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[Captopril versus digoxin in the treatment of mild to moderately severe heart failure].

Author: EsserH, HeckI, LüderitzB, MüllerH M

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Clinical TrialA clinical trial is a planned study conducted on humans to evaluate the efficacy and safety of pharmaceuticals, medical devices, and treatment methods. It aims to explore the possibilities of new treatments and improve the health of patients.
Comparative StudyResearch that compares multiple groups/interventions to determine differences/similarities in outcomes/characteristics.
English AbstractA summary of a research paper/publication written in English for a wider audience.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.

Overview

Captopril + hydrochlorothiazide (HCT) is more effective than digoxin + HCT in treating chronic heart failure. In a randomized, double-blind study of 116 patients, the captopril/HCT group showed significantly greater improvement in echocardiographic intracardiac diameters, exercise tolerance, and NYHA class after 12 months of treatment compared to the digoxin/HCT group.
Paper Details　
Original Abstract of the Article :
In a randomized and double-blind study of 116 patients with chronic heart failure (NYHA classes II or III) the effectiveness of captopril + hydrochlorothiazide (HCT) (group 1) and of digoxin + HCT (group 2) were compared. Treatment was effected for a 12-month period with a combination of 50 mg capto...See full text at original site
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引用元：
https://doi.org/10.1055/s-2008-1066657

データ提供：米国国立医学図書館（NLM）

Heart Failure: A Comparison of Treatment Options in the Desert of Heart Health

This study investigates the effectiveness of different treatment options for mild to moderately severe heart failure, a debilitating condition that affects the heart's ability to pump blood efficiently. The research compares the impact of captopril + hydrochlorothiazide (HCT) to that of digoxin + HCT, providing valuable insights for healthcare providers in choosing the most effective treatment approach.

Navigating the Desert of Heart Failure: Finding the Right Path

The study aims to determine which treatment strategy – captopril + HCT or digoxin + HCT – leads to better outcomes for patients with heart failure. The researchers found that captopril + HCT resulted in significantly greater improvement in cardiac function, exercise tolerance, and NYHA class than digoxin + HCT. This is like finding a more efficient camel caravan, one that traverses the desert of heart failure with greater ease and success.

A Journey Through the Desert: Managing Heart Failure

This research provides valuable information for healthcare providers seeking to optimize treatment strategies for heart failure. The findings suggest that initiating treatment with an angiotensin-converting enzyme inhibitor (ACEI) like captopril, along with a diuretic, may be a more effective approach than a digitalis-diuretic combination.

Dr.Camel's Conclusion

This study underscores the importance of tailoring treatment approaches to the specific needs of heart failure patients. The findings suggest that ACEIs, in combination with diuretics, may offer a more effective path through the desert of heart failure, improving cardiac function and quality of life for patients.

Date :
  1. Date Completed 1989-06-21
  2. Date Revised 2013-11-21
Further Info :

Pubmed ID

2653765

DOI: Digital Object Identifier

10.1055/s-2008-1066657

Related Literature

Article Analysis
・Effects of captopril and hydrochlorothiazide
SNS
PICO Info
in preparation
Languages

German

Positive IndicatorAn AI analysis index that serves as a benchmark for how positive the results of the study are. Note that it is a benchmark and requires careful interpretation and consideration of different perspectives.

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