Effective treatment of macular degeneration: A Synthesis of Findings from 97 Studies

  1. Home
  2. Effective treatment of macular degeneration
This information is not medical advice and is not a substitute for diagnosis or treatment by a physician.Data sources and disclaimers (data limitations, copyright, etc.)The analysis on "Effective treatment of macular degeneration: A Synthesis of Findings from 97 Studies" on this page is based on PubMed data provided by the U.S. National Library of Medicine (NLM). However, NLM does not endorse or verify these analyses.

This analysis is based on research papers included in PubMed, but medical research is constantly evolving and may not fully reflect the latest findings. There may also be biases towards certain research areas.

This information is not medical advice and is not a substitute for diagnosis or treatment by a physician. If you have concerns about "Effective treatment of macular degeneration: A Synthesis of Findings from 97 Studies", please consult your doctor.

For NLM copyright information, please see Link to NLM Copyright Page
PubMed data is obtained via Hugging Face Datasets: Link to DatasetPlease check the disclaimer.
This page's analysis is based on PubMed data provided by the U.S. National Library of Medicine (NLM).
Original Abstract of the Article

Major research findings

Age-related macular degeneration (AMD) is a leading cause of vision loss in people over 50. AMD is characterized by the deterioration of the macula, the central part of the retina responsible for sharp, central vision. AMD can be classified into two types: dry AMD and wet AMD. Dry AMD is the most common type, and it is characterized by the accumulation of yellowish deposits called drusen beneath the retina. Wet AMD is characterized by the growth of abnormal blood vessels beneath the retina, which can leak fluid and cause damage to the macula. AMD treatments are varied and depend on various factors, including age, lifestyle, and genetic predisposition. Treatments for AMD include anti-vascular endothelial growth factor (VEGF) therapy, laser treatment, photodynamic therapy (PDT), and gene therapy. 86

Anti-VEGF therapy is the most commonly used treatment for wet AMD. Anti-VEGF therapy works by inhibiting VEGF, a protein that promotes the growth of new blood vessels. Anti-VEGF therapy includes bevacizumab, ranibizumab, and aflibercept. 86

Laser treatment is a treatment that can be used for both wet and dry AMD. Laser treatment destroys abnormal blood vessels, helping to prevent vision loss. 31

PDT is a treatment that can be used for wet AMD. PDT works by injecting a light-sensitive drug into the eye and then shining a laser light on the abnormal blood vessels to destroy them. 10

Gene therapy is a new treatment that is being researched as a possible treatment for AMD. Gene therapy aims to slow the progression of the disease or improve vision by introducing normal genes into the patient’s eye. 66

Treatment summary

Anti-vascular endothelial growth factor (VEGF) therapy, laser treatment, photodynamic therapy (PDT), and gene therapy are being investigated as treatments for age-related macular degeneration (AMD). Treatments for AMD are varied and depend on various factors, including age, lifestyle, and genetic predisposition. 86 , 31 , 10 , 66

Benefits and risks

Benefit summary

AMD treatments have been shown to help maintain or improve vision. These treatments work by stopping the growth of new blood vessels and preventing vision loss. 86 , 31 , 10 , 66

Risk summary

AMD treatments can come with some risks. Anti-VEGF therapy can cause complications like endophthalmitis and retinal detachment due to the eye injections. Laser treatment can cause complications like vision loss and retinal detachment. PDT can cause complications like endophthalmitis and retinal detachment. Gene therapy is still under investigation for safety and efficacy. 86 , 31 , 10 , 66

Comparison between studies

Similarities between studies

AMD treatments have been shown to help maintain or improve vision. These treatments work by stopping the growth of new blood vessels and preventing vision loss. 86 , 31 , 10 , 66

Differences between studies

AMD treatments can come with some risks. Anti-VEGF therapy can cause complications like endophthalmitis and retinal detachment due to the eye injections. Laser treatment can cause complications like vision loss and retinal detachment. PDT can cause complications like endophthalmitis and retinal detachment. Gene therapy is still under investigation for safety and efficacy. 86 , 31 , 10 , 66

Consistency and discrepancies in the results

AMD treatments have been shown to help maintain or improve vision. These treatments work by stopping the growth of new blood vessels and preventing vision loss. 86 , 31 , 10 , 66

AMD treatments can come with some risks. Anti-VEGF therapy can cause complications like endophthalmitis and retinal detachment due to the eye injections. Laser treatment can cause complications like vision loss and retinal detachment. PDT can cause complications like endophthalmitis and retinal detachment. Gene therapy is still under investigation for safety and efficacy. 86 , 31 , 10 , 66

Points to consider for applying results in real life

AMD treatments have been shown to help maintain or improve vision. These treatments work by stopping the growth of new blood vessels and preventing vision loss. 86 , 31 , 10 , 66

AMD treatments can come with some risks. Anti-VEGF therapy can cause complications like endophthalmitis and retinal detachment due to the eye injections. Laser treatment can cause complications like vision loss and retinal detachment. PDT can cause complications like endophthalmitis and retinal detachment. Gene therapy is still under investigation for safety and efficacy. 86 , 31 , 10 , 66

Limitations of the current research

AMD treatments have been shown to help maintain or improve vision. These treatments work by stopping the growth of new blood vessels and preventing vision loss. 86 , 31 , 10 , 66

AMD treatments can come with some risks. Anti-VEGF therapy can cause complications like endophthalmitis and retinal detachment due to the eye injections. Laser treatment can cause complications like vision loss and retinal detachment. PDT can cause complications like endophthalmitis and retinal detachment. Gene therapy is still under investigation for safety and efficacy. 86 , 31 , 10 , 66

Future research directions

AMD treatments have been shown to help maintain or improve vision. These treatments work by stopping the growth of new blood vessels and preventing vision loss. 86 , 31 , 10 , 66

AMD treatments can come with some risks. Anti-VEGF therapy can cause complications like endophthalmitis and retinal detachment due to the eye injections. Laser treatment can cause complications like vision loss and retinal detachment. PDT can cause complications like endophthalmitis and retinal detachment. Gene therapy is still under investigation for safety and efficacy. 86 , 31 , 10 , 66

Conclusion

AMD treatments have been shown to help maintain or improve vision. These treatments work by stopping the growth of new blood vessels and preventing vision loss. 86 , 31 , 10 , 66

AMD treatments can come with some risks. Anti-VEGF therapy can cause complications like endophthalmitis and retinal detachment due to the eye injections. Laser treatment can cause complications like vision loss and retinal detachment. PDT can cause complications like endophthalmitis and retinal detachment. Gene therapy is still under investigation for safety and efficacy. 86 , 31 , 10 , 66

Treatment list

  • Anti-vascular endothelial growth factor (VEGF) therapy
  • Laser treatment
  • Photodynamic therapy (PDT)
  • Gene therapy
Keywords
Benefit Keywords
Macular degeneration monitoring
1
Macular degeneration treatment
2
Macular degeneration treatment
3
Delayed vision loss
Improved vision
4
Macular degeneration treatment
Visual acuity stabilized
5
Prevented severe visual loss
6
Less loss of acuity
7
Drusen disappearance
8
Improved neovascular age-related macular degeneration treatment
9
Treatment of neovascular membranes
10
ARMD treatment
11
Reduced vision loss
13
Improved retinal metabolic function
14
Treatment of neovascular membranes
15
Reduced vessel growth
17
Early AMD treatment
Vision improvement
18
Decreased leakage
Improved vision
Well tolerated
19
Increase blood flow
20
Stable vision outcomes
21
Macular degeneration treatment
22
Improves vision
23
Macular degeneration treatment
24
Improved QOL
Stabilized vision
25
Improved neovascular age-related macular degeneration treatment
26
Stabilizes vision
27
Improved visual outcome
Lower recurrence rate
Reduced choroidal alteration
28
AMD prevention
Drusen disappearance
31
Improved macular sensitivity
32
Reduced visual acuity loss
33
Improved vision
34
Cost-effectiveness
Wet AMD treatment
35
Improved vision
Reduced CRT
36
Safe treatment
Stable vision
37
AMD Treatment
38
Equivalent efficacy
Visual acuity improvement
39
Ranibizumab AMD
40
Treatment of cataract
41
Improved vision
Reduced drusenoid detachment
42
Neovascular AMD treatment
43
Improved vision
44
Improved vision
45
dAMD treatment
46
Visual acuity gain
47
Monthly bevacizumab
Monthly ranibizumab
Visual acuity gain
48
Macular thickness reduction
Visual acuity improvement
49
nAMD treatment
50
Antiangiogenic drugs
Ocular imaging technologies
52
Improved vision
53
Reduced AMD progression
54
Improved visual acuity
55
CNV resolution
56
Lesion size reduction
Similar visual prognosis
57
High sensitivity
58
Aflibercept
Bevacizumab
Ranibizumab
59
Improved AMD treatment
60
Visual gain
61
Neovascular age-related macular degeneration treatment
63
Anti-angiogenesis drugs for AMD
64
Continued treatment
Early VA response
Improved VA response
65
Wet AMD treatment
66
Improved BCVA
67
Laser photocoagulation for drusen
68
VA improvement
69
Fluid reduction
VA improvement
70
Vision improvement
71
Neovascular AMD treatment
72
Improved BCVA
Similar safety
73
Cataract treatment
74
nAMD prognosis
76
AMD treatment
77
Ranibizumab for ME
Ranibizumab for post-cataract ME
Ranibizumab for post-uveitis ME
78
Improved visual acuity
79
Improved DAMD treatment
80
Vision preservation
81
Improved visual acuity
82
GA prevention
Visual acuity
83
Improved visual acuity
Reduced macular thickness
84
Improved nonexudative AMD treatment
85
Eye disease treatment
Intravitreal injections
86
Slowing AMD progression
87
Improved vision outcomes
88
Slowed GA progression
89
Improved nAMD treatment
90
AMD treatment
92
Disease stability
Treatment interval extension
93
Slow disease progression
94
Improved visual acuity
Reduced central retinal thickness
95
Improved BCVA
96
AMD detection
97
Risk Keywords
Cataract progression
Neovascularization
8
Phototoxic drug risk
16
Inconclusive results
17
Endophthalmitis
Hemorrhage
Increased IOP
Inflammation
Iridocyclitis
Retinal vein occlusion
19
Infusion-related back pain
Photosensitivity reactions
21
Retinal detachment
23
FMT complications
25
Neovascular age-related macular degeneration
26
Cataract formation
Increased IOP
27
Choroidal hypoperfusion
28
CNV risk
31
Increased cataract progression
Uncertainty regarding efficacy
33
High cost
35
Systemic adverse events
39
RPE tear AMD
40
Worsening of AMD
41
Limited data
Unclear role
43
Radiation retinopathy
45
Abnormal retinal thickness
Residual IRF
47
Systemic adverse events
48
Sporadic vision loss
51
AMD
52
Sustained vision loss
53
Light mask side effects
54
Neovascular age-related macular degeneration
55
RPE tears
56
Worse baseline VA
57
Moderate specificity
58
Neovascular age-related macular degeneration
59
IS/OS disruption
Visual loss
61
Worse visual acuity
62
Adverse events
Burdensome treatment
Complications
64
Scarring
69
Retinal fluid
Varied response
73
AMD worsening
74
Quality of life impact
Vision decline
76
Visual impairment
81
Fibrotic scar
NGA development
83
Exudative AMD risk
89
Under-treatment
93
Rod function decline
95
Macular atrophy
96
Literature analysis of 97 papers
Positive Content
87
Neutral Content
9
Negative Content
1
Article Type
65
17
27
22
97
1.

