanAnnamarie, YooCaroline, HserYih-Ing

Improved OUD treatment

Factors influencing long-term opioid abstinence among individuals with opioid use disorder (OUD) are examined, specifically focusing on the impact of cocaine use, injection drug use, Hispanic ethnicity, treatment location, age at first opioid use, impulsivity, treatment duration, and social support.

Comparative StudyResearch that compares multiple groups/interventions to determine differences/similarities in outcomes/characteristics.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Multicenter StudyResearch conducted in collaboration with multiple research institutions. It aims to collect a wide range of data and obtain more generalizable results.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.
Research Support, N.I.H., ExtramuralResearch funding provided by the NIH to external research institutions and researchers.

Language : English

32.

Attentional bias in opioid users: A systematic review and meta-analysis.

Author: MacLeanR Ross, SofuogluMehmet, BredeEmily, RobinsonCendrine, WatersAndrew J

Improved OUD treatment

Opioid use is a major public health crisis in the US. Medication-assisted treatment (MAT) is an effective approach, but additional behavioral therapies are needed. This study examines the potential for addressing attentional biases, which may contribute to opioid use, as a target for additional behavioral treatments.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Meta-AnalysisA statistical technique that integrates the results of multiple studies to draw more general conclusions about a particular issue.
ReviewAn article that critically examines existing research on a particular topic and summarizes the current state of knowledge in the field.
Systematic ReviewA review that systematically collects, evaluates, and integrates relevant research to answer a specific research question.

Language : English

33.

A randomized controlled trial of buprenorphine for probationers and parolees: Bridging the gap into treatment.

Author: GordonMichael S, VocciFrank J, TaxmanFaye, FishmanMarc, SharmaBikash, BlueThomas R, O'GradyKevin E

Buprenorphine
Opioid use disorder treatment

Buprenorphine can be effective in helping people with opioid use disorder (OUD) in various settings outside of methadone treatment programs, such as outpatient clinics and doctors' offices. Despite its effectiveness and safety, it is rarely used for people with OUD who are on probation or parole.

Clinical Trial ProtocolA plan for conducting a clinical trial. It describes in detail the purpose, design, methodology, and statistical considerations of the trial, ensuring the transparency and consistency of the trial.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.
Research Support, N.I.H., ExtramuralResearch funding provided by the NIH to external research institutions and researchers.

Language : English

34.

A systematic review of sex differences in treatment outcomes among people with opioid use disorder receiving buprenorphine maintenance versus other treatment conditions.

Author: LingSara, MangaoilRemar, CleverleyKristin, SprouleBeth, PutsMartine

Buprenorphine
Opioid use disorder treatment

Opioid use disorder is a major health concern in North America. Buprenorphine is a common medication used to treat opioid use disorder. While opioid use disorder is becoming more common in women, we don't know enough about how buprenorphine affects women specifically.

Comparative StudyResearch that compares multiple groups/interventions to determine differences/similarities in outcomes/characteristics.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.
Systematic ReviewA review that systematically collects, evaluates, and integrates relevant research to answer a specific research question.

Language : English

35.

Efficacy and cost-effectiveness of an adjunctive personalised psychosocial intervention in treatment-resistant maintenance opioid agonist therapy: a pragmatic, open-label, randomised controlled trial.

Author: MarsdenJohn, StillwellGarry, JamesKirsty, ShearerJames, ByfordSarah, HellierJennifer, KelleherMichael, KellyJoanna, MurphyCaroline, MitchesonLuke

Opioid use disorder treatment
Personalised psychosocial intervention

Opioid use disorder is a serious problem that is increasing worldwide. While medication is the main treatment, many people continue to use illegal or non-prescribed opioids. This study examines a new personalized therapy, using behavioral change techniques, to see if it can improve outcomes and be cost-effective when used in addition to medication.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Pragmatic Clinical TrialA trial conducted in a real-world clinical setting. It evaluates the effectiveness of interventions in everyday healthcare environments.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.

Language : English

36.

Smokers with opioid use disorder may have worse drug use outcomes after varenicline than nicotine replacement.

Author: MartinRosemarie A, RohsenowDamaris J, TideyJennifer W

Improved smoking cessation

Smokers with opioid use disorder (OUD) have difficulty quitting smoking, potentially due to interactions between nicotine and opioid receptor systems. This study compares the response to smoking treatment in smokers with OUD versus non-opioid substance use disorders (NOUD).

Comparative StudyResearch that compares multiple groups/interventions to determine differences/similarities in outcomes/characteristics.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.
Research Support, N.I.H., ExtramuralResearch funding provided by the NIH to external research institutions and researchers.
Research Support, U.S. Gov't, Non-P.H.S.Research funding provided by US government agencies other than the Public Health Service.

Language : English

37.

Reduction in mortality risk with opioid agonist therapy: a systematic review and meta-analysis.

Author: BahjiA, ChengB, GrayS, StuartH

Improved quality of life
Reduced mortality
Overdose risk

Methadone and buprenorphine, opioid agonist therapies, were found to be associated with significantly reduced mortality rates, particularly during the first four weeks of treatment, compared to periods out of treatment. The greatest mortality reduction was observed with methadone. However, mortality estimates were heterogeneous and varied by country, region, and treatment provider.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Meta-AnalysisA statistical technique that integrates the results of multiple studies to draw more general conclusions about a particular issue.
Systematic ReviewA review that systematically collects, evaluates, and integrates relevant research to answer a specific research question.

Language : English

38.

Effects of access barriers and medication acceptability on buprenorphine-naloxone treatment utilization over 2 years: Results from a multisite randomized trial of adults with opioid use disorder.

Author: EvansElizabeth A, YooCaroline, HuangDavid, SaxonAndrew J, HserYih-Ing

Sustained benefits
Non-adherence

This study aims to understand why many people with opioid use disorder (OUD) who start buprenorphine treatment, a medication that helps manage opioid addiction, don't continue taking it long enough to fully benefit. The study will identify factors that influence how long people stick with buprenorphine treatment.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Multicenter StudyResearch conducted in collaboration with multiple research institutions. It aims to collect a wide range of data and obtain more generalizable results.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.
Research Support, N.I.H., ExtramuralResearch funding provided by the NIH to external research institutions and researchers.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.
Research Support, U.S. Gov't, P.H.S.Research funding provided by the Public Health Service (PHS).

