Paper Details

  1. Home
  2. Paper Details

Ticagrelor Does Not Inhibit Adenosine Transport at Relevant Concentrations: A Randomized Cross-Over Study in Healthy Subjects In Vivo.

Author: BilosA, DondersA R T, El MessaoudiS, GomesM E, RiksenN P, RongenG A, van den BergT N A, van den BroekP H H

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.

Overview

This study investigates the effects of ticagrelor, an antiplatelet drug, on the adenosine system in humans in vivo. Ticagrelor has been shown to reduce cardiovascular and sepsis-related mortality in patients with myocardial infarction, but it can also cause dyspnea. The study aims to elucidate the mechanism behind this adverse effect, which is thought to be related to adenosine receptor stimulation.
Paper Details　
Original Abstract of the Article :
In patients with myocardial infarction, ticagrelor reduces cardiovascular and sepsis-related mortality, and can cause dyspnea. It is suggested that this is caused by adenosine receptor stimulation, because in preclinical studies, ticagrelor blocks the nucleoside transporter and increases cellular AT...See full text at original site
Dr.Camel IconDr.Camel's Paper Summary Blogラクダ博士について

ラクダ博士は、Health Journal が論文の内容を分かりやすく解説するために作成した架空のキャラクターです。
難解な医学論文を、専門知識のない方にも理解しやすいように、噛み砕いて説明することを目指しています。

* ラクダ博士による解説は、あくまで論文の要点をまとめたものであり、原論文の完全な代替となるものではありません。詳細な内容については、必ず原論文をご参照ください。
* ラクダ博士は架空のキャラクターであり、実際の医学研究者や医療従事者とは一切関係がありません。
* 解説の内容は Health Journal が独自に解釈・作成したものであり、原論文の著者または出版社の見解を反映するものではありません。


引用元：
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4624811/

データ提供：米国国立医学図書館（NLM）

Ticagrelor and Adenosine: Unraveling the Mystery

This study investigates the effects of ticagrelor, an antiplatelet medication, on adenosine transport in humans. It's like a camel searching for a hidden oasis, trying to uncover the secrets of a complex biological system. The researchers conducted a randomized crossover study in healthy subjects to evaluate the impact of ticagrelor on adenosine transport. The study found that ticagrelor did not inhibit adenosine transport at relevant concentrations, suggesting that its effects on the adenosine system are likely mediated through other mechanisms. This research provides valuable insights into the potential mechanisms of action of ticagrelor, particularly its effects on the adenosine system, which may contribute to its therapeutic efficacy and side effects.

Ticagrelor and Adenosine: A Complex Interaction

This study reveals the intricate interplay between ticagrelor and adenosine, highlighting the importance of understanding these interactions to optimize treatment and manage potential side effects. It's like deciphering a complex sand dune formation – each element plays a role in the overall structure and function. This research provides a deeper understanding of ticagrelor's mechanisms of action, offering valuable insights for clinicians and researchers.

Exploring the Hidden Oasis of Ticagrelor's Effects

This research encourages further exploration of the mechanisms of action of ticagrelor, particularly its relationship with the adenosine system. It's like venturing into a vast and unexplored desert – there is much to discover and understand about the complex interplay of biological systems. By delving deeper into these interactions, we can develop more effective and targeted therapies for a variety of conditions.

Dr.Camel's Conclusion

This study sheds light on the complex relationship between ticagrelor and adenosine, offering valuable insights into its mechanisms of action and potential side effects. Further research is needed to fully understand these interactions and optimize the use of ticagrelor in clinical practice.

Date :
  1. Date Completed 2016-06-13
  2. Date Revised 2018-12-02
Further Info :

Pubmed ID

26509673

DOI: Digital Object Identifier

PMC4624811

Related Literature

Article Analysis
・Effects of ticagrelor
SNS
PICO Info
in preparation
Languages

English

Positive IndicatorAn AI analysis index that serves as a benchmark for how positive the results of the study are. Note that it is a benchmark and requires careful interpretation and consideration of different perspectives.

This site uses cookies. Visit our privacy policy page or click the link in any footer for more information and to change your preferences.