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Glucocorticoid (dexamethasone)-induced metabolome changes in healthy males suggest prediction of response and side effects.

Author: AlbrechtValerie, BordagNatalie, JürchottKathrin, KlieSebastian, SchichorChristian, SchieweHajo, SchwartzChristoph, SelbigJoachim, TonnJörg-Christian, VierhellerJanine

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.

Overview

This study investigated the metabolic effects of a single dose of dexamethasone on 20 healthy male volunteers. Dexamethasone significantly deregulated 150 out of 214 metabolites, demonstrating a substantial impact on the metabolome. The study also revealed a significant suppression and deregulation of the circadian rhythm by dexamethasone. These findings highlight the significant metabolic changes induced by short-term glucocorticoid use, suggesting potential for early detection of side effects and personalized countermeasures to improve quality of life.
Paper Details　
Original Abstract of the Article :
Glucocorticoids are indispensable anti-inflammatory and decongestant drugs with high prevalence of use at (~)0.9% of the adult population. Better holistic insights into glucocorticoid-induced changes are crucial for effective use as concurrent medication and management of adverse effects. The profil...See full text at original site
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引用元：
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4630650/

データ提供：米国国立医学図書館（NLM）

Dexamethasone: A Double-Edged Sword

Glucocorticoids, like dexamethasone, are powerful medications used to treat a wide range of conditions. But, like a desert mirage, they can sometimes have unexpected and potentially harmful side effects. This research investigates the metabolic changes induced by a single dose of dexamethasone in healthy individuals, providing a valuable insight into the drug's impact on the body.

Unveiling the Metabolic Landscape: A Deeper Understanding

The study, like a map revealing hidden oases in a vast desert, reveals significant metabolic changes induced by dexamethasone. It's like a carefully crafted sandcastle, revealing the intricate interplay between the drug and the body's metabolic processes. The researchers found that dexamethasone significantly alters the levels of over 150 metabolites in the blood, highlighting the drug's profound impact on the body's metabolic balance.

Navigating the Risks: Towards Personalized Therapy

The study's findings underscore the importance of personalized medicine. It's like choosing the right path through a desert, considering individual factors to minimize risks and optimize outcomes. By understanding the metabolic changes induced by dexamethasone, we can potentially predict side effects and develop tailored treatment strategies to minimize risks and maximize benefits.

Dr. Camel's Conclusion

This research is like a desert expedition, exploring the intricate landscape of metabolic changes induced by dexamethasone. It highlights the importance of understanding the drug's full impact on the body and underscores the need for personalized medicine to ensure safe and effective treatment.

Date :
  1. Date Completed 2016-09-07
  2. Date Revised 2018-12-02
Further Info :

Pubmed ID

26526738

DOI: Digital Object Identifier

PMC4630650

SNS
PICO Info
in preparation
Languages

English

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