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Clinical Outcomes and Survival Following Treatment of Metastatic Castrate-Refractory Prostate Cancer With Docetaxel Alone or With Strontium-89, Zoledronic Acid, or Both: The TRAPEZE Randomized Clinical Trial.

Author: AndronisLazaros, BartonDarren, BeesleySharon, BillinghamLucinda J, BirtleAlison, BrownJanet, ChakrabortiPrabir, CollinsStuart, DauntonAdam, GoranitisIlias, HussainSyed, JamesNicholas D, McLarenDuncan, O'SullivanJoe, ParkerChristopher, PirrieSarah J, PopeAnn M, PorfiriEmilio, RussellMartin, StaffurthJohn, StanleyAndrew, WylieJames

Clinical Trial, Phase IIIA Phase III trial is a trial that further rigorously verifies the efficacy and safety of a new drug or treatment, whose efficacy and safety have been confirmed in a Phase II trial, in a large number of patients, and evaluates whether it is superior to existing treatments.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Multicenter StudyResearch conducted in collaboration with multiple research institutions. It aims to collect a wide range of data and obtain more generalizable results.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.

Overview

A clinical trial is evaluating the combination of zoledronic acid and strontium-89 for treating bone metastases in prostate cancer.
Paper Details　
Original Abstract of the Article :
Bony metastatic castrate-refractory prostate cancer (CRPC) has a poor prognosis and high morbidity. Zoledronic acid (ZA) is commonly combined with docetaxel in practice but lacks evidence that combining is effective, and strontium-89 (Sr89) is generally used palliatively in patients unfit for chemot...See full text at original site
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引用元：
https://doi.org/10.1001/jamaoncol.2015.5570

データ提供：米国国立医学図書館（NLM）

Combating Metastatic Castrate-Refractory Prostate Cancer: TRAPEZE Trial Explores Treatment Options

[Metastatic castrate-refractory prostate cancer (CRPC)] is a challenging condition with a poor prognosis. This study investigates the effectiveness of various treatment combinations for [CRPC]. The TRAPEZE trial, a [randomized clinical trial], aims to assess the survival benefits of different therapeutic strategies, including [Docetaxel alone], [Docetaxel with Strontium-89], [Docetaxel with Zoledronic acid], and [Docetaxel with both Strontium-89 and Zoledronic acid]. This research holds significant implications for the treatment of [CRPC], potentially leading to improved outcomes and quality of life for patients.

TRAPEZE Trial Offers New Insights into CRPC Treatment

The TRAPEZE trial provides valuable insights into the management of [CRPC]. While the study is ongoing, early findings suggest that combining [Docetaxel] with [Zoledronic acid] is [safe and feasible]. The trial also aims to assess the impact of these treatments on survival, offering potential hope for extending life expectancy and improving overall health for patients with [CRPC].

Navigating the Desert of Prostate Cancer Treatment

This study represents a crucial step in the ongoing quest for effective [CRPC] treatments. The TRAPEZE trial provides valuable data on the safety and potential efficacy of different therapeutic approaches. This research underscores the commitment of researchers to develop innovative strategies to combat this challenging disease, offering a beacon of hope in the vast desert of prostate cancer treatment.

Dr.Camel's Conclusion

Like a camel traversing the vast desert, the fight against [CRPC] requires resilience and innovation. The TRAPEZE trial serves as an important research expedition, exploring different pathways in the search for effective treatments. The study's findings hold promise for improving outcomes and providing a glimmer of hope for patients facing this challenging diagnosis.

Date :
  1. Date Completed 2016-09-08
  2. Date Revised 2022-03-31
Further Info :

Pubmed ID

26794729

DOI: Digital Object Identifier

10.1001/jamaoncol.2015.5570

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Article Analysis
・Effects of strontium-89 chloride
SNS
PICO Info
in preparation
Languages

English

Positive IndicatorAn AI analysis index that serves as a benchmark for how positive the results of the study are. Note that it is a benchmark and requires careful interpretation and consideration of different perspectives.

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