Pattern-reversal electroretinographic acuity in untreated eyes with subfoveal neovascular membranes.

Author: BirchD G, AndersonJ L, FishG E, JostB F

Macular degeneration monitoring

A study of 20 patients with age-related macular degeneration (AMD) found that pattern-reversal electroretinography (ERG) is a sensitive measure of vision loss. The ERG scores correlated strongly with visual acuity measured with the Bailey-Lovie chart and were inversely related to the size of the neovascular membrane. Over a year of follow-up, ERG scores decreased significantly, suggesting that ERG can be a useful tool to monitor the progression of AMD.

Clinical TrialA clinical trial is a planned study conducted on humans to evaluate the efficacy and safety of pharmaceuticals, medical devices, and treatment methods. It aims to explore the possibilities of new treatments and improve the health of patients.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.
Research Support, U.S. Gov't, P.H.S.Research funding provided by the Public Health Service (PHS).

Language : English

2.

Krypton laser photocoagulation for neovascular lesions of age-related macular degeneration. Results of a randomized clinical trial. Macular Photocoagulation Study Group.

Author:

Macular degeneration treatment

A study of 496 patients with macular degeneration compared krypton laser photocoagulation to no treatment. After 3 years, 49% of treated eyes lost 6 or more lines of vision compared to 58% of untreated eyes. While laser treatment appeared to be beneficial for patients without hypertension, there was no apparent benefit for patients with high blood pressure or those taking antihypertensive medications. Therefore, laser treatment for macular degeneration is recommended for patients without hypertension, but not for those with high blood pressure.

Clinical TrialA clinical trial is a planned study conducted on humans to evaluate the efficacy and safety of pharmaceuticals, medical devices, and treatment methods. It aims to explore the possibilities of new treatments and improve the health of patients.
Comparative StudyResearch that compares multiple groups/interventions to determine differences/similarities in outcomes/characteristics.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Multicenter StudyResearch conducted in collaboration with multiple research institutions. It aims to collect a wide range of data and obtain more generalizable results.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.
Research Support, U.S. Gov't, P.H.S.Research funding provided by the Public Health Service (PHS).

Language : English

3.

Argon laser photocoagulation for neovascular maculopathy. Five-year results from randomized clinical trials. Macular Photocoagulation Study Group.

Author:

Macular degeneration treatment

A study of 236 patients with extrafoveal choroidal neovascular membranes found that laser treatment significantly reduced the risk of vision loss compared to no treatment for at least 5 years. For patients with senile macular degeneration, the risk of losing 6 or more lines of vision was 1.5 times higher in untreated eyes compared to treated eyes. For patients with ocular histoplasmosis, untreated eyes had 3.6 times the risk of vision loss.

Clinical TrialA clinical trial is a planned study conducted on humans to evaluate the efficacy and safety of pharmaceuticals, medical devices, and treatment methods. It aims to explore the possibilities of new treatments and improve the health of patients.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.
Research Support, U.S. Gov't, P.H.S.Research funding provided by the Public Health Service (PHS).

Language : English

4.

Argon laser photocoagulation for neovascular maculopathy. Three-year results from randomized clinical trials. Macular Photocoagulation Study Group.

Author:

Delayed vision loss
Improved vision

This study investigated the effectiveness of laser treatment for a condition called choroidal neovascular membrane (CNVM) in eyes with age-related macular degeneration, ocular histoplasmosis, or unknown causes. After 3 years, laser treatment significantly reduced the risk of severe vision loss compared to no treatment, particularly for patients with ocular histoplasmosis. The study concludes that laser treatment is effective in preventing vision loss from CNVM, and ongoing research is assessing its effectiveness over 5 years.

Clinical TrialA clinical trial is a planned study conducted on humans to evaluate the efficacy and safety of pharmaceuticals, medical devices, and treatment methods. It aims to explore the possibilities of new treatments and improve the health of patients.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.
Research Support, U.S. Gov't, P.H.S.Research funding provided by the Public Health Service (PHS).

Language : English

5.

[Indications, technics and results of argon laser photocoagulation of macular subretinal neovascularization].

Author: CoscasG, SoubraneG

Macular degeneration treatment
Visual acuity stabilized

A study of 60 patients with senile macular degeneration compared the effectiveness of argon laser treatment for destroying new blood vessels in the eye. Laser treatment was found to be significantly effective in stabilizing or improving vision compared to no treatment. The effectiveness was not significantly different based on the location of the new vessels in relation to the center of the eye. While laser treatment was effective for some, there was no difference in vision outcomes between treated and untreated groups for those who did not respond to treatment. The study concludes that laser treatment is a promising option for managing senile macular degeneration, but it is not effective for all patients.

Clinical TrialA clinical trial is a planned study conducted on humans to evaluate the efficacy and safety of pharmaceuticals, medical devices, and treatment methods. It aims to explore the possibilities of new treatments and improve the health of patients.
English AbstractA summary of a research paper/publication written in English for a wider audience.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.

Language : French

6.

Argon laser photocoagulation for senile macular degeneration. Results of a randomized clinical trial.

Author:

Prevented severe visual loss

Laser treatment was found to be effective in preventing severe vision loss in patients with senile macular degeneration, with 25% of treated eyes experiencing severe visual loss compared to 60% of untreated eyes after 18 months.

Clinical TrialA clinical trial is a planned study conducted on humans to evaluate the efficacy and safety of pharmaceuticals, medical devices, and treatment methods. It aims to explore the possibilities of new treatments and improve the health of patients.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.
Research Support, U.S. Gov't, P.H.S.Research funding provided by the Public Health Service (PHS).

Language : English

7.

Pattern-reversal electroretinographic follow-up of laser photocoagulation for subfoveal neovascular lesions in age-related macular degeneration.

Author: BirchD G, AndersonJ L, FishG E, JostB F

Less loss of acuity

This study of 42 patients with subfoveal neovascular lesions found that laser photocoagulation slowed the decline in pattern-reversal electroretinographic acuity compared to no treatment.

Clinical TrialA clinical trial is a planned study conducted on humans to evaluate the efficacy and safety of pharmaceuticals, medical devices, and treatment methods. It aims to explore the possibilities of new treatments and improve the health of patients.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.
Research Support, U.S. Gov't, P.H.S.Research funding provided by the Public Health Service (PHS).

Language : English

8.

Laser photocoagulation for macular soft drusen. Updated results.

Author: FigueroaM S, ReguerasA, BertrandJ, AparicioM J, ManriqueM G

Drusen disappearance
Cataract progression
Neovascularization

Laser treatment of macular soft drusen resulted in the disappearance of all treated drusen within 3.5 months, compared to 8.5 months for untreated drusen. The treatment may be effective for patients with high-risk bilateral soft drusen but does not appear to reduce the risk of choroidal neovascularization.

Clinical TrialA clinical trial is a planned study conducted on humans to evaluate the efficacy and safety of pharmaceuticals, medical devices, and treatment methods. It aims to explore the possibilities of new treatments and improve the health of patients.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.

Language : English

9.

Photodynamic therapy for neovascular age-related macular degeneration.

Author: WormaldR, EvansJ, SmeethL

Improved neovascular age-related macular degeneration treatment

Neovascular age-related macular degeneration involves abnormal blood vessel growth under the retina, causing vision problems and scarring. Leaking blood vessels worsen the condition. Photodynamic therapy, originally used for cancer, is being studied as a way to treat these abnormal blood vessels without damaging the retina.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
ReviewAn article that critically examines existing research on a particular topic and summarizes the current state of knowledge in the field.
Systematic ReviewA review that systematically collects, evaluates, and integrates relevant research to answer a specific research question.

Language : English

10.

Photodynamic therapy for neovascular age-related macular degeneration.

Author: WormaldR, EvansJ, SmeethL, HenshawK

Treatment of neovascular membranes

Neovascular age-related macular degeneration involves the growth of abnormal blood vessels under the retina, causing vision distortion and scarring. Leaking blood vessels worsen the condition. Photodynamic therapy, originally used for cancer, is being researched as a way to treat these abnormal blood vessels without harming the retina.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
ReviewAn article that critically examines existing research on a particular topic and summarizes the current state of knowledge in the field.
Systematic ReviewA review that systematically collects, evaluates, and integrates relevant research to answer a specific research question.

Language : English

11.

Predictors of drusen reduction after subthreshold infrared (810 nm) diode laser macular grid photocoagulation for nonexudative age-related macular degeneration.

Author: RodanantNuttawut, FribergThomas R, ChengLingyun, AuroraAjay, BartschDirk, ToyoguchiMitsuko, CorbinPatricia S, El-BradeyMohamed H, FreemanWilliam R

ARMD treatment

The study investigates predictors of drusen reduction and its relationship to visual acuity after subthreshold infrared laser treatment for nonexudative age-related macular degeneration (ARMD).

Clinical TrialA clinical trial is a planned study conducted on humans to evaluate the efficacy and safety of pharmaceuticals, medical devices, and treatment methods. It aims to explore the possibilities of new treatments and improve the health of patients.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Multicenter StudyResearch conducted in collaboration with multiple research institutions. It aims to collect a wide range of data and obtain more generalizable results.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.
Research Support, U.S. Gov't, P.H.S.Research funding provided by the Public Health Service (PHS).

Language : English

12.

Verteporfin therapy of subfoveal choroidal neovascularization in patients with age-related macular degeneration: additional information regarding baseline lesion composition's impact on vision outcomes-TAP report No. 3.

Author: BresslerNeil M, ArnoldJennifer, BenchabouneMustapha, BlumenkranzMark S, FishGary E, GragoudasEvangelos S, LewisHilel, Schmidt-ErfurthUrsula, SlakterJason S, BresslerSusan B, ManosKelly, HaoYong, HayesLaurie, KoesterJohn, ReavesAl, StrongH Andrew,

The study explores the relationship between baseline lesion composition and vision outcomes in patients with age-related macular degeneration (AMD) undergoing photodynamic therapy with verteporfin (Visudyne) for subfoveal choroidal neovascularization (CNV).

Clinical TrialA clinical trial is a planned study conducted on humans to evaluate the efficacy and safety of pharmaceuticals, medical devices, and treatment methods. It aims to explore the possibilities of new treatments and improve the health of patients.
Comparative StudyResearch that compares multiple groups/interventions to determine differences/similarities in outcomes/characteristics.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Meta-AnalysisA statistical technique that integrates the results of multiple studies to draw more general conclusions about a particular issue.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.

Language : English

13.

Effects of verteporfin therapy on contrast on sensitivity: Results From the Treatment of Age-Related Macular Degeneration With Photodynamic Therapy (TAP) investigation-TAP report No 4.

