Paper Details

  1. Home
  2. Paper Details

Penicillin Binding Protein 1 Is Important in the Compensatory Response of Staphylococcus aureus to Daptomycin-Induced Membrane Damage and Is a Potential Target for β-Lactam-Daptomycin Synergy.

Author: BertiAndrew D, NizetVictor, NonejuiePoochit, OlsonJoshua, PoglianoJoseph, ProctorRichard A, RoseWarren E, SakoulasGeorge, SauerJohn-Demian, TheisenErin

Research Support, N.I.H., ExtramuralResearch funding provided by the NIH to external research institutions and researchers.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.

Overview

Daptomycin (DAP) activity against methicillin-resistant Staphylococcus aureus (MRSA) is enhanced by β-lactam antibiotics, especially those that bind to penicillin binding protein 1 (PBP1). This study suggests that PBP1 plays a crucial role in responding to DAP-induced stress. Increased PBP1 expression reduces DAP susceptibility and killing. β-lactams that inactivate PBP1 increase DAP potency without increasing binding, suggesting synergy results from enhanced DAP efficacy. Combination therapy with DAP and β-lactams that target PBP1 leads to more rapid killing than with β-lactams targeting other PBPs. This study highlights the importance of PBP1 in MRSA survival during DAP-induced stress and suggests that targeted inactivation of PBP1 can enhance DAP efficacy, supporting the use of DAP-β-lactam combination therapy for serious MRSA infections.
Paper Details　
Original Abstract of the Article :
The activity of daptomycin (DAP) against methicillin-resistant Staphylococcus aureus (MRSA) is enhanced in the presence of β-lactam antibiotics. This effect is more pronounced with β-lactam antibiotics that exhibit avid binding to penicillin binding protein 1 (PBP1). Here, we present evidence that P...See full text at original site
Dr.Camel IconDr.Camel's Paper Summary Blogラクダ博士について

ラクダ博士は、Health Journal が論文の内容を分かりやすく解説するために作成した架空のキャラクターです。
難解な医学論文を、専門知識のない方にも理解しやすいように、噛み砕いて説明することを目指しています。

* ラクダ博士による解説は、あくまで論文の要点をまとめたものであり、原論文の完全な代替となるものではありません。詳細な内容については、必ず原論文をご参照ください。
* ラクダ博士は架空のキャラクターであり、実際の医学研究者や医療従事者とは一切関係がありません。
* 解説の内容は Health Journal が独自に解釈・作成したものであり、原論文の著者または出版社の見解を反映するものではありません。


引用元：
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4704217/

データ提供：米国国立医学図書館（NLM）

Synergy Between Daptomycin and β-Lactam Antibiotics

Sometimes, two forces working together can be much stronger than each alone. This is the case with daptomycin, a potent antibiotic, and β-lactam antibiotics, a class of drugs that target bacterial cell walls. This study investigates the potential for synergistic effects between these two drugs against methicillin-resistant Staphylococcus aureus (MRSA), a dangerous type of bacteria. The researchers found that β-lactam antibiotics, particularly those that bind to a specific bacterial protein called PBP1, enhanced the effectiveness of daptomycin.

A Powerful Partnership Against MRSA

The study suggests that combining daptomycin with specific β-lactam antibiotics could be a more effective strategy for combating MRSA infections. This research provides valuable insights into the potential for synergistic drug interactions in fighting bacterial infections.

Improving Treatment for MRSA Infections

The study's findings suggest that combining daptomycin with specific β-lactam antibiotics could improve treatment outcomes for MRSA infections. This approach could lead to more effective and potentially faster eradication of this dangerous bacteria.

Dr.Camel's Conclusion

This study illustrates the importance of understanding the complex interactions between different medications. The synergistic effect observed between daptomycin and β-lactam antibiotics highlights the potential for combining therapies to achieve better outcomes in the fight against antibiotic-resistant bacteria.
Date :
  1. Date Completed 2016-10-05
  2. Date Revised 2020-12-15
Further Info :

Pubmed ID

26525797

DOI: Digital Object Identifier

PMC4704217

Related Literature

Article Analysis
・Effects of cefaclor
SNS
PICO Info
in preparation
Languages

English

Positive IndicatorAn AI analysis index that serves as a benchmark for how positive the results of the study are. Note that it is a benchmark and requires careful interpretation and consideration of different perspectives.

This site uses cookies. Visit our privacy policy page or click the link in any footer for more information and to change your preferences.