Language : English

39.

Global patterns of opioid use and dependence: harms to populations, interventions, and future action.

Author: DegenhardtLouisa, GrebelyJason, StoneJack, HickmanMatthew, VickermanPeter, MarshallBrandon D L, BruneauJulie, AlticeFrederick L, HendersonGraeme, Rahimi-MovagharAfarin, LarneySarah

Improved health outcomes
Reduced opioid use
Opioid dependence
Opioid overdose

Opioid use disorder is a major global health problem, affecting millions of people and causing tens of thousands of deaths each year. Opioid agonist treatment (OAT) is very effective in reducing opioid use and improving overall health and social outcomes. While there are other interventions that can help, OAT has the broadest impact and is often underutilized, even in high-income countries. The authors recommend a human rights-based approach to opioid use and dependence, focusing on reducing harm and treating it as a public health issue.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Systematic ReviewA review that systematically collects, evaluates, and integrates relevant research to answer a specific research question.

Language : English

40.

Trajectory classes of opioid use among individuals in a randomized controlled trial comparing extended-release naltrexone and buprenorphine-naloxone.

Author: RuglassLesia M, ScodesJennifer, PavlicovaMartina, CampbellAimee N C, FitzpatrickSkye, Barbosa-LeikerCelestina, BurlewKathleen, GreenfieldShelly F, RotrosenJohn, NunesEdward V

Improved OUD treatment

This study examined how opioid use changed over time for people with opioid use disorder who were offered either buprenorphine-naloxone (BUP-NX) or extended-release naltrexone (XR-NTX) treatment. Researchers identified different patterns of opioid use in these patients and explored what factors were linked to each pattern.

Comparative StudyResearch that compares multiple groups/interventions to determine differences/similarities in outcomes/characteristics.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Multicenter StudyResearch conducted in collaboration with multiple research institutions. It aims to collect a wide range of data and obtain more generalizable results.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.
Research Support, N.I.H., ExtramuralResearch funding provided by the NIH to external research institutions and researchers.

Language : English

41.

Opioid-related treatment, interventions, and outcomes among incarcerated persons: A systematic review.

Author: MaltaMonica, VaratharajanThepikaa, RussellCayley, PangMichelle, BonatoSarah, FischerBenedikt

Improved OUD treatment

Opioid-related overdose is a major public health crisis. This study reviews interventions for opioid use disorder (OUD) in correctional facilities, which often use abstinence-only approaches, to inform more effective management.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.
Systematic ReviewA review that systematically collects, evaluates, and integrates relevant research to answer a specific research question.

Language : English

42.

Routes of non-traditional entry into buprenorphine treatment programs.

Author: Champagne-LangabeerTiffany, SwankMichael W, LangabeerJames R

OUD treatment

This study focuses on increasing access to buprenorphine, a medication used to treat opioid addiction. While buprenorphine is known to greatly reduce overdose risk, many people with opioid use disorder (OUD) face barriers to starting treatment. The study aims to explore new ways to help people begin buprenorphine treatment.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Systematic ReviewA review that systematically collects, evaluates, and integrates relevant research to answer a specific research question.

Language : English

43.

Secondary Analysis of Pain Outcomes in a Large Pragmatic Randomized Trial of Buprenorphine/Naloxone Versus Methadone for Opioid Use Disorder.

Author: ShulmanMatisyahu, LuoSean X, CampbellAimee N C, ScodesJennifer, PavlicovaMartina, BroffmanAndi, SaxonAndrew J, NunesEdward V

Increased retention

Nearly half of the participants in a large multisite randomized trial of medication treatments for OUD reported pain at baseline, and improvement in pain early in treatment was associated with increased likelihood of retention in treatment.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.
Research Support, N.I.H., ExtramuralResearch funding provided by the NIH to external research institutions and researchers.

Language : English

44.

Cognitive Outcomes of Young Children After Prenatal Exposure to Medications for Opioid Use Disorder: A Systematic Review and Meta-analysis.

Author: NelsonLeah F, YocumVictoria K, PatelKeisha D, QeadanFares, HsiAndrew, WeitzenSherry

Improved cognitive development
Prenatal tobacco exposure

This meta-analysis examined the association between prenatal exposure to medication for addiction treatment (MAT) and early childhood cognitive development. The study found that MAT exposure was associated with lower cognitive development scores, but the association disappeared when accounting for prenatal tobacco exposure.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Meta-AnalysisA statistical technique that integrates the results of multiple studies to draw more general conclusions about a particular issue.
Research Support, N.I.H., ExtramuralResearch funding provided by the NIH to external research institutions and researchers.
Research Support, U.S. Gov't, P.H.S.Research funding provided by the Public Health Service (PHS).
Systematic ReviewA review that systematically collects, evaluates, and integrates relevant research to answer a specific research question.

Language : English

45.

Slow release oral morphine versus methadone for opioid use disorder in the fentanyl era (pRESTO): Protocol for a non-inferiority randomized clinical trial.

Author: SociasM Eugenia, WoodEvan, DongHuiru, BrarRupinder, BachPaxton, MurphySean M, FairbairnNadia

Improved OUD treatment

This study aims to investigate the relative effectiveness and acceptability of slow-release oral morphine (SROM) compared to methadone for opioid use disorder (OUD) in the context of fentanyl use.

Clinical Trial ProtocolA plan for conducting a clinical trial. It describes in detail the purpose, design, methodology, and statistical considerations of the trial, ensuring the transparency and consistency of the trial.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.
Research Support, N.I.H., ExtramuralResearch funding provided by the NIH to external research institutions and researchers.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.

Language : English

46.

Psychosocial intervention utilization and substance abuse treatment outcomes in a multisite sample of individuals who use opioids.