Author: RubinGary S, BresslerNeil M,

Reduced vision loss

This study examined the effects of verteporfin therapy on contrast sensitivity (the ability to see differences in shades) in patients with age-related macular degeneration (AMD) who had abnormal blood vessel growth (choroidal neovascularization, CNV) under the macula. The study found that verteporfin therapy, a type of photodynamic therapy, reduced the risk of significant vision loss (at least 15 letters of vision acuity) in these patients. The study further analyzed contrast sensitivity outcomes in these patients over two years.

Clinical TrialA clinical trial is a planned study conducted on humans to evaluate the efficacy and safety of pharmaceuticals, medical devices, and treatment methods. It aims to explore the possibilities of new treatments and improve the health of patients.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Multicenter StudyResearch conducted in collaboration with multiple research institutions. It aims to collect a wide range of data and obtain more generalizable results.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.

Language : English

14.

[Photodynamic therapy for age related macular degeneration with and without antioxidants].

Author: ScorolliLucia, ScalinciSergio Z, LimoliPaolo G, MoraraMariachiara, VismaraSabrina, ScorolliLuigi, CorazzaDaniele, MeduriRenato

Improved retinal metabolic function

Treatment with antioxidants after photodynamic therapy for age-related macular degeneration (AMD) improves retinal metabolic function in the short term.

Clinical TrialA clinical trial is a planned study conducted on humans to evaluate the efficacy and safety of pharmaceuticals, medical devices, and treatment methods. It aims to explore the possibilities of new treatments and improve the health of patients.
Comparative StudyResearch that compares multiple groups/interventions to determine differences/similarities in outcomes/characteristics.
English AbstractA summary of a research paper/publication written in English for a wider audience.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.

Language : French

15.

Photodynamic therapy for neovascular age-related macular degeneration.

Author: WormaldR, EvansJ, SmeethL, HenshawK

Treatment of neovascular membranes

Neovascular age-related macular degeneration involves abnormal blood vessel growth under the retina, causing vision problems and scarring. Leaking blood vessels worsen the condition. Photodynamic therapy, originally used for cancer, is being studied as a way to treat these abnormal blood vessels without damaging the retina.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
ReviewAn article that critically examines existing research on a particular topic and summarizes the current state of knowledge in the field.
Systematic ReviewA review that systematically collects, evaluates, and integrates relevant research to answer a specific research question.

Language : English

16.

[Phototoxic drugs and age-related maculopathy].

Author: de La MarnierreE, GuigonB, QuarantaM, Mauget-FaÿsseM

Phototoxic drug risk

Severe neovascular AMD is associated with long-term thiazide diuretic treatment.

Clinical TrialA clinical trial is a planned study conducted on humans to evaluate the efficacy and safety of pharmaceuticals, medical devices, and treatment methods. It aims to explore the possibilities of new treatments and improve the health of patients.
English AbstractA summary of a research paper/publication written in English for a wider audience.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.

Language : French

17.

Radiotherapy for neovascular age-related macular degeneration.

Author: SivagnanavelV, EvansJ R, OckrimZ, ChongV

Reduced vessel growth
Inconclusive results

The review found no strong evidence that external beam radiotherapy is an effective treatment for neovascular age-related macular degeneration (AMD). Further trials are warranted, particularly comparing radiotherapy to photodynamic therapy.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Meta-AnalysisA statistical technique that integrates the results of multiple studies to draw more general conclusions about a particular issue.
ReviewAn article that critically examines existing research on a particular topic and summarizes the current state of knowledge in the field.
Systematic ReviewA review that systematically collects, evaluates, and integrates relevant research to answer a specific research question.

Language : English

18.

Enhanced efficacy associated with early treatment of neovascular age-related macular degeneration with pegaptanib sodium: an exploratory analysis.

Author: GonzalesChristine R,

Early AMD treatment
Vision improvement

Early detection and treatment with pegaptanib may result in superior vision outcomes in patients with neovascular AMD. Pegaptanib responder rates were significantly higher than those receiving usual care.

Clinical TrialA clinical trial is a planned study conducted on humans to evaluate the efficacy and safety of pharmaceuticals, medical devices, and treatment methods. It aims to explore the possibilities of new treatments and improve the health of patients.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Multicenter StudyResearch conducted in collaboration with multiple research institutions. It aims to collect a wide range of data and obtain more generalizable results.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.

Language : English

19.

Ranibizumab for treatment of neovascular age-related macular degeneration: a phase I/II multicenter, controlled, multidose study.

Author: HeierJeffrey S, AntoszykAndrew N, PavanPeter Reed, LeffSteven R, RosenfeldPhilip J, CiullaThomas A, DreyerRichard F, GentileRonald C, SyJudy P, HantsbargerGary, ShamsNaveed

Decreased leakage
Improved vision
Well tolerated
Endophthalmitis
Hemorrhage
Increased IOP
Inflammation
Iridocyclitis
Retinal vein occlusion

Repeated intravitreal injections of ranibizumab had a good safety profile and were associated with improved VA and decreased leakage from choroidal neovascularization in subjects with neovascular AMD.

Clinical Trial, Phase IThe first stage of clinical trials in humans. Evaluates the safety, tolerability, and pharmacokinetics of a new drug/treatment.
Clinical Trial, Phase IIA Phase II trial is a trial that further evaluates the efficacy and safety of a new drug or treatment, whose safety has been confirmed to some extent in a Phase I trial, in a small number of patients.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Multicenter StudyResearch conducted in collaboration with multiple research institutions. It aims to collect a wide range of data and obtain more generalizable results.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.

Language : English

20.

Long-term effect of laser treatment for dry age-related macular degeneration on choroidal hemodynamics.

Author: FigueroaMauricio, SchocketLisa S, DuPontJoan, MetelitsinaTatyana I, GrunwaldJuan E

Increase blood flow

Laser treatment according to the CAPT protocol was associated with an increase in choroidal blood flow 28 months after treatment.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.
Research Support, N.I.H., ExtramuralResearch funding provided by the NIH to external research institutions and researchers.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.

Language : English

21.

Verteporfin therapy of subfoveal choroidal neovascularization in age-related macular degeneration: 5-year results of two randomized clinical trials with an open-label extension: TAP report no. 8.

Author: KaiserPeter K,

Stable vision outcomes
Infusion-related back pain
Photosensitivity reactions

Vision outcomes with verteporfin therapy remained relatively stable over 5 years in patients with subfoveal choroidal neovascularization (CNV) in age-related macular degeneration. No new safety concerns were identified, allowing for repeated verteporfin therapy.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Multicenter StudyResearch conducted in collaboration with multiple research institutions. It aims to collect a wide range of data and obtain more generalizable results.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.

Language : English

22.

Prophylactic treatment of age-related macular degeneration report number 1: 810-nanometer laser to eyes with drusen. Unilaterally eligible patients.

Author: FribergThomas R, MuschDavid C, LimJennifer I, MorseLarry, FreemanWilliam, SinclairSteven,

Macular degeneration treatment

The study aimed to determine the effects of subthreshold 810-nm-diode laser treatment on the rate of development of choroidal neovascularization (primary end point) and the effect on visual acuity (VA) in participants with multiple large drusen in one eye and a preexisting neovascular age-related macular degeneration (AMD) lesion in the other.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Multicenter StudyResearch conducted in collaboration with multiple research institutions. It aims to collect a wide range of data and obtain more generalizable results.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.

Language : English

23.

Full macular translocation versus photodynamic therapy with verteporfin in the treatment of neovascular age-related macular degeneration: 1-year results of a prospective, controlled, randomised pilot trial (FMT-PDT).

Author: GeliskenFaik, VoelkerMichael, SchwabeRainer, BeschDorothea, AisenbreySabine, SzurmanPeter, GrisantiSalvatore, HerzauVolker, Bartz-SchmidtKarl U

Improves vision
Retinal detachment

Full macular translocation (FMT) had a higher chance of vision improvement compared with photodynamic therapy (PDT) in the treatment of neovascular AMD.

Comparative StudyResearch that compares multiple groups/interventions to determine differences/similarities in outcomes/characteristics.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.

Language : English

24.

TOZAL Study: an open case control study of an oral antioxidant and omega-3 supplement for dry AMD.

Author: CangemiFrancis E

Macular degeneration treatment

The study measured the change from baseline in visual function in subjects with atrophic (dry) age-related macular degeneration treated with a targeted nutritional supplement.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.

Language : English

25.

Quality of life in a prospective, randomised pilot-trial of photodynamic therapy versus full macular translocation in treatment of neovascular age-related macular degeneration--a report of 1 year results.

Author: LükeMatthias, ZiemssenFocke, Bartz-SchmidtKarl Ulrich, GeliskenFaik

Improved QOL
Stabilized vision
FMT complications

This study assessed visual function and its effects on vision-targeted, health-related quality of life (QOL) of patients with neovascular age-related macular degeneration (AMD) treated with photodynamic therapy (PDT) or full macular translocation (FMT). The study found that FMT and PDT can achieve a stabilisation in vision-related QOL, in which FMT was superior to the PDT after 1 year.

Comparative StudyResearch that compares multiple groups/interventions to determine differences/similarities in outcomes/characteristics.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.

Language : English

26.

Laser photocoagulation for neovascular age-related macular degeneration.

Author: VirgiliG, BiniA

Improved neovascular age-related macular degeneration treatment
Neovascular age-related macular degeneration

Laser photocoagulation was the first treatment used to try to stop the progression of neovascular age-related macular degeneration (AMD), a condition where abnormal blood vessels (choroidal neovascularization, CNV) grow under the macula, causing a blind spot in central vision.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Meta-AnalysisA statistical technique that integrates the results of multiple studies to draw more general conclusions about a particular issue.
ReviewAn article that critically examines existing research on a particular topic and summarizes the current state of knowledge in the field.
Systematic ReviewA review that systematically collects, evaluates, and integrates relevant research to answer a specific research question.

Language : English

27.

Surgical implantation of steroids with antiangiogenic characteristics for treating neovascular age-related macular degeneration.

Author: GeltzerA, TuralbaA, VedulaS S

Stabilizes vision
Cataract formation
Increased IOP

This review found that intravitreal triamcinolone injection for neovascular AMD does not appear to prevent severe vision loss and is associated with increased IOP and higher risk of cataract formation. Anecortave acetate 15 mg may have a mild benefit in stabilizing vision, but further better quality evidence is needed.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
ReviewAn article that critically examines existing research on a particular topic and summarizes the current state of knowledge in the field.
Systematic ReviewA review that systematically collects, evaluates, and integrates relevant research to answer a specific research question.

Language : English

28.

Reduced fluence versus standard photodynamic therapy in combination with intravitreal triamcinolone: short-term results of a randomised study.

Author: SacuS, VargaA, MichelsS, WeigertG, PolakK, Vécsei-MarlovitsP V, Schmidt-ErfurthU

Improved visual outcome
Lower recurrence rate
Reduced choroidal alteration
Choroidal hypoperfusion

Reduced fluence photodynamic therapy (rPDT) followed by intravitreal triamcinolone (IVTA) had a significantly better visual outcome, less alteration of the choroid, and a trend for lower recurrence rate than standard photodynamic therapy (sPDT) + IVTA in a study of 40 patients with neovascular age-related macular degeneration.

Comparative StudyResearch that compares multiple groups/interventions to determine differences/similarities in outcomes/characteristics.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.

