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A Randomized Trial of Time-Limited Antiretroviral Therapy in Acute/Early HIV Infection.

Author: ApuzzoLinda, ConwayBrian, El-HelouPhillippe, FraserChristopher, GallantJoel E, KasperKenneth, LeeTerry, LoutfyMona R, MargolickJoseph B, RachlisAnita, SingerJoel, TossonianHarout, TremblayCécile, WongHubert

Clinical TrialA clinical trial is a planned study conducted on humans to evaluate the efficacy and safety of pharmaceuticals, medical devices, and treatment methods. It aims to explore the possibilities of new treatments and improve the health of patients.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Multicenter StudyResearch conducted in collaboration with multiple research institutions. It aims to collect a wide range of data and obtain more generalizable results.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.
Research Support, N.I.H., ExtramuralResearch funding provided by the NIH to external research institutions and researchers.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.

Overview

A study of 113 people with documented HIV infection of less than 12 months' duration found no significant benefit from administration of a brief, time-limited (12-month) course of ART in acute or early HIV infection. The study compared a group who received immediate ART with a group who received observation and deferred ART. The treatment-free interval was about 18 months in both groups.
Paper Details　
Original Abstract of the Article :
BACKGROUND: It has been proposed that initiation of antiretroviral treatment (ART) very soon after establishment of HIV infection may be beneficial by improving host control of HIV replication and delaying disease progression. METHODS: People with documented HIV infection of less than 12 months' du...See full text at original site
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引用元：
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4658016/

データ提供：米国国立医学図書館（NLM）

The Shifting Sands of Antiretroviral Therapy: A Time-Limited Approach

The treatment of HIV infection, like a journey through a vast and unforgiving desert, often requires a long-term commitment to antiretroviral therapy. This research explores the potential benefits of a time-limited approach to treatment, aiming to optimize patient care while minimizing the potential for long-term side effects.

The authors, like skilled desert navigators, compare the outcomes of immediate versus delayed antiretroviral therapy in patients with recently acquired HIV infection. Their findings, like a carefully mapped route, suggest that a brief course of therapy may not significantly impact the overall treatment-free time for patients.

The authors' research, like a well-worn path through the desert, emphasizes the need for ongoing research to optimize treatment strategies for HIV infection, considering both the short-term and long-term effects of therapy.

A Shifting Landscape of Treatment Strategies

This research, like a compass guiding us through the changing landscape of HIV treatment, highlights the need for continued exploration and innovation in optimizing treatment strategies. The authors' findings, like a well-maintained oasis, offer valuable insights into the potential benefits and limitations of time-limited therapy.

Navigating the Desert of HIV Treatment

HIV infection, like a complex and unpredictable desert, requires careful navigation. This research, like a map guiding us through this challenging terrain, underscores the importance of ongoing research and individualized treatment approaches.

Dr. Camel's Conclusion

This research, like a journey through a shifting desert, reveals the ongoing quest for optimal treatment strategies for HIV infection. The authors' findings, like a refreshing oasis, provide valuable insights into the potential benefits and limitations of time-limited therapy, guiding our understanding of this complex condition.

Date :
  1. Date Completed 2016-06-27
  2. Date Revised 2020-12-15
Further Info :

Pubmed ID

26600459

DOI: Digital Object Identifier

PMC4658016

SNS
PICO Info
in preparation
Languages

English

Positive IndicatorAn AI analysis index that serves as a benchmark for how positive the results of the study are. Note that it is a benchmark and requires careful interpretation and consideration of different perspectives.

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