Apremilast, an oral phosphodiesterase 4 inhibitor, in patients with psoriatic arthritis and current skin involvement: a phase III, randomised, controlled trial (PALACE 3).

Author: AelionJacob, BirbaraCharles A, BirdPaul, BlancoFrancisco J, CrowleyJeffrey, EdwardsChristopher J, JaworskiJanusz, StevensRandall M, VesseyAdele, ZhanXiaojiang

Paper Details 
Original Abstract of the Article :
OBJECTIVE: To evaluate apremilast treatment in patients with active psoriatic arthritis, including current skin involvement, despite prior therapy with conventional disease-modifying antirheumatic drugs and/or biologic agents. METHODS: Patients (N=505) were randomised (1:1:1) to placebo, apremilast...See full text at original site
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引用元:
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4893110/

データ提供:米国国立医学図書館(NLM)

Apremilast: A Oasis of Relief for Psoriatic Arthritis

Psoriatic arthritis, a chronic inflammatory disease, can feel like traversing a desert of pain and discomfort. This research explores a potential oasis of relief – apremilast, an oral phosphodiesterase 4 inhibitor. The researchers conducted a phase III, randomized controlled trial, like a scientific expedition, to assess the efficacy and safety of apremilast in patients with active psoriatic arthritis.

Apremilast: A Beacon of Hope for Psoriatic Arthritis

The research showed that apremilast can provide significant relief from psoriatic arthritis symptoms, like finding a hidden spring in the desert. The study, like a map of the desert, reveals that apremilast can improve both joint pain and skin lesions, leading to a better quality of life. It's like finding a cool breeze in the desert – a welcome respite from the heat of inflammation.

Managing Psoriatic Arthritis with Apremilast

This research provides hope for patients struggling with psoriatic arthritis, suggesting that apremilast can be a valuable tool in their journey to manage this complex disease. However, like any treatment, it's important to work closely with a healthcare professional to determine if apremilast is right for you and to monitor for any potential side effects.

Dr.Camel's Conclusion

Apremilast, like a well-placed oasis, can provide significant relief from psoriatic arthritis symptoms, offering a glimmer of hope for those navigating the challenges of this chronic disease.

Date :
  1. Date Completed 2017-05-23
  2. Date Revised 2022-04-09
Further Info :

Pubmed ID

26792812

DOI: Digital Object Identifier

PMC4893110

Related Literature

SNS
PICO Info
in preparation
Languages

English

Positive IndicatorAn AI analysis index that serves as a benchmark for how positive the results of the study are. Note that it is a benchmark and requires careful interpretation and consideration of different perspectives.

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