Author: HarveyLaura M, FanWeihua, CanoMiguel Ángel, VaughanEllen L, ArbonaConsuelo, EssaSaman, SanchezHelen, de DiosMarcel A

OUD treatment

There are effective medications for opioid use disorder (OUD), but many people relapse. Adding therapy to medication can help, but it's unclear which types of therapy are most effective. This study will compare individual counseling, group therapy, and 12-step programs to see which helps people stay off opioids the longest.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.
Research Support, N.I.H., ExtramuralResearch funding provided by the NIH to external research institutions and researchers.

Language : English

47.

Health and economic outcomes of treatment with extended-release naltrexone among pre-release prisoners with opioid use disorder (HOPPER): protocol for an evaluation of two randomized effectiveness trials.

Author: MurphySean M, JengPhilip J, PooleSabrina A, JalaliAli, VocciFrank J, GordonMichael S, WoodyGeorge E, PolskyDaniel

Improved OUD treatment

Extended-release naltrexone (XR-NTX) is the most widely accepted, evidence-based pharmacotherapy for opioid use disorder (OUD) in correctional settings, but its high cost is a barrier to its use.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.
Research Support, N.I.H., ExtramuralResearch funding provided by the NIH to external research institutions and researchers.

Language : English

48.

Treatment Outcomes in Patients With Opioid Use Disorder Who Were First Introduced to Opioids by Prescription: A Systematic Review and Meta-Analysis.

Author: SangerNitika, BhattMeha, SinghalNikhita, PanesarBalpreet, D'EliaAlessia, TrottierMaegan, ShahidHamnah, HillmerAlannah, Baptist-MohseniNatasha, RoczykiVictoria, SoniDivya, BrushMaurana, LovellElizabeth, SangerStephanie, SamaanM Constantine, de SouzaRussell J, ThabaneLehana, SamaanZainab

OUD treatment

Opioid use disorder (OUD) is now more common in older people due to misuse of prescription opioids. While medication-assisted treatment (MAT) helps, its effectiveness varies. This study will investigate whether the source of the first opioid use—prescription or illicit—affects how well people respond to treatment, looking at whether they continue using illicit opioids and other drugs while on MAT.

Systematic ReviewA review that systematically collects, evaluates, and integrates relevant research to answer a specific research question.

Language : English

49.

A systematic review of patients' and providers' perspectives of medications for treatment of opioid use disorder.

Author: CioeKatharine, BiondiBreanne E, EaslyRebecca, SimardAmanda, ZhengXiao, SpringerSandra A

OUD treatment

Opioid use disorder (OUD) is a serious public health crisis. Medications used to treat OUD include buprenorphine, methadone, and extended-release naltrexone (XR-NTX). We need to understand how patients and doctors feel about these medications, as their opinions can influence whether people get prescribed these medications, whether they stay on treatment, and whether they recover.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Research Support, N.I.H., ExtramuralResearch funding provided by the NIH to external research institutions and researchers.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.
Systematic ReviewA review that systematically collects, evaluates, and integrates relevant research to answer a specific research question.

Language : English

50.

Buprenorphine-naloxone use in pregnancy: a systematic review and metaanalysis.

Author: LinkHeather M, JonesHendree, MillerLauren, KaltenbachKarol, SeligmanNeil

Opioid use disorder treatment

A systematic review and meta-analysis found that pregnant women taking buprenorphine-naloxone for opioid use disorder do not have significantly different pregnancy outcomes compared to those taking other forms of opioid agonist medication-assisted therapy. Of 1875 mother-baby dyads analyzed, there were no serious adverse maternal or neonatal outcomes associated with buprenorphine-naloxone. Women on buprenorphine-naloxone were less likely to have babies who needed treatment for neonatal abstinence syndrome.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Meta-AnalysisA statistical technique that integrates the results of multiple studies to draw more general conclusions about a particular issue.
ReviewAn article that critically examines existing research on a particular topic and summarizes the current state of knowledge in the field.
Systematic ReviewA review that systematically collects, evaluates, and integrates relevant research to answer a specific research question.

Language : English

51.

Technology-assisted methadone take-home dosing for dispensing methadone to persons with opioid use disorder during the Covid-19 pandemic.

Author: DunnKelly E, BroonerRobert K, StollerKenneth B

Methadone dispensing
Remote monitoring

This study evaluated the feasibility, satisfaction, and safety of using a secure pillbox to remotely manage take-home doses of methadone in patients with opioid use disorder (OUD). The study found that the pillbox was feasible, well-received by patients, and safe. The study suggests that remote monitoring of methadone take-home doses using secure pillboxes could improve access to methadone treatment and potentially be implemented in clinic operations.

Clinical Trial, Phase IIA Phase II trial is a trial that further evaluates the efficacy and safety of a new drug or treatment, whose safety has been confirmed to some extent in a Phase I trial, in a small number of patients.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.
Research Support, N.I.H., ExtramuralResearch funding provided by the NIH to external research institutions and researchers.

Language : English

52.

Barriers to accessing opioid substitution treatment for opioid use disorder: A systematic review from the client perspective.

Author: HallNatasha Yvonne, LeLong, MajmudarIshani, MihalopoulosCathrine

OST initiation
Barriers to OST

Barriers to initiating opioid substitution therapy (OST) for those with opioid use disorder (OUD) include stigma, fear, regulatory issues, logistical challenges, attitudinal factors, and social factors. The most common barriers are negative treatment perceptions, cost, stigma, and lack of flexibility.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Systematic ReviewA review that systematically collects, evaluates, and integrates relevant research to answer a specific research question.

Language : English

53.

Design of CLARO (Collaboration Leading to Addiction Treatment and Recovery from other Stresses): A randomized trial of collaborative care for opioid use disorder and co-occurring depression and/or posttraumatic stress disorder.

