Side Effects of pantoprazole: A Synthesis of Findings from 26 Studies

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Original Abstract of the Article

Major Research Findings

Pantoprazole is a medication that effectively reduces stomach acid secretion. Several studies have revealed that pantoprazole, in addition to its stomach acid-reducing properties, can also cause various side effects. For instance, a study referenced in 22 suggests that pantoprazole could increase the risk of falls in elderly individuals. Another study documented in 3 indicates that pantoprazole can interfere with metabolism and potentially lead to serious side effects. Furthermore, research presented in 17 suggests that pantoprazole can bind with iron ions, potentially causing side effects.

Reasons for Side Effects

Pantoprazole inhibits stomach acid secretion, which can disrupt the normal functioning of the stomach. This can lead to issues like indigestion, constipation, and other related symptoms. Additionally, pantoprazole is metabolized in the liver. Individuals with compromised liver function may be more prone to experiencing side effects. Moreover, pantoprazole can potentially decrease magnesium levels in the blood, potentially leading to side effects like hypomagnesemia.

Common Side Effects

Digestive System

Pantoprazole can potentially cause a variety of side effects related to the digestive system. A study cited in 10 indicates that while pantoprazole can alleviate symptoms of non-erosive reflux disease, it can also lead to side effects such as diarrhea. 1 highlights that long-term use of pantoprazole can alter the gut microbiome, potentially resulting in inflammation, increased intestinal permeability, and other adverse effects. Additionally, a study referenced in 25 suggests that pantoprazole could be effective in treating globus pharyngeus but mentions constipation and dry mouth as potential side effects.

Blood System

Pantoprazole can potentially cause thrombocytopenia, as indicated by a study in 5 . This is believed to be due to pantoprazole's ability to inhibit platelet production. Thrombocytopenia can increase the risk of bleeding, so it's crucial to be cautious. If you're taking pantoprazole, pay attention to any signs of bleeding and consult a doctor immediately if you notice any unusual symptoms.

Metabolic System

Research detailed in 3 suggests that pantoprazole can affect metabolism, potentially causing serious side effects. This is attributed to pantoprazole's impact on various metabolic pathways. Side effects related to the metabolic system can include hypoglycemia, hyperglycemia, and hyperlipidemia. If you're taking pantoprazole, be vigilant for these symptoms and consult a doctor promptly if you experience any irregularities.

Nervous System

A study documented in 22 suggests that pantoprazole might increase the risk of falls in older adults. This is believed to be caused by pantoprazole's effect on neurotransmitters in the brain. Side effects related to the nervous system can include dizziness, headaches, and drowsiness. If you're taking pantoprazole, be cautious when driving or operating machinery, and be aware of these potential symptoms.

Other

A study cited in 4 suggests that long-term use of pantoprazole might increase the risk of osteoporosis and fractures. Research in 17 indicates that pantoprazole can bind to iron ions, potentially causing side effects. This is believed to be due to pantoprazole's ability to hinder iron absorption. Impaired iron absorption can lead to symptoms such as anemia.

Side Effect Management

Digestive System Side Effects

Digestive system side effects can include diarrhea, constipation, abdominal pain, nausea, and vomiting. Managing these symptoms often involves dietary adjustments and lifestyle changes. For instance, consuming foods rich in fiber, staying well-hydrated, and maintaining a regular sleep schedule can be beneficial. If necessary, it may be necessary to discontinue the medication or switch to an alternative option.

Blood System Side Effects

Blood system side effects can include thrombocytopenia, which increases the risk of bleeding. If you experience symptoms of thrombocytopenia, consult a doctor immediately.

Metabolic System Side Effects

Metabolic system side effects can include hypoglycemia, hyperglycemia, and hyperlipidemia. If you experience these symptoms, consult a doctor promptly. Modifying your lifestyle is also crucial. For example, dietary changes and exercise programs can help prevent metabolic system-related side effects.

Nervous System Side Effects

Nervous system side effects can include dizziness, headaches, and drowsiness. If you experience these symptoms, refrain from driving or operating machinery. If the symptoms are severe, consult a doctor immediately.

Other Side Effects

Other side effects can include osteoporosis, fractures, and anemia. If you experience these symptoms, consult a doctor immediately. To prevent these side effects, it's important to make lifestyle changes. For example, consuming foods rich in calcium and vitamin D, and engaging in regular exercise, can be beneficial.

