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Macular Morphology and Visual Acuity in the Second Year of the Comparison of Age-Related Macular Degeneration Treatments Trials.

Author: , DanielEbenezer, GrunwaldJuan E, HuangJiayan, JaffeGlenn J, MaguireMaureen G, MartinDaniel F, SharmaSumit, TothCynthia A, YingGui-Shuang

Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.
Comparative StudyResearch that compares multiple groups/interventions to determine differences/similarities in outcomes/characteristics.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Multicenter StudyResearch conducted in collaboration with multiple research institutions. It aims to collect a wide range of data and obtain more generalizable results.
Research Support, N.I.H., ExtramuralResearch funding provided by the NIH to external research institutions and researchers.

Overview

In the second year of the Comparison of Age-related Macular Degeneration Treatments Trials (CATT), eyes with foveal intraretinal fluid, abnormally thin retina, greater thickness of the subretinal tissue complex, and subfoveal geographic atrophy or scar had the worst visual acuity. Subretinal fluid was associated with better visual acuity.
Paper Details　
Original Abstract of the Article :
PURPOSE: To describe the association between morphologic features on fundus photography (FP), fluorescein angiography (FA), and optical coherence tomography (OCT) and visual acuity (VA) in the second year of the Comparison of Age-related Macular Degeneration Treatments Trials (CATT). DESIGN: Prospe...See full text at original site
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引用元：
https://pubmed.ncbi.nlm.nih.gov/26783095

データ提供：米国国立医学図書館（NLM）

Macular Morphology and Visual Acuity: A Two-Year Journey Through the CATT Trials

Age-related macular degeneration (AMD) is a leading cause of vision loss, and choroidal neovascularization (CNV) is a significant complication. The Comparison of Age-related Macular Degeneration Treatments Trials (CATT) investigated the effectiveness of ranibizumab and bevacizumab in treating CNV. This study focuses on the relationship between macular morphology and visual acuity (VA) over a two-year period in the CATT participants.

Macular Morphology: A Window into Visual Acuity

The study revealed a strong correlation between macular morphology, as assessed through various imaging techniques, and visual acuity. The presence of intraretinal fluid (IRF) was associated with worse VA, while subretinal fluid (SRF) was linked to better VA. These findings highlight the importance of monitoring macular morphology for predicting visual outcomes in AMD patients with CNV.

Navigating the Landscape of AMD Treatment

This study provides valuable insights into the long-term effects of AMD treatment and the relationship between macular morphology and visual acuity. It emphasizes the importance of regular monitoring and personalized treatment approaches tailored to individual patient needs. These findings contribute to a better understanding of AMD and its treatment, guiding clinicians in making informed decisions for their patients.

Dr.Camel's Conclusion

This study is like a long caravan journey through the desert of AMD research. It reveals the intricate connections between macular morphology and visual acuity, showcasing the importance of regular monitoring and personalized treatment strategies. Just as a camel caravan relies on experienced guides, patients with AMD need to trust their healthcare providers to navigate the challenging landscape of this disease.

Date :
  1. Date Completed 2016-08-11
  2. Date Revised 2022-03-30
Further Info :

Pubmed ID

26783095

DOI: Digital Object Identifier

NIHMS811877

Related Literature

Article Analysis
・Effective treatment of macular degeneration
SNS
PICO Info
in preparation
Languages

English

Positive IndicatorAn AI analysis index that serves as a benchmark for how positive the results of the study are. Note that it is a benchmark and requires careful interpretation and consideration of different perspectives.

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