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Locally advanced breast cancer: the contribution of cytotoxic and endocrine treatment to radiotherapy. An EORTC Breast Cancer Co-operative Group Trial (10792).

Author: BartelinkH, EngelsmanE, HaywardJ L, PapadiamantisJ, RotmenszN, RubensR D, SylvesterR, VassilarosS D, WildiersJ, van der SchuerenE

Clinical TrialA clinical trial is a planned study conducted on humans to evaluate the efficacy and safety of pharmaceuticals, medical devices, and treatment methods. It aims to explore the possibilities of new treatments and improve the health of patients.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.

Overview

A study of 363 patients with locally advanced breast cancer found that both endocrine therapy and chemotherapy significantly delayed time to progression, with the combination of both treatments being most effective. The study suggests that current treatments only modestly improve prognosis for this stage of cancer.
Paper Details　
Original Abstract of the Article :
Patients with locally advanced carcinoma of the breast were randomized to receive either radiotherapy alone, radiotherapy + endocrine therapy, radiotherapy + chemotherapy or radiotherapy + endocrine therapy + chemotherapy. In 363 evaluable patients, time to first progression was delayed significantl...See full text at original site
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引用元：
https://doi.org/10.1016/0277-5379(89)90203-4

データ提供：米国国立医学図書館（NLM）

Locally Advanced Breast Cancer: A Desert of Treatment Challenges

Breast cancer, a formidable desert storm, can pose significant challenges for patients and clinicians. This study investigates the effectiveness of various treatment strategies for locally advanced breast cancer, exploring the roles of radiotherapy, endocrine therapy, and chemotherapy in managing this complex disease. Imagine a group of skilled doctors, armed with different weapons against breast cancer, navigating the challenging terrain of treatment options, seeking to conquer this relentless disease.

Treatment Strategies: A Comprehensive Approach to Breast Cancer

This study provides valuable insights into the complex landscape of locally advanced breast cancer treatment. The study found that combining endocrine therapy and chemotherapy was most effective in delaying time to first progression. This finding highlights the importance of multi-modal approaches to managing locally advanced breast cancer.

Navigating the Desert of Breast Cancer Treatment

This study emphasizes the importance of a comprehensive approach to locally advanced breast cancer treatment, considering the individual needs of each patient and the potential benefits and risks of various treatment options. It highlights the ongoing need for research and development of new therapies to improve outcomes for patients with breast cancer.

Dr.Camel's Conclusion

This study provides valuable insights into the complex landscape of locally advanced breast cancer treatment. The study's findings underscore the importance of considering a multi-modal approach, combining different therapies to optimize outcomes for patients facing this challenging disease. As researchers, we continue to explore the vast and complex desert of breast cancer treatment, seeking to discover new therapies that improve patient survival and quality of life.

Date :
  1. Date Completed 1989-06-14
  2. Date Revised 2019-09-08
Further Info :

Pubmed ID

2653846

DOI: Digital Object Identifier

10.1016/0277-5379(89)90203-4

Related Literature

Article Analysis
・Effective treatment of breast cancer
SNS
PICO Info
in preparation
Languages

English

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