Effects of cefaclor: A Synthesis of Findings from 19 Studies

  1. Home
  2. Effects of cefaclor
This information is not medical advice and is not a substitute for diagnosis or treatment by a physician.Data sources and disclaimers (data limitations, copyright, etc.)The analysis on "Effects of cefaclor: A Synthesis of Findings from 19 Studies" on this page is based on PubMed data provided by the U.S. National Library of Medicine (NLM). However, NLM does not endorse or verify these analyses.

This analysis is based on research papers included in PubMed, but medical research is constantly evolving and may not fully reflect the latest findings. There may also be biases towards certain research areas.

This information is not medical advice and is not a substitute for diagnosis or treatment by a physician. If you have concerns about "Effects of cefaclor: A Synthesis of Findings from 19 Studies", please consult your doctor.

For NLM copyright information, please see Link to NLM Copyright Page
PubMed data is obtained via Hugging Face Datasets: Link to DatasetPlease check the disclaimer.
This page's analysis is based on PubMed data provided by the U.S. National Library of Medicine (NLM).
Original Abstract of the Article

Main Research Findings

Cefaclor is a commonly prescribed cephalosporin antibiotic with potential benefits and risks. 4 indicated that cefaclor, administered for 5 days, demonstrated comparable clinical efficacy to 10-day amoxicillin for treating tonsillitis in children. Additionally, cefaclor showed a lower occurrence of adverse events compared to azithromycin. 1 found cefaclor to be effective in treating beta-hemolytic streptococcal throat infections in children. However, 3 highlighted the increasing resistance of *Streptococcus pneumoniae* to cefaclor in nine European countries. 5 revealed that cefaclor exhibited resistance against *Moraxella catarrhalis* strains isolated from children with pneumonia in China. 16 reported a higher incidence of hypersensitivity reactions, particularly anaphylaxis, to cefaclor compared to other second and third-generation cephalosporins in Korea.

Benefits and Risks

Benefit Summary

Cefaclor demonstrates potential efficacy in treating tonsillitis in children, and may have a lower incidence of adverse events than some other antibiotics. 4 Cefaclor is also considered effective in treating beta-hemolytic streptococcal throat infections in children. 1

Risk Summary

The emergence of antibiotic resistance against cefaclor is a growing concern. 3 , 5 Cefaclor can cause hypersensitivity reactions, including anaphylaxis. 16

Comparison between Studies

Commonalities among Studies

Several studies indicate cefaclor's effectiveness in treating infections in children, with a focus on tonsillitis, throat infections, and pneumonia. 4 , 1 , 5

Differences between Studies

Studies highlight varying levels of resistance against cefaclor, particularly in *Streptococcus pneumoniae* and *Moraxella catarrhalis*. 3 , 5 Discrepancies exist regarding the incidence of hypersensitivity reactions, with one study indicating a higher risk of anaphylaxis with cefaclor compared to other cephalosporins in Korea. 16

Consistency and Contradictions in Results

While several studies support the effectiveness of cefaclor in treating infections in children, inconsistencies exist regarding the severity of antibiotic resistance and hypersensitivity reactions associated with cefaclor. 3 , 5 , 16 Further research is crucial to better understand the specific risks and benefits of cefaclor in various populations.

Considerations for Real-World Application

Cefaclor may be a valuable option for treating certain infections in children. However, the potential for antibiotic resistance and hypersensitivity reactions must be considered. 3 , 5 , 16 It is vital for healthcare professionals to carefully consider the risks and benefits of cefaclor for each individual patient.

Limitations of Current Research

The limited number of studies focusing on cefaclor, particularly regarding hypersensitivity reactions, highlights the need for further investigation. 16 Additional research is necessary to better understand the impact of cefaclor on different populations and the extent of antibiotic resistance.

Future Research Directions

Further research is crucial to assess the specific risks and benefits of cefaclor in different populations. This includes investigating the prevalence and patterns of antibiotic resistance and conducting comprehensive studies on hypersensitivity reactions, particularly anaphylaxis. 3 , 5 , 16

Conclusion

While cefaclor shows potential as a treatment option for infections in children, it is important to be aware of its potential risks, such as antibiotic resistance and hypersensitivity reactions. 3 , 5 , 16 Continued research is needed to fully understand cefaclor's impact and guide appropriate clinical use. Healthcare professionals should carefully weigh the risks and benefits of cefaclor for each individual patient and consider alternative treatment options when necessary.

Literature analysis of 19 papers
Positive Content
10
Neutral Content
3
Negative Content
6
Article Type
2
0
0
0
18
1.

The use of cefaclor in the treatment of beta-haemolytic streptococcal throat infections in children.

Author: DisneyF A, BreeseB B, FrancisA B, GreenJ L, TalpeyW B

Streptococcal throat infection treatment
Minimal side effects

Cefaclor is an effective treatment for beta-haemolytic streptococcal throat infections in children.