Author: MeredithLisa S, KomaromyMiriam S, CefaluMatthew, Murray-KrezanCristina, PageKimberly, OsillaKaren Chan, DoppAlex R, LeamonIsabel, TarhuniLina, HindmarchGrace, JacobsohnVanessa, WatkinsKatherine E,

Primary care treatment for OUD
Low treatment receipt
Variable treatment quality

Many people with opioid use disorder (OUD) also have depression and/or posttraumatic stress disorder (PTSD), which can lead to serious problems if not treated. While effective treatments exist for these disorders, people often don't receive them or get inconsistent care. Primary care doctors are an important and underutilized resource for treating these co-occurring disorders because many people see their primary care doctor at least yearly and often have other medical conditions. This gap in treatment is a concern as opioid use and deaths related to opioids are increasing, leaving a vulnerable and often stigmatized population without adequate care.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.
Research Support, N.I.H., ExtramuralResearch funding provided by the NIH to external research institutions and researchers.

Language : English

54.

Opioid use disorder treatment for people experiencing homelessness: A scoping review.

Author: McLaughlinMatthew F, LiRick, CarreroNicolás Domínguez, BainPaul A, ChatterjeeAvik

OUD treatment for PEH

This study synthesized the literature on the intersection of housing status and opioid use disorder (OUD) treatment. The opioid overdose epidemic remains a major public health issue in the United States, and people experiencing homelessness are more likely to misuse opioids and experience overdose. This review highlights the underutilization of evidence-based treatments for OUD, particularly among people experiencing homelessness.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Systematic ReviewA review that systematically collects, evaluates, and integrates relevant research to answer a specific research question.

Language : English

55.

Remotely delivered incentives to promote buprenorphine treatment engagement in out-of-treatment adults with opioid use disorder.

Author: HoltynAugust F, ToegelForrest, NovakMatthew D, LeoutsakosJeannie-Marie, FingerhoodMichael, SilvermanKenneth

Remotely delivered incentive intervention for OUD

This randomized pilot trial evaluated the effectiveness of a remotely delivered incentive intervention in promoting engagement in buprenorphine treatment for opioid use disorder (OUD) among individuals who were not already in treatment. Expanding access to office-based buprenorphine treatment is crucial for addressing the opioid overdose epidemic.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.
Research Support, N.I.H., ExtramuralResearch funding provided by the NIH to external research institutions and researchers.
Research Support, U.S. Gov't, P.H.S.Research funding provided by the Public Health Service (PHS).

Language : English

56.

Naturalistic follow-up after a trial of medications for opioid use disorder: Medication status, opioid use, and relapse.

Author: GreinerMiranda G, ShulmanMatisyahu, ChooTse-Hwei, ScodesJennifer, PavlicovaMartina, CampbellAimee N C, NovoPatricia, FishmanMarc, LeeJoshua D, RotrosenJohn, NunesEdward V

XR-NTX and BUP-NX for opioid treatment

This report examined opioid use outcomes and the use of medications for opioid use disorder (MOUD) 36 weeks after randomization in a clinical trial comparing extended-release naltrexone (XR-NTX) and buprenorphine-naloxone (BUP-NX) for opioid treatment.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Multicenter StudyResearch conducted in collaboration with multiple research institutions. It aims to collect a wide range of data and obtain more generalizable results.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.
Research Support, N.I.H., ExtramuralResearch funding provided by the NIH to external research institutions and researchers.

Language : English

57.

Reductions in tobacco use in naltrexone, relative to buprenorphine-maintained individuals with opioid use disorder: Secondary analysis from the National Drug Abuse Treatment Clinical Trials Network.

Author: MontgomeryLaTrice, WinhusenTheresa, ScodesJennifer, PavlicovaMartina, TwittyDylanne, CampbellAimee N C, WangAn Li, NunesEdward V, RotrosenJohn

Smoking cessation

This study explores the relationship between opioid use and smoking cessation in people with opioid use disorder (OUD). The study suggests that opioid use may make it harder to quit smoking, even with standard treatments. The researchers aim to determine if a medication that blocks the effects of opioids (XR-NTX) leads to better smoking outcomes compared to another medication that partially activates opioid receptors (BUP-NX).

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.
Research Support, N.I.H., ExtramuralResearch funding provided by the NIH to external research institutions and researchers.

Language : English

58.

Opium tincture-assisted treatment for opioid use disorder: A systematic review.

Author: NorooziAlireza, KebriaeezadehAbbas, MirrahimiBahareh, ArmoonBahram, AhounbarElaheh, NarenjihaHooman, SalehiMohammad, KaramouzianMohammad

OT-assisted treatment for OUD

This systematic review evaluated the safety and efficacy of opium tincture (OT) assisted treatment for opioid use disorder (OUD). OT has gained popularity in Iran and other countries where opium use is prevalent and culturally accepted, offering an alternative to methadone and buprenorphine.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
ReviewAn article that critically examines existing research on a particular topic and summarizes the current state of knowledge in the field.
Systematic ReviewA review that systematically collects, evaluates, and integrates relevant research to answer a specific research question.

Language : English

59.

Economic Evaluations of Pharmacologic Treatment for Opioid Use Disorder: A Systematic Literature Review.

Author: OnuohaErica N, LeffJared A, SchackmanBruce R, McCollisterKathryn E, PolskyDaniel, MurphySean M

Pharmacologic treatment of OUD

The opioid crisis is a major problem in the US and globally, straining resources. Three medications are approved to treat opioid use disorder: methadone, buprenorphine, and injectable extended-release naltrexone (XR-NTX). These medications vary in effectiveness and cost. This study reviewed recent research on the economic value of these treatments to help make informed decisions about allocating resources.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Research Support, N.I.H., ExtramuralResearch funding provided by the NIH to external research institutions and researchers.
Systematic ReviewA review that systematically collects, evaluates, and integrates relevant research to answer a specific research question.

Language : English

60.

Contingency Management for Patients Receiving Medication for Opioid Use Disorder: A Systematic Review and Meta-analysis.

