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Effects of inhaled metaproterenol and atropine on the pulmonary mechanics of infants with bronchopulmonary dysplasia.

Author: DurandD J, KaoL C, NickersonB G

Clinical TrialA clinical trial is a planned study conducted on humans to evaluate the efficacy and safety of pharmaceuticals, medical devices, and treatment methods. It aims to explore the possibilities of new treatments and improve the health of patients.
Comparative StudyResearch that compares multiple groups/interventions to determine differences/similarities in outcomes/characteristics.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.

Overview

Inhaled metaproterenol and atropine both improve pulmonary function in infants with bronchopulmonary dysplasia. In a randomized, double-blind study of 15 infants, both drugs significantly improved airway resistance and maximal expiratory flow at functional residual capacity. There were no significant differences between the effects of the two drugs, and no synergy was observed when they were combined.
Paper Details　
Original Abstract of the Article :
We evaluated the individual and combined effects of an inhaled beta-adrenergic agent (metaproterenol) and an inhaled anticholinergic agent (atropine) on the pulmonary function of infants with bronchopulmonary dysplasia. In this randomized, double-blind study we studied 15 infants at a mean postnatal...See full text at original site
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引用元：
https://doi.org/10.1002/ppul.1950060204

データ提供：米国国立医学図書館（NLM）

Investigating the Benefits of Inhaled Medications for Bronchopulmonary Dysplasia

Bronchopulmonary dysplasia (BPD) is a challenging condition affecting premature infants, often requiring long-term respiratory support. This study, published in [Journal Name], explores the effects of inhaled medications, metaproterenol (a beta-adrenergic agent) and atropine (an anticholinergic agent), on pulmonary function in infants with BPD. The researchers conducted a randomized, double-blind study involving 15 infants. The study found that both metaproterenol and atropine, individually and in combination, improved airway resistance and maximal expiratory flow, suggesting that these medications could help alleviate breathing difficulties in infants with BPD. The effects, however, were temporary, lasting only a few hours.

Inhaled Medications Offer Short-Term Relief for BPD

The findings of this study highlight the potential of inhaled medications for improving pulmonary function in infants with BPD, but emphasize the need for short-term therapeutic interventions.

Managing BPD: A Complex Journey

BPD is a complex condition that requires ongoing management, and early intervention is crucial. Inhaled medications can offer temporary relief for breathing difficulties, but the ultimate goal is to promote long-term lung health. This study underscores the importance of ongoing research to understand the long-term effects of these medications and to develop new treatment strategies for BPD.

Dr. Camel's Conclusion

This research sheds light on the potential of inhaled medications like metaproterenol and atropine to improve pulmonary function in infants with BPD. It's like finding a temporary oasis in the desert of BPD management, offering a reprieve from the harsh realities of this condition. However, the need for long-term strategies and continued research remains crucial. Just like the desert requires consistent sources of water, infants with BPD need ongoing care and support.

Date :
  1. Date Completed 1989-05-03
  2. Date Revised 2019-09-12
Further Info :

Pubmed ID

2648286

DOI: Digital Object Identifier

10.1002/ppul.1950060204

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SNS
PICO Info
in preparation
Languages

English

Positive IndicatorAn AI analysis index that serves as a benchmark for how positive the results of the study are. Note that it is a benchmark and requires careful interpretation and consideration of different perspectives.

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