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Gastroprotective effects of several H2RAs on ibuprofen-induced gastric ulcer in rats.

Author: CaoHua, ChengPing, GuoGang, HeGu, HeJinfeng, HuTingting, LiuJing, LuoYoufu, SongXiangrong, SunDan, TongAi-Ping, XieYongmei, YangChengli, ZhangLijing, ZhengYu

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.

Overview

This study investigated the gastric protective effects of histamine-2 receptor antagonists (H2RAs) in combination with ibuprofen. Nizatidine showed the best protective effect without significant toxicity and is a good option for combination therapy.
Paper Details　
Original Abstract of the Article :
Ibuprofen is the first line of treatment for osteoarthritis and arthritis. The main side effects of ibuprofen especially in long-term treatment include gastric ulcer, duodenal ulcer and indigestion etc. Therefore, screening drugs with effective gastric protective effects and low toxicity for combina...See full text at original site
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引用元：
https://doi.org/10.1016/j.lfs.2016.02.045

データ提供：米国国立医学図書館（NLM）

H2RAs: Protecting the Stomach from Ibuprofen's Irritating Effects

The use of nonsteroidal anti-inflammatory drugs (NSAIDs) like ibuprofen is widespread for managing pain and inflammation. However, these drugs can have adverse effects on the gastrointestinal tract, leading to ulcers and other complications. This study explores the gastroprotective effects of several H2 receptor antagonists (H2RAs) in mitigating ibuprofen-induced gastric ulcers in rats. The researchers compared the efficacy of four different H2RAs in protecting against ibuprofen-induced gastric damage, providing valuable insights into the potential for these drugs to reduce gastrointestinal side effects.

Nizatidine: A Promising Gastroprotective Agent

The study found that nizatidine, one of the four H2RAs evaluated, exhibited the most potent gastroprotective effects. Nizatidine effectively reduced the gastric ulcer index, decreased lipid peroxidation, and enhanced antioxidant enzyme activity, suggesting its ability to protect against oxidative stress and cellular damage caused by ibuprofen. These findings highlight the potential of nizatidine as a valuable adjunct to ibuprofen therapy, reducing the risk of gastrointestinal complications.

Protecting Your Stomach: A Wise Choice

Just as a camel adapts its digestive system to survive in the desert, so too must individuals taking NSAIDs consider the potential for gastrointestinal complications. This study suggests that H2RAs, particularly nizatidine, may offer effective protection against ibuprofen-induced gastric damage, promoting safer and more comfortable use of these essential medications. It's important to discuss any concerns about gastrointestinal health with your healthcare provider.

Dr.Camel's Conclusion

This research provides a valuable reminder that even common medications can have unintended consequences. It highlights the importance of understanding the potential side effects of drugs and seeking out appropriate management strategies to minimize those risks.

Date :
  1. Date Completed 2016-07-28
  2. Date Revised 2016-03-15
Further Info :

Pubmed ID

26883979

DOI: Digital Object Identifier

10.1016/j.lfs.2016.02.045

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Languages

English

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