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Effects of Regional Differences in Asia on Efficacy and Safety of Edoxaban Compared With Warfarin--Insights From the ENGAGE AF-TIMI 48 Trial.

Author: AbeKenji, GiuglianoRobert P, KimuraTetsuya, KoretsuneYukihiro, MercuriMichele, RuffChristian T, SasakiShunichi, ShimadaYuichi J, YamashitaTakeshi

Multicenter StudyResearch conducted in collaboration with multiple research institutions. It aims to collect a wide range of data and obtain more generalizable results.
Comparative StudyResearch that compares multiple groups/interventions to determine differences/similarities in outcomes/characteristics.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.

Overview

Higher-dose edoxaban had greater efficacy and safety in East Asia than in Japan, which was not fully explained by differences in baseline characteristics and time-in-therapeutic range.
Paper Details　
Original Abstract of the Article :
BACKGROUND: In 21,105 patients with atrial fibrillation in the ENGAGE AF-TIMI 48 trial, edoxaban was non-inferior to warfarin in preventing thromboembolic events while reducing bleeding. We compared results in Japan with the rest of East Asia (EA), including China, Korea, and Taiwan. METHODS AND RE...See full text at original site
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引用元：
https://doi.org/10.1253/circj.CJ-15-0574

データ提供：米国国立医学図書館（NLM）

Edoxaban: A Safe and Effective Journey Through the Desert of Atrial Fibrillation

Atrial fibrillation, a condition that disrupts the heart's rhythm, is like a treacherous sandstorm that can lead to life-threatening complications. This study, like a skilled navigator, investigates the efficacy and safety of edoxaban, a medication used to prevent blood clots in patients with atrial fibrillation, across different regions of Asia. The study focuses on comparing the outcomes in Japan with those in other East Asian countries, including China, Korea, and Taiwan.

Regional Differences in Edoxaban's Effectiveness: A Desert Oasis

The study found that higher-dose edoxaban (HDE) had a greater relative efficacy and safety in East Asia compared to Japan. This finding suggests that regional differences in patient characteristics and drug metabolism could influence the effectiveness of edoxaban. The study provides valuable insights into the importance of considering regional factors when prescribing medications.

Navigating the Treatment Landscape

This research highlights the importance of understanding the nuances of drug efficacy and safety across different populations. It emphasizes the need for individualized treatment approaches that consider factors such as ethnicity, genetics, and environmental influences. The study underscores the importance of navigating the treatment landscape with a keen eye for detail, ensuring that each patient receives the best possible care.

Dr.Camel's Conclusion

This study explores the regional differences in the efficacy and safety of edoxaban, a medication used to prevent blood clots in patients with atrial fibrillation. The findings suggest that higher-dose edoxaban may be more effective and safer in some East Asian populations compared to Japan. This research underscores the importance of tailoring treatment strategies to individual patient needs, considering regional variations in drug response.

Date :
  1. Date Completed 2016-09-07
  2. Date Revised 2022-12-07
Further Info :

Pubmed ID

26460886

DOI: Digital Object Identifier

10.1253/circj.CJ-15-0574

Related Literature

Article Analysis
・Effects of edoxaban
SNS
PICO Info
in preparation
Languages

English

Positive IndicatorAn AI analysis index that serves as a benchmark for how positive the results of the study are. Note that it is a benchmark and requires careful interpretation and consideration of different perspectives.

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