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Effects of 1α,25-Dihydroxyvitamin D3 on Intestinal Absorption and Disposition of Adefovir Dipivoxil and Its Metabolite, Adefovir, in Rats.

Author: ChoiMin-Koo, KimSang-Bum, MaengHan-Joo, SonJun-Hyeng, YoonIn-Soo

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.

Overview

This study investigated the effect of 1α,25-dihydroxyvitamin D3 (1,25(OH)2D3) on the oral absorption and disposition of adefovir dipivoxil and its metabolite, adefovir, in rats. 1,25(OH)2D3 treatment significantly enhanced the oral absorption of adefovir dipivoxil, likely by inducing basolateral Mrp4 function in the intestine. This finding may have clinical implications for drug interactions involving P-gp and Mrp4.
Paper Details　
Original Abstract of the Article :
The aim of this study was to investigate the effect of 1α,25-dihydroxyvitamin D3 (1,25(OH)2D3), an active form of vitamin D, on the oral absorption and disposition of adefovir dipivoxil (P-glycoprotein (P-gp) substrate) and its major active metabolite, adefovir (multidrug resistance-associated prote...See full text at original site
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引用元：
https://doi.org/10.1248/bpb.b15-00356

データ提供：米国国立医学図書館（NLM）

Vitamin D: A Desert Oasis for Drug Absorption

Drug absorption, like a camel's journey through the desert, can be influenced by various factors. This study investigates the impact of 1α,25-dihydroxyvitamin D3 (1,25(OH)2D3), an active form of vitamin D, on the intestinal absorption and disposition of adefovir dipivoxil and its metabolite, adefovir, in rats. The researchers, like explorers seeking optimal routes through the desert, examine the role of vitamin D in drug absorption.

A Sun-Kissed Oasis: Vitamin D's Impact on Drug Absorption

The study demonstrates that 1,25(OH)2D3 treatment, like a refreshing oasis in the desert, can enhance the oral absorption of adefovir dipivoxil in rats. This finding highlights the potential of vitamin D to influence drug bioavailability, akin to a well-placed oasis providing a strategic advantage for a traveling caravan.

Navigating the Desert of Drug Absorption: Understanding the Role of Vitamin D

This research, like a compass guiding travelers through the desert, provides valuable insights into the potential influence of vitamin D on drug absorption. The findings underscore the importance of considering the role of vitamin D in drug interactions and its potential to impact therapeutic outcomes.

Dr. Camel's Conclusion

This study, like a desert mirage offering a glimpse of a hidden oasis, reveals the fascinating interplay between vitamin D and drug absorption. The findings suggest that vitamin D may play a significant role in optimizing drug delivery and achieving desired therapeutic effects.
Date :
  1. Date Completed 2016-08-22
  2. Date Revised 2018-12-02
Further Info :

Pubmed ID

26521823

DOI: Digital Object Identifier

10.1248/bpb.b15-00356

Related Literature

Article Analysis
・Effects of adefovir
SNS
PICO Info
in preparation
Languages

English

Positive IndicatorAn AI analysis index that serves as a benchmark for how positive the results of the study are. Note that it is a benchmark and requires careful interpretation and consideration of different perspectives.

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