Language : English

29.

Surgery for cataracts in people with age-related macular degeneration.

Author: CasparisHeather, LindsleyKristina, BresslerNeil B

Cataracts and age-related macular degeneration (AMD) are common causes of vision loss in older adults and often occur together. While cataract surgery is effective, some doctors are concerned that it might worsen AMD, leading to a greater loss of vision.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
ReviewAn article that critically examines existing research on a particular topic and summarizes the current state of knowledge in the field.
Systematic ReviewA review that systematically collects, evaluates, and integrates relevant research to answer a specific research question.

Language : English

30.

Full macular translocation (FMT) versus photodynamic therapy (PDT) with verteporfin in the treatment of neovascular age-related macular degeneration: 2-year results of a prospective, controlled, randomised pilot trial (FMT-PDT).

Author: LükeMatthias, ZiemssenFocke, VölkerMichael, AltpeterElke, BeutelJulia, BeschDorothea, Bartz-SchmidtKarl Ulrich, GeliskenFaik

This study reports on the visual outcomes of patients two years after undergoing photodynamic therapy (PDT) or full macular translocation (FMT) for neovascular age-related macular degeneration (AMD). The outcomes assessed included best-corrected visual acuity (BCVA), near visual acuity (NVA), contrast sensitivity (CS), and vision-related quality of life (VRQOL).

Comparative StudyResearch that compares multiple groups/interventions to determine differences/similarities in outcomes/characteristics.
Historical ArticleA research paper that analyzes past events and developments using primary sources and examines them from a historical perspective.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.

Language : English

31.

Laser treatment of drusen to prevent progression to advanced age-related macular degeneration.

Author: ParodiMaurizio B, VirgiliGianni, EvansJennifer R

AMD prevention
Drusen disappearance
CNV risk

Drusen are deposits under the retina that are associated with an increased risk of age-related macular degeneration (AMD), particularly the development of choroidal neovascularization (CNV). This study explores the potential of laser photocoagulation of drusen to prevent advanced AMD and visual loss.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Meta-AnalysisA statistical technique that integrates the results of multiple studies to draw more general conclusions about a particular issue.
ReviewAn article that critically examines existing research on a particular topic and summarizes the current state of knowledge in the field.
Systematic ReviewA review that systematically collects, evaluates, and integrates relevant research to answer a specific research question.

Language : English

32.

Changes in macular sensitivity after reduced fluence photodynamic therapy combined with intravitreal triamcinolone.

Author: DunavoelgyiRoman, SacuStefan, SimaderChristian, PruenteChristian, Schmidt-ErfurthUrsula

Improved macular sensitivity

This study evaluated the course of macular sensitivity (MS) following treatment with reduced fluence photodynamic therapy (RPDT) versus standard photodynamic therapy (SPDT).

Comparative StudyResearch that compares multiple groups/interventions to determine differences/similarities in outcomes/characteristics.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.

Language : English

33.

Radiotherapy for neovascular age-related macular degeneration.

Author: EvansJennifer R, SivagnanavelVasuki, ChongVictor

Reduced visual acuity loss
Increased cataract progression
Uncertainty regarding efficacy

Radiotherapy for neovascular age-related macular degeneration (AMD) has not been conclusively proven effective. While some studies showed positive results, heterogeneity and risk of bias were significant concerns. Further research is needed with improved trial design and blinding to assess the true efficacy of radiotherapy for AMD.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Meta-AnalysisA statistical technique that integrates the results of multiple studies to draw more general conclusions about a particular issue.
ReviewAn article that critically examines existing research on a particular topic and summarizes the current state of knowledge in the field.
Systematic ReviewA review that systematically collects, evaluates, and integrates relevant research to answer a specific research question.

Language : English

34.

Bevacizumab for neovascular age related macular degeneration (ABC Trial): multicentre randomised double masked study.

Author: TufailAdnan, PatelPraveen J, EganCatherine, HykinPhilip, da CruzLyndon, GregorZdenek, DowlerJonathan, MajidMohammed A, BaileyClare, MohamedQuresh, JohnstonRobert, BunceCatey, XingWen,

Improved vision

Intravitreous bevacizumab injections were significantly superior to standard care in treating neovascular age-related macular degeneration. At one year, 32% of patients in the bevacizumab group gained ≥15 letters of visual acuity compared to only 3% in the standard care group (P < 0.001). Bevacizumab also resulted in a significantly higher proportion of patients with stable vision and improved mean visual acuity (P < 0.001). Importantly, there were no cases of endophthalmitis or serious uveitis related to bevacizumab treatment.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Multicenter StudyResearch conducted in collaboration with multiple research institutions. It aims to collect a wide range of data and obtain more generalizable results.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.

Language : English

35.

Pharmacologic management of neovascular age-related macular degeneration: systematic review of economic evidence and primary economic evaluation.

Author: HodgeWilliam, BrownAllan, KymesSteve, CruessAlan, BlackhouseGord, HopkinsRobert, McGahanLynda, SharmaSanjay, PanIrene, BlairJason, VollmanDavid, MorrisonAndra

Cost-effectiveness
Wet AMD treatment
High cost

Ranibizumab is an effective treatment for wet AMD but its cost is unacceptably high based on cost-utility theory.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.
ReviewAn article that critically examines existing research on a particular topic and summarizes the current state of knowledge in the field.
Systematic ReviewA review that systematically collects, evaluates, and integrates relevant research to answer a specific research question.

Language : English

36.

Ranibizumab for choroidal neovascularization secondary to causes other than age-related macular degeneration: a phase I clinical trial.

Author: HeierJeffrey S, BrownDavid, CiullaThomas, AbrahamPrema, BankertJoy M, ChongSandy, DanielPaul E, KimIvana K

Improved vision
Reduced CRT

Ranibizumab was effective and safe for treating choroidal neovascularization due to causes other than age-related macular degeneration, with no significant difference in efficacy between monthly injections and pro re nata dosing.

Clinical Trial, Phase IThe first stage of clinical trials in humans. Evaluates the safety, tolerability, and pharmacokinetics of a new drug/treatment.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Multicenter StudyResearch conducted in collaboration with multiple research institutions. It aims to collect a wide range of data and obtain more generalizable results.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.

Language : English

37.

A pilot study on the combination treatment of reduced-fluence photodynamic therapy, intravitreal ranibizumab, intravitreal dexamethasone and oral minocycline for neovascular age-related macular degeneration.

Author: SivaprasadS, PatraS, DaCostaJ, AdewoyinT, ShonaO, PearceE, ChongN V

Safe treatment
Stable vision

A combination treatment with verteporfin, ranibizumab, dexamethasone, and minocycline showed safety and stable vision in patients with exudative AMD.

Comparative StudyResearch that compares multiple groups/interventions to determine differences/similarities in outcomes/characteristics.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.

Language : English

38.

[Observation on therapeutic effect of age-related macular degeneration treated with acupuncture].

Author: JiaoNai-jun

AMD Treatment

Acupuncture was more effective than medication in treating age-related macular degeneration (AMD), with a total effective rate of 88.3% in the acupuncture group versus 60.0% in the medication group.

English AbstractA summary of a research paper/publication written in English for a wider audience.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.

Language : Chinese

39.

Ranibizumab and bevacizumab for neovascular age-related macular degeneration.

Author: , MartinDaniel F, MaguireMaureen G, YingGui-shuang, GrunwaldJuan E, FineStuart L, JaffeGlenn J

Equivalent efficacy
Visual acuity improvement
Systemic adverse events

Bevacizumab and ranibizumab had equivalent effects on visual acuity at 1 year when administered according to the same schedule. Differences in rates of serious adverse events require further study.

Comparative StudyResearch that compares multiple groups/interventions to determine differences/similarities in outcomes/characteristics.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Multicenter StudyResearch conducted in collaboration with multiple research institutions. It aims to collect a wide range of data and obtain more generalizable results.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.
Research Support, N.I.H., ExtramuralResearch funding provided by the NIH to external research institutions and researchers.

Language : English

40.

Incidence of retinal pigment epithelial tears after intravitreal ranibizumab injection for neovascular age-related macular degeneration.

Author: CunninghamEmmett T, FeinerLeonard, ChungCarol, TuomiLisa, EhrlichJason S

Ranibizumab AMD
RPE tear AMD

No statistically significant differences in the incidence of retinal pigment epithelium (RPE) tears were observed between patients treated with ranibizumab for neovascular age-related macular degeneration (AMD) and those receiving control treatment.

Clinical Trial, Phase IIIA Phase III trial is a trial that further rigorously verifies the efficacy and safety of a new drug or treatment, whose efficacy and safety have been confirmed in a Phase II trial, in a large number of patients, and evaluates whether it is superior to existing treatments.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Multicenter StudyResearch conducted in collaboration with multiple research institutions. It aims to collect a wide range of data and obtain more generalizable results.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.

Language : English

41.

Surgery for cataracts in people with age-related macular degeneration.

Author: CasparisHeather, LindsleyKristina, KuoIrene C, SikderShameema, BresslerNeil B

Treatment of cataract
Worsening of AMD

Cataracts and age-related macular degeneration (AMD) are common eye conditions that often occur together in people over 50. While cataract surgery effectively treats vision loss from cataracts, some doctors worry that it might worsen AMD, ultimately having a negative impact on vision.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Research Support, N.I.H., ExtramuralResearch funding provided by the NIH to external research institutions and researchers.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.
ReviewAn article that critically examines existing research on a particular topic and summarizes the current state of knowledge in the field.
Systematic ReviewA review that systematically collects, evaluates, and integrates relevant research to answer a specific research question.

Language : English

42.

Rheohaemapheresis in the treatment of nonvascular age-related macular degeneration.

Author: BlahaM, RencovaE, LangrovaH, StudnickaJ, BlahaV, RozsivalP, LanskaM, SobotkaL

Improved vision
Reduced drusenoid detachment

Rheohaemapheresis (RH) therapy favourably influenced best-corrected visual acuity (BCVA). No progression of dry to wet AMD was observed in patients after 2.5 years. RH reduced the area of drusenoid retinal pigment epithelium detachment.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.

Language : English

43.

Surgical implantation of steroids with antiangiogenic characteristics for treating neovascular age-related macular degeneration.

Author: GeltzerArthur, TuralbaAngela, VedulaSatyanarayana S

Neovascular AMD treatment
Limited data
Unclear role

A review of three randomized controlled trials found no evidence that antiangiogenic steroids prevent visual loss in patients with neovascular age-related macular degeneration (AMD). Further research is needed to determine the role of steroids in the treatment of neovascular AMD.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
ReviewAn article that critically examines existing research on a particular topic and summarizes the current state of knowledge in the field.
Systematic ReviewA review that systematically collects, evaluates, and integrates relevant research to answer a specific research question.

Language : English

44.

Ranibizumab treatment outcomes in phakic versus pseudophakic eyes: an individual patient data analysis of 2 phase 3 trials.

Author: WeinbergDavid V, ShapiroHoward, EhrlichJason S

Improved vision

Lens status did not significantly influence visual acuity for eyes treated with monthly ranibizumab for exudative age-related macular degeneration (AMD).