Comparison between Studies

Commonalities

Numerous studies indicate that pantoprazole effectively reduces stomach acid secretion. They also highlight the potential for pantoprazole to cause various side effects.

Differences

The types and severity of side effects reported across studies vary. For example, 22 suggests a potential increase in fall risk with pantoprazole use, while other studies don't mention this risk. Due to these variations in findings, further research is needed to better understand the side effects of pantoprazole.

Important Considerations for Real-World Application

Pantoprazole is a medication effective in treating conditions like peptic ulcers and GERD. However, the potential for various side effects necessitates caution when taking this drug. When using pantoprazole, it's crucial to strictly follow the instructions provided by your doctor and adhere to the prescribed dosage. If you experience any side effects, it's essential to consult your doctor promptly.

Limitations of Current Research

Research on the side effects of pantoprazole is still ongoing and not entirely comprehensive. There's a particular lack of research focusing on long-term side effects. Additionally, the incidence and severity of side effects can vary between individuals based on factors like age, gender, and overall health. Further research is necessary to address these gaps.

Future Research Directions

Future research on the side effects of pantoprazole should focus on long-term side effects and investigate the incidence and severity of these effects in individual patients. Further research is also required to identify effective strategies for mitigating the side effects of pantoprazole.

Conclusion

Pantoprazole is an effective medication for treating conditions like peptic ulcers and GERD, but it can also cause various side effects. When taking pantoprazole, it's crucial to follow your doctor's instructions, adhere to the prescribed dosage, and consult your doctor immediately if you experience any side effects. Research on the side effects of pantoprazole is ongoing, and further studies are necessary to fully understand and address these potential issues.

Literature analysis of 26 papers
Positive Content
14
Neutral Content
0
Negative Content
12
Article Type
5
0
0
0
25
1.

The effects of a multispecies synbiotic on microbiome-related side effects of long-term proton pump inhibitor use: A pilot study.

Author: HorvathAngela, LeberBettina, FeldbacherNicole, SteinwenderMarkus, KomarovaIrina, RainerFlorian, BleslAndreas, StadlbauerVanessa

Gastrointestinal quality of life improvement
Gut barrier function improvement
Intestinal inflammation reduction

This study shows that a three-month intervention with a multispecies synbiotic can reduce microbiome-related side effects of long-term proton pump inhibitor (PPI) use.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.

Language : English

2.

Effect of multiple doses of omeprazole on the pharmacokinetics, pharmacodynamics, and safety of a single dose of rivaroxaban.

Author: MooreKenneth Todd, PlotnikovAlexei Nikolaevich, ThyssenAn, VaccaroNicole, AriyawansaJay, BurtonPaul Bryan

Gastrointestinal bleeding

A study found no significant drug interaction between omeprazole (a proton pump inhibitor) and rivaroxaban (a blood thinner). This suggests that using these drugs together is likely safe.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.

Language : English

4.

Use of Proton Pump Inhibitors in Hungary: Mixed-Method Study to Reveal Scale and Characteristics.

Author: MatuzMária, BenkőRia, EngiZsófia, SchvábKrisztina, DoróPéter, ViolaRéka, SzabóMária, SoósGyöngyvér

Drug interactions
Long-term side effects

The study aimed to analyse the trends in proton pump inhibitor (PPI) utilization.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.

Language : English

5.

Pantoprazole-induced thrombocytopenia in patients with upper gastrointestinal bleeding.

Author: BinnetoğluEmine, AkbalErdem, ŞenHacer, GüneşFahri, ErbağGökhan, AşıkMehmet, BozkurtNeslihan, UludağAyşegül, TekinMurat, TekinSati Zeynep

Thrombocytopenia

Short-term intravenous pantoprazole use can lead to thrombocytopenia, with platelet counts decreasing significantly over three days. Close monitoring is recommended for patients receiving PPI infusion therapy.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.

Language : English

6.

Pantoprazole associated dyspepsia hypocalcemia and hyponatremia: A disproportionality analysis in FDA adverse event reporting system (FAERS) database.

Author: NairHarsha Prakash, KulkarniApoorva Rachana, EswaranMaheswari, SubeeshViswam

Adverse events

This study used data mining to analyze the FDA database and identify novel adverse events associated with pantoprazole, a commonly used over-the-counter medication.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.

Language : English

9.

Ontology-based literature mining and class effect analysis of adverse drug reactions associated with neuropathy-inducing drugs.

