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Neuroprotective Effects of Etidronate and 2,3,3-Trisphosphonate Against Glutamate-Induced Toxicity in PC12 Cells.

Author: CheongYuen-Ki, LiWen, RenGuogang, WangHui, YangZhuo

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.

Overview

This study investigated the neuroprotective effects of etidronate and TrisPP, two bisphosphonate derivatives, on glutamate-injured PC12 cells. TrisPP exhibited remarkable cell protection and attenuated cell apoptosis, reactive oxygen species generation, Ca(2+) overloading and caspase-3 protein expression.
Paper Details　
Original Abstract of the Article :
Etidronate is one of the best known bisphosphonates (BP) derivatives. It is often used as a reference drug in research related to hypercalcaemia and other common bone diseases. 2,3,3-trisphosphonate (TrisPP) is brand new analogue of BP, that also contains a 'germinal bisphosphonate' unit with an add...See full text at original site
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引用元：
https://doi.org/10.1007/s11064-015-1761-4

データ提供：米国国立医学図書館（NLM）

Etidronate and TrisPP: Potential Neuroprotective Agents

This study explores the neuroprotective potential of two compounds, etidronate and TrisPP, both of which belong to a group of drugs called bisphosphonates. Bisphosphonates are often used to treat bone diseases. However, researchers have discovered that they may also have neuroprotective effects. This research used PC12 cells, a type of nerve cell, to investigate the effects of etidronate and TrisPP on glutamate-induced toxicity. Glutamate is a neurotransmitter that can be harmful to nerve cells in high concentrations. The results showed that both etidronate and TrisPP provided neuroprotection by reducing cell death, oxidative stress, and calcium overload. TrisPP was particularly effective.

A Ray of Hope for Neurodegenerative Diseases

This research offers a glimmer of hope for the treatment of neurodegenerative diseases like Alzheimer's, Parkinson's, and Huntington's. The findings suggest that etidronate and TrisPP could potentially be used to protect nerve cells from damage. Imagine these compounds like a refreshing oasis in a desert of neuron damage, providing vital protection and promoting recovery.

Protecting Our Brain Cells

The results of this study highlight the importance of further research into the potential neuroprotective effects of bisphosphonates. While these compounds are currently used to treat bone diseases, they may also hold the key to protecting our brain cells from damage. This is a fascinating area of study that could lead to new and innovative therapies for a range of neurological conditions.

Dr.Camel's Conclusion

Etidronate and TrisPP, like two sturdy camels navigating a treacherous desert landscape, offer hope for protecting brain cells from damage. These compounds could potentially be a valuable weapon in the fight against neurodegenerative diseases, offering a glimmer of hope in a challenging field of research.

Date :
  1. Date Completed 2016-11-10
  2. Date Revised 2018-11-13
Further Info :

Pubmed ID

26559687

DOI: Digital Object Identifier

10.1007/s11064-015-1761-4

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Languages

English

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