Author: BolívarHypatia A, KlempererElias M, ColemanSulamunn R M, DeSarnoMichael, SkellyJoan M, HigginsStephen T

Medication adherence
Polysubstance use reduction
Stimulant use reduction

Contingency management, a behavioral intervention that uses material incentives for behavior change, is associated with improved end-of-treatment outcomes for various clinical problems among patients receiving medication treatment for opioid use disorder (MOUD). A meta-analysis of 60 studies involving 10,444 participants found that contingency management was associated with improvements in stimulant use, cigarette smoking, illicit opioid use, medication adherence, polysubstance use, and therapy attendance.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Meta-AnalysisA statistical technique that integrates the results of multiple studies to draw more general conclusions about a particular issue.
Research Support, N.I.H., ExtramuralResearch funding provided by the NIH to external research institutions and researchers.
Systematic ReviewA review that systematically collects, evaluates, and integrates relevant research to answer a specific research question.

Language : English

61.

Intervention Stigma toward Medications for Opioid Use Disorder: A Systematic Review.

Author: MaddenErin Fanning, PrevedelSuzanne, LightTimothy, SulzerSandra H

Intervention stigma

Stigma associated with medication-assisted treatment (MAT) for opioid use disorder (OUD) was found to be prevalent among healthcare providers, patients seeking treatment, and the general public. This stigma was driven by factors such as lack of training, preference for abstinence-based treatment, and misconceptions about MAT.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Research Support, U.S. Gov't, Non-P.H.S.Research funding provided by US government agencies other than the Public Health Service.
Systematic ReviewA review that systematically collects, evaluates, and integrates relevant research to answer a specific research question.

Language : English

62.

The Predictive Value of Degree of Preference for Extended-Release Naltrexone for Treatment Adherence, Opioid Use, and Relapse.

Author: GaulenZhanna, BrennaIda Halvorsen, FadnesLars Thore, Šaltytė BenthJūratė, SolliKristin K, KunoeNikolaj, OpheimArild, TanumLars

Improved adherence
Opioid abstinence
Relapse risk

Patient preference for extended-release naltrexone (XR-NTX) was associated with better long-term adherence to treatment and lower illicit opioid use. Patients who matched their preference for XR-NTX had lower illicit opioid use in the short term, while those who did not match their preference had higher long-term opioid use and relapse rates.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.

Language : English

63.

Treatment-seeking behaviour among people with opioid use disorder in the high-income countries: A systematic review and meta-analysis.

Author: HallNatasha, LeLong, MajmudarIshani, TeessonMaree, MihalopoulosCathy

Treatment seeking
Low treatment seeking

This meta-analysis investigated treatment seeking behavior in individuals with opioid use disorder (OUD) in high-income countries. The results showed that 40% of individuals with OUD sought treatment in their lifetime, and 21% sought treatment in the past 12 months. The study highlights the need for further research to explore barriers and facilitators to treatment seeking in individuals with OUD.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Meta-AnalysisA statistical technique that integrates the results of multiple studies to draw more general conclusions about a particular issue.
Systematic ReviewA review that systematically collects, evaluates, and integrates relevant research to answer a specific research question.

Language : English

64.

Correlates of days of medication for opioid use disorder exposure among people living with HIV in Northern Vietnam.

Author: ButtonDana, CookRyan, KingCaroline, KhuyenTong Thi, KunkelLynn, BartGavin, ThuyDinh Thanh, NguyenDiep Bich, BlazesChristopher K, GiangLe Minh, KorthuisP Todd

Increased MOUD exposure
Suboptimal MOUD exposure

Medication for opioid use disorder (MOUD) treatment exposure was suboptimal among patients with HIV and opioid use disorder in Northern Vietnam. MOUD treatment exposure was influenced by age, income, and type of MOUD (methadone vs buprenorphine).

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.
Research Support, N.I.H., ExtramuralResearch funding provided by the NIH to external research institutions and researchers.

Language : English

65.

The Emergency Department Longitudinal Integrated Care (ED-LINC) intervention targeting opioid use disorder: A pilot randomized clinical trial.

Author: WhitesideLauren K, HuynhLy, MorseSophie, HallJane, MeurerWilliam, Banta-GreenCaleb J, ScheuerHannah, CunninghamRebecca, McGovernMark, ZatzickDouglas F

OUD treatment

This study highlights the need for better treatment strategies in emergency departments (ED) for people with opioid use disorder (OUD). While many people with OUD visit the ED, there are limited programs to address their opioid use and help them start and stay on medication treatment for opioid addiction.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.
Research Support, N.I.H., ExtramuralResearch funding provided by the NIH to external research institutions and researchers.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.

Language : English

66.

Advancing Pharmacological Treatments for Opioid Use Disorder (ADaPT-OUD): an Implementation Trial in Eight Veterans Health Administration Facilities.

Author: HagedornHildi J, GustavsonAllison M, AcklandPrincess E, BangerterAnn, BounthavongMark, ClothierBarbara, HarrisAlex H S, KennyMarie E, NoorbaloochiSiamak, SalamehHope A, GordonAdam J

MOUD access for veterans

This study highlights the need for implementation strategies to improve access to medication-assisted treatment (MAT) for opioid use disorder (OUD) within the Veterans Health Administration (VHA). MAT provision varies significantly across VHA facilities, underscoring the need for targeted strategies to increase access to these evidence-based treatments.

Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Research Support, U.S. Gov't, Non-P.H.S.Research funding provided by US government agencies other than the Public Health Service.

Language : English

67.

Interim opioid agonist treatment for opioid addiction: a systematic review.

Author: Samsó JofraLaura, PuigTeresa, SolàIvan, TrujolsJoan

Opioid use disorder treatment

Opioid use disorder is a serious problem, and access to treatment can be difficult. This study will evaluate the effects of a temporary medication-assisted treatment (OAT) program while people wait for longer-term treatment. It will look at how well people stay in treatment, how easy it is to get into longer-term treatment, and how the temporary treatment affects quality of life and satisfaction.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
ReviewAn article that critically examines existing research on a particular topic and summarizes the current state of knowledge in the field.
Systematic ReviewA review that systematically collects, evaluates, and integrates relevant research to answer a specific research question.

Language : English

68.

HIV clinic-based extended-release naltrexone versus treatment as usual for people with HIV and opioid use disorder: a non-blinded, randomized non-inferiority trial.