Comparative StudyResearch that compares multiple groups/interventions to determine differences/similarities in outcomes/characteristics.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Meta-AnalysisA statistical technique that integrates the results of multiple studies to draw more general conclusions about a particular issue.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.

Language : English

45.

Epimacular brachytherapy for neovascular age-related macular degeneration (CABERNET): fluorescein angiography and optical coherence tomography.

Author: JacksonTimothy L, DugelPravin U, BebchukJudith D, SmithKelly R, PetrarcaRobert, SlakterJason S, JaffeGlenn J, NauJeffrey A,

Improved vision
Radiation retinopathy

This study reports the results of a clinical trial comparing epimacular brachytherapy (EMBT) and ranibizumab injections for the treatment of neovascular age-related macular degeneration (AMD). Both FA and OCT suggest that EMBT with PRN ranibizumab results in an inferior structural outcome than quarterly plus PRN ranibizumab. A non-vision-threatening radiation retinopathy occurs in 2.9% of eyes over 24 months.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Multicenter StudyResearch conducted in collaboration with multiple research institutions. It aims to collect a wide range of data and obtain more generalizable results.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.

Language : English

46.

Alprostadil infusion in patients with dry age related macular degeneration: a randomized controlled clinical trial.

Author: AugustinAlbert J, DiehmCurt, GriegerFrank, BentzJuergen

dAMD treatment

Intravenous alprostadil infusion showed a numerical treatment effect in favor of alprostadil in patients with dry age-related macular degeneration (dAMD), which lasted until the end of follow-up. This suggests that alprostadil may have a therapeutic effect in the treatment of dAMD and justifies further clinical studies.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Multicenter StudyResearch conducted in collaboration with multiple research institutions. It aims to collect a wide range of data and obtain more generalizable results.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.

Language : English

47.

Macular morphology and visual acuity in the comparison of age-related macular degeneration treatments trials.

Author: JaffeGlenn J, MartinDaniel F, TothCynthia A, DanielEbenezer, MaguireMaureen G, YingGui-Shuang, GrunwaldJuan E, HuangJiayan,

Visual acuity gain
Abnormal retinal thickness
Residual IRF

Treatment with ranibizumab or bevacizumab for neovascular age-related macular degeneration (AMD) reduced lesion activity and improved visual acuity (VA) in all treatment groups. However, eyes with residual intraretinal fluid (IRF) had worse VA than those without. Eyes with abnormally thin or thick retinas, residual large lesions, and scar also had worse VA. Monthly ranibizumab dosing yielded more eyes with no fluid and an abnormally thin retina, although the long-term significance of this is unknown.

Comparative StudyResearch that compares multiple groups/interventions to determine differences/similarities in outcomes/characteristics.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Multicenter StudyResearch conducted in collaboration with multiple research institutions. It aims to collect a wide range of data and obtain more generalizable results.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.
Research Support, N.I.H., ExtramuralResearch funding provided by the NIH to external research institutions and researchers.

Language : English

49.

Effects of core vitrectomy in the treatment of age-related macular degeneration.

Author: SchrammKatharina, MuellerMichael, KochFrank H, SinghPankaj, KohnenThomas, KossMichael J

Macular thickness reduction
Visual acuity improvement

A study of 50 patients with exudative age-related macular degeneration (ARMD) found that an initial core vitrectomy combined with a conventional ranibizumab injection regimen was safe and led to similar functional results with fewer intravitreal ranibizumab injections over 48 weeks compared to 3x Rbz alone. The study found that 70.8% of patients in the vitrectomy group gained more than 1 line of BCVA, compared to 78.3% in the control group. The average injection rate was 3.66 in the vitrectomy group and 4.17 in the control group.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.

Language : English

50.

Differences of frequency in administration of ranibizumab and bevacizumab in patients with neovascular AMD.

Author: SchollerAndreas, Richter-MuekschSibylla, WeingesselBirgit, Vécsei-MarlovitsPia-Veronika

nAMD treatment

This study evaluated the number of intravitreal ranibizumab or bevacizumab injections needed within one year for treating neovascular age-related macular degeneration (nAMD).

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.

Language : English

51.

Sporadic visual acuity loss in the Comparison of Age-Related Macular Degeneration Treatments Trials (CATT).

Author: KimBenjamin J, YingGui-Shuang, HuangJiayan, LevyNicole E, MaguireMaureen G,

Sporadic vision loss

A cohort within a randomized clinical trial of 1185 patients with neovascular age-related macular degeneration (AMD) found that approximately 10% of patients experienced sporadic vision loss during anti-vascular endothelial growth factor treatment. This was defined as a decline of ≥15 letters from the previous visit, followed by a return at the next visit to no more than 5 letters worse than the visit before the VA loss. Baseline predictors for sporadic vision loss included worse baseline VA, scar, intraretinal foveal fluid on OCT, and medical history of anxiety and syncope. Refraction decreased the likelihood of sporadic vision loss.

Comparative StudyResearch that compares multiple groups/interventions to determine differences/similarities in outcomes/characteristics.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.
Research Support, N.I.H., ExtramuralResearch funding provided by the NIH to external research institutions and researchers.
Research Support, U.S. Gov't, Non-P.H.S.Research funding provided by US government agencies other than the Public Health Service.

Language : English

52.

Age-related macular degeneration: clinical findings, histopathology and imaging techniques.

Author: ZarbinMarco A, Casaroli-MaranoRicardo P, RosenfeldPhilip J

Antiangiogenic drugs
Ocular imaging technologies
AMD

Age-related macular degeneration (AMD) is a leading cause of blindness in older adults. Risk factors include age, smoking, race, and certain genetic mutations. AMD involves changes in the back of the eye, leading to vision loss. While treatments exist for some forms of AMD, there are no proven treatments for non-exudative AMD. New imaging technologies can track changes in the eye as AMD progresses, potentially leading to better ways to assess treatment effectiveness and to monitor the effects of new treatments like cell therapy.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Meta-AnalysisA statistical technique that integrates the results of multiple studies to draw more general conclusions about a particular issue.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.
ReviewAn article that critically examines existing research on a particular topic and summarizes the current state of knowledge in the field.

Language : English

53.

Sustained visual acuity loss in the comparison of age-related macular degeneration treatments trials.

Author: YingGui-shuang, KimBenjamin J, MaguireMaureen G, HuangJiayan, DanielEbenezer, JaffeGlenn J, GrunwaldJuan E, BlinderKevin J, FlaxelChristina J, RahhalFiras, RegilloCarl, MartinDaniel F,

Improved vision
Sustained vision loss

Sustained visual acuity loss was relatively rare in CATT. The development of foveal scar, pigmentary abnormalities, or GA contributed to most of the sustained visual acuity loss. Risk was 3% higher among eyes treated with bevacizumab. Treatment that targeted the prevention of scarring or GA may improve vision outcomes.

Comparative StudyResearch that compares multiple groups/interventions to determine differences/similarities in outcomes/characteristics.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.
Research Support, N.I.H., ExtramuralResearch funding provided by the NIH to external research institutions and researchers.

Language : English

54.

Low-level night-time light therapy for age-related macular degeneration (ALight): study protocol for a randomized controlled trial.

Author: McKeagueClaire, MargrainTom H, BaileyClare, BinnsAlison M

Reduced AMD progression
Light mask side effects

Age-related macular degeneration (AMD) is a leading cause of blindness in older adults. This trial investigates the potential of a light mask emitting dim, green light during the night to prevent the progression of early AMD, based on the hypothesis that hypoxia plays a role in AMD development.

Clinical Trial, Phase IThe first stage of clinical trials in humans. Evaluates the safety, tolerability, and pharmacokinetics of a new drug/treatment.
Clinical Trial, Phase IIA Phase II trial is a trial that further evaluates the efficacy and safety of a new drug or treatment, whose safety has been confirmed to some extent in a Phase I trial, in a small number of patients.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Multicenter StudyResearch conducted in collaboration with multiple research institutions. It aims to collect a wide range of data and obtain more generalizable results.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.

Language : English

55.

Intraretinal cysts are the most relevant prognostic biomarker in neovascular age-related macular degeneration independent of the therapeutic strategy.

Author: RitterMarkus, SimaderChristian, BolzMatthias, DeákGábor G, Mayr-SponerUlrike, SayeghRamzi, KundiMichael, Schmidt-ErfurthUrsula M

Improved visual acuity
Neovascular age-related macular degeneration

A study investigated the impact of antiangiogenic monotherapy and photodynamic therapy (PDT) on retinal morphology in patients with neovascular age-related macular degeneration (nAMD). The study found that the combination therapy (PDT and ranibizumab) decreased intraretinal cysts (IRC) and subretinal fluid (SRF) more effectively than monotherapy. Patients with IRC had the lowest initial visual acuity and were less likely to improve functionally.

Clinical Trial, Phase IIA Phase II trial is a trial that further evaluates the efficacy and safety of a new drug or treatment, whose safety has been confirmed to some extent in a Phase I trial, in a small number of patients.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Multicenter StudyResearch conducted in collaboration with multiple research institutions. It aims to collect a wide range of data and obtain more generalizable results.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.

Language : English

56.

Earlier therapeutic effects associated with high dose (2.0 mg) Ranibizumab for treatment of vascularized pigment epithelial detachments in age-related macular degeneration.

Author: ChanC K, AbrahamP, SarrafD, NuthiA S D, LinS G, McCannelC A

CNV resolution
RPE tears

This prospective study of 136 patients with vascularized pigment epithelial detachment (vPED) due to age-related macular degeneration compared the outcomes of 0.5 vs 2.0 mg intravitreal ranibizumab injections (RI). Both doses yielded similar visual and anatomical outcomes at the end of the study; however, the higher dose yielded more rapid reductions and more complete resolution of the PED, although there was possible increased tendency for an RPE tear with the higher dose.

Comparative StudyResearch that compares multiple groups/interventions to determine differences/similarities in outcomes/characteristics.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Multicenter StudyResearch conducted in collaboration with multiple research institutions. It aims to collect a wide range of data and obtain more generalizable results.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.

Language : English

57.

Outcomes of eyes with lesions composed of >50% blood in the Comparison of Age-related Macular Degeneration Treatments Trials (CATT).

Author: AltaweelMichael M, DanielEbenezer, MartinDaniel F, MittraRobert A, GrunwaldJuan E, LaiMichael M, MelamudAlexander, MorseLawrence S, HuangJiayan, FerrisFrederick L, FineStuart L, MaguireMaureen G,

Lesion size reduction
Similar visual prognosis
Worse baseline VA

This prospective cohort study of 1185 patients enrolled in the Comparison of Age-Related Macular Degeneration Treatments Trials (CATT) found that eyes with >50% of the lesion composed of blood had a visual prognosis similar to eyes with less or no blood. Lesion size decreased markedly through 2 years.

Comparative StudyResearch that compares multiple groups/interventions to determine differences/similarities in outcomes/characteristics.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Multicenter StudyResearch conducted in collaboration with multiple research institutions. It aims to collect a wide range of data and obtain more generalizable results.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.
Research Support, N.I.H., ExtramuralResearch funding provided by the NIH to external research institutions and researchers.

Language : English

58.

Optical coherence tomography for the diagnosis, monitoring and guiding of treatment for neovascular age-related macular degeneration: a systematic review and economic evaluation.