Author: HurJunguk, ÖzgürArzucan, HeYongqun

Neuropathy drug mechanism

This study aimed to develop a system to identify adverse drug reactions (ADRs) like peripheral neuropathy from drug labels and understand their mechanisms, particularly for over 240 drugs previously identified as potential neuropathy-inducing agents.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.

Language : English

11.

Efficacy of a modified sequential therapy including bismuth subcitrate as first-line therapy to eradicate Helicobacter pylori in a Turkish population.

Author: UygunAhmet, OzelA Melih, SivriBulent, PolatZulfikar, GençHalil, SakinYusuf Serdar, ÇelebiGürkan, Uygur-BayramiçliOya, ErçinCemal Nuri, KadayifçiAbdurrahman, EmerOzdes, GunalArmagan, BagciSait

High eradication rate
Minor side effects

A modified sequential treatment, including bismuth, achieves a high eradication rate in patients with Helicobacter pylori infection, with satisfactory patient compliance and minimal side effects.

Clinical TrialA clinical trial is a planned study conducted on humans to evaluate the efficacy and safety of pharmaceuticals, medical devices, and treatment methods. It aims to explore the possibilities of new treatments and improve the health of patients.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Multicenter StudyResearch conducted in collaboration with multiple research institutions. It aims to collect a wide range of data and obtain more generalizable results.

Language : English

12.

Lactobacillus ruteri compared with placebo as an adjuvant in quadruple therapy for Helicobacter pylori eradication: A randomized, double-blind, controlled trial.

Author: MohtashamMahsa, JoukarFarahnaz, MaroufizadehSaman, MojtahediKourosh, AsgharnezhadMehrnaz, Mansour-GhanaeiFariborz

Reduced side effects

This randomized, double-blind, controlled trial evaluated the efficacy of adding Lactobacillus ruteri probiotic to quadruple therapy for H. pylori eradication. The probiotic did not significantly improve eradication rates, but it reduced the frequency of drug-associated side effects, such as headache and gastrointestinal adverse events.

Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.

Language : English

13.

Comparison Between 10- and 14-Day Hybrid Regimens for Helicobacter pylori Eradication: A Randomized Clinical Trial.

Author: MetanatHassan Ali, ValizadehSeyed Mohammad, FakheriHafez, MalekiIradj, TaghvaeiTarang, HosseiniVahid, BariZohreh

Effective eradication
Side effects

This study compared the efficacy of 10-day and 14-day hybrid regimens for Helicobacter pylori eradication in patients with peptic ulcer disease. The 14-day regimen achieved a higher eradication rate than the 10-day regimen. Both regimens demonstrated good compliance and minimal side effects.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.

Language : English

14.

Pantoprazole associated dyspepsia hypocalcemia and hyponatremia: A disproportionality analysis in FDA adverse event reporting system (FAERS) database.

Author: NairHarsha Prakash, KulkarniApoorva Rachana, EswaranMaheswari, SubeeshViswam

Adverse events

This study used data mining to analyze the FDA database and identify novel adverse events associated with pantoprazole, a commonly used over-the-counter medication.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.

Language : English

17.

Spectroscopic study of in situ-formed metallocomplexes of proton pump inhibitors in water.

Author: AbramenkoNikita, KejíkZdeněk, KaplánekRobert, TatarAmeneh, BrogyányiTereza, PajkováMartina, SýkoraDavid, VeseláKateřina, AntonyováVeronika, DytrychPetr, Ikeda-SaitoMasao, MartásekPavel, JakubekMilan

Amnesia
Neurodegenerative risk
Oncological risk

Proton pump inhibitors (PPIs), such as omeprazole, pantoprazole, and lansoprazole, are widely used for acid reflux and other conditions. This study investigated the potential interaction between these drugs and iron ions in water systems. The results suggest that PPIs may form complexes with iron ions, raising concerns about potential side effects related to iron metabolism.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.

Language : English

18.

[Stability of pantoprazole in parenteral nutrition units].

Author: Valverde MolinaE, González MuñizV, Gómez-MaldonadoJ, Muñoz CastilloI

Simplified administration

This study investigated the stability of pantoprazole, a proton pump inhibitor, in parenteral nutrition units (PNU) with the goal of potentially simplifying its administration to patients.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.

Language : Spanish

20.

Nivolumab-Induced Pneumonitis in a Patient With Urothelial Cancer.

