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Effects of simvastatin, ezetimibe and simvastatin/ezetimibe on mitochondrial function and leukocyte/endothelial cell interactions in patients with hypercholesterolemia.

Author: AlvarezAngeles, BañulsCelia, Diaz-MoralesNoelia, Escribano-LopezIrene, Hernandez-MijaresAntonio, RochaMilagros, Rovira-LlopisSusana, VesesSilvia, VictorVictor M, de PabloCarmen

Comparative StudyResearch that compares multiple groups/interventions to determine differences/similarities in outcomes/characteristics.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.

Overview

Co-administration of simvastatin and ezetimibe has an additive cholesterol-lowering effect and beneficial consequences for mitochondrial function and leukocyte/endothelium interactions in leukocytes of hypercholesterolemic patients. An improvement in lipid profile was observed after administration of simvastatin or ezetimibe alone (LDLc: -40.2 vs -19.6%, respectively), though this effect was stronger with the former (p < 0.001), and a further reduction was registered when the two were combined (LDLc: -50.7% vs -56.8%, respectively).
Paper Details　
Original Abstract of the Article :
BACKGROUND: Cholesterol-lowering therapy has been related with several beneficial effects; however, its influence on oxidative stress and endothelial function is not fully elucidated. AIMS: To investigate the effect of simvastatin and ezetimibe on mitochondrial function and leukocyte-endothelium in...See full text at original site
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引用元：
https://doi.org/10.1016/j.atherosclerosis.2016.01.044

データ提供：米国国立医学図書館（NLM）

Cholesterol-Lowering Therapy and Mitochondrial Function

This study investigates the effects of simvastatin and ezetimibe, common cholesterol-lowering medications, on mitochondrial function and leukocyte-endothelium interactions in hyperlipidemic patients. The study found that both simvastatin and ezetimibe, individually and in combination, significantly improved mitochondrial function by increasing oxygen consumption, membrane potential, and glutathione content, while decreasing reactive oxygen species (ROS) levels. The study also found that combined therapy with simvastatin and ezetimibe had a positive effect on leukocyte-endothelium interactions, reducing leukocyte adhesion and increasing rolling velocity.

The Benefits of Cholesterol-Lowering Therapy

This study offers valuable insights into the benefits of cholesterol-lowering therapy beyond simply reducing cholesterol levels. It's like discovering a hidden oasis in the desert of cardiovascular health, where these medications not only quench thirst but also revitalize the entire ecosystem. The study's findings highlight the potential for these medications to improve mitochondrial function and reduce inflammation.

Cardiovascular Health and Cholesterol Management

This study emphasizes the importance of managing cholesterol levels for overall cardiovascular health. It is crucial to discuss cholesterol management strategies with your healthcare provider to determine the best approach for your needs. This research provides evidence that cholesterol-lowering therapies may offer broader benefits beyond simply reducing cholesterol levels.

Dr.Camel's Conclusion

This study shows that cholesterol-lowering therapy is not just about lowering numbers; it's about improving the entire landscape of cardiovascular health. It's like nurturing a thriving oasis in the desert, promoting a healthier and more resilient ecosystem.

Date :
  1. Date Completed 2016-12-26
  2. Date Revised 2022-03-31
Further Info :

Pubmed ID

26868507

DOI: Digital Object Identifier

10.1016/j.atherosclerosis.2016.01.044

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・Effective treatment of cholesterol
SNS
PICO Info
in preparation
Languages

English

Positive IndicatorAn AI analysis index that serves as a benchmark for how positive the results of the study are. Note that it is a benchmark and requires careful interpretation and consideration of different perspectives.

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