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Treatment of seasonal depression with d-fenfluramine.

Author: ChebliR, GleasonR, O'RourkeD, WurtmanJ J, WurtmanR J

Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Clinical TrialA clinical trial is a planned study conducted on humans to evaluate the efficacy and safety of pharmaceuticals, medical devices, and treatment methods. It aims to explore the possibilities of new treatments and improve the health of patients.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.
Research Support, U.S. Gov't, P.H.S.Research funding provided by the Public Health Service (PHS).

Overview

This study investigated the effectiveness of d-fenfluramine, a serotonin-releasing drug, in treating seasonal affective disorder (SAD) in 18 patients. Patients received either d-fenfluramine or a placebo for four weeks, with a two-week washout period between treatments. D-fenfluramine significantly reduced depression scores compared to placebo, with a 71% decrease in overall depression scores and a 73% decrease in SAD-specific scores. Thirteen patients (72%) experienced a complete reversal of their symptoms while taking d-fenfluramine. The group also lost weight while taking d-fenfluramine. A follow-up study confirmed that d-fenfluramine remained effective for the full three-month duration of SAD symptoms. These findings suggest that d-fenfluramine may be a useful treatment for SAD and that serotonin plays a role in both the mood and appetite changes associated with the condition.
Paper Details　
Original Abstract of the Article :
Eighteen patients with seasonal affective disorder (SAD) participated in a double-blind, placebo-controlled crossover study in 1986-1987. Each received, in random order, d-fenfluramine (15 mg p.o. twice daily)-a serotonin-releasing drug previously shown to suppress carbohydrate craving-or a placebo;...See full text at original site
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引用元：
https://pubmed.ncbi.nlm.nih.gov/2670915

データ提供：米国国立医学図書館（NLM）

D-Fenfluramine: A Potential Treatment for Seasonal Depression

Seasonal Affective Disorder (SAD), a type of depression often linked to changes in seasons, is a common condition. This research investigates the [psychiatry] of SAD and explores the potential of d-fenfluramine as a treatment. The study, a double-blind, placebo-controlled crossover investigation, assessed the effects of d-fenfluramine on SAD symptoms in 18 patients. This study presents promising findings regarding the potential of d-fenfluramine as a treatment for SAD. The study demonstrates that d-fenfluramine significantly reduces symptoms of depression, suggesting a potential role for serotonin in both the affective and appetitive symptoms of SAD. The research offers a valuable contribution to the field of [psychiatry], providing evidence for a new treatment option for SAD.

The Study's Implication: A Novel Treatment for SAD

The research suggests that d-fenfluramine could be a viable treatment option for SAD. The study found that d-fenfluramine effectively reduced depression scores and reversed abnormal test scores in a majority of the participants. The findings also suggest that serotonin plays a significant role in both the mood and appetite-related symptoms of SAD. These findings could lead to the development of new and more effective treatments for this condition.

The Research's Implications on Patient Care

This research provides valuable insights for healthcare professionals treating patients with SAD. The study highlights the potential benefits of d-fenfluramine as a treatment option for this condition. The findings also emphasize the importance of considering the role of serotonin in the development and treatment of SAD. This research could lead to the development of more personalized and effective treatment strategies for patients suffering from this condition.

Dr.Camel's Conclusion

This study, like a camel navigating the changing seasons, reminds us that even in the harsh reality of depression, there is hope for finding effective treatments. The research into d-fenfluramine offers a promising path to alleviate the symptoms of SAD and improve the lives of those affected by this condition.

Date :
  1. Date Completed 1989-10-12
  2. Date Revised 2013-11-21
Further Info :

Pubmed ID

2670915

DOI: Digital Object Identifier

2670915

SNS
PICO Info
in preparation
Languages

English

Positive IndicatorAn AI analysis index that serves as a benchmark for how positive the results of the study are. Note that it is a benchmark and requires careful interpretation and consideration of different perspectives.

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