Author: MowattGraham, HernándezRodolfo, CastilloMayret, LoisNoemi, EldersAndrew, FraserCynthia, AremuOlatunde, AmoakuWinfried, BurrJennifer, LoteryAndrew, RamsayCraig, Azuara-BlancoAugusto

High sensitivity
Moderate specificity

Optical coherence tomography (OCT) showed high sensitivity and moderate specificity for diagnosing neovascular age-related macular degeneration (nAMD) and relatively high sensitivity but low specificity for monitoring. Strategies involving OCT alone for diagnosis or monitoring were unlikely to be cost-effective.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.
ReviewAn article that critically examines existing research on a particular topic and summarizes the current state of knowledge in the field.
Systematic ReviewA review that systematically collects, evaluates, and integrates relevant research to answer a specific research question.

Language : English

59.

Systemic safety of anti-VEGF drugs: a commentary.

Author: ScottLauren J, ChakravarthyUsha, ReevesBarnaby C, RogersChris A

Aflibercept
Bevacizumab
Ranibizumab
Neovascular age-related macular degeneration

This research addresses concerns regarding the use of VEGF inhibitors for treating neovascular age-related macular degeneration (nAMD). The study examines the use of ranibizumab, aflibercept, and bevacizumab, VEGF inhibitors that have been licensed or used off-label for nAMD, exploring the potential risks and benefits of these therapies.

Comparative StudyResearch that compares multiple groups/interventions to determine differences/similarities in outcomes/characteristics.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Meta-AnalysisA statistical technique that integrates the results of multiple studies to draw more general conclusions about a particular issue.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.
ReviewAn article that critically examines existing research on a particular topic and summarizes the current state of knowledge in the field.
Systematic ReviewA review that systematically collects, evaluates, and integrates relevant research to answer a specific research question.

Language : English

60.

Pigment epithelial detachment followed by retinal cystoid degeneration leads to vision loss in treatment of neovascular age-related macular degeneration.

Author: Schmidt-ErfurthUrsula, WaldsteinSebastian M, DeakGabor-Gyoergy, KundiMichael, SimaderChristian

Improved AMD treatment

This study examines the use of optical coherence tomography (OCT) for monitoring intravitreal antiangiogenic therapy in neovascular age-related macular degeneration (AMD). The study investigates the relationship between structural and functional outcomes using FDA- and EMA-approved treatments.

Clinical Trial, Phase IIIA Phase III trial is a trial that further rigorously verifies the efficacy and safety of a new drug or treatment, whose efficacy and safety have been confirmed in a Phase II trial, in a large number of patients, and evaluates whether it is superior to existing treatments.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Multicenter StudyResearch conducted in collaboration with multiple research institutions. It aims to collect a wide range of data and obtain more generalizable results.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.

Language : English

61.

Predictors of 1-year visual outcome in OCT analysis comparing ranibizumab monotherapy versus combination therapy with PDT in exsudative age-related macular degeneration.

Author: WeingesselBirgit, MihaltzKata, Vécsei-MarlovitsPia Veronika

Visual gain
IS/OS disruption
Visual loss

Better baseline best-corrected visual acuity (BCVA) and the integrity of the inner segment/outer segment (IS/OS) junction at 12 months were the most important predictive factors for final BCVA. Combination therapy caused worse final BCVA and a higher degree of IS/OS disruption.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.

Language : English

62.

Subretinal Hyperreflective Material in the Comparison of Age-Related Macular Degeneration Treatments Trials.

Author: WilloughbyAlex S, YingGui-Shuang, TothCynthia A, MaguireMaureen G, BurnsRussell E, GrunwaldJuan E, DanielEbenezer, JaffeGlenn J,

Worse visual acuity

Subretinal hyperreflective material (SHRM) is common and often persists after anti-VEGF treatment. At 2 years, eyes with scar were more likely to have SHRM. Greater SHRM dimensions were associated with worse VA.

Comparative StudyResearch that compares multiple groups/interventions to determine differences/similarities in outcomes/characteristics.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Multicenter StudyResearch conducted in collaboration with multiple research institutions. It aims to collect a wide range of data and obtain more generalizable results.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.
Research Support, N.I.H., ExtramuralResearch funding provided by the NIH to external research institutions and researchers.

Language : English

63.

CONVERSION TO AFLIBERCEPT THERAPY VERSUS CONTINUING WITH RANIBIZUMAB THERAPY FOR NEOVASCULAR AGE-RELATED MACULAR DEGENERATION DEPENDENT ON MONTHLY RANIBIZUMAB TREATMENT.

Author: MantelIrmela, GianniouChristina, DiraniAli

Neovascular age-related macular degeneration treatment

This study compared the effects of converting to aflibercept therapy versus continuing ranibizumab therapy in eyes with neovascular age-related macular degeneration. The study found that there was no statistical difference between the two treatments, and both groups responded similarly.

Comparative StudyResearch that compares multiple groups/interventions to determine differences/similarities in outcomes/characteristics.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.

Language : English

64.

Optical Coherence Tomography Monitoring Strategies for A-VEGF-Treated Age-Related Macular Degeneration: An Evidence-Based Analysis.

Author: PronG

Anti-angiogenesis drugs for AMD
Adverse events
Burdensome treatment
Complications

New medications for age-related macular degeneration (AMD), a leading cause of blindness in older adults, have improved treatment, but the monthly injections are inconvenient and carry risks. While the medications work well for most people, the individual response to treatment is highly variable. This means that using the same treatment plan for everyone may not be optimal, and can lead to under- or over-treatment, as well as unnecessary costs.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
ReviewAn article that critically examines existing research on a particular topic and summarizes the current state of knowledge in the field.
Systematic ReviewA review that systematically collects, evaluates, and integrates relevant research to answer a specific research question.

Language : English

65.

Association of Baseline Characteristics and Early Vision Response with 2-Year Vision Outcomes in the Comparison of AMD Treatments Trials (CATT).

Author: YingGui-shuang, MaguireMaureen G, DanielEbenezer, FerrisFrederick L, JaffeGlenn J, GrunwaldJuan E, TothCynthia A, HuangJiayan, MartinDaniel F,

Continued treatment
Early VA response
Improved VA response

This study found that visual acuity response at week 12 was more predictive of 2-year vision outcomes in patients with age-related macular degeneration (AMD) than baseline characteristics or week 4 response. Eyes with poor initial response may benefit from continued treatment with the same drug and regimen without switching to another drug.

Comparative StudyResearch that compares multiple groups/interventions to determine differences/similarities in outcomes/characteristics.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Multicenter StudyResearch conducted in collaboration with multiple research institutions. It aims to collect a wide range of data and obtain more generalizable results.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.
Research Support, N.I.H., ExtramuralResearch funding provided by the NIH to external research institutions and researchers.

Language : English

66.

Gene therapy with recombinant adeno-associated vectors for neovascular age-related macular degeneration: 1 year follow-up of a phase 1 randomised clinical trial.

Author: RakoczyElizabeth P, LaiChooi-May, MagnoAaron L, WikstromMatthew E, FrenchMartyn A, PierceCora M, SchwartzSteven D, BlumenkranzMark S, ChalbergThomas W, Degli-EspostiMariapia A, ConstableIan J

Wet AMD treatment

Neovascular age-related macular degeneration (AMD) causes vision loss and is currently treated with frequent injections. This study examines the safety of a single subretinal injection of rAAV.sFLT-1 as a potential gene therapy for wet AMD.

Clinical Trial, Phase IThe first stage of clinical trials in humans. Evaluates the safety, tolerability, and pharmacokinetics of a new drug/treatment.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Multicenter StudyResearch conducted in collaboration with multiple research institutions. It aims to collect a wide range of data and obtain more generalizable results.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.

Language : English

67.

Predictive Value of Retinal Morphology for Visual Acuity Outcomes of Different Ranibizumab Treatment Regimens for Neovascular AMD.

Author: WaldsteinSebastian M, WrightJonathan, WarburtonJames, MargaronPhilippe, SimaderChristian, Schmidt-ErfurthUrsula

Improved BCVA

Patients with neovascular age-related macular degeneration (nAMD) who have both subretinal fluid (SRF) and posterior vitreous detachment (PVD) at baseline may require less frequent treatments compared with patients without SRF or PVD.

Clinical Trial, Phase IIIA Phase III trial is a trial that further rigorously verifies the efficacy and safety of a new drug or treatment, whose efficacy and safety have been confirmed in a Phase II trial, in a large number of patients, and evaluates whether it is superior to existing treatments.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Multicenter StudyResearch conducted in collaboration with multiple research institutions. It aims to collect a wide range of data and obtain more generalizable results.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.

Language : English

68.

Laser treatment of drusen to prevent progression to advanced age-related macular degeneration.

Author: VirgiliGianni, MichelessiManuele, ParodiMaurizio B, BacheriniDaniela, EvansJennifer R

Laser photocoagulation for drusen

This research examines the use of laser photocoagulation for treating drusen, a common precursor to age-related macular degeneration (AMD). The study explores the potential of laser therapy in preventing advanced AMD and visual loss.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Meta-AnalysisA statistical technique that integrates the results of multiple studies to draw more general conclusions about a particular issue.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.
ReviewAn article that critically examines existing research on a particular topic and summarizes the current state of knowledge in the field.
Systematic ReviewA review that systematically collects, evaluates, and integrates relevant research to answer a specific research question.

Language : English

69.

Angiographic Cystoid Macular Edema and Outcomes in the Comparison of Age-Related Macular Degeneration Treatments Trials.

Author: ShahNeepa, MaguireMaureen G, MartinDaniel F, ShafferJames, YingGui-Shuang, GrunwaldJuan E, TothCynthia A, JaffeGlenn J, DanielEbenezer,

VA improvement
Scarring

Eyes with CME had worse baseline and follow-up VA, although all groups showed similar rates of improvement in VA during 2 years of follow-up. Cystoid macular edema seems to be a marker for poorer visual outcomes in nAMD because of underlying baseline retinal dysfunction and subsequent scarring. At baseline, eyes with CME had worse mean VA (letters) than eyes with IRF without CME and eyes with neither CME nor IRF (52 vs. 60 vs. 66 letters, P < 0.001).

Comparative StudyResearch that compares multiple groups/interventions to determine differences/similarities in outcomes/characteristics.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Multicenter StudyResearch conducted in collaboration with multiple research institutions. It aims to collect a wide range of data and obtain more generalizable results.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.
Research Support, N.I.H., ExtramuralResearch funding provided by the NIH to external research institutions and researchers.

Language : English

70.

Macular Morphology and Visual Acuity in the Second Year of the Comparison of Age-Related Macular Degeneration Treatments Trials.

Author: SharmaSumit, TothCynthia A, DanielEbenezer, GrunwaldJuan E, MaguireMaureen G, YingGui-Shuang, HuangJiayan, MartinDaniel F, JaffeGlenn J,

Fluid reduction
VA improvement

In the second year of the Comparison of Age-related Macular Degeneration Treatments Trials (CATT), eyes with foveal intraretinal fluid, abnormally thin retina, greater thickness of the subretinal tissue complex, and subfoveal geographic atrophy or scar had the worst visual acuity. Subretinal fluid was associated with better visual acuity.