Clinical TrialA clinical trial is a planned study conducted on humans to evaluate the efficacy and safety of pharmaceuticals, medical devices, and treatment methods. It aims to explore the possibilities of new treatments and improve the health of patients.
Comparative StudyResearch that compares multiple groups/interventions to determine differences/similarities in outcomes/characteristics.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.

Language : English

2.

Pulp revascularization on an adult mandibular right second premolar: A case report.

Author: YangYe-Qing, WuBu-Ling, ZengJun-Kai, JiangChong, ChenMing

Periapical disease treatment
Tooth root development

Pulp revascularization, a new approach for treating periapical diseases in young permanent teeth, involves root canal flushing, disinfection, and apical stem cell guidance. This article discusses the efficacy of pulp revascularization compared to apical barrier technology for treating adult patients with chronic periapical periodontitis.

Case ReportsIn the medical field, a report that describes in detail a unique case, an unusual medical condition, or the effect of a treatment. Provides new insights and possibilities for treatment through individual patient cases.

Language : English

3.

Prevalence and antibiotic resistance of commensal Streptococcus pneumoniae in nine European countries.

Author: YahiaouiRachid Y, den HeijerCasper Dj, van BijnenEvelien Me, PagetW John, PringleMike, GoossensHerman, BruggemanCathrien A, SchellevisFrançois G, StobberinghEllen E,

Antibiotic resistance

The study found a 2.9% prevalence of S. pneumoniae nasal carriage in 9 European countries, with higher rates in men (3.7%) and children (4-9 years) (27.2%). The highest resistance was observed to cefaclor, with the highest prevalence of multidrug resistance found in Spain and the lowest prevalence in Sweden.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.

Language : English

4.

Evaluation of 3-day azithromycin or 5-day cefaclor in comparison with 10-day amoxicillin for treatment of tonsillitis in children.

Author: LiPeng, JiangGenqin, ShenXiaofei

Treat pediatric tonsillitis
Adverse reactions

Azithromycin is an effective treatment for pediatric tonsillitis with a lower occurrence rate of adverse reactions.

Comparative StudyResearch that compares multiple groups/interventions to determine differences/similarities in outcomes/characteristics.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.

Language : English

6.

Drug-induced anaphylactic reactions in children: A retrospective analysis of 159 validated spontaneous reports.

Author: SachsBernhardt, DubrallDiana, Fischer-BarthWilma, SchmidMatthias, StinglJulia

Anaphylaxis in children
Drug identification

This study analyzed validated cases of drug-induced anaphylactic reactions in children, identifying the incriminated drugs, clinical characteristics, and associated factors. The study compared these findings to a reference dataset excluding anaphylactic reactions, revealing significant differences in incriminated drugs and characteristics between the two groups.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.

Language : English

7.

Antimicrobial susceptibility of pathogens in acute uncomplicated cystitis cases in the urology department of a community hospital in Japan: Comparison with treatment outcome and hospital-wide antibiogram.

Author: EtaniToshiki, NaikiTaku, YamaguchiSachiyo, MoriSaori, NagaiTakashi, IidaKeitaro, AndoRyosuke, KawaiNoriyasu, TozawaKeiichi, MogamiTohru, YasuiTakahiro

Cystitis treatment
Antimicrobial resistance

It’s been thought that urinary tract infections are becoming more difficult to treat with antibiotics. This study found that certain antibiotics were still effective at treating uncomplicated cystitis.

Comparative StudyResearch that compares multiple groups/interventions to determine differences/similarities in outcomes/characteristics.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.

Language : English

9.

Proper Cut-off Levels of Serum Specific IgE to Cefaclor for Patients with Cefaclor Allergy.

Author: NamYoung Hee, LeeSo Hee, RhyouHyo In, LeeYoung Soo, ParkSeung Hee, LeeYoung Hee, ShinYoo Seob, ParkHae Sim, YeYoung Min

Cefaclor allergy

A study is evaluating the optimal serum-specific IgE (sIgE) cut-off levels for diagnosing immediate hypersensitivity to cefaclor.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.

Language : English

10.

Pharmacokinetics of cefaclor in renal failure: effects of multiple doses and hemodialysis.

Author: SpykerD A, GoberL L, ScheldW M, SandeM A, BoltonW K

No accumulation
Safe for anephric patients
Treats infections

Cefaclor, a cephalosporin antibiotic, was found to be safe and effective in treating functionally anephric patients on hemodialysis. In a study involving 15 patients, cefaclor was cleared with an average half-life of 2.9 hours without hemodialysis and 1.5 hours during hemodialysis.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Research Support, U.S. Gov't, P.H.S.Research funding provided by the Public Health Service (PHS).

Language : English

12.

Clinical and pro-host effects of cefaclor in prophylaxis of recurrent otitis media in HIV-infected children.

