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Antiviral therapy for chronic hepatitis B viral infection in adults: A systematic review and meta-analysis.

Author: Abu DabrhAbd Moain, AhmedAhmed T, AlahdabFares, AlmasriJehad, BenkhadraKhalid, BrownRobert S, FarahWigdan, LokAnna S F, McMahonBrian J, MohamedEssa A, MohammedKhaled, MouchliMohamed A, MuradMohammad Hassan, ProkopLarry J, SinghSiddharth, WangZhen, WongJohn B

Meta-AnalysisA statistical technique that integrates the results of multiple studies to draw more general conclusions about a particular issue.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
ReviewAn article that critically examines existing research on a particular topic and summarizes the current state of knowledge in the field.
Systematic ReviewA review that systematically collects, evaluates, and integrates relevant research to answer a specific research question.

Overview

This systematic review examines the use of antiviral therapy for chronic hepatitis B viral (HBV) infection. The study provides evidence-based recommendations on when to start treatment, which medications are most effective, and when treatment can be safely stopped.
Paper Details　
Original Abstract of the Article :
Chronic hepatitis B viral (HBV) infection remains a significant global health problem. Evidence-based guidelines are needed to help providers determine when treatment should be initiated, which medication is most appropriate, and when treatment can safely be stopped. The American Association for the...See full text at original site
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引用元：
https://doi.org/10.1002/hep.28280

データ提供：米国国立医学図書館（NLM）

Navigating the Treatment Landscape for Chronic Hepatitis B

Chronic hepatitis B viral (HBV) infection poses a significant global health threat. This study provides a comprehensive review of antiviral therapies for chronic HBV infection in adults, aiming to inform evidence-based clinical guidelines. The researchers systematically analyzed randomized controlled trials and observational studies to assess the effectiveness and safety of different antiviral treatments.

Antiviral Therapy for Chronic Hepatitis B: A Review

The study found moderate-quality evidence supporting the effectiveness of antiviral therapy in reducing the risk of cirrhosis, decompensated liver disease, and hepatocellular carcinoma in patients with immune active chronic HBV infection. Antiviral therapy also demonstrated improved intermediate outcomes in immune tolerant patients. However, the evidence regarding the safety and effectiveness of antiviral therapy in specific patient groups, such as those with persistent viremia during treatment, was limited.

Tailoring Treatment to Individual Needs

This study highlights the importance of individualized treatment approaches for chronic HBV infection, considering the unique characteristics of each patient. The researchers emphasize the need for further research to address knowledge gaps and develop optimal treatment strategies for different patient groups.

Dr.Camel's Conclusion

The fight against chronic hepatitis B is a journey that requires perseverance and adaptability. This study provides a valuable overview of antiviral therapies, highlighting the need for evidence-based decision-making and individualized treatment plans. As we continue to learn more about this complex disease, we can work towards better outcomes for patients living with chronic HBV infection.

Date :
  1. Date Completed 2016-05-10
  2. Date Revised 2022-03-30
Further Info :

Pubmed ID

26566246

DOI: Digital Object Identifier

10.1002/hep.28280

SNS
PICO Info
in preparation
Languages

English

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