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Glucocorticosteroid-free versus glucocorticosteroid-containing immunosuppression for liver transplanted patients.

Author: FairfieldCameron, HarrisonEwen M, PenningaLuit, PowellJames, WigmoreStephen J

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Meta-AnalysisA statistical technique that integrates the results of multiple studies to draw more general conclusions about a particular issue.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.
ReviewAn article that critically examines existing research on a particular topic and summarizes the current state of knowledge in the field.
Systematic ReviewA review that systematically collects, evaluates, and integrates relevant research to answer a specific research question.

Overview

This Cochrane review assesses the benefits and harms of glucocorticosteroid avoidance or withdrawal versus glucocorticosteroid-containing immunosuppression following liver transplantation. There was no statistically significant difference in mortality, graft loss, or infection. Glucocorticosteroid avoidance or withdrawal appeared to reduce diabetes mellitus and hypertension but increased acute rejection, glucocorticosteroid-resistant rejection, and renal impairment.
Paper Details　
Original Abstract of the Article :
BACKGROUND: Liver transplantation is an established treatment option for end-stage liver failure. Now that newer, more potent immunosuppressants have been developed, glucocorticosteroids may no longer be needed and their removal may prevent adverse effects. OBJECTIVES: To assess the benefits and ha...See full text at original site
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ラクダ博士は、Health Journal が論文の内容を分かりやすく解説するために作成した架空のキャラクターです。
難解な医学論文を、専門知識のない方にも理解しやすいように、噛み砕いて説明することを目指しています。

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引用元：
https://doi.org/10.1002/14651858.CD007606.pub3

データ提供：米国国立医学図書館（NLM）

Glucocorticosteroids: A Shifting Sands Debate

The world of [liver transplantation] is a complex landscape, much like a shifting desert. This research explores the role of [glucocorticosteroids] in immunosuppression following liver transplantation. It's a debate about the best way to navigate the delicate balance between suppressing the immune system and minimizing side effects. The authors conducted a [systematic review] of [randomized clinical trials] to assess the benefits and harms of [glucocorticosteroid avoidance or withdrawal] versus [glucocorticosteroid-containing immunosuppression] after liver transplantation. This study highlights the potential [benefits and risks] of different treatment approaches.

Navigating the Risks and Rewards

The review suggests that [glucocorticosteroid avoidance or withdrawal] might [reduce the risk of certain side effects], such as [diabetes mellitus] and [hypertension]. However, it also appears to [increase the risk of other complications], such as [acute rejection] and [glucocorticosteroid-resistant rejection]. The authors found that the quality of evidence is limited, and more research is needed to fully understand the long-term effects of these different approaches.

Finding the Right Path in the Sand

This research emphasizes the need for careful consideration when making decisions about [glucocorticosteroid use] following liver transplantation. It's like choosing the right path through a desert. It's important to weigh the potential risks and benefits of each approach and consult with a medical professional to determine the best course of action for your individual situation.

Dr. Camel's Conclusion

The use of glucocorticosteroids after liver transplantation remains a complex and evolving area. Like a desert landscape, the landscape of immunosuppression is constantly shifting, and more research is needed to find the most effective and safe approaches. This review highlights the importance of individualized care and careful consideration of all options.

Date :
  1. Date Completed 2016-04-28
  2. Date Revised 2021-12-03
Further Info :

Pubmed ID

26666504

DOI: Digital Object Identifier

10.1002/14651858.CD007606.pub3

Related Literature

Article Analysis
・Effective treatment of liver transplantation
SNS
PICO Info
in preparation
Languages

English

Positive IndicatorAn AI analysis index that serves as a benchmark for how positive the results of the study are. Note that it is a benchmark and requires careful interpretation and consideration of different perspectives.

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