Author: ZuccottiG, DauriaE, TorcolettiM, LodiF, BernardoL, RivaE

Increased myeloperoxidase activity
Reduced AOM episodes

This study evaluated the efficacy of cefaclor in the prophylaxis of recurrent acute otitis media (AOM) in human immunodeficiency virus (HIV)-infected children. Cefaclor administration (20 mg/kg once daily for 6 months) was associated with a reduction in the number of AOM episodes in all 17 children and a mean increase in myeloperoxidase activity in 57% of cases. No significant differences were observed in natural killer-cell activity or CD4-cell counts.

Clinical TrialA clinical trial is a planned study conducted on humans to evaluate the efficacy and safety of pharmaceuticals, medical devices, and treatment methods. It aims to explore the possibilities of new treatments and improve the health of patients.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.

Language : English

13.

Spectrophotometric analysis of crown discoloration induced by various antibiotic pastes used in revascularization.

Author: AkcayMerve, ArslanHakan, YasaBilal, KavrıkFevzi, YasaElif

Crown discoloration

The study found that all antibiotic pastes, except DAP, induced crown discoloration. TAP with minocycline, doxycycline, and cefaclor induced more coronal discoloration compared with the control group (P < .05). The control, calcium hydroxide, and DAP groups showed no color changes exceeding the perceptibility threshold at all time points.

Comparative StudyResearch that compares multiple groups/interventions to determine differences/similarities in outcomes/characteristics.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.

Language : English

14.

Penicillin Binding Protein 1 Is Important in the Compensatory Response of Staphylococcus aureus to Daptomycin-Induced Membrane Damage and Is a Potential Target for β-Lactam-Daptomycin Synergy.

Author: BertiAndrew D, TheisenErin, SauerJohn-Demian, NonejuiePoochit, OlsonJoshua, PoglianoJoseph, SakoulasGeorge, NizetVictor, ProctorRichard A, RoseWarren E

MRSA treatment

Daptomycin (DAP) activity against methicillin-resistant Staphylococcus aureus (MRSA) is enhanced by β-lactam antibiotics, especially those that bind to penicillin binding protein 1 (PBP1). This study suggests that PBP1 plays a crucial role in responding to DAP-induced stress. Increased PBP1 expression reduces DAP susceptibility and killing. β-lactams that inactivate PBP1 increase DAP potency without increasing binding, suggesting synergy results from enhanced DAP efficacy. Combination therapy with DAP and β-lactams that target PBP1 leads to more rapid killing than with β-lactams targeting other PBPs. This study highlights the importance of PBP1 in MRSA survival during DAP-induced stress and suggests that targeted inactivation of PBP1 can enhance DAP efficacy, supporting the use of DAP-β-lactam combination therapy for serious MRSA infections.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Research Support, N.I.H., ExtramuralResearch funding provided by the NIH to external research institutions and researchers.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.

Language : English

15.

Penicillin-binding protein PBP2a provides variable levels of protection toward different β-lactams in Staphylococcus aureus RN4220.

Author: FergestadMarte Ekeland, StamsåsGro Anita, Morales AngelesDanae, SalehianZhian, WastesonYngvild, KjosMorten

Beta-lactam resistance
MRSA resistance

Methicillin-resistant Staphylococcus aureus (MRSA) is resistant to many antibiotics due to the PBP2a protein. This study found that PBP2a expression protects against different β-lactams, but the level of protection varies between different antibiotics. This finding might have implications for treating MRSA infections.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.

Language : English

16.

Cefaclor-induced hypersensitivity: Differences in the incidence of anaphylaxis relative to other 2nd and 3rd generation cephalosporins.

Author: RhyouHyo-In, NamYoung-Hee, KimSu-Chin, DooGo-Eun, HaChae-Yeon, NamHee-Joo, WooSung-Dae, LeeYoungsoo, JangJae-Hyuk, LeeHyun-Young, YeYoung-Min

Anaphylaxis
Hypersensitivity

Cefaclor is a commonly prescribed cephalosporin in Korea. This study found that cefaclor had a high incidence of adverse drug reactions (ADRs), particularly hypersensitivity (HS) and anaphylaxis. The incidence of ADRs, HS, and anaphylaxis was 1.92/10,000 persons, 1.17/10,000 persons, and 0.38/10,000 persons, respectively. HS was more common in women, individuals under 65 years old, and those who were using other medications.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.

Language : English

17.

Infantile Acute Conjunctivitis Induced by β-Lactamase-Positive Amoxicillin-Clavulanate-Resistant Strain of Haemophilus influenzae: A Report of Three Cases.

Author: InadaNoriko, ShojiJun, YamagamiSatoru

BLPACR conjunctivitis

Three infants presented with acute conjunctivitis induced by β-lactamase-positive, ampicillin/clavulanic acid-resistant strains of Haemophilus influenzae (BLPACR). The cases highlight the importance of simultaneous investigation for the determination of causative organism and antibiotic susceptibility testing in infantile BLPACR conjunctivitis.

Case ReportsIn the medical field, a report that describes in detail a unique case, an unusual medical condition, or the effect of a treatment. Provides new insights and possibilities for treatment through individual patient cases.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.

Language : English

This site uses cookies. Visit our privacy policy page or click the link in any footer for more information and to change your preferences.