Author: KasiArbab Furquan Ud Din, NagiMohammad Imran, KasiBurhanuddin A

Pneumonitis

This case report describes a 66-year-old man with interstitial pneumonitis secondary to nivolumab, a PD-1 inhibitor used to treat cancer. The patient presented with dyspnea and cough and was treated with methylprednisolone. Nivolumab therapy was discontinued, and the patient recovered well. The report highlights the importance of recognizing and addressing lung inflammation in patients receiving immune checkpoint inhibitors.

Case ReportsIn the medical field, a report that describes in detail a unique case, an unusual medical condition, or the effect of a treatment. Provides new insights and possibilities for treatment through individual patient cases.

Language : English

21.

Stop of proton-pump inhibitor treatment in patients with liver cirrhosis (STOPPIT): study protocol for a prospective, multicentre, controlled, randomized, double-blind trial.

Author: WehmeyerMalte H, HorvatitsThomas, BuchholzAnika, KrauseLinda, WalterSarah, ZapfAntonia, LohseAnsgar W, KluweJohannes,

Hepatic encephalopathy
Hospitalization risk
Infectious complications
Mortality risk

Proton-pump inhibitors (PPIs) are frequently used in patients with liver cirrhosis. However, observational studies suggest a link between PPI use and increased risk of infections, hepatic encephalopathy, hospitalization, and death. The STOPPIT trial aims to investigate whether stopping PPI therapy in hospitalized liver cirrhosis patients reduces the risk of rehospitalization or death compared to continued PPI use.

Clinical Trial ProtocolA plan for conducting a clinical trial. It describes in detail the purpose, design, methodology, and statistical considerations of the trial, ensuring the transparency and consistency of the trial.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.

Language : English

23.

Rifabutin Containing Triple Therapy and Rifabutin with Bismuth Containing Quadruple Therapy for Third-Line Treatment of Helicobacter pylori Infection: Two Pilot Studies.

Author: CiccaglioneAntonio Francesco, TavaniRoberta, GrossiLaurino, CelliniLuigina, ManzoliLamberto, MarzioLeonardo

H. pylori eradication

The addition of bismuth subcitrate to a triple therapy that includes proton pump inhibitors, amoxicillin, and rifabutin in patients who are treated for the third time for H. pylori infection resulted in a 30% therapeutic gain.

Clinical StudyResearch involving human participants to assess the safety, efficacy, and effects of an intervention/treatment.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.

Language : English

24.

Equivalent Efficacies of Reverse Hybrid and Bismuth Quadruple Therapies in Eradication of Helicobacter pylori Infection in a Randomized Controlled Trial.

Author: HsuPing-I, TsayFeng-Woei, GrahamDavid Y, TsaiTzung-Jiun, TsaiKuo-Wang, KaoJohn Y, PengNan-Jing, KuoChao-Hung, KaoSung-Shuo, WangHuay-Min, LinTe-Fu, WuDeng-Chyang,

H pylori treatment

This study compared two treatment regimens for Helicobacter pylori infection: bismuth quadruple therapy and reverse hybrid therapy. The goal was to determine which treatment is more effective as a first-line treatment option.

Comparative StudyResearch that compares multiple groups/interventions to determine differences/similarities in outcomes/characteristics.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.

Language : English

25.

Effect of low-dose amitriptyline on globus pharyngeus and its side effects.

Author: YouLe-Qing, LiuJing, JiaLin, JiangShu-Man, WangGui-Qin

Globus pharyngeus treatment
Sleep quality improvement
Constipation
Dizziness
Dry mouth
Sleepiness

Low-dose amitriptyline (AMT) was more effective than proton pump inhibitor treatment in improving symptoms, sleep, and quality of life in patients with globus pharyngeus. AMT led to a greater response rate (75% vs 35.7%) and greater improvement in GETS score and sleep quality compared to the conventional group. The most common side effects of AMT were dry mouth, sleepiness, dizziness, and constipation.

Comparative StudyResearch that compares multiple groups/interventions to determine differences/similarities in outcomes/characteristics.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.

Language : English

26.

[Clinical signs of Cushing's syndrome after long-term local application of steroid in the oral cavity].

Author: LingsKristina, DeleuranMette

Skin inflammation treatment
Cushing's syndrome

A case study describes the development of Cushing's syndrome in a 26-year-old woman due to prolonged use of potent topical glucocorticoids in the oral cavity. This emphasizes the importance of monitoring patients for side effects when using potent topical steroids.

Case ReportsIn the medical field, a report that describes in detail a unique case, an unusual medical condition, or the effect of a treatment. Provides new insights and possibilities for treatment through individual patient cases.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.

Language : Danish

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