Comparative StudyResearch that compares multiple groups/interventions to determine differences/similarities in outcomes/characteristics.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Multicenter StudyResearch conducted in collaboration with multiple research institutions. It aims to collect a wide range of data and obtain more generalizable results.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.
Research Support, N.I.H., ExtramuralResearch funding provided by the NIH to external research institutions and researchers.

Language : English

71.

Patterns of Early and Delayed Visual Response to Ranibizumab Treatment for Neovascular Age-Related Macular Degeneration.

Author: StollerGlenn L, KokameGregg T, DreyerRichard F, ShapiroHoward, TuomiLisa L

Vision improvement

In patients with neovascular age-related macular degeneration, improvement of 15 letters or more from baseline occurred in 25.2% of patients within 3 months of beginning ranibizumab treatment, whereas an additional 13.7% achieved this gain by 12 months. PRN treatment with monthly monitoring was effective in maintaining early vision gains and allowing delayed vision gains.

Clinical Trial, Phase IIIA Phase III trial is a trial that further rigorously verifies the efficacy and safety of a new drug or treatment, whose efficacy and safety have been confirmed in a Phase II trial, in a large number of patients, and evaluates whether it is superior to existing treatments.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Multicenter StudyResearch conducted in collaboration with multiple research institutions. It aims to collect a wide range of data and obtain more generalizable results.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.

Language : English

72.

Five-Year Outcomes with Anti-Vascular Endothelial Growth Factor Treatment of Neovascular Age-Related Macular Degeneration: The Comparison of Age-Related Macular Degeneration Treatments Trials.

Author: , MaguireMaureen G, MartinDaniel F, YingGui-Shuang, JaffeGlenn J, DanielEbenezer, GrunwaldJuan E, TothCynthia A, FerrisFrederick L, FineStuart L

Neovascular AMD treatment

Vision gains achieved during the first 2 years of anti-vascular endothelial growth factor therapy were not maintained at 5 years, but 50% of eyes still had visual acuity of 20/40 or better.

Comparative StudyResearch that compares multiple groups/interventions to determine differences/similarities in outcomes/characteristics.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.
Research Support, N.I.H., ExtramuralResearch funding provided by the NIH to external research institutions and researchers.

Language : English

73.

Comparing the Effectiveness of Bevacizumab to Ranibizumab in Patients with Exudative Age-Related Macular Degeneration. The BRAMD Study.

Author: SchauwvliegheA M E, DijkmanG, HooymansJ M, VerbraakF D, HoyngC B, DijkgraafM G W, PetoT, VingerlingJ R, SchlingemannR O

Improved BCVA
Similar safety
Retinal fluid
Varied response

Bevacizumab was not inferior to ranibizumab in the treatment of exudative age-related macular degeneration. The response to bevacizumab was more varied, with higher percentages of both gainers and losers and more frequently observed retinal fluid on SD-OCT at 12 months compared to the ranibizumab group.

Comparative StudyResearch that compares multiple groups/interventions to determine differences/similarities in outcomes/characteristics.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Multicenter StudyResearch conducted in collaboration with multiple research institutions. It aims to collect a wide range of data and obtain more generalizable results.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.

Language : English

74.

Surgery for cataracts in people with age-related macular degeneration.

Author: CasparisHeather, LindsleyKristina, KuoIrene C, SikderShameema, BresslerNeil M

Cataract treatment
AMD worsening

Cataracts and age-related macular degeneration (AMD) are common vision problems in older adults. While cataract surgery improves vision loss caused by cataracts, some doctors believe it may worsen AMD, leading to poorer vision overall. This study aims to investigate whether cataract surgery increases the risk of worsening AMD.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Meta-AnalysisA statistical technique that integrates the results of multiple studies to draw more general conclusions about a particular issue.
Research Support, N.I.H., ExtramuralResearch funding provided by the NIH to external research institutions and researchers.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.
ReviewAn article that critically examines existing research on a particular topic and summarizes the current state of knowledge in the field.
Systematic ReviewA review that systematically collects, evaluates, and integrates relevant research to answer a specific research question.

Language : English

75.

Association between polymorphism rs11200638 in the HTRA1 gene and the response to anti-VEGF treatment of exudative AMD: a meta-analysis.

Author: ZhouYa-Li, ChenChun-Li, WangYi-Xiao, TongYao, FangXiao-Ling, LiLin, WangZhao-Yang

This study discussed the use of anti-angiogenesis treatments, particularly anti-vascular endothelial growth factor (VEGF) drugs like ranibizumab and bevacizumab, for exudative age-related macular degeneration (AMD), acknowledging the variability in treatment response.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Meta-AnalysisA statistical technique that integrates the results of multiple studies to draw more general conclusions about a particular issue.
ReviewAn article that critically examines existing research on a particular topic and summarizes the current state of knowledge in the field.

Language : English

76.

Tracing the natural course of visual acuity and quality of life in neovascular age-related macular degeneration: a systematic review and quality of life study.

Author: ElshoutMari, WebersCarroll A, van der ReisMargriet I, de Jong-HesseYvonne, SchoutenJan S

nAMD prognosis
Quality of life impact
Vision decline

Visual acuity in the best eye decreases to below 0.5 in 4.3 years, which affects QoL significantly.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
ReviewAn article that critically examines existing research on a particular topic and summarizes the current state of knowledge in the field.
Systematic ReviewA review that systematically collects, evaluates, and integrates relevant research to answer a specific research question.

Language : English

77.

Understanding AMD by analogy: systematic review of lipid-related common pathogenic mechanisms in AMD, AD, AS and GN.

Author: XuQinyuan, CaoSijia, RajapakseSanjeeva, MatsubaraJoanne A

AMD treatment

This study explores the commonalities between age-related macular degeneration (AMD), Alzheimer's disease, atherosclerosis, and glomerulonephritis, suggesting that understanding these shared pathways might provide insights into AMD etiology.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
ReviewAn article that critically examines existing research on a particular topic and summarizes the current state of knowledge in the field.
Systematic ReviewA review that systematically collects, evaluates, and integrates relevant research to answer a specific research question.

Language : English

78.

Efficacy and Safety of Ranibizumab 0.5 mg for the Treatment of Macular Edema Resulting from Uncommon Causes: Twelve-Month Findings from PROMETHEUS.

Author: StaurenghiGiovanni, LaiTimothy Y Y, MitchellPaul, WolfSebastian, WenzelAndreas, LiJun, BhaumikAmitabha, HykinPhilip G,

Ranibizumab for ME
Ranibizumab for post-cataract ME
Ranibizumab for post-uveitis ME

Ranibizumab showed superiority in BCVA gain over sham in treating ME due to uncommon causes.

Clinical Trial, Phase IIIA Phase III trial is a trial that further rigorously verifies the efficacy and safety of a new drug or treatment, whose efficacy and safety have been confirmed in a Phase II trial, in a large number of patients, and evaluates whether it is superior to existing treatments.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Multicenter StudyResearch conducted in collaboration with multiple research institutions. It aims to collect a wide range of data and obtain more generalizable results.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.

Language : English

79.

Influence of the Vitreoretinal Interface on the Treatment with Anti-VEGF for Exudative Age-Related Macular Degeneration.

Author: GilPedro, GilJoão, OliveiraNuno, LaínsInês, CamiloEduardo Nery Rossi, FonsecaCristina, RaimundoMiguel, CachuloMaria da Luz, SilvaRufino

Improved visual acuity

This study investigated the influence of the vitreoretinal interface on the outcomes of different ranibizumab regimens for exudative age-related macular degeneration. Patients with posterior vitreous detachment (PVD) showed greater visual improvement than those without PVD, especially in the pro-re-nata (PRN) regimen. However, monthly dosing provided similar outcomes for both groups. This suggests that PRN should be avoided in the absence of PVD, and treat and extend (T&amp;E) might be an alternative.

Clinical Trial, Phase IIIA Phase III trial is a trial that further rigorously verifies the efficacy and safety of a new drug or treatment, whose efficacy and safety have been confirmed in a Phase II trial, in a large number of patients, and evaluates whether it is superior to existing treatments.
Clinical Trial, Phase IVPost-marketing surveillance. Monitors long-term safety/efficacy after approval.
Comparative StudyResearch that compares multiple groups/interventions to determine differences/similarities in outcomes/characteristics.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Multicenter StudyResearch conducted in collaboration with multiple research institutions. It aims to collect a wide range of data and obtain more generalizable results.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.

Language : English

80.

Therapeutic effects of various therapeutic strategies on non-exudative age-related macular degeneration: A PRISMA-compliant network meta-analysis of randomized controlled trials.

Author: WeiYanli, LiaoHongxia, YeJian

Improved DAMD treatment

Age-related macular degeneration (AMD) is a chronic eye disease that can lead to blindness. Geographic atrophy (GA) is a late stage of the dry form of AMD, and it causes permanent vision loss over time. This study aims to assess different treatment strategies for AMD, including those that focus on preventing and treating GA.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Meta-AnalysisA statistical technique that integrates the results of multiple studies to draw more general conclusions about a particular issue.
ReviewAn article that critically examines existing research on a particular topic and summarizes the current state of knowledge in the field.

Language : English

81.

Treatments for dry age-related macular degeneration and Stargardt disease: a systematic review.

Author: WaughNorman, LovemanEmma, ColquittJill, RoylePamela, YeongJian Lee, HoadGeraldine, LoisNoemi

Vision preservation
Visual impairment

There is a need for more good-quality studies regarding treatments for dry AMD and STGD. Promising research topics include drug treatments, stem cells, new forms of laser treatment, and implantable intraocular lens telescopes.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.
Systematic ReviewA review that systematically collects, evaluates, and integrates relevant research to answer a specific research question.

Language : English

82.

Macular Morphology and Visual Acuity in Year Five of the Comparison of Age-related Macular Degeneration Treatments Trials.

Author: JaffeGlenn J, YingGui-Shuang, TothCynthia A, DanielEbenezer, GrunwaldJuan E, MartinDaniel F, MaguireMaureen G,

Improved visual acuity

Subretinal hyper-reflective material (SHRM), thinner retina, greater choroidal neovascularization (CNV) lesion area, foveal center pathology, and intraretinal fluid (IRF) were independently associated with worse visual acuity (VA) in patients with age-related macular degeneration (AMD). VA was significantly lower in patients with geographic atrophy (GA) and fibrotic scars compared to those without. New foveal scar, CNV, IRF, SHRM, and retinal thinning, development or worsening of foveal GA, and increased lesion size were associated with greater VA loss.

Comparative StudyResearch that compares multiple groups/interventions to determine differences/similarities in outcomes/characteristics.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.
Research Support, N.I.H., ExtramuralResearch funding provided by the NIH to external research institutions and researchers.

Language : English

83.

Five-Year Follow-up of Nonfibrotic Scars in the Comparison of Age-Related Macular Degeneration Treatments Trials.