Author: KorthuisP Todd, CookRyan R, LumPaula J, WaddellElizabeth Needham, TookesHansel, Vergara-RodriguezPamela, KunkelLynn E, LucasGregory M, RodriguezAllan E, BielavitzSarann, FanucchiLaura C, HoffmanKim A, BachrachKen, PayneElizabeth H, CollinsJulia A, MatthewsAbigail, OdenNeal, JacobsPetra, JelstromEve, SorensenJames L, McCartyDennis

HIV viral suppression
Opioid use reduction

Extended-release naltrexone was comparable to treatment as usual for facilitating human immunodeficiency virus (HIV) viral suppression, but non-inferiority could not be demonstrated. Participants who initiated extended-release naltrexone used fewer opioids than those who received treatment as usual.

Equivalence TrialA clinical trial designed to show that a new treatment is equivalent in efficacy/safety to an existing treatment.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.
Research Support, N.I.H., ExtramuralResearch funding provided by the NIH to external research institutions and researchers.

Language : English

69.

Substance of choice, impact of heroin or opium on treatment retention in a multicentre randomised controlled trial in Iran.

Author: SongMichael Jae, WestenbergJean Nicolas, KianpoorKiana, NikooMohammadali, KazemiAlireza, SchuetzChristian, JangKerry, GholamiAli, AkhondzadehShahin, KrauszMichael

Opioid agonist treatment for OUD

This study investigated the relationship between primary opioid of choice (heroin or opium) and retention in opium tincture and methadone treatment in Iran, considering the prevalence of illicit opioid use in the Middle East and Asia.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Multicenter StudyResearch conducted in collaboration with multiple research institutions. It aims to collect a wide range of data and obtain more generalizable results.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.

Language : English

70.

Innovating for real-world care: A systematic review of interventions to improve post-detoxification outcomes for opioid use disorder.

Author: AmeralVictoria, HockingElise, LeviyahXenia, NewbergerNoam G, TimkoChristine, LivingstonNicholas

OUD treatment linkage

This systematic review explores interventions specifically designed to improve substance use outcomes and treatment linkage after inpatient detoxification for Opioid Use Disorder (OUD).

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Research Support, U.S. Gov't, Non-P.H.S.Research funding provided by US government agencies other than the Public Health Service.
ReviewAn article that critically examines existing research on a particular topic and summarizes the current state of knowledge in the field.
Systematic ReviewA review that systematically collects, evaluates, and integrates relevant research to answer a specific research question.

Language : English

71.

Systematic review on the clinical management of chronic pain and comorbid opioid use disorder.

Author: Jiménez-FernándezBeltrán, Calomarde-GómezCristina, López-LazcanoAna, LligoñaAnna, GualAntoni, López-PelayoHugo

Treatment for OUD and comorbid chronic pain

This systematic review evaluates the efficacy of treatments for chronic pain in patients with opioid use disorder (OUD). The coexistence of chronic pain and OUD poses a complex challenge, and this study explores effective management strategies.

Systematic ReviewA review that systematically collects, evaluates, and integrates relevant research to answer a specific research question.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.

Language : English

72.

Methamphetamine/amphetamine use over time among persons with opioid use disorders treated with buprenorphine/naloxone versus extended-release naltrexone.

Author: TsuiJudith I, CampbellAimee N C, PavlicovaMartina, ChooTse-Hwei, LeeJoshua D, CookRyan R, ShulmanMatisyahu, NunesEdward V, RotrosenJohn

BUP-NX and XR-NTX for OUD

This study examines methamphetamine/amphetamine (MA/A) use among patients receiving treatment for opioid use disorder (OUD) with buprenorphine/naloxone (BUP-NX) or extended-release naltrexone (XR-NTX). Methamphetamine use is increasing among individuals with OUD.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.
Research Support, N.I.H., ExtramuralResearch funding provided by the NIH to external research institutions and researchers.

Language : English

73.

Impact of fentanyl use on initiation and discontinuation of methadone and buprenorphine/naloxone among people with prescription-type opioid use disorder: secondary analysis of a Canadian treatment trial.

Author: SociasM Eugenia, WoodEvan, Le FollBernard, LimRon, ChoiJin Cheol, MokWing Yin, BruneauJulie, RehmJürgen, WildT Cameron, BozinoffNikki, HassanAhmed, Jutras-AswadDidier,

MOUD engagement

Fentanyl is a major contributor to the current opioid overdose crisis. While medications for opioid use disorder (MOUD) can help, we need more information about how fentanyl use affects treatment outcomes. This study will examine whether exposure to fentanyl impacts whether people with prescription opioid use disorder (POUD) start and stay on MOUD.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.

Language : English

74.

Polysubstance use before and during treatment with medication for opioid use disorder: Prevalence and association with treatment outcomes.

Author: BuntingAmanda M, KrawczykNoa, ChooTse-Hwei, PavlicovaMartina, McNeelyJennifer, TofighiBabak, RotrosenJohn, NunesEdward, LeeJoshua D

Opioid relapse

Polysubstance use was not strongly associated with treatment outcomes for opioid use disorder. In this study of individuals receiving medication for opioid use disorder, only pretreatment sedative use and cocaine use during the initial 4 weeks of treatment were marginally associated with increased relapse rates. These findings suggest that polysubstance use may not significantly impact opioid treatment outcomes in all cases.

Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Research Support, N.I.H., ExtramuralResearch funding provided by the NIH to external research institutions and researchers.
Research Support, U.S. Gov't, P.H.S.Research funding provided by the Public Health Service (PHS).

Language : English

75.

Management of opioid use disorder, opioid withdrawal, and opioid overdose prevention in hospitalized adults: A systematic review of existing guidelines.

