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Effects of probenecid and cimetidine on the pharmacokinetics of nemonoxacin in healthy Chinese volunteers.

Author: ChangLi-Wen, ChangYu-Ting, ChenXiao-Yan, DaiXiao-Jian, TangYun-Biao, TsaiCheng-Yuan, WangTing, YangYong, ZhangYi-Fan, ZhongDa-Fang

Comparative StudyResearch that compares multiple groups/interventions to determine differences/similarities in outcomes/characteristics.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.

Overview

Probenecid reduced the renal clearance and increased the plasma exposure of nemonoxacin by 22.6% and 26.2%, respectively, but these effects are unlikely to be clinically meaningful at therapeutic doses. Cimetidine had weaker effects on the pharmacokinetics of nemonoxacin, which are also unlikely to be clinically meaningful.
Paper Details　
Original Abstract of the Article :
PURPOSE: To investigate the effects of probenecid and cimetidine on the pharmacokinetics of nemonoxacin in humans. METHODS: Two independent, open-label, randomized, crossover studies were conducted in 24 (12 per study) healthy Chinese volunteers. In Study 1, each volunteer received a single oral do...See full text at original site
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引用元：
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4725632/

データ提供：米国国立医学図書館（NLM）

Probenecid and Cimetidine: Impact on the Pharmacokinetics of Nemonoxacin

Pharmacokinetics, the study of how drugs move through the body, is a critical aspect of drug development and patient safety. This study investigates the potential interactions between nemonoxacin, an antibiotic, and two commonly used drugs, probenecid and cimetidine. The authors explore how these co-administrations affect the pharmacokinetic profile of nemonoxacin in healthy volunteers.

Co-Administration Effects: A Closer Look at Drug Interactions

The study reveals that both probenecid and cimetidine, when co-administered with nemonoxacin, reduce its renal clearance and increase its plasma exposure. However, the researchers conclude that these effects are unlikely to be clinically significant at therapeutic doses. Imagine probenecid and cimetidine as desert winds, slightly influencing the course of nemonoxacin's journey through the body, but not significantly altering its overall trajectory.

Navigating Drug Interactions: Ensuring Patient Safety

The study emphasizes the importance of understanding potential drug interactions, particularly when co-administering medications. While the observed effects of probenecid and cimetidine on nemonoxacin pharmacokinetics may be minor, it is crucial to be aware of such interactions to ensure patient safety and optimize drug efficacy. The study serves as a reminder that the desert of drug interactions can be unpredictable, and navigating this landscape requires careful attention to detail and a thorough understanding of drug interactions.

Dr.Camel's Conclusion

This study explores the potential interactions between nemonoxacin and two commonly used drugs, probenecid and cimetidine. While co-administration slightly alters nemonoxacin's pharmacokinetic profile, the effects are unlikely to be clinically significant at therapeutic doses. This study reinforces the importance of understanding drug interactions to ensure patient safety and optimize treatment outcomes.
Date :
  1. Date Completed 2016-10-11
  2. Date Revised 2022-12-07
Further Info :

Pubmed ID

26855561

DOI: Digital Object Identifier

PMC4725632

Related Literature

Article Analysis
・Effects of probenecid・Effects of cimetidine
SNS
PICO Info
in preparation
Languages

English

Positive IndicatorAn AI analysis index that serves as a benchmark for how positive the results of the study are. Note that it is a benchmark and requires careful interpretation and consideration of different perspectives.

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