Author: DanielEbenezer, YingGui-Shuang, KimBenjamin J, TothCynthia A, FerrisFrederick, MartinDaniel F, GrunwaldJuan E, JaffeGlenn J, DunaiefJoshua L, PanWei, MaguireMaureen G,

GA prevention
Visual acuity
Fibrotic scar
NGA development

This prospective cohort study assessed changes in visual acuity (VA) and macular morphologic features at 5 years in eyes with nonfibrotic scar (NFS) identified at 1 year in the Comparison of Age-Related Macular Degeneration Treatments Trials (CATT). Eyes with NFS after anti-VEGF treatment had good VA through 5 years.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Multicenter StudyResearch conducted in collaboration with multiple research institutions. It aims to collect a wide range of data and obtain more generalizable results.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.
Research Support, N.I.H., ExtramuralResearch funding provided by the NIH to external research institutions and researchers.

Language : English

84.

Effectiveness of monthly and fortnightly anti-VEGF treatments for age-related macular degeneration.

Author: NunesRenata Portella, HiraiFlávio Eduardo, BarrosoLetícia Fernandes, BadaróEmmerson, NovaisEduardo, RodriguesEduardo Buchele, MaiaMauricio, MagalhãesOctaviano, FarahMichel Eid

Improved visual acuity
Reduced macular thickness

This study compared the efficacy and safety of three treatment regimens for exudative age-related macular degeneration: bevacizumab every month, bevacizumab every 2 weeks, and ranibizumab every month. After one year of follow-up, all groups showed statistically significant improvements in visual acuity and central macular thickness reduction. However, no statistically significant differences were found between the three groups, suggesting that bi-weekly bevacizumab is effective and both drugs are comparable in efficacy and safety.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.

Language : English

85.

Preventing Progression in Nonexudative Age-Related Macular Degeneration With Subthreshold Laser Therapy: A Systematic Review.

Author: EngVictor A, WoodEdward H, BodduSucharita, KarthPeter A, LengTheodore

Improved nonexudative AMD treatment

This review summarized the published literature on subthreshold retinal laser therapy as a prophylactic treatment for nonexudative age-related macular degeneration (AMD), exploring its potential to prevent vision loss.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Systematic ReviewA review that systematically collects, evaluates, and integrates relevant research to answer a specific research question.

Language : English

86.

Anti-vascular endothelial growth factor treatment for retinal conditions: a systematic review and meta-analysis.

Author: PhamBa', ThomasSonia M, LillieErin, LeeTaehoon, HamidJemila, RichterTrevor, JanoudiGhayath, AgarwalArnav, SharpeJane P, ScottAlistair, WarrenRachel, BrahmbhattRonak, MacdonaldErin, StrausSharon E, TriccoAndrea C

Eye disease treatment
Intravitreal injections

This review evaluated the comparative effectiveness and safety of three intravitreal medications, bevacizumab, ranibizumab, and aflibercept, for treating various macular diseases including choroidal neovascular age-related macular degeneration (cn-AMD), diabetic macular edema (DMO), macular edema due to retinal vein occlusion (RVO-MO), and myopic choroidal neovascularisation (m-CNV). The review aimed to provide insights into the relative benefits and risks of these medications for different macular conditions.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Meta-AnalysisA statistical technique that integrates the results of multiple studies to draw more general conclusions about a particular issue.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.
Systematic ReviewA review that systematically collects, evaluates, and integrates relevant research to answer a specific research question.

Language : English

87.

Secondary and Exploratory Outcomes of the Subthreshold Nanosecond Laser Intervention Randomized Trial in Age-Related Macular Degeneration: A LEAD Study Report.

Author: WuZhichao, LuuChi D, HodgsonLauren A B, CarusoEmily, BrassingtonKate H, TindillNicole, AungKhin Zaw, HarperColin A, WickremasingheSanjeewa S, SandhuSukhpal S, McGuinnessMyra B, ChenFred K, ChakravarthyUsha, ArnoldJennifer J, HeriotWilson J, DurkinShane R, WintergerstMaximilian W M, Gorgi ZadehShekoufeh, SchultzThomas, FingerRobert P, CohnAmy C, BaglinElizabeth K, SharanganPyrawy, GuymerRobyn H,

Slowing AMD progression

This study evaluated the secondary and exploratory outcomes of the Laser Intervention in Early Stages of Age-Related Macular Degeneration (LEAD) study, which investigated the use of subthreshold nanosecond laser (SNL) treatment for slowing the progression of age-related macular degeneration (AMD).

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Multicenter StudyResearch conducted in collaboration with multiple research institutions. It aims to collect a wide range of data and obtain more generalizable results.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.

Language : English

88.

Are Dilated Fundus Examinations Needed for OCT-Guided Retreatment of Exudative Age-Related Macular Degeneration?

Author: PatelYogin, MillerDaniel M, FungAnne E, HillLauren F, RosenfeldPhilip J

Improved vision outcomes

The study explored the impact of macular hemorrhage on visual outcomes in patients with neovascular age-related macular degeneration (nAMD) treated with OCT-guided pro re nata (PRN) ranibizumab. The research investigated whether the presence of hemorrhage without detectable fluid on OCT influenced visual outcomes, providing insights into the role of hemorrhage in treatment decisions.

Clinical Trial, Phase IIIA Phase III trial is a trial that further rigorously verifies the efficacy and safety of a new drug or treatment, whose efficacy and safety have been confirmed in a Phase II trial, in a large number of patients, and evaluates whether it is superior to existing treatments.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Multicenter StudyResearch conducted in collaboration with multiple research institutions. It aims to collect a wide range of data and obtain more generalizable results.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.

Language : English

89.

Nonexudative Macular Neovascularization - A Systematic Review of Prevalence, Natural History, and Recent Insights from OCT Angiography.

Author: LaiginhasRita, YangJin, RosenfeldPhilip J, FalcãoManuel

Slowed GA progression
Exudative AMD risk

A review of 12 studies using optical coherence tomography angiography (OCTA) to evaluate subclinical nonexudative macular neovascularization (MNV) in patients with age-related macular degeneration (AMD) found a prevalence of 6.25% to 27%. While nonexudative MNV may be a precursor to exudative AMD, it also appears to have a protective effect in slowing the progression of geographic atrophy (GA).

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Research Support, N.I.H., ExtramuralResearch funding provided by the NIH to external research institutions and researchers.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.
Systematic ReviewA review that systematically collects, evaluates, and integrates relevant research to answer a specific research question.

Language : English

90.

Treatment regimens for administration of anti-vascular endothelial growth factor agents for neovascular age-related macular degeneration.

Author: LiEmily, DonatiSimone, LindsleyKristina B, KrzystolikMagdalena G, VirgiliGianni

Improved nAMD treatment

This study investigates the optimal approach to managing neovascular AMD (nAMD), considering the varying injection frequencies of anti-vascular endothelial growth factor (anti-VEGF) agents (aflibercept, ranibizumab, and bevacizumab).

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Meta-AnalysisA statistical technique that integrates the results of multiple studies to draw more general conclusions about a particular issue.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.
Systematic ReviewA review that systematically collects, evaluates, and integrates relevant research to answer a specific research question.

Language : English

91.

Radiotherapy for neovascular age-related macular degeneration.

Author: EvansJennifer R, IgweChinedu, JacksonTimothy L, ChongVictor

The evidence regarding the use of radiotherapy for neovascular age-related macular degeneration (AMD) is uncertain. Most studies were conducted before the widespread use of anti-VEGF therapy and modern radiotherapy techniques, making it difficult to draw definitive conclusions.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Meta-AnalysisA statistical technique that integrates the results of multiple studies to draw more general conclusions about a particular issue.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.
Systematic ReviewA review that systematically collects, evaluates, and integrates relevant research to answer a specific research question.

Language : English

92.

Visual cycle modulators versus placebo or observation for the prevention and treatment of geographic atrophy due to age-related macular degeneration.

Author: YeongJian Lee, LovemanEmma, ColquittJill L, RoylePamela, WaughNorman, LoisNoemi

AMD treatment

Age-related macular degeneration (AMD) is a common eye condition, especially in older people. Advanced AMD can cause serious vision loss. One type of AMD called geographic atrophy has no effective treatment, while another type, neovascular AMD, is treated with injections. Geographic atrophy progresses slowly, giving doctors time to test new treatments. One promising treatment is visual cycle modulators, which have been shown to reduce harmful substances in the eye in early studies. This review examines the research on these medications and clinical trials.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Meta-AnalysisA statistical technique that integrates the results of multiple studies to draw more general conclusions about a particular issue.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.
Systematic ReviewA review that systematically collects, evaluates, and integrates relevant research to answer a specific research question.

Language : English

94.

Dose Response in the Subthreshold Nanosecond Laser Trial in Early Stages of AMD: A LEAD Study Report.

Author: CohnAmy C, RuncimanJim, HodgsonLauren A B, CarusoEmily, ArnoldJennifer J, ChenFred K, ChakravarthyUsha, HeriotWilson J, GuymerRobyn H, WuZhichao,

Slow disease progression

This study examined the relationship between treatment parameters and the progression of late age-related macular degeneration (AMD) in the Laser Intervention in Early Stages of Age-Related Macular Degeneration (LEAD) study. The LEAD study was a randomized, controlled trial of a subthreshold nanosecond laser (SNL) for slowing disease progression in the early stages of AMD.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.

Language : English

95.

Electrophysiological evaluation and 18-month follow-up of two regimens with aflibercept for neovascular age-related macular degeneration.

Author: SchroederMarion, KjellströmUlrika, Lövestam-AdrianMonica

Improved visual acuity
Reduced central retinal thickness
Rod function decline

This randomized clinical trial compared two aflibercept treatment regimens for age-related macular degeneration (nAMD) over 18 months. Both treatment arms received a similar number of injections at comparable intervals. Electrophysiological evaluation showed no signs of toxicity concerning cone function, but the combined and isolated rod response declined, possibly reflecting either toxic effects of the drug to rods or the natural course of the disease.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.

Language : English

96.

Hyperreflective Material Boundary Remodeling in Neovascular Age-Related Macular Degeneration: A Post Hoc Analysis of the AVENUE Trial.

Author: YuSiqing, BachmeierIsabel, Hernandez-SanchezJules, Garcia ArmendarizBeatriz, EbneterAndreas, PauleikhoffDaniel, ChakravarthyUsha, FauserSascha

Improved BCVA
Macular atrophy

In patients with neovascular age-related macular degeneration (nAMD) under antiangiogenic treatment, hyperreflective material boundary remodeling (HRM-BR) was associated with better visual acuity outcomes.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Multicenter StudyResearch conducted in collaboration with multiple research institutions. It aims to collect a wide range of data and obtain more generalizable results.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.

Language : English

97.

Clinical effectiveness of screening for age-related macular degeneration: A systematic review.

Author: GomesDalila Fernandes, CuradoDaniel da Silva Pereira, GomesRosângela Maria, LeiteBetânia Ferreira, RamosMaíra Catharina, SilvaEverton Nunes da

AMD detection

Age-related macular degeneration (AMD) is an eye disease that affects older people. Early detection is crucial for effective treatment, but AMD doesn't cause symptoms in its early stages. This study suggests that screening for AMD in certain situations can help diagnose the disease sooner, reducing its impact on vision and quality of life.

Systematic ReviewA review that systematically collects, evaluates, and integrates relevant research to answer a specific research question.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.

Language : English

This site uses cookies. Visit our privacy policy page or click the link in any footer for more information and to change your preferences.