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Asthma severity, not asthma control, is worse in atopic compared with nonatopic adolescents with asthma.

Author: ArroyaveWhitney D, CarlsonJohn C, LefanteJohn, RabitoFelicia A, SeverMichelle L

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Multicenter StudyResearch conducted in collaboration with multiple research institutions. It aims to collect a wide range of data and obtain more generalizable results.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.

Overview

Atopic asthma was associated with worse asthma severity and higher fractional exhaled nitric oxide (FeNO) compared to nonatopic asthma, but not with control. Higher total IgE levels in all participants indicated worse severity and higher FeNO, suggesting a role of IgE in both asthma phenotypes.
Paper Details　
Original Abstract of the Article :
BACKGROUND: The effects of atopic and nonatopic asthma phenotypes on asthma morbidity are unclear. Moreover, asthma morbidity in patients without atopy might be mediated by immunoglobulin E (IgE). OBJECTIVE: To determine differences in morbidity in patients with asthma with and without atopy in a p...See full text at original site
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引用元：
https://doi.org/10.1016/j.anai.2015.10.015

データ提供：米国国立医学図書館（NLM）

Asthma Severity: A Closer Look at Atopic and Non-Atopic Adolescents

The management of [asthma] is a complex endeavor, requiring tailored approaches for different patient populations. This study investigates the impact of [atopic] and [non-atopic] phenotypes on [asthma severity] and [asthma control] in a group of [adolescents with asthma]. The authors analyzed data from [546 adolescents] to explore the differences in asthma morbidity between these two groups. The study aims to clarify the role of [atopic status] and [immunoglobulin E (IgE)] in influencing asthma severity and control.

Asthma Severity and IgE: Unveiling the Influence on Morbidity

This study demonstrates the distinct effects of atopic and non-atopic phenotypes on asthma morbidity in adolescents. The researchers found that adolescents with atopic asthma had worse asthma severity, as measured by [Composite Asthma Severity Index (CASI)], and higher [fractional exhaled nitric oxide (FeNO)] levels compared to those with non-atopic asthma. Furthermore, the study revealed a correlation between higher [total IgE (tIgE)] levels and increased asthma severity, suggesting that IgE plays a significant role in influencing asthma outcomes.

Tailored Management of Asthma: Addressing Phenotypic Differences

This study highlights the importance of considering atopic status and IgE levels in the management of asthma. The findings suggest that adolescents with atopic asthma may require more aggressive treatment strategies to control their symptoms and prevent exacerbations. Furthermore, monitoring IgE levels may provide valuable insights into asthma severity and guide treatment decisions.

Dr.Camel's Conclusion

The study on asthma severity in adolescents is like a desert landscape, revealing different oases of asthma phenotypes. Understanding the distinct effects of atopic and non-atopic asthma, along with the role of IgE, is crucial for developing personalized treatment strategies that optimize asthma management and improve patient outcomes.

Date :
  1. Date Completed 2016-05-02
  2. Date Revised 2022-04-08
Further Info :

Pubmed ID

26560898

DOI: Digital Object Identifier

10.1016/j.anai.2015.10.015

SNS
PICO Info
in preparation
Languages

English

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