Author: CalcaterraSusan L, BottnerRichard, MartinMarlene, EnglanderHonora, WeinsteinZoe M, WeimerMelissa B, LambertEugene, RonanMatthew V, HuertaSergio, ZamanTauheed, UllalMonish, PeterkinAlyssa F, Torres-LockhartKristine, BureshMegan, O'BrienMeghan T, SnyderHannah, HerzigShoshana J

Methadone/buprenorphine treatment
Multimodal therapy
Naloxone access
Non-stigmatizing language
Psychosocial treatment
Fentanyl use
Pain management

Existing guidelines for opioid use disorder (OUD) treatment recommend non-stigmatizing language, comprehensive assessment, and use of methadone or buprenorphine for OUD and withdrawal management. More research is needed to optimize OUD management in hospitalized patients, particularly those using fentanyl or experiencing pain.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Systematic ReviewA review that systematically collects, evaluates, and integrates relevant research to answer a specific research question.
Research Support, N.I.H., ExtramuralResearch funding provided by the NIH to external research institutions and researchers.
Research Support, U.S. Gov't, P.H.S.Research funding provided by the Public Health Service (PHS).

Language : English

76.

Buprenorphine/naloxone and methadone effectiveness for reducing craving in individuals with prescription opioid use disorder: Exploratory results from an open-label, pragmatic randomized controlled trial.

Author: McAnultyChristina, BastienGabriel, Eugenia SociasM, BruneauJulie, FollBernard Le, LimRon, BrissetteSuzanne, LedjiarOmar, MarsanStephanie, TalbotAnnie, Jutras-AswadDidier,

Craving reduction
POUD

This study compared the effectiveness of buprenorphine/naloxone (BUP/NX) with flexible take-home dosing to methadone for craving reduction in individuals with prescription-type opioid use disorder (POUD). The study found that BUP/NX was associated with lower craving levels compared to methadone. These findings support the use of flexible take-home dosing of BUP/NX as a viable treatment option for POUD.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.

Language : English

77.

Transcutaneous cervical vagus nerve stimulation reduces behavioral and physiological manifestations of withdrawal in patients with opioid use disorder: A double-blind, randomized, sham-controlled pilot study.

Author: GaziAsim H, HarrisonAnna B, LambertTamara P, ObideenMalik, AlaviParvaneh, MurrahNancy, ShallenbergerLucy, DriggersEmily G, OrtegaRebeca Alvarado, WashingtonBrianna P, WaltonKevin M, WelshJustine W, VaccarinoViola, ShahAmit J, TangYi-Lang, GuptaRahul, BackSudie E, InanOmer T, BremnerJ Douglas

Opioid withdrawal relief
OUD

This study found that transcutaneous cervical vagus nerve stimulation (tcVNS) can reduce both behavioral and physiological manifestations of opioid withdrawal. Compared to sham stimulation, tcVNS was associated with statistically significant reductions in subjective opioid withdrawal, pain, and distress. The results suggest that tcVNS could be a useful non-pharmacological approach for adjunctive treatment of opioid use disorder (OUD).

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.
Research Support, U.S. Gov't, Non-P.H.S.Research funding provided by US government agencies other than the Public Health Service.
Research Support, N.I.H., ExtramuralResearch funding provided by the NIH to external research institutions and researchers.

Language : English

78.

The impact of race, gender, and heroin use on opioid addiction stigma.

Author: GoodyearKimberly, AhluwaliaJasjit, ChavanneDavid

Opioid addiction
Stigmatization

This study examined the influence of race and other identity markers on the stigmatization of opioid addiction. White individuals received higher stigma ratings compared to Black individuals, demonstrating the impact of multiple identities on stigmatizing attitudes.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.
Research Support, N.I.H., ExtramuralResearch funding provided by the NIH to external research institutions and researchers.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.

Language : English

79.

Patterns of use and adverse events reported among persons who regularly inject buprenorphine: a systematic review.

Author: BozinoffNikki, TardelliVitor Soares, Rubin-KahanaDafna Sara, Le FollBernard

BUP iOAT for OUD

This study characterized injecting practices among individuals who regularly inject buprenorphine, considering the potential for intravenous buprenorphine for the treatment of OUD.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
ReviewAn article that critically examines existing research on a particular topic and summarizes the current state of knowledge in the field.
Systematic ReviewA review that systematically collects, evaluates, and integrates relevant research to answer a specific research question.

Language : English

80.

Digital interventions for opioid use disorder treatment: A systematic review of randomized controlled trials.

Author: KiburiSarah Kanana, NgarachuElizabeth, TomitaAndrew, ParukSaeeda, ChilizaBonginkosi

Opioid use disorder treatment

This review examined research on the use of digital tools to treat opioid use disorder (OUD). Many people with OUD don't receive treatment, and this study explores the potential of using online interventions, either as an alternative to or alongside traditional in-person therapy. The review aimed to assess the effectiveness and use of digital interventions for OUD around the world.

ReviewAn article that critically examines existing research on a particular topic and summarizes the current state of knowledge in the field.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Systematic ReviewA review that systematically collects, evaluates, and integrates relevant research to answer a specific research question.

Language : English

81.

Bupropion Slow Release vs Placebo With Adaptive Incentives for Cocaine Use Disorder in Persons Receiving Methadone for Opioid Use Disorder: A Randomized Clinical Trial.

Author: WareOrrin D, SweeneyMary M, CunninghamColin, UmbrichtAnnie, StitzerMaxine, DunnKelly E

Cocaine abstinence
Cocaine use disorder
Opioid use disorder

A randomized clinical trial of 80 participants with opioid use disorder and cocaine use disorder found that bupropion SR did not significantly enhance the effects of a tailored abstinence incentive program. However, sensitivity analyses suggested that bupropion SR may be beneficial for participants in the abstinence initiation group.

Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Research Support, N.I.H., ExtramuralResearch funding provided by the NIH to external research institutions and researchers.

Language : English

83.

Differential effect of cannabis use on opioid agonist treatment outcomes: Exploratory analyses from the OPTIMA study.

Author: ElkriefLaurent, BastienGabriel, McAnultyChristina, BakouniHamzah, HébertFrançois-Olivier, SociasM Eugenia, Le FollBernard, LimRon, LedjiarOmar, MarsanStéphanie, BrissetteSuzanne, Jutras-AswadDidier,

OAT treatment

This exploratory analysis examines the effect of recent cannabis use on opioid use, craving, and withdrawal symptoms in individuals receiving opioid agonist therapy (OAT). There is conflicting evidence regarding the impact of cannabis use on OAT outcomes.

Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.

Language : English

84.

Effectiveness of Conditioned Open-label Placebo With Methadone in Treatment of Opioid Use Disorder: A Randomized Clinical Trial.

Author: BelcherAnnabelle M, ColeThomas O, MasseyEbonie, BillingAmy S, WagnerMichael, WootenWilliam, EpsteinDavid H, HoagStephen W, WickwireEmerson M, GreenblattAaron D, CollocaLuana, RotrosenJohn, MagderLawrence, WeintraubEric, WishEric D, KaptchukTed J

OUD treatment

Methadone is a highly effective treatment for opioid addiction, but challenges with dosing and people stopping treatment early highlight the need for additional support. This study explores the potential of using the placebo effect, which involves the power of belief, as a low-risk intervention to improve treatment outcomes for people on methadone.

Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Research Support, N.I.H., ExtramuralResearch funding provided by the NIH to external research institutions and researchers.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.

Language : English

85.

Prevalence of Buprenorphine Providers Requiring Cash Payment From Insured Women Seeking Opioid Use Disorder Treatment.

Author: RichardsMichael R, LeechAshley A, SteinBradley D, BuntinMelinda B, PatrickStephen W

Access barriers to OUD treatment

This audit study examined appointment-granting behavior by buprenorphine prescribers in 10 US states, simulating patients with opioid use disorder (OUD) and varying insurance status. The study found that Medicaid and privately insured women were frequently asked to pay cash for treatment, indicating a potential barrier to access.

Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Research Support, N.I.H., ExtramuralResearch funding provided by the NIH to external research institutions and researchers.

Language : English

86.

Adapting psychotherapy in collaborative care for treating opioid use disorder and co-occurring psychiatric conditions in primary care.

Author: FrenchRachel, WorleyJulie, LowensteinMargaret, BognerHillary R, CalderbankTara, DePhilippisDominick, ForrestAndrew, Connolly GibbonsMary Beth, HarrisRebecca Arden, HeywoodSaida, KampmanKyle, MandellDavid S, McKayJames R, NewmanSchyler Tristen, OslinDavid W, WaddenSteven, WolkCourtney Benjamin

OUD treatment

Opioid use disorder (OUD) often occurs alongside mental health conditions, but effective treatments are not widely used. Both OUD and mental health conditions individually present challenges in starting, continuing, and successfully completing treatment. These challenges are even greater when someone has both conditions.

Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Research Support, N.I.H., ExtramuralResearch funding provided by the NIH to external research institutions and researchers.

Language : English

87.

Health care use and cost of treatment for adolescents and young adults with opioid use disorder.

Author: OrmeStephen, ZarkinGary A, DunlapLaura J, MonicoLaura B, GryczynskiJan, FishmanMarc J, SchwartzRobert P, O'GradyKevin E, MitchellShannon Gwin

MOUD treatment

This study examines the cost of medication-assisted treatment (MOUD) for opioid use disorder, along with other substance use disorder treatments and general healthcare, for teenagers and young adults receiving treatment for opioid addiction.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.
Research Support, N.I.H., ExtramuralResearch funding provided by the NIH to external research institutions and researchers.

Language : English

88.

Inpatient Low-dose Transitions From Full Agonist Opioids Including Methadone Onto Long-acting Depot Buprenorphine: Case Series From a Multicenter Clinical Trial.

Author: SevalNikhil, NunezJohnathan, RothPrerana, SchadeMeredith, StrongMichelle, FrankCynthia A, LitwinAlain H, LevinFrances R, BradyKathleen T, NunesEdward V, SpringerSandra A

Care linkage
OUD treatment

People with opioid addiction have a high risk of serious infections requiring hospitalization. Long-acting buprenorphine (LAB) is a medication that can help people stay on treatment after they're released from the hospital, but it's not used enough. Switching to buprenorphine while in the hospital can be challenging due to pain, ongoing infections, potential surgery, and the risk of withdrawal symptoms. This study explores how to overcome these challenges and make LAB more accessible for patients.

Case ReportsIn the medical field, a report that describes in detail a unique case, an unusual medical condition, or the effect of a treatment. Provides new insights and possibilities for treatment through individual patient cases.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Multicenter StudyResearch conducted in collaboration with multiple research institutions. It aims to collect a wide range of data and obtain more generalizable results.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.

Language : English

89.

Correlates of nonfatal overdose among treatment-seeking individuals with non-heroin opioid use disorder: Findings from a pragmatic, pan-Canadian, randomized control trial.

Author: CrepeaultHannah, TiLianping, Jutras-AswadDidier, WoodEvan, Le FollBernard, LimRon, BachPaxton, BrarRupinder, SociasM Eugenia

Nonfatal overdose

This study investigates factors associated with nonfatal overdose (NFO) among treatment-seeking adults with an opioid use disorder (OUD) not related to heroin use. Misuse of prescription and synthetic opioids is a significant contributor to the overdose crisis.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Multicenter StudyResearch conducted in collaboration with multiple research institutions. It aims to collect a wide range of data and obtain more generalizable results.
Pragmatic Clinical TrialA trial conducted in a real-world clinical setting. It evaluates the effectiveness of interventions in everyday healthcare environments.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.

Language : English

90.

Methamphetamine use and illicit opioid use during buprenorphine treatment.

Author: Kratina-HathawayZoë, RadickAndrea C, LerouxBrian G, BlalockKendra, KimTheresa W, DarntonJames, SaxonAndrew J, SametJeffrey H, TsuiJudith I

OUD treatment

This study investigates the association between baseline methamphetamine/amphetamine (MA/A) use and subsequent illicit opioid use among patients with opioid use disorder (OUD) initiating buprenorphine treatment. Methamphetamine use is increasing in the US, and its impact on OUD treatment outcomes is not well understood.

Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Research Support, N.I.H., ExtramuralResearch funding provided by the NIH to external research institutions and researchers.

Language : English

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